Incidental Mutation 'R1577:Olfr1395'
ID171235
Institutional Source Beutler Lab
Gene Symbol Olfr1395
Ensembl Gene ENSMUSG00000050763
Gene Nameolfactory receptor 1395
SynonymsMOR277-1, GA_x6K02T2QP88-6286247-6285294
MMRRC Submission 039615-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.069) question?
Stock #R1577 (G1)
Quality Score225
Status Not validated
Chromosome11
Chromosomal Location49142274-49150453 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 49149189 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Serine at position 311 (C311S)
Ref Sequence ENSEMBL: ENSMUSP00000150679 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059379] [ENSMUST00000203377] [ENSMUST00000214195]
Predicted Effect probably benign
Transcript: ENSMUST00000059379
AA Change: C311S

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000050142
Gene: ENSMUSG00000050763
AA Change: C311S

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 1e-50 PFAM
Pfam:7TM_GPCR_Srsx 36 252 4.8e-6 PFAM
Pfam:7tm_1 42 291 1.9e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203377
AA Change: C311S

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000145357
Gene: ENSMUSG00000050763
AA Change: C311S

DomainStartEndE-ValueType
Pfam:7tm_1 1 219 1.9e-18 PFAM
Pfam:7tm_4 1 237 2.4e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214195
AA Change: C311S

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.6%
  • 20x: 87.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb3 T C 1: 25,094,183 N404S possibly damaging Het
Cep85 T C 4: 134,152,288 E383G probably damaging Het
Chst4 A T 8: 110,029,844 H379Q probably benign Het
Clca3b A T 3: 144,823,519 I798N probably damaging Het
Cldnd1 T G 16: 58,732,653 L159R possibly damaging Het
Cntnap3 T C 13: 64,758,290 E834G probably damaging Het
Col2a1 C T 15: 97,979,202 R1065Q probably damaging Het
Dchs1 T C 7: 105,765,955 D674G probably damaging Het
Dntt A G 19: 41,055,785 Y463C probably damaging Het
Egfr A G 11: 16,869,241 E257G probably benign Het
Eif4b C T 15: 102,089,901 R339* probably null Het
Fat1 C T 8: 45,023,383 T1822M probably benign Het
Fgd3 T C 13: 49,281,937 N282D probably damaging Het
Fmo4 T C 1: 162,803,700 M233V possibly damaging Het
Gabbr2 T A 4: 46,684,319 M652L probably benign Het
Gal3st2c G A 1: 94,006,928 V13M probably damaging Het
Gapvd1 C T 2: 34,709,228 G686D probably damaging Het
Gdap1l1 T G 2: 163,438,604 L20R probably damaging Het
Gm5800 A T 14: 51,714,559 M82K probably benign Het
Grm6 T A 11: 50,863,145 C759S probably damaging Het
Hs3st1 A T 5: 39,615,050 D83E probably benign Het
Il12rb1 A G 8: 70,810,606 D39G probably damaging Het
Ldhb C A 6: 142,492,598 K244N possibly damaging Het
Lypd6 C T 2: 50,190,698 R133* probably null Het
Med13l G A 5: 118,721,392 G215S probably damaging Het
Ncoa1 T C 12: 4,295,196 D606G probably damaging Het
Noc2l C T 4: 156,240,622 T151M probably damaging Het
Olfr1107 T C 2: 87,071,397 T246A probably benign Het
Olfr1419 T C 19: 11,870,377 T280A probably damaging Het
Olfr520 T C 7: 99,735,356 L71P probably damaging Het
Olfr706 T C 7: 106,886,010 K269R probably benign Het
Ppm1l G A 3: 69,553,070 G327R probably damaging Het
Rapgef5 C T 12: 117,595,291 A282V probably benign Het
Rnf139 T C 15: 58,899,518 V464A probably damaging Het
Rprd2 C T 3: 95,764,735 E1119K probably damaging Het
Sipa1l2 G A 8: 125,492,262 T112I probably benign Het
Skint6 T C 4: 113,148,523 T363A possibly damaging Het
Slc22a16 G T 10: 40,603,815 E607* probably null Het
Slc24a2 T C 4: 86,991,411 Y690C probably damaging Het
Slc25a23 T C 17: 57,047,306 S115G probably benign Het
Slc4a3 T C 1: 75,550,891 L168P probably damaging Het
Spats2 T A 15: 99,178,452 I137N possibly damaging Het
Stard4 A T 18: 33,205,098 V133D probably damaging Het
Syn3 A G 10: 86,448,864 probably null Het
Tfpi A G 2: 84,433,103 I305T probably damaging Het
Tmtc1 T A 6: 148,412,820 probably null Het
Tpcn1 A C 5: 120,544,420 W508G probably damaging Het
Ubr5 A T 15: 38,030,730 N406K possibly damaging Het
Xrcc1 T A 7: 24,565,627 L118* probably null Het
Zbtb5 T C 4: 44,995,129 Y85C probably damaging Het
Zfand4 C A 6: 116,329,412 Y735* probably null Het
Zfp180 G T 7: 24,105,908 C584F probably damaging Het
Other mutations in Olfr1395
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02413:Olfr1395 APN 11 49148557 missense probably damaging 1.00
IGL02946:Olfr1395 APN 11 49148892 missense probably damaging 1.00
R0030:Olfr1395 UTSW 11 49149040 missense possibly damaging 0.81
R1013:Olfr1395 UTSW 11 49149150 missense probably damaging 1.00
R1908:Olfr1395 UTSW 11 49148274 missense possibly damaging 0.95
R3715:Olfr1395 UTSW 11 49148815 missense probably damaging 0.99
R4386:Olfr1395 UTSW 11 49149015 missense probably damaging 1.00
R4496:Olfr1395 UTSW 11 49148387 missense possibly damaging 0.86
R5030:Olfr1395 UTSW 11 49148361 missense probably benign 0.01
R6044:Olfr1395 UTSW 11 49148695 missense probably benign 0.29
R6226:Olfr1395 UTSW 11 49148833 missense possibly damaging 0.81
R7177:Olfr1395 UTSW 11 49149185 nonsense probably null
R7282:Olfr1395 UTSW 11 49149118 missense probably damaging 1.00
R7391:Olfr1395 UTSW 11 49148979 missense probably damaging 1.00
R7411:Olfr1395 UTSW 11 49148994 missense probably benign 0.01
R7888:Olfr1395 UTSW 11 49148439 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCCATGATCACATACATGAGGCCAC -3'
(R):5'- TCCATCCACAGTCTAAGGGAAAGGG -3'

Sequencing Primer
(F):5'- TACACCATGATCACGCCCAT -3'
(R):5'- tgtgagaccttttcaaaaatggac -3'
Posted On2014-04-13