Incidental Mutation 'R1555:Neurl3'
ID170203
Institutional Source Beutler Lab
Gene Symbol Neurl3
Ensembl Gene ENSMUSG00000047180
Gene Nameneuralized E3 ubiquitin protein ligase 3
SynonymsLincr, 2010300P06Rik
MMRRC Submission 039594-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #R1555 (G1)
Quality Score225
Status Validated
Chromosome1
Chromosomal Location36264597-36274679 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 36266532 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 198 (V198A)
Ref Sequence ENSEMBL: ENSMUSP00000055437 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056946] [ENSMUST00000188666]
Predicted Effect probably benign
Transcript: ENSMUST00000056946
AA Change: V198A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000055437
Gene: ENSMUSG00000047180
AA Change: V198A

DomainStartEndE-ValueType
Pfam:Neuralized 19 85 8.3e-25 PFAM
RING 197 235 7.16e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000188666
SMART Domains Protein: ENSMUSP00000139665
Gene: ENSMUSG00000047180

DomainStartEndE-ValueType
NEUZ 15 138 6.4e-30 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 92.0%
Validation Efficiency 96% (43/45)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ace A G 11: 105,974,901 probably null Het
Adamts1 T A 16: 85,797,888 T358S probably benign Het
Ate1 A T 7: 130,509,091 F169I probably benign Het
Cdkl4 T A 17: 80,543,614 probably benign Het
Clcnkb T C 4: 141,411,739 probably null Het
Col6a4 C T 9: 106,000,886 R1964Q possibly damaging Het
Dcakd C T 11: 103,000,213 V17I probably damaging Het
Dcdc5 T G 2: 106,384,135 noncoding transcript Het
Erc2 T A 14: 28,011,665 D557E probably damaging Het
Grid2 A T 6: 64,429,684 D676V possibly damaging Het
Hebp2 G T 10: 18,544,415 T90K possibly damaging Het
Igkv10-96 C T 6: 68,632,381 probably benign Het
Mier3 T A 13: 111,708,359 N248K probably damaging Het
Myo5b A T 18: 74,569,782 I15F probably damaging Het
Notch2 C A 3: 98,131,340 N1266K possibly damaging Het
Nup107 A G 10: 117,751,490 probably benign Het
Olfr214 A T 6: 116,556,826 I134F probably damaging Het
Olfr675 T C 7: 105,024,522 I153V probably benign Het
Phf3 G T 1: 30,805,877 H1334N possibly damaging Het
Phyhd1 T A 2: 30,274,706 I100N probably damaging Het
Rad21l T A 2: 151,658,428 T224S probably benign Het
Rxra C T 2: 27,748,678 A231V probably benign Het
Sac3d1 T C 19: 6,118,405 D61G probably damaging Het
Sbf1 A G 15: 89,305,076 Y481H probably damaging Het
Spg11 T C 2: 122,097,377 E642G probably damaging Het
Spta1 A G 1: 174,178,749 Y159C probably damaging Het
Sry C G Y: 2,662,975 Q228H unknown Het
Tedc1 G T 12: 113,156,497 probably benign Het
Tmem200a A T 10: 25,993,884 D162E probably damaging Het
Tmprss11e T A 5: 86,715,588 Q206L probably damaging Het
Tpra1 A G 6: 88,910,203 N175S probably damaging Het
Ttll10 T C 4: 156,035,139 E601G probably benign Het
Ttll6 G T 11: 96,145,582 D346Y probably damaging Het
U2surp A G 9: 95,466,577 V874A probably damaging Het
Vwa5b1 T C 4: 138,605,477 K258R probably benign Het
Xkr6 A G 14: 63,818,925 Y95C unknown Het
Zfp180 T C 7: 24,101,574 probably benign Het
Zfp90 A G 8: 106,424,095 T147A probably benign Het
Other mutations in Neurl3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1615:Neurl3 UTSW 1 36269389 missense possibly damaging 0.95
R5055:Neurl3 UTSW 1 36273382 start gained probably benign
R5242:Neurl3 UTSW 1 36269420 nonsense probably null
R5444:Neurl3 UTSW 1 36269490 missense probably damaging 1.00
R5698:Neurl3 UTSW 1 36266506 missense possibly damaging 0.67
R6823:Neurl3 UTSW 1 36268704 nonsense probably null
R7088:Neurl3 UTSW 1 36269221 missense possibly damaging 0.67
Predicted Primers PCR Primer
(F):5'- GTCCCATCTGCCCAAGAAGTCATC -3'
(R):5'- CCGGGAAGCAAAAGCCTAGATTCAG -3'

Sequencing Primer
(F):5'- GAAGTCATCTTCTCAGGAGCC -3'
(R):5'- AAGCCTAGATTCAGGGCTGTG -3'
Posted On2014-04-13