Incidental Mutation 'R1560:Trim38'
ID 170571
Institutional Source Beutler Lab
Gene Symbol Trim38
Ensembl Gene ENSMUSG00000064140
Gene Name tripartite motif-containing 38
Synonyms LOC214158
MMRRC Submission 039599-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R1560 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 23962483-23975721 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 23966685 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 44 (Y44C)
Ref Sequence ENSEMBL: ENSMUSP00000153540 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074067] [ENSMUST00000223911] [ENSMUST00000226039]
AlphaFold Q5SZ99
Predicted Effect probably benign
Transcript: ENSMUST00000074067
AA Change: Y44C

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000073709
Gene: ENSMUSG00000064140
AA Change: Y44C

DomainStartEndE-ValueType
RING 16 61 8.95e-7 SMART
BBOX 90 131 4.34e-5 SMART
coiled coil region 202 249 N/A INTRINSIC
PRY 293 347 2.31e-9 SMART
SPRY 348 469 6.71e-21 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000223911
AA Change: Y44C

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000226039
AA Change: Y44C

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased poly(I:C) and LPS-induced IFN-beta, TNFalpha and IL6 with increased induced mortality induced by poly(I:C), LPS or S. typhimurium infection, [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik A G 7: 41,275,466 (GRCm39) T390A probably benign Het
Adamts8 T A 9: 30,867,963 (GRCm39) C596S probably damaging Het
Avl9 T A 6: 56,702,113 (GRCm39) Y89* probably null Het
Cacna1e G A 1: 154,296,850 (GRCm39) R18* probably null Het
Cacng2 A G 15: 77,897,518 (GRCm39) F97S probably benign Het
Calu A G 6: 29,361,657 (GRCm39) D107G probably benign Het
Capns2 G A 8: 93,628,771 (GRCm39) R220Q probably damaging Het
Catsperb C T 12: 101,591,985 (GRCm39) T1105I probably benign Het
Cep350 T C 1: 155,804,825 (GRCm39) N753D possibly damaging Het
D6Ertd527e C G 6: 87,088,506 (GRCm39) T223S unknown Het
Dnah5 G T 15: 28,420,149 (GRCm39) V3816F probably damaging Het
Dzip3 T C 16: 48,771,903 (GRCm39) probably null Het
Ep400 A T 5: 110,818,972 (GRCm39) probably null Het
Epb41l2 T A 10: 25,371,334 (GRCm39) probably null Het
Fetub T C 16: 22,758,117 (GRCm39) V300A probably benign Het
Gabrb3 A T 7: 57,466,043 (GRCm39) M308L probably damaging Het
Galnt16 A T 12: 80,648,566 (GRCm39) D546V possibly damaging Het
Gimap8 G T 6: 48,633,068 (GRCm39) G296W probably damaging Het
Gpr158 A G 2: 21,831,125 (GRCm39) K742E probably damaging Het
Hmbs T C 9: 44,248,657 (GRCm39) H72R possibly damaging Het
Krt16 A G 11: 100,137,475 (GRCm39) I410T probably damaging Het
Lamb3 G A 1: 193,021,710 (GRCm39) A971T probably benign Het
Lilra6 A C 7: 3,914,407 (GRCm39) probably null Het
Mroh7 A T 4: 106,568,451 (GRCm39) M418K possibly damaging Het
Myh11 T A 16: 14,044,484 (GRCm39) K640* probably null Het
Nsd1 T A 13: 55,394,533 (GRCm39) C711* probably null Het
Or1j17 T A 2: 36,578,155 (GRCm39) L47Q probably damaging Het
Or2ak5 A T 11: 58,611,513 (GRCm39) Y120* probably null Het
Or3a10 A G 11: 73,935,441 (GRCm39) S220P probably damaging Het
Or4c111 T C 2: 88,843,550 (GRCm39) Y286C probably damaging Het
Otop3 A T 11: 115,235,289 (GRCm39) H307L possibly damaging Het
Plekhm3 T C 1: 64,976,976 (GRCm39) T165A probably benign Het
Poldip3 G A 15: 83,022,527 (GRCm39) R86W probably damaging Het
Rif1 A T 2: 52,001,143 (GRCm39) R1532S probably damaging Het
Sf3b1 C G 1: 55,058,554 (GRCm39) E12Q possibly damaging Het
Slc27a6 T A 18: 58,712,904 (GRCm39) L242* probably null Het
Spata45 T C 1: 190,772,017 (GRCm39) S80P probably benign Het
Taf4 A G 2: 179,577,746 (GRCm39) V525A probably benign Het
Tbck A G 3: 132,543,809 (GRCm39) T887A probably damaging Het
Tnrc6c C T 11: 117,650,463 (GRCm39) T1571I probably damaging Het
Tsg101 A T 7: 46,542,208 (GRCm39) probably null Het
Tsku T A 7: 98,002,151 (GRCm39) D60V probably damaging Het
Ttc28 G A 5: 111,373,543 (GRCm39) S962N probably damaging Het
Upf1 G A 8: 70,791,092 (GRCm39) P550L probably damaging Het
Vipr2 A G 12: 116,058,401 (GRCm39) D106G probably benign Het
Vps13c T C 9: 67,843,745 (GRCm39) probably null Het
Washc4 T C 10: 83,391,973 (GRCm39) Y220H probably damaging Het
Wdr81 C T 11: 75,342,449 (GRCm39) W939* probably null Het
Zfp512b T C 2: 181,230,472 (GRCm39) T473A probably benign Het
Other mutations in Trim38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00915:Trim38 APN 13 23,975,015 (GRCm39) missense possibly damaging 0.91
IGL01592:Trim38 APN 13 23,975,410 (GRCm39) missense possibly damaging 0.85
IGL02339:Trim38 APN 13 23,972,213 (GRCm39) missense probably damaging 1.00
IGL03062:Trim38 APN 13 23,966,946 (GRCm39) missense probably damaging 1.00
IGL03278:Trim38 APN 13 23,974,979 (GRCm39) missense possibly damaging 0.65
R0630:Trim38 UTSW 13 23,975,115 (GRCm39) nonsense probably null
R1263:Trim38 UTSW 13 23,975,117 (GRCm39) missense probably damaging 1.00
R1978:Trim38 UTSW 13 23,975,081 (GRCm39) missense probably damaging 1.00
R4407:Trim38 UTSW 13 23,975,474 (GRCm39) missense probably benign 0.04
R4462:Trim38 UTSW 13 23,975,435 (GRCm39) missense probably null 1.00
R4649:Trim38 UTSW 13 23,966,952 (GRCm39) missense probably damaging 1.00
R4651:Trim38 UTSW 13 23,966,952 (GRCm39) missense probably damaging 1.00
R4653:Trim38 UTSW 13 23,966,952 (GRCm39) missense probably damaging 1.00
R4816:Trim38 UTSW 13 23,972,264 (GRCm39) missense probably damaging 1.00
R4970:Trim38 UTSW 13 23,975,312 (GRCm39) missense probably damaging 0.98
R5946:Trim38 UTSW 13 23,966,717 (GRCm39) missense probably benign 0.04
R6538:Trim38 UTSW 13 23,969,932 (GRCm39) missense probably damaging 0.97
R6974:Trim38 UTSW 13 23,973,502 (GRCm39) missense probably benign 0.05
R7227:Trim38 UTSW 13 23,969,946 (GRCm39) missense possibly damaging 0.88
R7319:Trim38 UTSW 13 23,975,384 (GRCm39) missense probably damaging 1.00
R7425:Trim38 UTSW 13 23,972,365 (GRCm39) missense probably benign 0.02
R8243:Trim38 UTSW 13 23,975,378 (GRCm39) missense probably damaging 1.00
R8965:Trim38 UTSW 13 23,975,006 (GRCm39) missense possibly damaging 0.65
R9354:Trim38 UTSW 13 23,969,875 (GRCm39) missense probably benign 0.09
R9573:Trim38 UTSW 13 23,966,688 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGAGAGGAAGCTATCTTACCTCTGCC -3'
(R):5'- CCGTCATCTTCACAAAAGCGATTGAAC -3'

Sequencing Primer
(F):5'- aaatggaatgtgagcaataaaacag -3'
(R):5'- CTTCACAAAAGCGATTGAACTTCTC -3'
Posted On 2014-04-13