Incidental Mutation 'R0104:Tas2r135'
ID 17082
Institutional Source Beutler Lab
Gene Symbol Tas2r135
Ensembl Gene ENSMUSG00000056203
Gene Name taste receptor, type 2, member 135
Synonyms mt2r38, Tas2r35
MMRRC Submission 038390-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R0104 (G1)
Quality Score
Status Validated
Chromosome 6
Chromosomal Location 42382463-42383428 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 42383258 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 266 (I266F)
Ref Sequence ENSEMBL: ENSMUSP00000070247 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070178]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000070178
AA Change: I266F

PolyPhen 2 Score 0.793 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000070247
Gene: ENSMUSG00000056203
AA Change: I266F

DomainStartEndE-ValueType
Pfam:TAS2R 22 320 1.3e-63 PFAM
Meta Mutation Damage Score 0.4938 question?
Coding Region Coverage
  • 1x: 75.5%
  • 3x: 52.6%
  • 10x: 7.5%
  • 20x: 3.0%
Validation Efficiency 100% (37/37)
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3100002H09Rik C A 4: 124,504,469 (GRCm39) A28S probably damaging Het
Arhgap5 A T 12: 52,563,500 (GRCm39) D157V probably damaging Het
Cfap54 G T 10: 92,864,514 (GRCm39) H142N probably damaging Het
Dpp10 A T 1: 123,295,572 (GRCm39) M525K probably benign Het
Fsip2 A T 2: 82,809,317 (GRCm39) T1879S possibly damaging Het
Gm14129 T C 2: 148,773,493 (GRCm39) noncoding transcript Het
Ighv2-7 A T 12: 113,771,088 (GRCm39) W66R probably damaging Het
Kif11 T A 19: 37,401,663 (GRCm39) V880D probably benign Het
Mcpt1 T A 14: 56,256,888 (GRCm39) M142K possibly damaging Het
Mlst8 T C 17: 24,695,091 (GRCm39) N264S possibly damaging Het
Nmrk1 T A 19: 18,618,582 (GRCm39) S88R probably benign Het
Or14j2 T A 17: 37,885,817 (GRCm39) I166F probably damaging Het
Or8d23 A G 9: 38,842,261 (GRCm39) S265G possibly damaging Het
Rtn1 A T 12: 72,355,619 (GRCm39) I109N probably damaging Het
Slc15a2 T A 16: 36,594,997 (GRCm39) L156F possibly damaging Het
Slc22a21 A C 11: 53,842,635 (GRCm39) M498R probably null Het
Ssc5d T C 7: 4,939,285 (GRCm39) S574P probably benign Het
Taf2 T C 15: 54,901,734 (GRCm39) D820G probably benign Het
Trgv4 C T 13: 19,369,480 (GRCm39) H75Y probably damaging Het
Vil1 A G 1: 74,457,525 (GRCm39) K53E probably benign Het
Zfc3h1 T A 10: 115,251,192 (GRCm39) M1261K possibly damaging Het
Zfp655 T C 5: 145,180,825 (GRCm39) S228P probably damaging Het
Zfyve9 C A 4: 108,575,360 (GRCm39) D574Y probably damaging Het
Other mutations in Tas2r135
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01357:Tas2r135 APN 6 42,383,078 (GRCm39) missense probably benign 0.00
IGL01395:Tas2r135 APN 6 42,382,846 (GRCm39) nonsense probably null
IGL02479:Tas2r135 APN 6 42,382,685 (GRCm39) nonsense probably null
IGL02526:Tas2r135 APN 6 42,383,214 (GRCm39) missense probably damaging 1.00
IGL02806:Tas2r135 APN 6 42,383,382 (GRCm39) missense probably benign 0.00
IGL02982:Tas2r135 APN 6 42,383,187 (GRCm39) missense probably benign
IGL03057:Tas2r135 APN 6 42,378,061 (GRCm39) unclassified probably benign
R0057:Tas2r135 UTSW 6 42,383,354 (GRCm39) missense probably benign 0.07
R1412:Tas2r135 UTSW 6 42,382,768 (GRCm39) missense probably benign 0.00
R4517:Tas2r135 UTSW 6 42,383,013 (GRCm39) missense probably benign
R4629:Tas2r135 UTSW 6 42,383,160 (GRCm39) missense probably benign 0.03
R5788:Tas2r135 UTSW 6 42,382,531 (GRCm39) missense probably damaging 1.00
R6021:Tas2r135 UTSW 6 42,383,321 (GRCm39) missense probably damaging 1.00
R6586:Tas2r135 UTSW 6 42,382,952 (GRCm39) missense probably benign 0.18
R7180:Tas2r135 UTSW 6 42,382,685 (GRCm39) nonsense probably null
R7458:Tas2r135 UTSW 6 42,382,881 (GRCm39) missense possibly damaging 0.95
R7850:Tas2r135 UTSW 6 42,383,072 (GRCm39) missense probably benign
R9113:Tas2r135 UTSW 6 42,383,315 (GRCm39) missense probably benign 0.00
Z1176:Tas2r135 UTSW 6 42,383,168 (GRCm39) missense probably benign 0.03
Posted On 2013-01-20