Incidental Mutation 'R0104:Tas2r135'
| ID |
17082 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tas2r135
|
| Ensembl Gene |
ENSMUSG00000056203 |
| Gene Name |
taste receptor, type 2, member 135 |
| Synonyms |
mt2r38, Tas2r35 |
| MMRRC Submission |
038390-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
R0104 (G1)
|
| Quality Score |
|
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
42382463-42383428 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 42383258 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 266
(I266F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000070247
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000070178]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000070178
AA Change: I266F
PolyPhen 2
Score 0.793 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000070247
Gene: ENSMUSG00000056203
AA Change: I266F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
22 |
320 |
1.3e-63 |
PFAM |
|
| Meta Mutation Damage Score |
0.4938 |
| Coding Region Coverage |
- 1x: 75.5%
- 3x: 52.6%
- 10x: 7.5%
- 20x: 3.0%
|
| Validation Efficiency |
100% (37/37) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 23 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3100002H09Rik |
C |
A |
4: 124,504,469 (GRCm39) |
A28S |
probably damaging |
Het |
| Arhgap5 |
A |
T |
12: 52,563,500 (GRCm39) |
D157V |
probably damaging |
Het |
| Cfap54 |
G |
T |
10: 92,864,514 (GRCm39) |
H142N |
probably damaging |
Het |
| Dpp10 |
A |
T |
1: 123,295,572 (GRCm39) |
M525K |
probably benign |
Het |
| Fsip2 |
A |
T |
2: 82,809,317 (GRCm39) |
T1879S |
possibly damaging |
Het |
| Gm14129 |
T |
C |
2: 148,773,493 (GRCm39) |
|
noncoding transcript |
Het |
| Ighv2-7 |
A |
T |
12: 113,771,088 (GRCm39) |
W66R |
probably damaging |
Het |
| Kif11 |
T |
A |
19: 37,401,663 (GRCm39) |
V880D |
probably benign |
Het |
| Mcpt1 |
T |
A |
14: 56,256,888 (GRCm39) |
M142K |
possibly damaging |
Het |
| Mlst8 |
T |
C |
17: 24,695,091 (GRCm39) |
N264S |
possibly damaging |
Het |
| Nmrk1 |
T |
A |
19: 18,618,582 (GRCm39) |
S88R |
probably benign |
Het |
| Or14j2 |
T |
A |
17: 37,885,817 (GRCm39) |
I166F |
probably damaging |
Het |
| Or8d23 |
A |
G |
9: 38,842,261 (GRCm39) |
S265G |
possibly damaging |
Het |
| Rtn1 |
A |
T |
12: 72,355,619 (GRCm39) |
I109N |
probably damaging |
Het |
| Slc15a2 |
T |
A |
16: 36,594,997 (GRCm39) |
L156F |
possibly damaging |
Het |
| Slc22a21 |
A |
C |
11: 53,842,635 (GRCm39) |
M498R |
probably null |
Het |
| Ssc5d |
T |
C |
7: 4,939,285 (GRCm39) |
S574P |
probably benign |
Het |
| Taf2 |
T |
C |
15: 54,901,734 (GRCm39) |
D820G |
probably benign |
Het |
| Trgv4 |
C |
T |
13: 19,369,480 (GRCm39) |
H75Y |
probably damaging |
Het |
| Vil1 |
A |
G |
1: 74,457,525 (GRCm39) |
K53E |
probably benign |
Het |
| Zfc3h1 |
T |
A |
10: 115,251,192 (GRCm39) |
M1261K |
possibly damaging |
Het |
| Zfp655 |
T |
C |
5: 145,180,825 (GRCm39) |
S228P |
probably damaging |
Het |
| Zfyve9 |
C |
A |
4: 108,575,360 (GRCm39) |
D574Y |
probably damaging |
Het |
|
| Other mutations in Tas2r135 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01357:Tas2r135
|
APN |
6 |
42,383,078 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01395:Tas2r135
|
APN |
6 |
42,382,846 (GRCm39) |
nonsense |
probably null |
|
|
IGL02479:Tas2r135
|
APN |
6 |
42,382,685 (GRCm39) |
nonsense |
probably null |
|
|
IGL02526:Tas2r135
|
APN |
6 |
42,383,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02806:Tas2r135
|
APN |
6 |
42,383,382 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02982:Tas2r135
|
APN |
6 |
42,383,187 (GRCm39) |
missense |
probably benign |
|
|
IGL03057:Tas2r135
|
APN |
6 |
42,378,061 (GRCm39) |
unclassified |
probably benign |
|
|
R0057:Tas2r135
|
UTSW |
6 |
42,383,354 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1412:Tas2r135
|
UTSW |
6 |
42,382,768 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4517:Tas2r135
|
UTSW |
6 |
42,383,013 (GRCm39) |
missense |
probably benign |
|
|
R4629:Tas2r135
|
UTSW |
6 |
42,383,160 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5788:Tas2r135
|
UTSW |
6 |
42,382,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6021:Tas2r135
|
UTSW |
6 |
42,383,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6586:Tas2r135
|
UTSW |
6 |
42,382,952 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7180:Tas2r135
|
UTSW |
6 |
42,382,685 (GRCm39) |
nonsense |
probably null |
|
|
R7458:Tas2r135
|
UTSW |
6 |
42,382,881 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7850:Tas2r135
|
UTSW |
6 |
42,383,072 (GRCm39) |
missense |
probably benign |
|
|
R9113:Tas2r135
|
UTSW |
6 |
42,383,315 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Tas2r135
|
UTSW |
6 |
42,383,168 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Posted On |
2013-01-20 |
Incidental Mutation