Incidental Mutation 'R1558:Or4e5'
ID 170446
Institutional Source Beutler Lab
Gene Symbol Or4e5
Ensembl Gene ENSMUSG00000059887
Gene Name olfactory receptor family 4 subfamily E member 5
Synonyms MOR28, MOR244-1, GA_x6K02T2RJGY-491851-492792, Olfr1507
MMRRC Submission 039597-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R1558 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 52727392-52733152 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 52727603 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 273 (I273F)
Ref Sequence ENSEMBL: ENSMUSP00000146152 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073571] [ENSMUST00000205963] [ENSMUST00000206062] [ENSMUST00000206069] [ENSMUST00000206931]
AlphaFold Q0VEP0
Predicted Effect probably benign
Transcript: ENSMUST00000073571
AA Change: I273F

PolyPhen 2 Score 0.264 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000073260
Gene: ENSMUSG00000059887
AA Change: I273F

DomainStartEndE-ValueType
Pfam:7tm_4 34 308 1.1e-47 PFAM
Pfam:7TM_GPCR_Srsx 38 305 3.6e-9 PFAM
Pfam:7tm_1 44 290 9.1e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205963
Predicted Effect probably benign
Transcript: ENSMUST00000206062
AA Change: I273F

PolyPhen 2 Score 0.264 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000206069
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206087
AA Change: I273F
Predicted Effect probably benign
Transcript: ENSMUST00000206931
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.5%
  • 20x: 90.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 T A 4: 53,092,887 (GRCm39) Q299L probably null Het
Adamts9 T G 6: 92,885,692 (GRCm39) K399N possibly damaging Het
Alox12b T C 11: 69,056,711 (GRCm39) F369S probably damaging Het
Alpk2 A G 18: 65,483,301 (GRCm39) Y236H probably benign Het
Ankrd36 T C 11: 5,585,329 (GRCm39) L380P probably damaging Het
Atp2a1 C T 7: 126,051,844 (GRCm39) A468T possibly damaging Het
Caprin1 A T 2: 103,606,332 (GRCm39) F303I possibly damaging Het
Casp7 A T 19: 56,421,684 (GRCm39) R41* probably null Het
Ccdc66 T A 14: 27,208,463 (GRCm39) H753L probably benign Het
Ccnc T C 4: 21,742,671 (GRCm39) M166T probably benign Het
Cdkl3 T A 11: 51,923,337 (GRCm39) M538K possibly damaging Het
Cemip2 T A 19: 21,775,346 (GRCm39) Y196* probably null Het
Cercam G A 2: 29,766,251 (GRCm39) A345T probably benign Het
Chmp3 T A 6: 71,537,954 (GRCm39) C60* probably null Het
Ddx1 C T 12: 13,289,542 (GRCm39) G125S probably damaging Het
Defb7 A G 8: 19,547,567 (GRCm39) D24G probably benign Het
Dgcr8 A T 16: 18,077,452 (GRCm39) Y653N probably damaging Het
Dsc2 T C 18: 20,183,208 (GRCm39) D70G probably damaging Het
Erich3 T G 3: 154,419,705 (GRCm39) N266K probably damaging Het
Fastk A T 5: 24,649,045 (GRCm39) probably null Het
Fat4 A G 3: 38,943,135 (GRCm39) N676S probably damaging Het
Fermt1 A T 2: 132,776,739 (GRCm39) probably null Het
Fmn1 A G 2: 113,523,463 (GRCm39) T1149A possibly damaging Het
Foxo3 A G 10: 42,073,068 (GRCm39) V483A probably damaging Het
Fpgs T C 2: 32,575,852 (GRCm39) T364A possibly damaging Het
Gm12185 A G 11: 48,806,262 (GRCm39) S310P probably damaging Het
Gm15056 A T 8: 21,391,949 (GRCm39) probably benign Het
Hcn1 T C 13: 118,112,112 (GRCm39) V692A unknown Het
Izumo3 A C 4: 92,035,140 (GRCm39) C26G probably damaging Het
Kcnf1 T C 12: 17,225,474 (GRCm39) Y249C probably damaging Het
Kcnj6 T C 16: 94,563,358 (GRCm39) E380G possibly damaging Het
Kdm3b A G 18: 34,942,149 (GRCm39) T747A probably damaging Het
Lrba G A 3: 86,258,622 (GRCm39) G1370R probably damaging Het
Mei1 G A 15: 81,991,334 (GRCm39) R504Q probably damaging Het
Mgat4f G A 1: 134,318,512 (GRCm39) G428D probably damaging Het
Mipol1 T C 12: 57,379,127 (GRCm39) I195T probably damaging Het
Ncor2 G A 5: 125,110,610 (GRCm39) T1350I probably damaging Het
Npy A G 6: 49,800,705 (GRCm39) E43G probably damaging Het
Or5w19 T A 2: 87,698,459 (GRCm39) N41K probably damaging Het
Or8d2 T A 9: 38,760,200 (GRCm39) N263K probably benign Het
Pcdhb3 T C 18: 37,434,634 (GRCm39) L200P probably damaging Het
Pcnt G A 10: 76,258,756 (GRCm39) H570Y possibly damaging Het
Phf8-ps T A 17: 33,284,679 (GRCm39) I708F probably benign Het
Pkd1l2 A C 8: 117,808,991 (GRCm39) D66E possibly damaging Het
Plekhg4 A G 8: 106,108,467 (GRCm39) D1170G possibly damaging Het
Poln T A 5: 34,190,143 (GRCm39) H672L probably benign Het
Ptprq T C 10: 107,479,904 (GRCm39) Y1122C probably damaging Het
Ptrhd1 A G 12: 4,286,505 (GRCm39) Y132C probably damaging Het
Pwwp3a G T 10: 80,068,778 (GRCm39) R307S probably benign Het
Riok1 G T 13: 38,234,831 (GRCm39) R300L probably damaging Het
Sbf2 G T 7: 110,027,553 (GRCm39) T481K probably damaging Het
Sidt2 A T 9: 45,863,098 (GRCm39) M11K probably damaging Het
Slc66a1 A T 4: 139,027,391 (GRCm39) probably benign Het
Syne1 G A 10: 5,299,280 (GRCm39) R992* probably null Het
Tmem8b C A 4: 43,681,134 (GRCm39) R384S possibly damaging Het
Trim28 T C 7: 12,761,761 (GRCm39) Y243H probably damaging Het
Trpm6 T C 19: 18,764,192 (GRCm39) M266T probably benign Het
Tsg101 A T 7: 46,539,437 (GRCm39) S368T probably damaging Het
Ttc28 G A 5: 111,373,543 (GRCm39) S962N probably damaging Het
Ttc6 G A 12: 57,733,132 (GRCm39) V1092I probably benign Het
Vps13b C T 15: 35,534,465 (GRCm39) T927I probably damaging Het
Zfr C T 15: 12,140,730 (GRCm39) T259I unknown Het
Other mutations in Or4e5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01336:Or4e5 APN 14 52,728,205 (GRCm39) missense probably damaging 1.00
IGL01367:Or4e5 APN 14 52,727,624 (GRCm39) missense probably benign 0.42
IGL01664:Or4e5 APN 14 52,728,002 (GRCm39) missense probably benign 0.01
IGL02890:Or4e5 APN 14 52,728,368 (GRCm39) missense probably benign
IGL03108:Or4e5 APN 14 52,727,533 (GRCm39) missense probably damaging 0.97
IGL03184:Or4e5 APN 14 52,728,380 (GRCm39) missense probably benign 0.20
R0563:Or4e5 UTSW 14 52,727,714 (GRCm39) nonsense probably null
R1080:Or4e5 UTSW 14 52,728,042 (GRCm39) nonsense probably null
R1653:Or4e5 UTSW 14 52,728,229 (GRCm39) missense probably damaging 1.00
R1714:Or4e5 UTSW 14 52,727,871 (GRCm39) splice site probably null
R1720:Or4e5 UTSW 14 52,728,051 (GRCm39) nonsense probably null
R3430:Or4e5 UTSW 14 52,727,882 (GRCm39) missense possibly damaging 0.92
R4995:Or4e5 UTSW 14 52,727,988 (GRCm39) nonsense probably null
R5954:Or4e5 UTSW 14 52,727,624 (GRCm39) missense probably benign 0.42
R6183:Or4e5 UTSW 14 52,728,188 (GRCm39) missense probably benign 0.05
R6518:Or4e5 UTSW 14 52,728,077 (GRCm39) missense probably damaging 1.00
R6651:Or4e5 UTSW 14 52,728,250 (GRCm39) missense probably benign 0.07
R6652:Or4e5 UTSW 14 52,728,250 (GRCm39) missense probably benign 0.07
R6653:Or4e5 UTSW 14 52,728,250 (GRCm39) missense probably benign 0.07
R7385:Or4e5 UTSW 14 52,727,638 (GRCm39) missense probably damaging 1.00
R7524:Or4e5 UTSW 14 52,727,750 (GRCm39) missense probably damaging 1.00
R8902:Or4e5 UTSW 14 52,728,010 (GRCm39) missense probably benign 0.02
R9165:Or4e5 UTSW 14 52,727,830 (GRCm39) missense possibly damaging 0.71
R9763:Or4e5 UTSW 14 52,728,307 (GRCm39) missense probably damaging 1.00
X0025:Or4e5 UTSW 14 52,727,923 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGTAGCAGGGTAACTTTCAGCATGG -3'
(R):5'- CATCCTTGTGAGTCTGAGGCAACAG -3'

Sequencing Primer
(F):5'- GATGAGCATGTAACTACTGCTG -3'
(R):5'- GTCTGAGGCAACAGATCTCTGAC -3'
Posted On 2014-04-13