Mutagenetix > Incidental Mutation

Incidental Mutation 'R1561:Gpr151'

170644

Institutional Source

Beutler Lab

Gene Symbol

Gpr151

Ensembl Gene

ENSMUSG00000042816

Gene Name

G protein-coupled receptor 151

Synonyms

GalRL, PGR7, C130082O03Rik

MMRRC Submission

039600-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1561 (G1)

Quality Score

174

Status

Not validated

Chromosome

Chromosomal Location

42710946-42712717 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 42712221 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 152 (S152R)

Ref Sequence

ENSEMBL: ENSMUSP00000058887 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025375] [ENSMUST00000054738] [ENSMUST00000173642]

AlphaFold

Q7TSN6

Predicted Effect

probably benign
Transcript: ENSMUST00000025375

SMART Domains

Protein: ENSMUSP00000025375
Gene: ENSMUSG00000024498

Domain	Start	End	E-Value	Type
low complexity region	3	13	N/A	INTRINSIC
low complexity region	40	92	N/A	INTRINSIC
WW	132	164	8.27e-10	SMART
low complexity region	178	257	N/A	INTRINSIC
low complexity region	260	347	N/A	INTRINSIC
low complexity region	350	373	N/A	INTRINSIC
WW	432	464	2.65e-8	SMART
WW	531	563	1.2e-6	SMART
low complexity region	611	623	N/A	INTRINSIC
coiled coil region	629	654	N/A	INTRINSIC
FF	661	714	2.67e-13	SMART
FF	727	781	1.51e-12	SMART
FF	794	848	4.29e-17	SMART
FF	898	954	8.33e-15	SMART
FF	956	1012	1.47e-15	SMART
FF	1014	1079	1.3e-16	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000054738
AA Change: S152R

PolyPhen 2 Score 0.418 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000058887
Gene: ENSMUSG00000042816
AA Change: S152R

Domain	Start	End	E-Value	Type
Pfam:7tm_1	57	310	1.6e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000173642

SMART Domains

Protein: ENSMUSP00000134458
Gene: ENSMUSG00000024498

Domain	Start	End	E-Value	Type
low complexity region	3	13	N/A	INTRINSIC
low complexity region	40	92	N/A	INTRINSIC
WW	132	164	8.27e-10	SMART
low complexity region	178	257	N/A	INTRINSIC
low complexity region	260	347	N/A	INTRINSIC
low complexity region	350	373	N/A	INTRINSIC
WW	432	464	2.65e-8	SMART
WW	531	563	1.2e-6	SMART
low complexity region	611	623	N/A	INTRINSIC
coiled coil region	629	654	N/A	INTRINSIC
FF	661	714	2.67e-13	SMART
FF	727	781	1.51e-12	SMART
FF	794	848	4.29e-17	SMART
FF	898	954	8.33e-15	SMART
FF	956	1012	1.47e-15	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184771

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.6%
20x: 89.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is similar to the galanin receptor subfamily of G protein-coupled receptors. The encoded protein is found predominantly in the central nervous system. [provided by RefSeq, Feb 2017]
PHENOTYPE: Homozygous mutation of this gene does not appear to result in a phenotype. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsbg3	A	G	17: 57,184,431 (GRCm39)	N69D	probably benign	Het
Alms1	T	A	6: 85,606,034 (GRCm39)	Y2561*	probably null	Het
Ap1g2	T	C	14: 55,342,344 (GRCm39)	E171G	probably damaging	Het
Atg7	T	C	6: 114,678,133 (GRCm39)	V341A	possibly damaging	Het
Bace1	G	T	9: 45,750,492 (GRCm39)	R56L	probably benign	Het
Cd200l1	A	G	16: 45,262,875 (GRCm39)	V88A	possibly damaging	Het
Chfr	A	T	5: 110,306,674 (GRCm39)	D472V	probably benign	Het
Ckap2l	G	A	2: 129,112,645 (GRCm39)	T621I	probably benign	Het
Cmip	A	G	8: 118,180,589 (GRCm39)	T554A	probably benign	Het
Crocc	C	T	4: 140,757,579 (GRCm39)	E905K	probably damaging	Het
D6Ertd527e	C	G	6: 87,088,506 (GRCm39)	T223S	unknown	Het
Dna2	C	T	10: 62,784,966 (GRCm39)	R28W	probably benign	Het
Ecm1	G	A	3: 95,643,275 (GRCm39)	R342C	probably damaging	Het
F5	C	A	1: 164,014,472 (GRCm39)	S581*	probably null	Het
Fam227a	T	A	15: 79,520,963 (GRCm39)	Y291F	possibly damaging	Het
Gpr158	A	T	2: 21,820,505 (GRCm39)		probably null	Het
Kcna5	T	C	6: 126,511,546 (GRCm39)	Y194C	probably damaging	Het
Khsrp	A	G	17: 57,332,639 (GRCm39)	S214P	probably benign	Het
Mrgprb1	C	G	7: 48,096,873 (GRCm39)		probably null	Het
Mrnip	C	T	11: 50,067,676 (GRCm39)	T30I	probably damaging	Het
Mtus2	A	C	5: 148,013,362 (GRCm39)	K52Q	probably benign	Het
Naca	G	T	10: 127,876,267 (GRCm39)		probably benign	Het
Obscn	T	G	11: 58,926,899 (GRCm39)	T5539P	probably damaging	Het
Or13p3	T	A	4: 118,566,751 (GRCm39)	I49N	probably damaging	Het
Or9m1	C	T	2: 87,733,505 (GRCm39)	V172I	probably benign	Het
Ovca2	A	G	11: 75,068,805 (GRCm39)	L198P	probably damaging	Het
Pdzrn4	T	C	15: 92,575,518 (GRCm39)	V308A	possibly damaging	Het
Pkd1l3	A	G	8: 110,341,445 (GRCm39)	I99M	unknown	Het
Polr3b	T	A	10: 84,470,776 (GRCm39)	M139K	probably damaging	Het
Prkag2	T	C	5: 25,076,593 (GRCm39)	Y191C	probably damaging	Het
Prss47	A	T	13: 65,194,062 (GRCm39)	C278S	probably damaging	Het
Ptprm	T	C	17: 67,247,536 (GRCm39)	T600A	probably damaging	Het
Ruvbl1	T	C	6: 88,456,136 (GRCm39)	V70A	probably damaging	Het
Sf3a1	T	C	11: 4,129,217 (GRCm39)	V726A	probably benign	Het
Sf3b1	C	G	1: 55,058,554 (GRCm39)	E12Q	possibly damaging	Het
Slc26a3	A	G	12: 31,516,451 (GRCm39)	N603S	probably benign	Het
Slc2a1	A	G	4: 118,993,606 (GRCm39)	E481G	possibly damaging	Het
Slc35a5	A	C	16: 44,971,884 (GRCm39)	S127A	possibly damaging	Het
Spen	C	A	4: 141,199,694 (GRCm39)	G2978*	probably null	Het
Srrt	T	A	5: 137,298,281 (GRCm39)	E297V	probably benign	Het
Srsf4	T	A	4: 131,625,006 (GRCm39)	D134E	probably damaging	Het
Tdrd6	G	A	17: 43,936,515 (GRCm39)	S1511L	probably damaging	Het
Tmem65	T	A	15: 58,694,707 (GRCm39)	I91F	probably benign	Het
Top2b	A	G	14: 16,398,993 (GRCm38)	K538E	possibly damaging	Het
Trappc8	G	A	18: 20,974,680 (GRCm39)	R883*	probably null	Het
Ttc28	G	A	5: 111,373,543 (GRCm39)	S962N	probably damaging	Het
Vav3	T	C	3: 109,402,154 (GRCm39)		probably null	Het
Vmn1r42	C	T	6: 89,822,363 (GRCm39)	G69S	probably damaging	Het
Zan	A	T	5: 137,379,100 (GRCm39)	Y5333*	probably null	Het
Zfp994	A	C	17: 22,420,206 (GRCm39)	F248V	probably damaging	Het

Other mutations in Gpr151

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02631:Gpr151	APN	18	42,711,835 (GRCm39)	missense	probably benign	0.03
IGL03167:Gpr151	APN	18	42,711,439 (GRCm39)	missense	probably benign	0.06
R3875:Gpr151	UTSW	18	42,711,661 (GRCm39)	missense	probably benign	0.02
R4294:Gpr151	UTSW	18	42,711,602 (GRCm39)	missense	probably benign	0.00
R5188:Gpr151	UTSW	18	42,711,820 (GRCm39)	missense	probably benign
R5431:Gpr151	UTSW	18	42,711,932 (GRCm39)	missense	probably damaging	1.00
R5815:Gpr151	UTSW	18	42,712,450 (GRCm39)	missense	probably benign	0.00
R6199:Gpr151	UTSW	18	42,711,619 (GRCm39)	missense	probably benign	0.31
R6302:Gpr151	UTSW	18	42,712,459 (GRCm39)	missense	probably damaging	1.00
R6891:Gpr151	UTSW	18	42,711,985 (GRCm39)	missense	probably benign	0.15
R7180:Gpr151	UTSW	18	42,712,021 (GRCm39)	nonsense	probably null
R8262:Gpr151	UTSW	18	42,711,437 (GRCm39)	nonsense	probably null
R9328:Gpr151	UTSW	18	42,712,270 (GRCm39)	missense	probably damaging	0.98
R9421:Gpr151	UTSW	18	42,712,220 (GRCm39)	missense	probably benign	0.00
R9524:Gpr151	UTSW	18	42,712,710 (GRCm39)	unclassified	probably benign

Predicted Primers

PCR Primer
(F):5'- TATCCACTCTGGGAGCCACAGAAG -3'
(R):5'- GCGTTTGGAAAAGAAAGCCATCCAC -3'

Sequencing Primer
(F):5'- AGTGCTTAGCAGCATCACTG -3'
(R):5'- TGAATCTAAGCCTGGCTGAC -3'

Posted On

2014-04-13