Incidental Mutation 'R1574:Zfp61'
ID 171028
Institutional Source Beutler Lab
Gene Symbol Zfp61
Ensembl Gene ENSMUSG00000050605
Gene Name zinc finger protein 61
Synonyms
MMRRC Submission 045014-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R1574 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 23990464-24000657 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 23990635 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 505 (K505N)
Ref Sequence ENSEMBL: ENSMUSP00000132551 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077780] [ENSMUST00000145131] [ENSMUST00000165241]
AlphaFold Q923D1
Predicted Effect probably damaging
Transcript: ENSMUST00000077780
AA Change: K505N

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000076954
Gene: ENSMUSG00000050605
AA Change: K505N

DomainStartEndE-ValueType
KRAB 4 63 2.28e-27 SMART
ZnF_C2H2 311 333 1.4e-4 SMART
ZnF_C2H2 339 361 5.5e-3 SMART
ZnF_C2H2 367 389 2.99e-4 SMART
ZnF_C2H2 395 417 1.18e-2 SMART
ZnF_C2H2 423 445 2.4e-3 SMART
ZnF_C2H2 451 473 2.95e-3 SMART
ZnF_C2H2 479 501 9.88e-5 SMART
ZnF_C2H2 507 529 1.5e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137342
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138619
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138924
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139811
Predicted Effect probably benign
Transcript: ENSMUST00000145131
SMART Domains Protein: ENSMUSP00000117077
Gene: ENSMUSG00000050605

DomainStartEndE-ValueType
KRAB 4 64 4.63e-19 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000165241
AA Change: K505N

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000132551
Gene: ENSMUSG00000050605
AA Change: K505N

DomainStartEndE-ValueType
KRAB 4 63 2.28e-27 SMART
ZnF_C2H2 311 333 1.4e-4 SMART
ZnF_C2H2 339 361 5.5e-3 SMART
ZnF_C2H2 367 389 2.99e-4 SMART
ZnF_C2H2 395 417 1.18e-2 SMART
ZnF_C2H2 423 445 2.4e-3 SMART
ZnF_C2H2 451 473 2.95e-3 SMART
ZnF_C2H2 479 501 9.88e-5 SMART
ZnF_C2H2 507 529 1.5e-4 SMART
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 96.3%
  • 10x: 84.0%
  • 20x: 52.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl3 T A 5: 81,935,296 (GRCm39) N1276K probably damaging Het
Als2cl A G 9: 110,713,128 (GRCm39) E6G probably damaging Het
Ankrd12 A T 17: 66,293,269 (GRCm39) D721E probably benign Het
Anpep A G 7: 79,488,155 (GRCm39) probably null Het
Apob A T 12: 8,040,839 (GRCm39) I655L possibly damaging Het
Atp2b1 T A 10: 98,832,810 (GRCm39) L437Q probably damaging Het
Cacna2d3 T A 14: 29,073,779 (GRCm39) R222S probably damaging Het
Cenpf C T 1: 189,384,910 (GRCm39) D2457N probably damaging Het
Cenpo A T 12: 4,265,433 (GRCm39) probably null Het
Ces2b G T 8: 105,562,521 (GRCm39) A284S probably benign Het
Clock T C 5: 76,390,679 (GRCm39) D311G probably damaging Het
Csmd3 T C 15: 47,559,257 (GRCm39) probably null Het
D430041D05Rik GTGATGATGATGATGATGATG GTGATGATGATGATGATG 2: 104,051,553 (GRCm39) probably benign Het
Dbil5 A G 11: 76,109,308 (GRCm39) M71V probably benign Het
Ddhd1 A C 14: 45,833,004 (GRCm39) L864R probably damaging Het
Dnah11 A G 12: 118,024,052 (GRCm39) C1900R probably damaging Het
Dnah2 A G 11: 69,405,514 (GRCm39) V666A probably benign Het
Dnah5 T A 15: 28,252,569 (GRCm39) M754K probably benign Het
Dnajc15 A T 14: 78,063,854 (GRCm39) S145T probably benign Het
Drap1 A G 19: 5,474,285 (GRCm39) F25S probably damaging Het
Fam83e G A 7: 45,376,135 (GRCm39) E283K probably damaging Het
Fbxo48 G T 11: 16,903,368 (GRCm39) probably benign Het
Fndc3a A T 14: 72,793,997 (GRCm39) I892N probably damaging Het
Gcn1 A G 5: 115,753,611 (GRCm39) T2321A probably benign Het
Greb1l A G 18: 10,554,997 (GRCm39) D1681G possibly damaging Het
Hmcn2 A C 2: 31,294,899 (GRCm39) T2563P probably damaging Het
Iqcd A T 5: 120,738,300 (GRCm39) K39N probably damaging Het
Kank2 A G 9: 21,685,871 (GRCm39) S668P probably damaging Het
Kcng1 T A 2: 168,110,961 (GRCm39) N68Y probably damaging Het
Kmt5b T A 19: 3,836,633 (GRCm39) probably null Het
Lama2 T A 10: 27,200,750 (GRCm39) I533F possibly damaging Het
Lcmt1 T A 7: 123,002,131 (GRCm39) I132N probably damaging Het
Mcph1 T C 8: 18,851,428 (GRCm39) I807T probably damaging Het
Mdn1 A G 4: 32,722,315 (GRCm39) I2366V probably benign Het
Moxd1 T C 10: 24,176,217 (GRCm39) W558R probably damaging Het
Mtus2 A C 5: 148,013,362 (GRCm39) K52Q probably benign Het
Myrf T C 19: 10,202,851 (GRCm39) D141G probably damaging Het
Naca G T 10: 127,876,267 (GRCm39) probably benign Het
Ncoa7 T C 10: 30,570,097 (GRCm39) I249M probably damaging Het
Obox5 T C 7: 15,492,558 (GRCm39) V171A probably damaging Het
Or13e8 A T 4: 43,697,134 (GRCm39) V13D possibly damaging Het
Or13p3 T A 4: 118,566,751 (GRCm39) I49N probably damaging Het
Or2c1 T C 16: 3,657,521 (GRCm39) I228T probably damaging Het
Or5ak20 A T 2: 85,184,243 (GRCm39) V9E probably damaging Het
Or6c219 A G 10: 129,781,379 (GRCm39) L69P probably damaging Het
Or7a36 C A 10: 78,819,820 (GRCm39) N32K probably damaging Het
Parp4 A G 14: 56,839,752 (GRCm39) T487A probably damaging Het
Pclo A G 5: 14,729,845 (GRCm39) probably benign Het
Pcnx2 G A 8: 126,500,669 (GRCm39) R1474C probably damaging Het
Pkd1l3 A G 8: 110,341,445 (GRCm39) I99M unknown Het
Ruvbl1 T C 6: 88,456,136 (GRCm39) V70A probably damaging Het
Sart1 G A 19: 5,430,287 (GRCm39) P788L probably damaging Het
Sdk1 A G 5: 141,984,634 (GRCm39) T740A probably benign Het
Serpinb1c T C 13: 33,072,979 (GRCm39) D61G possibly damaging Het
Sfi1 TCGC TC 11: 3,096,254 (GRCm39) probably null Het
Slc24a5 G A 2: 124,922,782 (GRCm39) G152S probably damaging Het
Slc6a4 A T 11: 76,910,022 (GRCm39) I426F possibly damaging Het
Srsf4 T A 4: 131,625,006 (GRCm39) D134E probably damaging Het
Stk33 C T 7: 108,879,027 (GRCm39) V441I probably benign Het
Sult1c2 A G 17: 54,143,927 (GRCm39) probably null Het
Tdpoz4 T A 3: 93,703,835 (GRCm39) V44E probably benign Het
Tdrd6 G A 17: 43,936,515 (GRCm39) S1511L probably damaging Het
Tmprss13 C A 9: 45,254,529 (GRCm39) T432K probably damaging Het
Traf7 A G 17: 24,729,527 (GRCm39) L428P probably damaging Het
Tubb1 T C 2: 174,299,215 (GRCm39) I299T probably benign Het
Vmn1r158 A T 7: 22,489,772 (GRCm39) W146R probably damaging Het
Vmn1r42 A G 6: 89,822,059 (GRCm39) I170T possibly damaging Het
Vmn1r42 C T 6: 89,822,363 (GRCm39) G69S probably damaging Het
Vmn2r116 A T 17: 23,606,063 (GRCm39) H325L probably damaging Het
Zfp516 T A 18: 83,011,300 (GRCm39) L1111H possibly damaging Het
Zfp653 C A 9: 21,969,274 (GRCm39) E331* probably null Het
Zfp949 A T 9: 88,451,830 (GRCm39) K467* probably null Het
Other mutations in Zfp61
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00588:Zfp61 APN 7 23,990,520 (GRCm39) missense probably benign 0.00
R0771:Zfp61 UTSW 7 23,992,779 (GRCm39) missense probably benign 0.00
R1574:Zfp61 UTSW 7 23,990,635 (GRCm39) missense probably damaging 0.98
R2029:Zfp61 UTSW 7 23,991,714 (GRCm39) missense probably benign 0.00
R2443:Zfp61 UTSW 7 23,991,194 (GRCm39) missense probably benign 0.01
R3771:Zfp61 UTSW 7 23,995,406 (GRCm39) start codon destroyed probably null 0.01
R3773:Zfp61 UTSW 7 23,995,406 (GRCm39) start codon destroyed probably null 0.01
R4093:Zfp61 UTSW 7 23,990,700 (GRCm39) splice site probably null
R4095:Zfp61 UTSW 7 23,990,700 (GRCm39) splice site probably null
R7533:Zfp61 UTSW 7 23,990,504 (GRCm39) missense probably benign 0.01
R8423:Zfp61 UTSW 7 23,991,459 (GRCm39) missense probably benign 0.18
R9057:Zfp61 UTSW 7 23,990,702 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGCTCTTGCAAAGGAAGAACCCATC -3'
(R):5'- AAGAATTCAGTCGCCCTTCGAGTC -3'

Sequencing Primer
(F):5'- cacacacacacacacacacC -3'
(R):5'- tcagggcattcacaccg -3'
Posted On 2014-04-13