|Institutional Source||Beutler Lab|
|Gene Name||CD70 antigen|
|Synonyms||CD27LG, Ki-24 antigen, Tnfsf7|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R1575 (G1)|
|Chromosomal Location||57145997-57149777 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 57146364 bp (GRCm38)|
|Amino Acid Change||Isoleucine to Threonine at position 100 (I100T)|
|Ref Sequence||ENSEMBL: ENSMUSP00000019633 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000019633]|
AA Change: I100T
PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
AA Change: I100T
|Meta Mutation Damage Score||0.3879|
|Coding Region Coverage||
|Validation Efficiency||100% (72/72)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Expansion of CD8+ cells after viral expansion is significantly less in mice with a homozygous deletion than in controls. However, the restimulation response is comparable to controls. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cd70||
(F):5'- ATGTCAGGCGCTGTAATGCCAC -3'
(R):5'- ACCAGTCTTGAGCTTTCCAGGCAC -3'
(F):5'- CACTGTACAGTCCTGTCCAAAG -3'
(R):5'- TGTCCCCAGTTCCTCGGAA -3'