Incidental Mutation 'R1562:Coro2a'
ID 170662
Institutional Source Beutler Lab
Gene Symbol Coro2a
Ensembl Gene ENSMUSG00000028337
Gene Name coronin, actin binding protein 2A
Synonyms 9030208C03Rik, IR10, coronin 4
MMRRC Submission 039601-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R1562 (G1)
Quality Score 212
Status Not validated
Chromosome 4
Chromosomal Location 46536937-46601929 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 46548917 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 126 (I126V)
Ref Sequence ENSEMBL: ENSMUSP00000103386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030021] [ENSMUST00000107756] [ENSMUST00000107757]
AlphaFold Q8C0P5
Predicted Effect probably benign
Transcript: ENSMUST00000030021
AA Change: I107V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000030021
Gene: ENSMUSG00000028337
AA Change: I107V

DomainStartEndE-ValueType
DUF1899 5 69 3.93e-33 SMART
WD40 68 111 2.04e-5 SMART
WD40 121 161 1.58e-2 SMART
WD40 169 208 2.55e-6 SMART
DUF1900 261 397 9.15e-84 SMART
coiled coil region 488 521 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000107756
AA Change: I107V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000103385
Gene: ENSMUSG00000028337
AA Change: I107V

DomainStartEndE-ValueType
DUF1899 5 69 3.93e-33 SMART
WD40 68 111 2.04e-5 SMART
WD40 121 161 1.58e-2 SMART
WD40 169 208 2.55e-6 SMART
DUF1900 261 397 9.15e-84 SMART
coiled coil region 488 521 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000107757
AA Change: I126V

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000103386
Gene: ENSMUSG00000028337
AA Change: I126V

DomainStartEndE-ValueType
DUF1899 24 88 3.93e-33 SMART
WD40 87 130 2.04e-5 SMART
WD40 140 180 1.58e-2 SMART
WD40 188 227 2.55e-6 SMART
DUF1900 280 416 9.15e-84 SMART
coiled coil region 507 540 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139179
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.8%
  • 20x: 91.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca2 A G 2: 25,336,331 (GRCm39) I2201V probably benign Het
Adam22 T C 5: 8,145,007 (GRCm39) N817S probably damaging Het
Alox12 C A 11: 70,140,991 (GRCm39) R348L probably damaging Het
Asb17 A T 3: 153,559,143 (GRCm39) T285S probably benign Het
Casp4 T C 9: 5,324,733 (GRCm39) S182P possibly damaging Het
Cenpe T C 3: 134,944,155 (GRCm39) M985T possibly damaging Het
Clcn1 C T 6: 42,277,169 (GRCm39) P420L probably benign Het
Cubn T C 2: 13,432,778 (GRCm39) Y1181C probably damaging Het
Cyp2d22 A T 15: 82,258,179 (GRCm39) L147Q probably damaging Het
Dna2 C T 10: 62,784,966 (GRCm39) R28W probably benign Het
Ecm1 G A 3: 95,643,275 (GRCm39) R342C probably damaging Het
Fat2 T C 11: 55,200,800 (GRCm39) N758S probably damaging Het
Fbxo43 T C 15: 36,163,162 (GRCm39) D15G probably damaging Het
Flt3 T C 5: 147,281,323 (GRCm39) E803G probably damaging Het
Folr1 T G 7: 101,507,801 (GRCm39) D213A probably damaging Het
Fus T C 7: 127,579,094 (GRCm39) V359A probably damaging Het
Gabrb3 C T 7: 57,415,262 (GRCm39) R111* probably null Het
Gm17324 T C 9: 78,355,964 (GRCm39) probably benign Het
Hormad2 A T 11: 4,358,848 (GRCm39) probably null Het
Ifi27l2b T A 12: 103,422,780 (GRCm39) probably null Het
Isg20 G T 7: 78,569,891 (GRCm39) C176F probably benign Het
Katnip C A 7: 125,442,020 (GRCm39) S643Y probably damaging Het
Krt15 C A 11: 100,024,007 (GRCm39) V346L probably benign Het
Liat1 A T 11: 75,894,024 (GRCm39) I134F probably damaging Het
Med13l A G 5: 118,876,584 (GRCm39) K920R probably damaging Het
Mlh3 A T 12: 85,313,694 (GRCm39) F831I probably benign Het
Mtmr9 A G 14: 63,771,786 (GRCm39) S267P probably benign Het
Mybpc1 C T 10: 88,389,193 (GRCm39) A406T probably damaging Het
Myh1 T C 11: 67,102,196 (GRCm39) M829T probably benign Het
Myo10 A G 15: 25,780,497 (GRCm39) Q209R possibly damaging Het
Nceh1 T A 3: 27,293,701 (GRCm39) V153D probably damaging Het
Oog3 A T 4: 143,889,169 (GRCm39) I3N probably damaging Het
Or1j19 A G 2: 36,676,696 (GRCm39) D53G probably damaging Het
Or2ag1b C T 7: 106,288,187 (GRCm39) M250I probably benign Het
Or4c103 T A 2: 88,513,423 (GRCm39) I218F probably benign Het
Or8c20 C A 9: 38,260,658 (GRCm39) S87* probably null Het
Pcnt G A 10: 76,203,164 (GRCm39) T2646M probably benign Het
Phf10 A T 17: 15,166,512 (GRCm39) C453S probably damaging Het
Plcb4 T A 2: 135,812,367 (GRCm39) probably null Het
Plekhh1 A G 12: 79,123,482 (GRCm39) H1185R probably benign Het
Prmt3 G T 7: 49,476,602 (GRCm39) V404L probably benign Het
Ptprb T A 10: 116,175,372 (GRCm39) D1122E probably benign Het
Rars1 A G 11: 35,711,921 (GRCm39) probably null Het
Rasa2 G T 9: 96,427,803 (GRCm39) N687K possibly damaging Het
Rbm11 A G 16: 75,393,423 (GRCm39) T40A probably damaging Het
Rem2 T C 14: 54,713,775 (GRCm39) V16A probably benign Het
Rlf A T 4: 121,007,588 (GRCm39) M574K possibly damaging Het
Rpap3 A T 15: 97,592,098 (GRCm39) V186D possibly damaging Het
Sertad3 G A 7: 27,176,048 (GRCm39) E161K probably damaging Het
Sh3gl2 T C 4: 85,304,130 (GRCm39) S278P probably benign Het
Strn3 T C 12: 51,680,401 (GRCm39) T400A probably benign Het
Sycp2 A T 2: 178,024,178 (GRCm39) I402N probably damaging Het
Synj1 C T 16: 90,784,290 (GRCm39) V283I probably benign Het
Tas2r108 A G 6: 40,471,000 (GRCm39) probably null Het
Ttpal A G 2: 163,457,323 (GRCm39) N265S probably benign Het
Unc80 G A 1: 66,677,116 (GRCm39) G2015D probably damaging Het
Upf1 C T 8: 70,796,017 (GRCm39) W138* probably null Het
Vmn1r25 T G 6: 57,955,786 (GRCm39) M168L probably benign Het
Vmn2r18 A T 5: 151,510,301 (GRCm39) F24Y probably benign Het
Vmn2r4 G T 3: 64,296,865 (GRCm39) T640N probably damaging Het
Wdr75 T A 1: 45,843,030 (GRCm39) probably null Het
Zdbf2 T G 1: 63,342,747 (GRCm39) S375R possibly damaging Het
Zfp648 A G 1: 154,080,138 (GRCm39) Q99R probably benign Het
Zfp964 C T 8: 70,115,654 (GRCm39) P85S probably benign Het
Other mutations in Coro2a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00478:Coro2a APN 4 46,540,455 (GRCm39) missense probably benign 0.06
IGL03093:Coro2a APN 4 46,544,158 (GRCm39) missense possibly damaging 0.93
lonewolf UTSW 4 46,542,255 (GRCm39) missense probably damaging 1.00
R1862:Coro2a UTSW 4 46,548,797 (GRCm39) missense possibly damaging 0.93
R1931:Coro2a UTSW 4 46,539,138 (GRCm39) makesense probably null
R4385:Coro2a UTSW 4 46,541,961 (GRCm39) missense possibly damaging 0.93
R5171:Coro2a UTSW 4 46,542,372 (GRCm39) intron probably benign
R5243:Coro2a UTSW 4 46,545,620 (GRCm39) missense probably damaging 1.00
R5393:Coro2a UTSW 4 46,542,255 (GRCm39) missense probably damaging 1.00
R5785:Coro2a UTSW 4 46,564,691 (GRCm39) missense probably benign 0.03
R6014:Coro2a UTSW 4 46,542,261 (GRCm39) missense probably damaging 1.00
R6184:Coro2a UTSW 4 46,540,504 (GRCm39) missense probably benign
R6264:Coro2a UTSW 4 46,562,912 (GRCm39) missense probably damaging 1.00
R6601:Coro2a UTSW 4 46,543,421 (GRCm39) nonsense probably null
R6732:Coro2a UTSW 4 46,551,374 (GRCm39) missense probably damaging 0.99
R6760:Coro2a UTSW 4 46,540,572 (GRCm39) missense probably benign
R7499:Coro2a UTSW 4 46,539,188 (GRCm39) missense probably benign 0.01
R7516:Coro2a UTSW 4 46,562,992 (GRCm39) missense probably benign 0.12
R7567:Coro2a UTSW 4 46,546,674 (GRCm39) missense probably damaging 0.99
R7816:Coro2a UTSW 4 46,546,809 (GRCm39) missense probably benign 0.01
R8008:Coro2a UTSW 4 46,551,349 (GRCm39) missense probably damaging 1.00
R8236:Coro2a UTSW 4 46,548,796 (GRCm39) missense possibly damaging 0.93
R8513:Coro2a UTSW 4 46,544,117 (GRCm39) frame shift probably null
R8515:Coro2a UTSW 4 46,544,117 (GRCm39) frame shift probably null
R9024:Coro2a UTSW 4 46,542,323 (GRCm39) missense probably benign 0.34
R9113:Coro2a UTSW 4 46,563,047 (GRCm39) missense
R9445:Coro2a UTSW 4 46,540,558 (GRCm39) missense probably benign 0.00
R9534:Coro2a UTSW 4 46,548,884 (GRCm39) missense probably benign 0.00
RF012:Coro2a UTSW 4 46,542,336 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGTGTGTGGTTTCCCAGGTACAG -3'
(R):5'- GCTCAGGTCACCATGATGGTCAAAG -3'

Sequencing Primer
(F):5'- TTTCCCAGGTACAGGAGCTG -3'
(R):5'- CCATGATGGTCAAAGTCCCTG -3'
Posted On 2014-04-13