Incidental Mutation 'R1536:Vmn2r27'
ID 169525
Institutional Source Beutler Lab
Gene Symbol Vmn2r27
Ensembl Gene ENSMUSG00000072778
Gene Name vomeronasal 2, receptor27
Synonyms EG232367
MMRRC Submission 039575-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R1536 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 124191596-124231784 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 124200690 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 452 (R452G)
Ref Sequence ENSEMBL: ENSMUSP00000098528 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100968]
AlphaFold D3YUK6
Predicted Effect probably damaging
Transcript: ENSMUST00000100968
AA Change: R452G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000098528
Gene: ENSMUSG00000072778
AA Change: R452G

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 81 475 1.1e-27 PFAM
Pfam:NCD3G 519 570 1.3e-18 PFAM
Pfam:7tm_3 603 838 2.6e-50 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.3%
  • 20x: 89.5%
Validation Efficiency 98% (59/60)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310003L06Rik A T 5: 87,970,665 (GRCm38) I3F probably benign Het
4930590J08Rik A G 6: 91,917,035 (GRCm38) N211S probably benign Het
A2ml1 A T 6: 128,547,233 (GRCm38) Y1145* probably null Het
Abca7 A G 10: 80,014,230 (GRCm38) D1972G probably benign Het
Adamts19 A T 18: 59,052,615 (GRCm38) D1187V probably damaging Het
Adcy6 G C 15: 98,600,007 (GRCm38) I421M probably damaging Het
Afap1 C A 5: 35,974,491 (GRCm38) H387Q probably damaging Het
Atp8b1 C T 18: 64,545,264 (GRCm38) V854M probably damaging Het
Auts2 C T 5: 131,487,463 (GRCm38) probably benign Het
Cbll1 T C 12: 31,487,856 (GRCm38) D300G probably damaging Het
Cd200r4 A T 16: 44,833,049 (GRCm38) T61S possibly damaging Het
Chmp4c G T 3: 10,389,684 (GRCm38) V207L probably benign Het
Cntn5 T C 9: 9,976,316 (GRCm38) T413A possibly damaging Het
Cox7a2 T A 9: 79,758,581 (GRCm38) probably null Het
Cwc27 A G 13: 104,797,306 (GRCm38) L236P probably damaging Het
Diaph1 A G 18: 37,896,093 (GRCm38) probably null Het
Dst T A 1: 34,260,372 (GRCm38) probably benign Het
Ear1 T A 14: 43,819,126 (GRCm38) H95L probably damaging Het
Enpp1 T A 10: 24,641,834 (GRCm38) H898L probably benign Het
Entpd5 G A 12: 84,382,295 (GRCm38) R321* probably null Het
Ercc6l2 C A 13: 63,824,871 (GRCm38) N177K possibly damaging Het
Ergic1 T C 17: 26,641,706 (GRCm38) probably null Het
Erich6 A T 3: 58,626,598 (GRCm38) I336N probably benign Het
Fmnl2 A G 2: 53,105,537 (GRCm38) E424G probably damaging Het
Galnt3 A T 2: 66,084,206 (GRCm38) D622E probably damaging Het
Gjd4 T A 18: 9,280,569 (GRCm38) T170S probably damaging Het
Gm5611 G A 9: 17,030,607 (GRCm38) noncoding transcript Het
Gpc5 T A 14: 115,399,250 (GRCm38) N448K probably benign Het
Klra3 G C 6: 130,333,144 (GRCm38) R138G probably benign Het
Man2b2 T C 5: 36,820,927 (GRCm38) T338A probably benign Het
Mbtps1 A T 8: 119,546,125 (GRCm38) S94T probably benign Het
Muc3a A T 5: 137,210,081 (GRCm38) S205T unknown Het
Nav2 C A 7: 49,545,934 (GRCm38) D1019E probably damaging Het
Neurl4 T A 11: 69,903,426 (GRCm38) L236* probably null Het
Olfr272 A G 4: 52,911,260 (GRCm38) V178A probably benign Het
Plcxd3 T C 15: 4,516,611 (GRCm38) probably benign Het
Pprc1 T C 19: 46,071,526 (GRCm38) probably benign Het
Prkaa2 T A 4: 105,075,450 (GRCm38) N67I probably damaging Het
Prom1 T A 5: 44,018,353 (GRCm38) Y508F probably benign Het
Prx A G 7: 27,517,258 (GRCm38) M534V probably damaging Het
Rps6kc1 C T 1: 190,871,768 (GRCm38) R219Q possibly damaging Het
Sbf2 T C 7: 110,378,043 (GRCm38) Y628C probably damaging Het
Slc1a2 A T 2: 102,777,510 (GRCm38) D501V probably benign Het
Spata31 A T 13: 64,921,382 (GRCm38) Q448L probably damaging Het
Stk35 T C 2: 129,811,235 (GRCm38) probably benign Het
Stxbp5 T A 10: 9,838,092 (GRCm38) R234S probably damaging Het
Tifab A G 13: 56,176,288 (GRCm38) V114A probably benign Het
Tiprl A G 1: 165,228,406 (GRCm38) M49T probably benign Het
Tlr12 A G 4: 128,617,752 (GRCm38) L235P possibly damaging Het
Tmem57 A G 4: 134,804,507 (GRCm38) V617A probably damaging Het
Trim43b A T 9: 89,085,358 (GRCm38) C407* probably null Het
Txndc17 C A 11: 72,207,707 (GRCm38) F28L probably damaging Het
Vmn2r3 T A 3: 64,275,117 (GRCm38) D387V probably damaging Het
Vps13b T C 15: 35,875,566 (GRCm38) I2699T probably damaging Het
Zfp944 G T 17: 22,339,716 (GRCm38) Y183* probably null Het
Other mutations in Vmn2r27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Vmn2r27 APN 6 124,192,411 (GRCm38) missense possibly damaging 0.86
IGL01388:Vmn2r27 APN 6 124,223,832 (GRCm38) missense possibly damaging 0.55
IGL01923:Vmn2r27 APN 6 124,200,525 (GRCm38) missense probably benign 0.20
IGL01954:Vmn2r27 APN 6 124,192,248 (GRCm38) missense probably damaging 1.00
IGL02105:Vmn2r27 APN 6 124,197,349 (GRCm38) splice site probably benign
IGL02586:Vmn2r27 APN 6 124,224,475 (GRCm38) nonsense probably null
IGL03130:Vmn2r27 APN 6 124,192,317 (GRCm38) missense possibly damaging 0.82
IGL03330:Vmn2r27 APN 6 124,230,180 (GRCm38) nonsense probably null
R0124:Vmn2r27 UTSW 6 124,231,619 (GRCm38) missense probably benign
R0234:Vmn2r27 UTSW 6 124,231,619 (GRCm38) missense probably benign
R0234:Vmn2r27 UTSW 6 124,231,619 (GRCm38) missense probably benign
R0384:Vmn2r27 UTSW 6 124,223,912 (GRCm38) missense probably benign 0.01
R0582:Vmn2r27 UTSW 6 124,224,290 (GRCm38) missense probably benign 0.02
R0733:Vmn2r27 UTSW 6 124,192,188 (GRCm38) missense probably benign 0.18
R0738:Vmn2r27 UTSW 6 124,223,702 (GRCm38) missense possibly damaging 0.48
R0835:Vmn2r27 UTSW 6 124,200,624 (GRCm38) missense probably damaging 0.99
R1183:Vmn2r27 UTSW 6 124,200,532 (GRCm38) missense probably benign
R1401:Vmn2r27 UTSW 6 124,191,632 (GRCm38) nonsense probably null
R1484:Vmn2r27 UTSW 6 124,200,515 (GRCm38) missense probably damaging 0.96
R1539:Vmn2r27 UTSW 6 124,191,771 (GRCm38) missense probably damaging 1.00
R1565:Vmn2r27 UTSW 6 124,231,634 (GRCm38) missense probably benign
R1595:Vmn2r27 UTSW 6 124,231,615 (GRCm38) missense probably benign 0.00
R1614:Vmn2r27 UTSW 6 124,223,934 (GRCm38) missense probably benign 0.01
R1742:Vmn2r27 UTSW 6 124,200,677 (GRCm38) missense possibly damaging 0.48
R1816:Vmn2r27 UTSW 6 124,230,371 (GRCm38) nonsense probably null
R1822:Vmn2r27 UTSW 6 124,231,634 (GRCm38) missense probably benign
R1824:Vmn2r27 UTSW 6 124,231,634 (GRCm38) missense probably benign
R1870:Vmn2r27 UTSW 6 124,224,211 (GRCm38) missense probably benign 0.11
R1942:Vmn2r27 UTSW 6 124,223,763 (GRCm38) missense probably damaging 1.00
R1962:Vmn2r27 UTSW 6 124,223,834 (GRCm38) missense possibly damaging 0.70
R2069:Vmn2r27 UTSW 6 124,224,483 (GRCm38) missense probably damaging 1.00
R2075:Vmn2r27 UTSW 6 124,200,551 (GRCm38) missense possibly damaging 0.85
R2379:Vmn2r27 UTSW 6 124,224,383 (GRCm38) missense possibly damaging 0.89
R3748:Vmn2r27 UTSW 6 124,230,392 (GRCm38) missense probably benign 0.35
R4384:Vmn2r27 UTSW 6 124,224,156 (GRCm38) missense probably benign 0.05
R4392:Vmn2r27 UTSW 6 124,230,176 (GRCm38) missense probably benign 0.01
R4758:Vmn2r27 UTSW 6 124,231,637 (GRCm38) missense possibly damaging 0.87
R5018:Vmn2r27 UTSW 6 124,224,182 (GRCm38) missense probably benign 0.02
R5235:Vmn2r27 UTSW 6 124,192,054 (GRCm38) missense probably damaging 0.99
R5718:Vmn2r27 UTSW 6 124,192,144 (GRCm38) missense possibly damaging 0.66
R5859:Vmn2r27 UTSW 6 124,200,688 (GRCm38) missense probably damaging 1.00
R5958:Vmn2r27 UTSW 6 124,231,727 (GRCm38) missense probably benign 0.00
R6044:Vmn2r27 UTSW 6 124,231,772 (GRCm38) missense probably benign
R6086:Vmn2r27 UTSW 6 124,191,999 (GRCm38) missense probably damaging 1.00
R6396:Vmn2r27 UTSW 6 124,224,166 (GRCm38) nonsense probably null
R6546:Vmn2r27 UTSW 6 124,192,410 (GRCm38) missense possibly damaging 0.49
R6746:Vmn2r27 UTSW 6 124,200,593 (GRCm38) missense possibly damaging 0.47
R6976:Vmn2r27 UTSW 6 124,224,353 (GRCm38) nonsense probably null
R7091:Vmn2r27 UTSW 6 124,223,945 (GRCm38) missense possibly damaging 0.85
R7145:Vmn2r27 UTSW 6 124,191,752 (GRCm38) missense probably benign
R7176:Vmn2r27 UTSW 6 124,192,036 (GRCm38) missense probably benign 0.01
R7382:Vmn2r27 UTSW 6 124,197,317 (GRCm38) missense probably damaging 1.00
R7482:Vmn2r27 UTSW 6 124,224,261 (GRCm38) missense probably damaging 1.00
R7853:Vmn2r27 UTSW 6 124,192,021 (GRCm38) missense probably damaging 1.00
R7859:Vmn2r27 UTSW 6 124,224,242 (GRCm38) missense probably benign 0.00
R7959:Vmn2r27 UTSW 6 124,192,081 (GRCm38) missense probably benign
R8266:Vmn2r27 UTSW 6 124,191,978 (GRCm38) missense probably benign 0.00
R8353:Vmn2r27 UTSW 6 124,192,445 (GRCm38) missense probably damaging 0.99
R8394:Vmn2r27 UTSW 6 124,191,817 (GRCm38) missense possibly damaging 0.71
R8463:Vmn2r27 UTSW 6 124,192,209 (GRCm38) missense probably damaging 1.00
R8477:Vmn2r27 UTSW 6 124,224,241 (GRCm38) missense probably benign 0.11
R8705:Vmn2r27 UTSW 6 124,230,229 (GRCm38) missense probably damaging 1.00
R8752:Vmn2r27 UTSW 6 124,224,059 (GRCm38) missense probably benign 0.00
R9109:Vmn2r27 UTSW 6 124,197,265 (GRCm38) missense possibly damaging 0.95
R9140:Vmn2r27 UTSW 6 124,192,248 (GRCm38) missense probably damaging 1.00
R9157:Vmn2r27 UTSW 6 124,224,285 (GRCm38) missense probably benign 0.09
R9431:Vmn2r27 UTSW 6 124,191,897 (GRCm38) missense probably damaging 1.00
R9477:Vmn2r27 UTSW 6 124,191,951 (GRCm38) missense probably damaging 0.99
R9758:Vmn2r27 UTSW 6 124,191,678 (GRCm38) missense possibly damaging 0.89
Z1177:Vmn2r27 UTSW 6 124,191,901 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGAGCAGCACACAGTGATGACTTC -3'
(R):5'- ATCTGGTGGACAGAGTCCTCCTTC -3'

Sequencing Primer
(F):5'- GTGATGACTTCAAGAATACTCACC -3'
(R):5'- GTGCATAGAGCACTACTGCTAC -3'
Posted On 2014-04-13