Incidental Mutation 'R1572:Kntc1'
| ID |
170833 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kntc1
|
| Ensembl Gene |
ENSMUSG00000029414 |
| Gene Name |
kinetochore associated 1 |
| Synonyms |
|
| MMRRC Submission |
039611-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.947)
|
| Stock # |
R1572 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
123749716-123821593 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 123772113 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 525
(T525A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000031366
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031366]
|
| AlphaFold |
Q8C3Y4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000031366
AA Change: T525A
PolyPhen 2
Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000031366
Gene: ENSMUSG00000029414
AA Change: T525A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
345 |
357 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
764 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1044 |
N/A |
INTRINSIC |
|
Pfam:Rod_C
|
1579 |
2128 |
3.2e-256 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197665
|
| Meta Mutation Damage Score |
0.4587 |
| Coding Region Coverage |
- 1x: 98.7%
- 3x: 97.5%
- 10x: 92.9%
- 20x: 80.7%
|
| Validation Efficiency |
97% (130/134) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice have a kinked tail. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 112 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310030G06Rik |
G |
A |
9: 50,740,673 |
T85M |
probably damaging |
Het |
| 5430419D17Rik |
T |
A |
7: 131,244,831 |
Y777* |
probably null |
Het |
| Actn1 |
A |
G |
12: 80,172,957 |
|
probably benign |
Het |
| Afap1l1 |
A |
T |
18: 61,737,499 |
S603T |
probably damaging |
Het |
| Ahcy |
T |
C |
2: 155,068,931 |
Y39C |
probably benign |
Het |
| Ankmy2 |
T |
C |
12: 36,186,942 |
|
probably null |
Het |
| Anxa13 |
A |
T |
15: 58,348,807 |
|
noncoding transcript |
Het |
| Aoc1 |
T |
C |
6: 48,905,786 |
S221P |
possibly damaging |
Het |
| Arhgef10 |
C |
A |
8: 14,991,211 |
A770D |
possibly damaging |
Het |
| Arhgef19 |
A |
G |
4: 141,254,754 |
D707G |
probably benign |
Het |
| Arhgef3 |
G |
A |
14: 27,401,735 |
R444H |
probably damaging |
Het |
| Asphd1 |
T |
C |
7: 126,949,099 |
I11V |
probably benign |
Het |
| Atp2b1 |
A |
G |
10: 98,994,675 |
M333V |
probably benign |
Het |
| BC051665 |
T |
C |
13: 60,785,027 |
Y40C |
probably damaging |
Het |
| Ccdc87 |
T |
A |
19: 4,840,313 |
S278T |
probably benign |
Het |
| Chaf1b |
G |
A |
16: 93,901,230 |
G463D |
possibly damaging |
Het |
| Chrna4 |
T |
C |
2: 181,029,307 |
T219A |
possibly damaging |
Het |
| Clcnkb |
T |
G |
4: 141,407,095 |
T584P |
possibly damaging |
Het |
| Clptm1l |
T |
C |
13: 73,607,747 |
S161P |
probably benign |
Het |
| Cmya5 |
T |
C |
13: 93,094,269 |
E1437G |
possibly damaging |
Het |
| Col13a1 |
A |
T |
10: 61,866,426 |
|
probably null |
Het |
| Col3a1 |
T |
C |
1: 45,345,968 |
S82P |
possibly damaging |
Het |
| Cpeb3 |
A |
T |
19: 37,139,082 |
M383K |
probably benign |
Het |
| Cr2 |
T |
A |
1: 195,163,314 |
H111L |
probably damaging |
Het |
| Cttnbp2 |
T |
C |
6: 18,375,975 |
S1522G |
possibly damaging |
Het |
| Cul3 |
T |
C |
1: 80,282,789 |
D281G |
possibly damaging |
Het |
| Cyp2c70 |
T |
G |
19: 40,183,982 |
K72T |
probably benign |
Het |
| Cyp39a1 |
A |
T |
17: 43,680,129 |
I110F |
probably damaging |
Het |
| Cyp46a1 |
T |
A |
12: 108,351,939 |
M203K |
probably null |
Het |
| Cyp8b1 |
A |
T |
9: 121,914,958 |
V436D |
possibly damaging |
Het |
| Ddx17 |
T |
C |
15: 79,538,565 |
D324G |
probably damaging |
Het |
| Dopey2 |
A |
G |
16: 93,770,153 |
N1274S |
probably damaging |
Het |
| Dscaml1 |
G |
A |
9: 45,721,333 |
V1166I |
probably benign |
Het |
| Dsp |
T |
C |
13: 38,195,738 |
V1554A |
probably damaging |
Het |
| Dusp27 |
C |
T |
1: 166,099,455 |
V863M |
possibly damaging |
Het |
| Efr3a |
T |
A |
15: 65,854,792 |
|
probably null |
Het |
| Egfem1 |
A |
T |
3: 29,648,271 |
N223I |
probably benign |
Het |
| Egr2 |
T |
C |
10: 67,539,975 |
S147P |
probably damaging |
Het |
| Elmo3 |
A |
G |
8: 105,308,301 |
T408A |
probably benign |
Het |
| Flnb |
A |
G |
14: 7,883,908 |
D378G |
probably damaging |
Het |
| Foxj2 |
T |
A |
6: 122,833,261 |
M193K |
probably benign |
Het |
| Gm6327 |
A |
G |
16: 12,760,156 |
|
noncoding transcript |
Het |
| Gm7694 |
T |
C |
1: 170,302,766 |
H21R |
probably benign |
Het |
| Gpr107 |
A |
G |
2: 31,167,025 |
D43G |
probably damaging |
Het |
| Grid2 |
T |
A |
6: 64,429,694 |
Y679* |
probably null |
Het |
| Grin2c |
G |
A |
11: 115,256,074 |
P432S |
possibly damaging |
Het |
| H2-M10.1 |
A |
G |
17: 36,325,733 |
F60L |
possibly damaging |
Het |
| Hectd4 |
A |
G |
5: 121,301,878 |
D1147G |
possibly damaging |
Het |
| Idua |
G |
T |
5: 108,680,589 |
A223S |
probably benign |
Het |
| Ifi206 |
T |
C |
1: 173,486,853 |
Q7R |
probably benign |
Het |
| Itgad |
T |
A |
7: 128,203,234 |
V986E |
probably damaging |
Het |
| Itsn2 |
G |
A |
12: 4,650,044 |
R670H |
probably benign |
Het |
| Kdm4a |
T |
C |
4: 118,138,949 |
E961G |
possibly damaging |
Het |
| Klra5 |
T |
A |
6: 129,906,622 |
I91L |
probably damaging |
Het |
| Lct |
A |
G |
1: 128,294,195 |
F1536L |
probably benign |
Het |
| Lmod1 |
T |
A |
1: 135,363,933 |
D175E |
probably benign |
Het |
| Lonrf1 |
A |
C |
8: 36,233,972 |
D361E |
probably benign |
Het |
| Lrrc19 |
T |
C |
4: 94,638,429 |
Y297C |
probably damaging |
Het |
| Mast4 |
T |
C |
13: 102,736,923 |
E1787G |
possibly damaging |
Het |
| Mpp2 |
G |
A |
11: 102,060,548 |
A452V |
probably benign |
Het |
| Msh2 |
T |
C |
17: 87,718,652 |
V686A |
possibly damaging |
Het |
| Mthfd1 |
C |
T |
12: 76,270,419 |
Q15* |
probably null |
Het |
| Mtnr1b |
A |
T |
9: 15,863,142 |
I207N |
probably damaging |
Het |
| Nid2 |
A |
G |
14: 19,805,412 |
T1207A |
probably benign |
Het |
| Nin |
A |
T |
12: 70,038,750 |
V1569D |
probably damaging |
Het |
| Nov |
T |
A |
15: 54,749,252 |
M219K |
possibly damaging |
Het |
| Nrcam |
T |
A |
12: 44,537,364 |
|
probably benign |
Het |
| Nsd1 |
T |
A |
13: 55,246,969 |
H897Q |
probably damaging |
Het |
| Olfr102 |
A |
T |
17: 37,313,480 |
N301K |
probably benign |
Het |
| Olfr1364 |
T |
A |
13: 21,574,310 |
I49F |
possibly damaging |
Het |
| Olfr77 |
G |
T |
9: 19,920,912 |
K234N |
probably benign |
Het |
| Olfr979 |
A |
G |
9: 40,001,194 |
F11S |
probably benign |
Het |
| Paip1 |
T |
C |
13: 119,451,784 |
|
probably benign |
Het |
| Pcnx3 |
G |
A |
19: 5,685,347 |
R484* |
probably null |
Het |
| Pdxk |
A |
G |
10: 78,447,980 |
Y127H |
probably damaging |
Het |
| Phf20 |
T |
A |
2: 156,287,834 |
V442E |
probably benign |
Het |
| Phlpp1 |
G |
A |
1: 106,392,789 |
D1505N |
probably damaging |
Het |
| Pkhd1 |
T |
C |
1: 20,347,440 |
T2496A |
probably benign |
Het |
| Pkhd1l1 |
A |
G |
15: 44,543,473 |
T2369A |
probably benign |
Het |
| Plod2 |
T |
A |
9: 92,603,067 |
|
probably benign |
Het |
| Pnpla7 |
T |
A |
2: 25,015,251 |
M617K |
possibly damaging |
Het |
| Ppp1r16a |
C |
T |
15: 76,693,669 |
Q328* |
probably null |
Het |
| Prkch |
T |
A |
12: 73,649,357 |
|
probably null |
Het |
| Prr12 |
G |
A |
7: 45,028,800 |
H1974Y |
unknown |
Het |
| Prr16 |
A |
G |
18: 51,302,970 |
I174V |
probably benign |
Het |
| Prss45 |
A |
T |
9: 110,838,429 |
T39S |
probably benign |
Het |
| Pum1 |
T |
A |
4: 130,718,204 |
D161E |
probably damaging |
Het |
| Rad51ap2 |
A |
G |
12: 11,457,112 |
D345G |
probably damaging |
Het |
| Ralgapb |
A |
G |
2: 158,446,199 |
|
probably benign |
Het |
| Rasgrp3 |
A |
G |
17: 75,500,734 |
H262R |
possibly damaging |
Het |
| Rnf213 |
T |
A |
11: 119,436,611 |
I1809N |
probably damaging |
Het |
| Ryr1 |
A |
G |
7: 29,062,191 |
L3177P |
probably damaging |
Het |
| Scyl2 |
C |
A |
10: 89,650,956 |
R230L |
probably damaging |
Het |
| Sfxn2 |
T |
C |
19: 46,582,476 |
|
probably benign |
Het |
| Slc18b1 |
T |
C |
10: 23,798,741 |
|
probably benign |
Het |
| Spata31d1d |
T |
C |
13: 59,728,191 |
H510R |
probably benign |
Het |
| Stab1 |
A |
T |
14: 31,150,823 |
N1109K |
probably damaging |
Het |
| Sult3a2 |
A |
G |
10: 33,781,977 |
S47P |
probably damaging |
Het |
| Tenm3 |
T |
C |
8: 48,228,993 |
N2518S |
possibly damaging |
Het |
| Tex21 |
G |
T |
12: 76,206,891 |
P416Q |
probably benign |
Het |
| Tex38 |
T |
C |
4: 115,780,306 |
N100S |
probably benign |
Het |
| Thsd4 |
A |
C |
9: 60,394,553 |
|
probably benign |
Het |
| Ticrr |
T |
C |
7: 79,681,824 |
V723A |
probably damaging |
Het |
| Tmprss15 |
A |
G |
16: 79,090,829 |
V30A |
probably benign |
Het |
| Uba3 |
A |
G |
6: 97,185,337 |
|
probably benign |
Het |
| Ubr1 |
T |
C |
2: 120,935,319 |
|
probably benign |
Het |
| Uchl4 |
A |
T |
9: 64,235,731 |
I165L |
probably benign |
Het |
| Vmn2r112 |
A |
T |
17: 22,603,144 |
T268S |
possibly damaging |
Het |
| Wfdc3 |
T |
C |
2: 164,744,194 |
|
probably benign |
Het |
| Zfp282 |
T |
A |
6: 47,892,867 |
L282Q |
probably damaging |
Het |
| Zfp422 |
A |
T |
6: 116,626,784 |
C85S |
probably damaging |
Het |
| Zfp790 |
A |
T |
7: 29,828,139 |
Q83L |
probably benign |
Het |
|
| Other mutations in Kntc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00087:Kntc1
|
APN |
5 |
123,790,159 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL00514:Kntc1
|
APN |
5 |
123,791,527 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01103:Kntc1
|
APN |
5 |
123,764,220 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL01106:Kntc1
|
APN |
5 |
123,762,603 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01357:Kntc1
|
APN |
5 |
123,757,814 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01367:Kntc1
|
APN |
5 |
123,758,483 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01538:Kntc1
|
APN |
5 |
123,781,658 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01546:Kntc1
|
APN |
5 |
123,765,005 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL01595:Kntc1
|
APN |
5 |
123,803,695 (GRCm38) |
missense |
probably benign |
0.30 |
|
IGL01725:Kntc1
|
APN |
5 |
123,764,190 (GRCm38) |
missense |
probably benign |
|
|
IGL01916:Kntc1
|
APN |
5 |
123,801,913 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01936:Kntc1
|
APN |
5 |
123,811,376 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01942:Kntc1
|
APN |
5 |
123,778,267 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01973:Kntc1
|
APN |
5 |
123,765,958 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01982:Kntc1
|
APN |
5 |
123,809,096 (GRCm38) |
missense |
probably benign |
0.12 |
|
IGL02145:Kntc1
|
APN |
5 |
123,762,598 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
IGL02510:Kntc1
|
APN |
5 |
123,819,062 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02611:Kntc1
|
APN |
5 |
123,812,065 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02669:Kntc1
|
APN |
5 |
123,755,664 (GRCm38) |
splice site |
probably benign |
|
|
IGL02737:Kntc1
|
APN |
5 |
123,819,120 (GRCm38) |
missense |
probably benign |
0.17 |
|
IGL02793:Kntc1
|
APN |
5 |
123,778,277 (GRCm38) |
splice site |
probably null |
|
|
IGL02809:Kntc1
|
APN |
5 |
123,776,582 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02860:Kntc1
|
APN |
5 |
123,769,873 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
IGL02875:Kntc1
|
APN |
5 |
123,778,277 (GRCm38) |
splice site |
probably null |
|
|
IGL02931:Kntc1
|
APN |
5 |
123,799,811 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03169:Kntc1
|
APN |
5 |
123,775,821 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
IGL03267:Kntc1
|
APN |
5 |
123,758,480 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0006:Kntc1
|
UTSW |
5 |
123,789,138 (GRCm38) |
missense |
probably benign |
0.19 |
|
R0006:Kntc1
|
UTSW |
5 |
123,789,138 (GRCm38) |
missense |
probably benign |
0.19 |
|
R0017:Kntc1
|
UTSW |
5 |
123,780,981 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0125:Kntc1
|
UTSW |
5 |
123,765,057 (GRCm38) |
splice site |
probably benign |
|
|
R0324:Kntc1
|
UTSW |
5 |
123,778,112 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0580:Kntc1
|
UTSW |
5 |
123,803,669 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0608:Kntc1
|
UTSW |
5 |
123,786,074 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0725:Kntc1
|
UTSW |
5 |
123,769,704 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R0733:Kntc1
|
UTSW |
5 |
123,790,916 (GRCm38) |
missense |
probably null |
|
|
R0781:Kntc1
|
UTSW |
5 |
123,799,902 (GRCm38) |
splice site |
probably benign |
|
|
R0787:Kntc1
|
UTSW |
5 |
123,796,104 (GRCm38) |
missense |
probably benign |
|
|
R1250:Kntc1
|
UTSW |
5 |
123,784,199 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R1253:Kntc1
|
UTSW |
5 |
123,810,862 (GRCm38) |
frame shift |
probably null |
|
|
R1467:Kntc1
|
UTSW |
5 |
123,786,984 (GRCm38) |
missense |
probably benign |
0.04 |
|
R1467:Kntc1
|
UTSW |
5 |
123,786,984 (GRCm38) |
missense |
probably benign |
0.04 |
|
R1481:Kntc1
|
UTSW |
5 |
123,778,275 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1624:Kntc1
|
UTSW |
5 |
123,758,477 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R1749:Kntc1
|
UTSW |
5 |
123,789,099 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1993:Kntc1
|
UTSW |
5 |
123,810,811 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R1993:Kntc1
|
UTSW |
5 |
123,759,099 (GRCm38) |
critical splice donor site |
probably null |
|
|
R2071:Kntc1
|
UTSW |
5 |
123,794,277 (GRCm38) |
splice site |
probably null |
|
|
R2237:Kntc1
|
UTSW |
5 |
123,803,670 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R2239:Kntc1
|
UTSW |
5 |
123,803,670 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R2366:Kntc1
|
UTSW |
5 |
123,781,192 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2367:Kntc1
|
UTSW |
5 |
123,781,192 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2382:Kntc1
|
UTSW |
5 |
123,760,348 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2389:Kntc1
|
UTSW |
5 |
123,781,192 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2413:Kntc1
|
UTSW |
5 |
123,764,149 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2442:Kntc1
|
UTSW |
5 |
123,810,859 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2504:Kntc1
|
UTSW |
5 |
123,778,347 (GRCm38) |
nonsense |
probably null |
|
|
R2943:Kntc1
|
UTSW |
5 |
123,797,784 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R3116:Kntc1
|
UTSW |
5 |
123,802,058 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4107:Kntc1
|
UTSW |
5 |
123,762,598 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4176:Kntc1
|
UTSW |
5 |
123,776,617 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R4275:Kntc1
|
UTSW |
5 |
123,767,779 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4440:Kntc1
|
UTSW |
5 |
123,794,153 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4575:Kntc1
|
UTSW |
5 |
123,765,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4576:Kntc1
|
UTSW |
5 |
123,765,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4578:Kntc1
|
UTSW |
5 |
123,765,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4612:Kntc1
|
UTSW |
5 |
123,812,643 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4704:Kntc1
|
UTSW |
5 |
123,811,433 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4720:Kntc1
|
UTSW |
5 |
123,765,023 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R4784:Kntc1
|
UTSW |
5 |
123,816,762 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R4785:Kntc1
|
UTSW |
5 |
123,816,762 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R4824:Kntc1
|
UTSW |
5 |
123,790,133 (GRCm38) |
nonsense |
probably null |
|
|
R4847:Kntc1
|
UTSW |
5 |
123,802,274 (GRCm38) |
missense |
probably benign |
0.18 |
|
R4849:Kntc1
|
UTSW |
5 |
123,759,065 (GRCm38) |
missense |
probably benign |
0.02 |
|
R4904:Kntc1
|
UTSW |
5 |
123,778,333 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R4922:Kntc1
|
UTSW |
5 |
123,802,246 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5080:Kntc1
|
UTSW |
5 |
123,762,586 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R5114:Kntc1
|
UTSW |
5 |
123,781,055 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5171:Kntc1
|
UTSW |
5 |
123,799,844 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5220:Kntc1
|
UTSW |
5 |
123,812,097 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5226:Kntc1
|
UTSW |
5 |
123,794,172 (GRCm38) |
missense |
probably benign |
0.09 |
|
R5278:Kntc1
|
UTSW |
5 |
123,781,014 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5329:Kntc1
|
UTSW |
5 |
123,764,191 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5496:Kntc1
|
UTSW |
5 |
123,784,182 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5503:Kntc1
|
UTSW |
5 |
123,819,876 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R5633:Kntc1
|
UTSW |
5 |
123,819,057 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5638:Kntc1
|
UTSW |
5 |
123,818,475 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R5697:Kntc1
|
UTSW |
5 |
123,765,007 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5757:Kntc1
|
UTSW |
5 |
123,807,309 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5773:Kntc1
|
UTSW |
5 |
123,794,157 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5940:Kntc1
|
UTSW |
5 |
123,786,195 (GRCm38) |
missense |
probably benign |
0.05 |
|
R6019:Kntc1
|
UTSW |
5 |
123,762,516 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6230:Kntc1
|
UTSW |
5 |
123,789,009 (GRCm38) |
splice site |
probably null |
|
|
R6437:Kntc1
|
UTSW |
5 |
123,769,691 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6888:Kntc1
|
UTSW |
5 |
123,811,310 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6907:Kntc1
|
UTSW |
5 |
123,801,825 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7123:Kntc1
|
UTSW |
5 |
123,781,726 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7262:Kntc1
|
UTSW |
5 |
123,786,973 (GRCm38) |
missense |
probably benign |
0.18 |
|
R7381:Kntc1
|
UTSW |
5 |
123,810,908 (GRCm38) |
missense |
probably benign |
0.12 |
|
R7485:Kntc1
|
UTSW |
5 |
123,786,956 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R7512:Kntc1
|
UTSW |
5 |
123,790,938 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7581:Kntc1
|
UTSW |
5 |
123,816,755 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7687:Kntc1
|
UTSW |
5 |
123,759,089 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7798:Kntc1
|
UTSW |
5 |
123,819,117 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7798:Kntc1
|
UTSW |
5 |
123,786,294 (GRCm38) |
missense |
probably benign |
|
|
R7871:Kntc1
|
UTSW |
5 |
123,784,227 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7876:Kntc1
|
UTSW |
5 |
123,775,787 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7947:Kntc1
|
UTSW |
5 |
123,781,888 (GRCm38) |
missense |
unknown |
|
|
R7997:Kntc1
|
UTSW |
5 |
123,778,054 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8231:Kntc1
|
UTSW |
5 |
123,782,896 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R8257:Kntc1
|
UTSW |
5 |
123,758,523 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8345:Kntc1
|
UTSW |
5 |
123,786,930 (GRCm38) |
missense |
probably benign |
0.37 |
|
R8354:Kntc1
|
UTSW |
5 |
123,778,267 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8732:Kntc1
|
UTSW |
5 |
123,790,117 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8754:Kntc1
|
UTSW |
5 |
123,759,052 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8947:Kntc1
|
UTSW |
5 |
123,786,978 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9041:Kntc1
|
UTSW |
5 |
123,789,030 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9182:Kntc1
|
UTSW |
5 |
123,802,292 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9432:Kntc1
|
UTSW |
5 |
123,787,049 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R9460:Kntc1
|
UTSW |
5 |
123,803,315 (GRCm38) |
nonsense |
probably null |
|
|
R9468:Kntc1
|
UTSW |
5 |
123,816,713 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9643:Kntc1
|
UTSW |
5 |
123,811,377 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9646:Kntc1
|
UTSW |
5 |
123,759,056 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9721:Kntc1
|
UTSW |
5 |
123,801,885 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9789:Kntc1
|
UTSW |
5 |
123,760,643 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
X0027:Kntc1
|
UTSW |
5 |
123,810,929 (GRCm38) |
missense |
probably benign |
0.00 |
|
X0065:Kntc1
|
UTSW |
5 |
123,778,037 (GRCm38) |
nonsense |
probably null |
|
|
X0067:Kntc1
|
UTSW |
5 |
123,778,074 (GRCm38) |
unclassified |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGGAGAAGACTGGCCCTTGTT -3'
(R):5'- GCAACTGTGCTCCCAAATACTGACT -3'
Sequencing Primer
(F):5'- atgtggaggtcaggacaatg -3'
(R):5'- CTTGAGCCAATTCTTGCTGGAAAG -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation