Incidental Mutation 'R1556:Pecr'
ID 170247
Institutional Source Beutler Lab
Gene Symbol Pecr
Ensembl Gene ENSMUSG00000026189
Gene Name peroxisomal trans-2-enoyl-CoA reductase
Synonyms 2400003B18Rik
MMRRC Submission 039595-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # R1556 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 72298326-72323473 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 72298542 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 293 (I293L)
Ref Sequence ENSEMBL: ENSMUSP00000027381 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027381] [ENSMUST00000129458] [ENSMUST00000134840]
AlphaFold Q99MZ7
Predicted Effect probably benign
Transcript: ENSMUST00000027381
AA Change: I293L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000027381
Gene: ENSMUSG00000026189
AA Change: I293L

DomainStartEndE-ValueType
Pfam:adh_short 19 216 5e-47 PFAM
Pfam:KR 20 148 2.3e-10 PFAM
Pfam:adh_short_C2 25 266 4.1e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000129458
Predicted Effect probably benign
Transcript: ENSMUST00000134840
SMART Domains Protein: ENSMUSP00000120890
Gene: ENSMUSG00000026189

DomainStartEndE-ValueType
Pfam:adh_short 19 89 1.7e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000179876
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180722
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181973
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.4%
  • 20x: 89.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik T C 8: 73,203,477 (GRCm39) S302P probably damaging Het
Anapc1 T C 2: 128,466,819 (GRCm39) T1626A probably benign Het
Arhgef6 T C X: 56,383,922 (GRCm39) M5V probably benign Het
Arid5a T A 1: 36,359,245 (GRCm39) Y520* probably null Het
Aven G A 2: 112,461,230 (GRCm39) M215I probably damaging Het
Cabyr A G 18: 12,877,837 (GRCm39) D58G probably damaging Het
Ccdc146 A G 5: 21,535,551 (GRCm39) Y168H probably damaging Het
Ccnd2 A T 6: 127,107,363 (GRCm39) S269T probably benign Het
Cd68 T A 11: 69,556,676 (GRCm39) T44S probably damaging Het
Clstn2 A T 9: 97,338,558 (GRCm39) I867N probably benign Het
Cmss1 C T 16: 57,136,560 (GRCm39) R104H probably benign Het
Col6a6 A G 9: 105,586,672 (GRCm39) V1783A possibly damaging Het
Dach2 T C X: 112,208,214 (GRCm39) S31P probably benign Het
Dpp8 T A 9: 64,958,761 (GRCm39) W279R probably damaging Het
Fras1 A T 5: 96,890,921 (GRCm39) I2817F possibly damaging Het
Gabrr3 G A 16: 59,281,763 (GRCm39) D373N probably benign Het
Gdf7 T C 12: 8,351,698 (GRCm39) N79S unknown Het
Gpam A G 19: 55,064,763 (GRCm39) V647A possibly damaging Het
Gpatch1 T C 7: 34,994,776 (GRCm39) T497A probably benign Het
Grin2a A T 16: 9,525,579 (GRCm39) F337L probably benign Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
H2-Aa A T 17: 34,503,390 (GRCm39) V69D possibly damaging Het
H2-M10.5 T C 17: 37,084,205 (GRCm39) Y56H probably damaging Het
Kcnu1 G A 8: 26,351,219 (GRCm39) probably null Het
Krt77 A G 15: 101,769,713 (GRCm39) S386P probably damaging Het
L3mbtl2 T A 15: 81,566,203 (GRCm39) M342K probably benign Het
Ldlrad1 A G 4: 107,075,010 (GRCm39) T186A probably benign Het
Lins1 C A 7: 66,360,385 (GRCm39) C168* probably null Het
Lrrtm3 G A 10: 63,923,928 (GRCm39) T413M probably damaging Het
Macf1 T C 4: 123,348,813 (GRCm39) D4038G probably damaging Het
Mark3 T G 12: 111,594,275 (GRCm39) N308K probably damaging Het
Mdga2 T A 12: 66,597,367 (GRCm39) Y709F possibly damaging Het
Mtus2 T A 5: 148,014,198 (GRCm39) S330R probably benign Het
Or1p1 T A 11: 74,179,762 (GRCm39) C97S probably damaging Het
Or4k15c G A 14: 50,321,916 (GRCm39) A74V possibly damaging Het
Or51a24 T A 7: 103,733,468 (GRCm39) H273L probably benign Het
Or6c76 T C 10: 129,612,242 (GRCm39) V168A probably benign Het
Ovgp1 A G 3: 105,894,068 (GRCm39) probably benign Het
P4ha2 A G 11: 54,015,836 (GRCm39) T408A probably damaging Het
Pcdh8 T G 14: 80,007,843 (GRCm39) D240A probably damaging Het
Pcyt2 T C 11: 120,502,911 (GRCm39) probably null Het
Pogk A G 1: 166,226,402 (GRCm39) V583A possibly damaging Het
Prkg1 T C 19: 30,602,143 (GRCm39) K371R probably benign Het
Psmd2 T A 16: 20,474,335 (GRCm39) M297K possibly damaging Het
Rgs12 A G 5: 35,196,626 (GRCm39) R769G possibly damaging Het
Sgtb T A 13: 104,276,284 (GRCm39) N237K probably damaging Het
Sh3bgrl2 T C 9: 83,476,751 (GRCm39) V91A probably damaging Het
Slc4a1ap G A 5: 31,691,554 (GRCm39) probably null Het
Slc4a7 T C 14: 14,778,872 (GRCm38) V940A probably benign Het
Tep1 T C 14: 51,090,499 (GRCm39) T740A probably benign Het
Tnk2 G T 16: 32,489,737 (GRCm39) probably null Het
Trpv2 A G 11: 62,483,059 (GRCm39) Y450C probably damaging Het
Tut7 T C 13: 59,948,054 (GRCm39) T354A probably benign Het
Tvp23a A T 16: 10,264,862 (GRCm39) D16E probably damaging Het
Twnk T C 19: 44,997,850 (GRCm39) F460L possibly damaging Het
Unc80 C T 1: 66,560,740 (GRCm39) H823Y possibly damaging Het
Urb2 T C 8: 124,757,356 (GRCm39) L1021P probably damaging Het
Vps13c T C 9: 67,837,993 (GRCm39) Y1848H probably damaging Het
Vwa8 T G 14: 79,324,121 (GRCm39) N1141K probably benign Het
Yipf3 A G 17: 46,561,793 (GRCm39) Y200C probably damaging Het
Zbtb38 A G 9: 96,569,044 (GRCm39) V680A probably benign Het
Znrf3 T C 11: 5,231,347 (GRCm39) E722G probably benign Het
Zzef1 T A 11: 72,806,059 (GRCm39) L2665H probably damaging Het
Other mutations in Pecr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03124:Pecr APN 1 72,316,499 (GRCm39) missense probably benign 0.04
R1711:Pecr UTSW 1 72,316,568 (GRCm39) missense possibly damaging 0.93
R1882:Pecr UTSW 1 72,314,136 (GRCm39) splice site probably null
R2150:Pecr UTSW 1 72,316,517 (GRCm39) missense possibly damaging 0.73
R2507:Pecr UTSW 1 72,301,135 (GRCm39) missense probably benign 0.11
R2516:Pecr UTSW 1 72,316,469 (GRCm39) missense probably damaging 1.00
R3774:Pecr UTSW 1 72,298,530 (GRCm39) missense probably benign 0.00
R3775:Pecr UTSW 1 72,298,530 (GRCm39) missense probably benign 0.00
R3968:Pecr UTSW 1 72,315,468 (GRCm39) missense probably damaging 0.99
R3969:Pecr UTSW 1 72,315,468 (GRCm39) missense probably damaging 0.99
R3970:Pecr UTSW 1 72,315,468 (GRCm39) missense probably damaging 0.99
R4171:Pecr UTSW 1 72,315,428 (GRCm39) missense probably damaging 1.00
R4773:Pecr UTSW 1 72,306,594 (GRCm39) missense probably damaging 1.00
R4864:Pecr UTSW 1 72,316,490 (GRCm39) missense probably benign 0.35
R5191:Pecr UTSW 1 72,314,136 (GRCm39) splice site probably null
R5259:Pecr UTSW 1 72,316,444 (GRCm39) critical splice donor site probably null
R5331:Pecr UTSW 1 72,314,005 (GRCm39) intron probably benign
R6828:Pecr UTSW 1 72,306,616 (GRCm39) nonsense probably null
R7238:Pecr UTSW 1 72,298,592 (GRCm39) missense probably damaging 0.99
R7358:Pecr UTSW 1 72,306,624 (GRCm39) missense probably benign 0.01
R7745:Pecr UTSW 1 72,306,157 (GRCm39) splice site probably null
R7997:Pecr UTSW 1 72,315,475 (GRCm39) nonsense probably null
R8123:Pecr UTSW 1 72,314,094 (GRCm39) missense probably benign 0.16
R8155:Pecr UTSW 1 72,309,443 (GRCm39) missense probably damaging 1.00
R8399:Pecr UTSW 1 72,306,624 (GRCm39) missense probably benign 0.01
R8702:Pecr UTSW 1 72,306,661 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCGGTTTGCACAGGAAGAGACAT -3'
(R):5'- TGAGGAGTGACACTGAAGTTACCCC -3'

Sequencing Primer
(F):5'- GCACAGGAAGAGACATTTATTTTGG -3'
(R):5'- GAAGTTACCCCTTTTATACGCAGG -3'
Posted On 2014-04-13