Incidental Mutation 'R1580:Vmn2r10'
ID 171342
Institutional Source Beutler Lab
Gene Symbol Vmn2r10
Ensembl Gene ENSMUSG00000067010
Gene Name vomeronasal 2, receptor 10
Synonyms VR16, V2r16
MMRRC Submission 039617-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R1580 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 109141278-109154337 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 109154117 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 62 (N62K)
Ref Sequence ENSEMBL: ENSMUSP00000135274 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079163] [ENSMUST00000176594]
AlphaFold K7N621
Predicted Effect probably benign
Transcript: ENSMUST00000079163
AA Change: N62K

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: N62K

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 75 464 8.5e-29 PFAM
Pfam:NCD3G 506 560 3.8e-17 PFAM
Pfam:7tm_3 593 828 4e-55 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000176594
AA Change: N62K

PolyPhen 2 Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010
AA Change: N62K

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.4%
  • 20x: 89.8%
Validation Efficiency 96% (43/45)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 C T 1: 71,305,124 (GRCm39) V2044I possibly damaging Het
Adgrv1 A G 13: 81,614,279 (GRCm39) probably null Het
Arhgef38 T C 3: 132,839,465 (GRCm39) Q526R probably benign Het
Atp2c2 A G 8: 120,479,726 (GRCm39) N752D probably benign Het
Atp6v0a1 T C 11: 100,920,030 (GRCm39) I221T probably damaging Het
Atp8b5 T C 4: 43,355,673 (GRCm39) V551A possibly damaging Het
B3galnt1 A G 3: 69,483,040 (GRCm39) S74P possibly damaging Het
Bcl2l13 A G 6: 120,842,675 (GRCm39) I123V probably benign Het
Brms1l A T 12: 55,915,007 (GRCm39) K305N probably damaging Het
Ccdc82 C T 9: 13,252,385 (GRCm39) R226C probably damaging Het
Chst9 T G 18: 15,586,122 (GRCm39) K147T probably benign Het
Clec16a A G 16: 10,413,762 (GRCm39) R390G probably damaging Het
Clec5a G T 6: 40,562,153 (GRCm39) H4N probably benign Het
Csmd1 T A 8: 15,975,299 (GRCm39) Q2970L probably damaging Het
Cyp2a4 T C 7: 26,007,076 (GRCm39) I61T possibly damaging Het
Cyp3a16 T A 5: 145,378,884 (GRCm39) K379I possibly damaging Het
Cyp3a16 T C 5: 145,378,885 (GRCm39) K379E probably damaging Het
Dok2 A G 14: 71,014,397 (GRCm39) D195G probably benign Het
Emilin1 A G 5: 31,074,764 (GRCm39) E335G probably damaging Het
Gm7361 G T 5: 26,462,768 (GRCm39) L3F probably damaging Het
Haus1 T C 18: 77,854,620 (GRCm39) D50G probably damaging Het
Igf1r T C 7: 67,857,617 (GRCm39) V1099A probably benign Het
Kif15 T C 9: 122,789,021 (GRCm39) V71A probably benign Het
Klk10 C T 7: 43,432,286 (GRCm39) A73V probably damaging Het
Lins1 C A 7: 66,364,239 (GRCm39) D711E probably benign Het
Mbtps1 C T 8: 120,265,639 (GRCm39) V303I possibly damaging Het
Mest G A 6: 30,745,822 (GRCm39) probably benign Het
Nup214 C T 2: 31,924,478 (GRCm39) S1669F probably damaging Het
Or14c43 A G 7: 86,114,658 (GRCm39) E13G probably benign Het
Or6c210 G T 10: 129,496,184 (GRCm39) V170F probably benign Het
Rfwd3 C T 8: 112,014,874 (GRCm39) R326Q probably damaging Het
Rtf2 A G 2: 172,287,285 (GRCm39) D68G probably damaging Het
Sbspon C A 1: 15,962,692 (GRCm39) C62F probably damaging Het
Spata31f3 T C 4: 42,874,020 (GRCm39) probably null Het
Spg7 T A 8: 123,816,977 (GRCm39) probably benign Het
Trabd2b T C 4: 114,437,531 (GRCm39) V236A possibly damaging Het
Vmn2r45 T G 7: 8,474,746 (GRCm39) S761R possibly damaging Het
Zfp580 C T 7: 5,056,284 (GRCm39) R215C probably damaging Het
Zfpm2 A G 15: 40,966,605 (GRCm39) D898G possibly damaging Het
Other mutations in Vmn2r10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00816:Vmn2r10 APN 5 109,150,451 (GRCm39) missense possibly damaging 0.75
IGL01618:Vmn2r10 APN 5 109,150,345 (GRCm39) missense probably damaging 1.00
IGL01624:Vmn2r10 APN 5 109,154,112 (GRCm39) missense possibly damaging 0.83
IGL01941:Vmn2r10 APN 5 109,143,820 (GRCm39) missense probably damaging 1.00
IGL01959:Vmn2r10 APN 5 109,145,571 (GRCm39) missense probably benign 0.00
IGL01973:Vmn2r10 APN 5 109,143,543 (GRCm39) missense probably damaging 1.00
IGL01985:Vmn2r10 APN 5 109,154,125 (GRCm39) missense probably benign 0.21
IGL02451:Vmn2r10 APN 5 109,143,788 (GRCm39) nonsense probably null
IGL02503:Vmn2r10 APN 5 109,151,341 (GRCm39) missense probably damaging 1.00
IGL03275:Vmn2r10 APN 5 109,151,243 (GRCm39) missense probably benign 0.00
R0035:Vmn2r10 UTSW 5 109,145,467 (GRCm39) splice site probably benign
R0395:Vmn2r10 UTSW 5 109,149,859 (GRCm39) missense probably damaging 1.00
R0454:Vmn2r10 UTSW 5 109,151,327 (GRCm39) missense probably benign 0.25
R0648:Vmn2r10 UTSW 5 109,143,782 (GRCm39) missense probably benign 0.00
R1251:Vmn2r10 UTSW 5 109,143,890 (GRCm39) missense probably benign 0.01
R1845:Vmn2r10 UTSW 5 109,149,861 (GRCm39) nonsense probably null
R1986:Vmn2r10 UTSW 5 109,154,120 (GRCm39) nonsense probably null
R2137:Vmn2r10 UTSW 5 109,151,410 (GRCm39) missense possibly damaging 0.87
R2495:Vmn2r10 UTSW 5 109,143,961 (GRCm39) missense probably damaging 1.00
R3932:Vmn2r10 UTSW 5 109,150,088 (GRCm39) missense possibly damaging 0.47
R3933:Vmn2r10 UTSW 5 109,150,088 (GRCm39) missense possibly damaging 0.47
R4899:Vmn2r10 UTSW 5 109,151,324 (GRCm39) missense probably damaging 1.00
R4992:Vmn2r10 UTSW 5 109,145,592 (GRCm39) missense possibly damaging 0.89
R5124:Vmn2r10 UTSW 5 109,154,286 (GRCm39) missense probably benign 0.01
R5145:Vmn2r10 UTSW 5 109,143,761 (GRCm39) missense possibly damaging 0.64
R5156:Vmn2r10 UTSW 5 109,143,466 (GRCm39) missense probably benign 0.11
R5265:Vmn2r10 UTSW 5 109,143,586 (GRCm39) missense probably damaging 1.00
R5311:Vmn2r10 UTSW 5 109,154,121 (GRCm39) missense probably damaging 1.00
R5321:Vmn2r10 UTSW 5 109,143,505 (GRCm39) missense probably damaging 1.00
R5666:Vmn2r10 UTSW 5 109,146,910 (GRCm39) nonsense probably null
R5670:Vmn2r10 UTSW 5 109,146,910 (GRCm39) nonsense probably null
R5872:Vmn2r10 UTSW 5 109,151,377 (GRCm39) missense possibly damaging 0.84
R6004:Vmn2r10 UTSW 5 109,146,944 (GRCm39) missense probably benign 0.30
R6108:Vmn2r10 UTSW 5 109,143,667 (GRCm39) missense probably damaging 1.00
R6332:Vmn2r10 UTSW 5 109,151,328 (GRCm39) missense probably damaging 1.00
R6599:Vmn2r10 UTSW 5 109,143,944 (GRCm39) missense probably benign 0.09
R6651:Vmn2r10 UTSW 5 109,143,488 (GRCm39) missense probably null 0.22
R6891:Vmn2r10 UTSW 5 109,149,845 (GRCm39) missense probably damaging 1.00
R7023:Vmn2r10 UTSW 5 109,149,894 (GRCm39) missense probably damaging 0.96
R7146:Vmn2r10 UTSW 5 109,151,200 (GRCm39) missense probably damaging 1.00
R7941:Vmn2r10 UTSW 5 109,144,306 (GRCm39) missense probably damaging 1.00
R8058:Vmn2r10 UTSW 5 109,149,955 (GRCm39) missense probably benign 0.00
R8478:Vmn2r10 UTSW 5 109,143,636 (GRCm39) missense probably damaging 1.00
R8526:Vmn2r10 UTSW 5 109,145,572 (GRCm39) missense possibly damaging 0.51
R8698:Vmn2r10 UTSW 5 109,151,390 (GRCm39) missense probably benign 0.00
R8796:Vmn2r10 UTSW 5 109,143,917 (GRCm39) missense possibly damaging 0.74
R8854:Vmn2r10 UTSW 5 109,144,126 (GRCm39) missense probably benign 0.20
R8871:Vmn2r10 UTSW 5 109,146,899 (GRCm39) missense possibly damaging 0.67
R8893:Vmn2r10 UTSW 5 109,143,677 (GRCm39) missense probably benign 0.09
R8907:Vmn2r10 UTSW 5 109,149,791 (GRCm39) missense probably benign
R8957:Vmn2r10 UTSW 5 109,149,780 (GRCm39) missense possibly damaging 0.60
R8976:Vmn2r10 UTSW 5 109,145,479 (GRCm39) missense probably damaging 1.00
R9155:Vmn2r10 UTSW 5 109,144,212 (GRCm39) missense probably benign 0.10
R9308:Vmn2r10 UTSW 5 109,145,476 (GRCm39) nonsense probably null
R9800:Vmn2r10 UTSW 5 109,150,404 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r10 UTSW 5 109,143,979 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r10 UTSW 5 109,149,854 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACAGGTGGTGATTGTGAATTTAAGGCA -3'
(R):5'- GTGGATCTTCAGAGAGCAGTAGCCATA -3'

Sequencing Primer
(F):5'- GGCAGATGATGAGACATCTTTC -3'
(R):5'- CCTTAGCAGATATGAAAAACCTGTG -3'
Posted On 2014-04-13