Mutagenetix > Incidental Mutation

Incidental Mutation 'R1550:Vmn2r118'

169878

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r118

Ensembl Gene

ENSMUSG00000091504

Gene Name

vomeronasal 2, receptor 118

Synonyms

EG383258, Vmn2r119, EG668547

MMRRC Submission

039589-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

R1550 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

55592341-55624672 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 55608083 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Tyrosine at position 521 (C521Y)

Ref Sequence

ENSEMBL: ENSMUSP00000131128 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168440]

AlphaFold

E9Q1C1

Predicted Effect

probably damaging
Transcript: ENSMUST00000168440
AA Change: C521Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000131128
Gene: ENSMUSG00000091504
AA Change: C521Y

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	142	470	4.6e-27	PFAM
Pfam:NCD3G	513	566	2.6e-20	PFAM
Pfam:7tm_3	599	834	5.9e-55	PFAM

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.4%
20x: 89.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700015F17Rik	C	A	5: 5,452,019	W144C	probably benign	Het
Abcc6	A	G	7: 46,005,244	V551A	probably benign	Het
Acss1	A	T	2: 150,642,795	L176Q	probably damaging	Het
Aldh7a1	A	G	18: 56,550,382	I117T	possibly damaging	Het
Arf5	C	T	6: 28,426,153	R180C	probably damaging	Het
Arhgap21	A	T	2: 20,881,765	Y39*	probably null	Het
Arrdc1	A	G	2: 24,926,339	L206P	probably damaging	Het
Cby3	A	T	11: 50,359,486	Y173F	probably damaging	Het
Cdh18	T	A	15: 23,436,548	C497S	probably damaging	Het
Cyp11b2	T	C	15: 74,853,593	I226V	probably benign	Het
Ddit4l	T	A	3: 137,624,275		probably null	Het
Ddx11	C	T	17: 66,138,220	T405I	probably benign	Het
Dhx40	A	T	11: 86,776,739		probably null	Het
Dlgap2	A	G	8: 14,822,499	D659G	probably damaging	Het
Eef2	A	G	10: 81,180,847	E586G	probably benign	Het
Fam161a	A	G	11: 23,020,470	Q216R	possibly damaging	Het
Fbxw24	G	T	9: 109,607,044	R307S	probably benign	Het
Gbp2b	G	T	3: 142,606,830	A325S	probably damaging	Het
Gli1	A	T	10: 127,338,516	F2Y	probably damaging	Het
Gm7075	A	G	10: 63,421,648	L31P	probably damaging	Het
Gnl2	T	C	4: 125,044,234	V269A	probably damaging	Het
Grin1	A	G	2: 25,305,131	V292A	probably benign	Het
Heg1	T	A	16: 33,735,553	V1001E	probably damaging	Het
Herc2	T	A	7: 56,135,658	I1552N	probably damaging	Het
Htr1a	A	G	13: 105,445,280	T343A	probably benign	Het
Itk	G	T	11: 46,389,326	R29S	probably damaging	Het
Ivns1abp	G	T	1: 151,361,491	G469C	probably damaging	Het
Jph3	A	T	8: 121,784,859	N529Y	possibly damaging	Het
Kdm2b	A	G	5: 122,881,057	L829P	probably damaging	Het
Kprp	T	A	3: 92,824,726	Y339F	probably damaging	Het
Lrp2	A	G	2: 69,502,661	V1504A	possibly damaging	Het
Lypd6b	A	G	2: 49,943,603	D85G	probably damaging	Het
Mansc4	T	C	6: 147,075,638	Y160C	probably damaging	Het
Mgll	C	A	6: 88,813,889	H164N	probably benign	Het
Mtmr4	A	T	11: 87,613,516	D1097V	probably damaging	Het
Nfasc	T	C	1: 132,608,503	K571E	probably damaging	Het
Nfat5	A	T	8: 107,370,573	N1527Y	probably damaging	Het
Nlgn1	A	G	3: 25,912,644	L215P	probably damaging	Het
Olfr6	T	A	7: 106,956,028	I303L	probably benign	Het
Pde4dip	T	C	3: 97,719,704	S1173G	probably damaging	Het
Prrt3	A	T	6: 113,495,507	V568E	probably damaging	Het
Ptpra	G	A	2: 130,541,393	R503Q	possibly damaging	Het
Sema5a	G	A	15: 32,618,849	A508T	probably benign	Het
Serpinb11	T	C	1: 107,379,688	I283T	possibly damaging	Het
Setbp1	A	T	18: 78,858,592	L620Q	probably damaging	Het
Sipa1l3	A	T	7: 29,383,203	C756S	probably benign	Het
Sirpa	A	T	2: 129,630,041	I463F	probably damaging	Het
Slc13a2	G	T	11: 78,403,164	N257K	probably damaging	Het
Slc4a5	C	A	6: 83,271,057	T530N	probably damaging	Het
Stab2	A	T	10: 86,878,926	F125L	probably benign	Het
Tet2	G	T	3: 133,469,519	Q1356K	probably benign	Het
Tet3	A	T	6: 83,386,028	S856T	probably damaging	Het
Tg	C	T	15: 66,693,430	T1207I	possibly damaging	Het
Tkt	A	G	14: 30,565,568	Y173C	probably damaging	Het
Tlr6	T	A	5: 64,953,411	I718F	probably damaging	Het
Tnfrsf11b	A	G	15: 54,254,058	V267A	possibly damaging	Het
Ubqln3	T	A	7: 104,141,546	N446Y	probably damaging	Het
Vps16	A	G	2: 130,440,340	D394G	probably benign	Het
Zfp236	A	T	18: 82,674,424	M142K	possibly damaging	Het
Zfp780b	T	C	7: 27,964,857	D91G	probably benign	Het
Zfp97	T	A	17: 17,145,206	Y322*	probably null	Het

Other mutations in Vmn2r118

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Vmn2r118	APN	17	55592708	missense	probably damaging	1.00
IGL00976:Vmn2r118	APN	17	55593204	missense	probably damaging	1.00
IGL01419:Vmn2r118	APN	17	55593000	missense	probably benign	0.01
IGL01796:Vmn2r118	APN	17	55608585	missense	probably benign	0.30
IGL01799:Vmn2r118	APN	17	55592990	missense	probably damaging	1.00
IGL02002:Vmn2r118	APN	17	55592619	missense	probably damaging	1.00
IGL02075:Vmn2r118	APN	17	55610517	missense	probably benign	0.18
IGL02172:Vmn2r118	APN	17	55624598	missense	probably benign	0.00
IGL02529:Vmn2r118	APN	17	55610870	missense	possibly damaging	0.58
IGL02712:Vmn2r118	APN	17	55592655	missense	probably benign	0.21
IGL03096:Vmn2r118	APN	17	55607996	missense	probably damaging	1.00
R0306:Vmn2r118	UTSW	17	55608616	missense	possibly damaging	0.89
R0329:Vmn2r118	UTSW	17	55610717	missense	probably damaging	1.00
R0330:Vmn2r118	UTSW	17	55610717	missense	probably damaging	1.00
R0396:Vmn2r118	UTSW	17	55608643	missense	probably benign	0.00
R0411:Vmn2r118	UTSW	17	55611021	splice site	probably benign
R0513:Vmn2r118	UTSW	17	55610970	nonsense	probably null
R0627:Vmn2r118	UTSW	17	55610772	missense	probably benign	0.01
R0638:Vmn2r118	UTSW	17	55608466	missense	probably benign	0.03
R1328:Vmn2r118	UTSW	17	55608620	missense	probably benign	0.01
R1366:Vmn2r118	UTSW	17	55593237	nonsense	probably null
R1465:Vmn2r118	UTSW	17	55610935	missense	probably benign	0.33
R1465:Vmn2r118	UTSW	17	55610935	missense	probably benign	0.33
R1511:Vmn2r118	UTSW	17	55608496	nonsense	probably null
R1515:Vmn2r118	UTSW	17	55610643	missense	probably benign	0.25
R1779:Vmn2r118	UTSW	17	55611530	missense	probably benign	0.03
R1834:Vmn2r118	UTSW	17	55592456	missense	probably damaging	1.00
R1840:Vmn2r118	UTSW	17	55610406	nonsense	probably null
R1854:Vmn2r118	UTSW	17	55611556	missense	possibly damaging	0.57
R1967:Vmn2r118	UTSW	17	55592882	missense	probably damaging	1.00
R1976:Vmn2r118	UTSW	17	55592925	missense	probably damaging	1.00
R2308:Vmn2r118	UTSW	17	55624650	missense	probably benign	0.33
R3700:Vmn2r118	UTSW	17	55608421	missense	possibly damaging	0.68
R4334:Vmn2r118	UTSW	17	55610347	missense	possibly damaging	0.58
R4647:Vmn2r118	UTSW	17	55610665	missense	probably damaging	1.00
R4709:Vmn2r118	UTSW	17	55610860	missense	probably damaging	1.00
R4805:Vmn2r118	UTSW	17	55592581	missense	probably damaging	1.00
R4858:Vmn2r118	UTSW	17	55592894	missense	probably damaging	0.98
R5384:Vmn2r118	UTSW	17	55611565	missense	probably benign	0.00
R5385:Vmn2r118	UTSW	17	55611565	missense	probably benign	0.00
R5664:Vmn2r118	UTSW	17	55592765	missense	possibly damaging	0.46
R5740:Vmn2r118	UTSW	17	55593103	missense	probably benign	0.00
R5927:Vmn2r118	UTSW	17	55624494	missense	probably benign	0.04
R6143:Vmn2r118	UTSW	17	55592871	missense	possibly damaging	0.92
R6513:Vmn2r118	UTSW	17	55608093	missense	probably damaging	1.00
R6573:Vmn2r118	UTSW	17	55592996	missense	probably damaging	1.00
R6760:Vmn2r118	UTSW	17	55592714	missense	possibly damaging	0.92
R6794:Vmn2r118	UTSW	17	55592348	missense	possibly damaging	0.48
R6929:Vmn2r118	UTSW	17	55610440	missense	probably benign	0.01
R7201:Vmn2r118	UTSW	17	55608496	nonsense	probably null
R7539:Vmn2r118	UTSW	17	55592853	missense	probably damaging	0.98
R7836:Vmn2r118	UTSW	17	55593242	missense	probably damaging	0.99
R8179:Vmn2r118	UTSW	17	55608484	missense	probably benign	0.36
R8248:Vmn2r118	UTSW	17	55610936	missense	probably benign	0.18
R8347:Vmn2r118	UTSW	17	55610423	missense	possibly damaging	0.94
R8415:Vmn2r118	UTSW	17	55608057	missense	probably benign	0.08
R8428:Vmn2r118	UTSW	17	55608642	missense	probably benign	0.33
R8917:Vmn2r118	UTSW	17	55610216	missense	possibly damaging	0.82
R8993:Vmn2r118	UTSW	17	55610835	missense	possibly damaging	0.72
R9038:Vmn2r118	UTSW	17	55611649	missense	probably damaging	1.00
R9155:Vmn2r118	UTSW	17	55610207	missense	probably null	0.83
R9603:Vmn2r118	UTSW	17	55592837	missense	probably damaging	1.00
R9742:Vmn2r118	UTSW	17	55611009	missense	probably damaging	0.98
R9749:Vmn2r118	UTSW	17	55608415	critical splice donor site	probably null
R9792:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
R9793:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
R9795:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
X0022:Vmn2r118	UTSW	17	55593218	missense	probably damaging	1.00
Z1176:Vmn2r118	UTSW	17	55610655	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TTTGTCTCTTCATtgtcccgccc -3'
(R):5'- AGGTGAGTTTGGCCCAACTTAATGTTTT -3'

Sequencing Primer
(F):5'- agggtatggggaggggg -3'
(R):5'- GGCCCAACTTAATGTTTTACAAGTAG -3'

Posted On

2014-04-13