Incidental Mutation 'IGL00157:Yrdc'
ID 1703
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Yrdc
Ensembl Gene ENSMUSG00000028889
Gene Name yrdC domain containing (E.coli)
Synonyms IRIP
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.961) question?
Stock # IGL00157
Quality Score
Status
Chromosome 4
Chromosomal Location 124850679-124855242 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 124853961 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 86 (S86P)
Ref Sequence ENSEMBL: ENSMUSP00000114150 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030723] [ENSMUST00000064444] [ENSMUST00000102628] [ENSMUST00000106190] [ENSMUST00000106193] [ENSMUST00000137769] [ENSMUST00000144851] [ENSMUST00000163946] [ENSMUST00000185036]
AlphaFold Q3U5F4
Predicted Effect probably benign
Transcript: ENSMUST00000030723
SMART Domains Protein: ENSMUSP00000030723
Gene: ENSMUSG00000028890

DomainStartEndE-ValueType
ZnF_C2H2 139 163 1.22e-4 SMART
ZnF_C2H2 169 193 6.42e-4 SMART
ZnF_C2H2 199 223 2.4e-3 SMART
ZnF_C2H2 228 252 2.57e-3 SMART
ZnF_C2H2 258 282 2.57e-3 SMART
ZnF_C2H2 288 312 7.37e-4 SMART
low complexity region 429 456 N/A INTRINSIC
low complexity region 500 526 N/A INTRINSIC
low complexity region 545 558 N/A INTRINSIC
low complexity region 628 638 N/A INTRINSIC
low complexity region 656 669 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000064444
SMART Domains Protein: ENSMUSP00000066000
Gene: ENSMUSG00000042763

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
low complexity region 31 46 N/A INTRINSIC
low complexity region 55 79 N/A INTRINSIC
Pfam:Glyco_hydro_99 95 445 8.7e-160 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000102628
AA Change: S239P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000099688
Gene: ENSMUSG00000028889
AA Change: S239P

DomainStartEndE-ValueType
low complexity region 32 63 N/A INTRINSIC
Pfam:Sua5_yciO_yrdC 76 256 1.3e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106190
SMART Domains Protein: ENSMUSP00000101796
Gene: ENSMUSG00000078570

DomainStartEndE-ValueType
Pfam:DUF4726 10 110 2e-66 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106193
SMART Domains Protein: ENSMUSP00000101799
Gene: ENSMUSG00000028890

DomainStartEndE-ValueType
ZnF_C2H2 139 163 1.22e-4 SMART
ZnF_C2H2 169 193 6.42e-4 SMART
ZnF_C2H2 199 223 2.4e-3 SMART
ZnF_C2H2 228 252 2.57e-3 SMART
ZnF_C2H2 258 282 2.57e-3 SMART
ZnF_C2H2 288 312 7.37e-4 SMART
low complexity region 429 456 N/A INTRINSIC
low complexity region 500 526 N/A INTRINSIC
low complexity region 545 558 N/A INTRINSIC
low complexity region 628 638 N/A INTRINSIC
low complexity region 656 669 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000125776
Predicted Effect probably benign
Transcript: ENSMUST00000137769
Predicted Effect probably damaging
Transcript: ENSMUST00000144851
AA Change: S86P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000114150
Gene: ENSMUSG00000028889
AA Change: S86P

DomainStartEndE-ValueType
Pfam:Sua5_yciO_yrdC 1 103 2.5e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000163946
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173434
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184704
Predicted Effect probably benign
Transcript: ENSMUST00000185036
SMART Domains Protein: ENSMUSP00000139121
Gene: ENSMUSG00000078570

DomainStartEndE-ValueType
low complexity region 66 89 N/A INTRINSIC
low complexity region 123 137 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp4 A G 7: 44,253,451 V331A possibly damaging Het
Casr C A 16: 36,495,810 V633F probably damaging Het
Cblb T G 16: 52,183,307 V716G probably benign Het
Cbln2 C T 18: 86,716,384 Q156* probably null Het
Cnn1 G T 9: 22,099,397 L14F possibly damaging Het
D830013O20Rik T C 12: 73,364,247 noncoding transcript Het
Drd1 A G 13: 54,053,878 S99P probably damaging Het
Fam35a A G 14: 34,268,625 V108A probably benign Het
Fat1 T C 8: 44,951,670 V486A possibly damaging Het
Galnt7 T C 8: 57,540,039 N416S probably damaging Het
Gm10735 T C 13: 113,041,484 probably benign Het
Gm8909 A T 17: 36,165,354 probably null Het
Jag2 T C 12: 112,912,718 T790A probably benign Het
Klhdc1 T A 12: 69,242,008 Y31N possibly damaging Het
Lama1 A T 17: 67,815,928 M2769L probably benign Het
Mms19 A G 19: 41,945,457 probably null Het
Msrb2 C A 2: 19,394,341 P172T probably damaging Het
Olfr228 T C 2: 86,483,218 S175G probably benign Het
Olfr955 A G 9: 39,470,243 V161A probably benign Het
Pcdhb9 T A 18: 37,403,279 D775E possibly damaging Het
Pkhd1 T C 1: 20,566,874 probably null Het
Preb A T 5: 30,955,964 D375E probably damaging Het
Prkdc T C 16: 15,697,226 I1010T probably damaging Het
Rbp2 A G 9: 98,498,897 probably null Het
Sept9 A G 11: 117,352,184 T66A probably damaging Het
Serpinb9b A T 13: 33,035,625 E178D probably benign Het
Tg A G 15: 66,847,166 Y258C probably damaging Het
Tmprss7 T C 16: 45,663,368 R548G probably benign Het
Uba7 G A 9: 107,979,111 A536T probably benign Het
Vmn2r114 G A 17: 23,291,665 P614S probably damaging Het
Xpc A G 6: 91,492,264 probably benign Het
Zbed6 G T 1: 133,657,376 A741D probably damaging Het
Other mutations in Yrdc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01142:Yrdc APN 4 124853994 missense probably damaging 0.98
R0525:Yrdc UTSW 4 124851766 missense probably damaging 1.00
R1162:Yrdc UTSW 4 124854461 unclassified probably benign
R1220:Yrdc UTSW 4 124854536 missense possibly damaging 0.62
R1952:Yrdc UTSW 4 124851946 missense probably benign 0.00
R3829:Yrdc UTSW 4 124851761 start codon destroyed probably null 0.92
R7121:Yrdc UTSW 4 124850955 missense probably benign 0.06
R7272:Yrdc UTSW 4 124851027 missense probably benign 0.23
R8169:Yrdc UTSW 4 124851087 missense probably benign
R8837:Yrdc UTSW 4 124853884 missense probably benign 0.01
R9159:Yrdc UTSW 4 124854018 critical splice donor site probably null
Z1176:Yrdc UTSW 4 124851497 unclassified probably benign
Posted On 2011-07-12