Mutagenetix > Incidental Mutation

Incidental Mutation 'R1580:Vmn2r45'

171350

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r45

Ensembl Gene

ENSMUSG00000090662

Gene Name

vomeronasal 2, receptor 45

Synonyms

MMRRC Submission

039617-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.091) question?

Stock #

R1580 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

8470525-8489075 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 8471747 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 761 (S761R)

Ref Sequence

ENSEMBL: ENSMUSP00000129466 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164845]

AlphaFold

L7N2B5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000164845
AA Change: S761R

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000129466
Gene: ENSMUSG00000090662
AA Change: S761R

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	154	469	4.5e-26	PFAM
Pfam:NCD3G	512	565	6.4e-21	PFAM
Pfam:7tm_3	598	833	2.1e-54	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.0%
3x: 98.0%
10x: 95.4%
20x: 89.8%

Validation Efficiency

96% (43/45)

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	C	T	1: 71,265,965 (GRCm38)	V2044I	possibly damaging	Het
Adgrv1	A	G	13: 81,466,160 (GRCm38)		probably null	Het
Arhgef38	T	C	3: 133,133,704 (GRCm38)	Q526R	probably benign	Het
Atp2c2	A	G	8: 119,752,987 (GRCm38)	N752D	probably benign	Het
Atp6v0a1	T	C	11: 101,029,204 (GRCm38)	I221T	probably damaging	Het
Atp8b5	T	C	4: 43,355,673 (GRCm38)	V551A	possibly damaging	Het
B3galnt1	A	G	3: 69,575,707 (GRCm38)	S74P	possibly damaging	Het
Bcl2l13	A	G	6: 120,865,714 (GRCm38)	I123V	probably benign	Het
Brms1l	A	T	12: 55,868,222 (GRCm38)	K305N	probably damaging	Het
Ccdc82	C	T	9: 13,252,760 (GRCm38)	R226C	probably damaging	Het
Chst9	T	G	18: 15,453,065 (GRCm38)	K147T	probably benign	Het
Clec16a	A	G	16: 10,595,898 (GRCm38)	R390G	probably damaging	Het
Clec5a	G	T	6: 40,585,219 (GRCm38)	H4N	probably benign	Het
Csmd1	T	A	8: 15,925,299 (GRCm38)	Q2970L	probably damaging	Het
Cyp2a4	T	C	7: 26,307,651 (GRCm38)	I61T	possibly damaging	Het
Cyp3a16	T	A	5: 145,442,074 (GRCm38)	K379I	possibly damaging	Het
Cyp3a16	T	C	5: 145,442,075 (GRCm38)	K379E	probably damaging	Het
Dok2	A	G	14: 70,776,957 (GRCm38)	D195G	probably benign	Het
Emilin1	A	G	5: 30,917,420 (GRCm38)	E335G	probably damaging	Het
Gm7361	G	T	5: 26,257,770 (GRCm38)	L3F	probably damaging	Het
Haus1	T	C	18: 77,766,920 (GRCm38)	D50G	probably damaging	Het
Igf1r	T	C	7: 68,207,869 (GRCm38)	V1099A	probably benign	Het
Kif15	T	C	9: 122,959,956 (GRCm38)	V71A	probably benign	Het
Klk10	C	T	7: 43,782,862 (GRCm38)	A73V	probably damaging	Het
Lins1	C	A	7: 66,714,491 (GRCm38)	D711E	probably benign	Het
Mbtps1	C	T	8: 119,538,900 (GRCm38)	V303I	possibly damaging	Het
Mest	G	A	6: 30,745,823 (GRCm38)		probably benign	Het
Nup214	C	T	2: 32,034,466 (GRCm38)	S1669F	probably damaging	Het
Or14c43	A	G	7: 86,465,450 (GRCm38)	E13G	probably benign	Het
Or6c210	G	T	10: 129,660,315 (GRCm38)	V170F	probably benign	Het
Rfwd3	C	T	8: 111,288,242 (GRCm38)	R326Q	probably damaging	Het
Rtf2	A	G	2: 172,445,365 (GRCm38)	D68G	probably damaging	Het
Sbspon	C	A	1: 15,892,468 (GRCm38)	C62F	probably damaging	Het
Spata31f3	T	C	4: 42,874,020 (GRCm38)		probably null	Het
Spg7	T	A	8: 123,090,238 (GRCm38)		probably benign	Het
Trabd2b	T	C	4: 114,580,334 (GRCm38)	V236A	possibly damaging	Het
Vmn2r10	A	T	5: 109,006,251 (GRCm38)	N62K	possibly damaging	Het
Zfp580	C	T	7: 5,053,285 (GRCm38)	R215C	probably damaging	Het
Zfpm2	A	G	15: 41,103,209 (GRCm38)	D898G	possibly damaging	Het

Other mutations in Vmn2r45

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01287:Vmn2r45	APN	7	8,485,623 (GRCm38)	missense	probably benign	0.00
IGL01322:Vmn2r45	APN	7	8,481,333 (GRCm38)	missense	possibly damaging	0.49
IGL01402:Vmn2r45	APN	7	8,481,468 (GRCm38)	missense	probably damaging	0.98
IGL01404:Vmn2r45	APN	7	8,481,468 (GRCm38)	missense	probably damaging	0.98
IGL01529:Vmn2r45	APN	7	8,483,494 (GRCm38)	missense	probably benign
IGL01596:Vmn2r45	APN	7	8,483,273 (GRCm38)	missense	probably damaging	0.98
IGL01646:Vmn2r45	APN	7	8,483,338 (GRCm38)	missense	probably benign	0.18
IGL01819:Vmn2r45	APN	7	8,485,557 (GRCm38)	missense	probably benign	0.00
IGL02096:Vmn2r45	APN	7	8,481,444 (GRCm38)	missense	probably damaging	0.99
IGL02130:Vmn2r45	APN	7	8,483,557 (GRCm38)	missense	possibly damaging	0.46
IGL02409:Vmn2r45	APN	7	8,485,728 (GRCm38)	missense	probably benign	0.03
IGL02517:Vmn2r45	APN	7	8,483,186 (GRCm38)	nonsense	probably null
IGL02633:Vmn2r45	APN	7	8,485,729 (GRCm38)	missense	probably benign	0.01
IGL02940:Vmn2r45	APN	7	8,472,370 (GRCm38)	missense	probably damaging	0.99
IGL03281:Vmn2r45	APN	7	8,483,604 (GRCm38)	missense	probably damaging	1.00
IGL03358:Vmn2r45	APN	7	8,471,716 (GRCm38)	missense	probably damaging	1.00
BB004:Vmn2r45	UTSW	7	8,483,514 (GRCm38)	missense	probably benign
BB014:Vmn2r45	UTSW	7	8,483,514 (GRCm38)	missense	probably benign
R0382:Vmn2r45	UTSW	7	8,483,099 (GRCm38)	missense	probably benign	0.06
R0532:Vmn2r45	UTSW	7	8,471,821 (GRCm38)	missense	probably damaging	0.99
R0932:Vmn2r45	UTSW	7	8,475,381 (GRCm38)	missense	probably damaging	1.00
R1125:Vmn2r45	UTSW	7	8,485,543 (GRCm38)	missense	probably benign	0.00
R1817:Vmn2r45	UTSW	7	8,472,373 (GRCm38)	missense	probably damaging	1.00
R1996:Vmn2r45	UTSW	7	8,472,025 (GRCm38)	missense	probably damaging	1.00
R2050:Vmn2r45	UTSW	7	8,472,022 (GRCm38)	missense	probably damaging	1.00
R2284:Vmn2r45	UTSW	7	8,485,766 (GRCm38)	missense	probably benign	0.02
R4019:Vmn2r45	UTSW	7	8,471,581 (GRCm38)	nonsense	probably null
R4227:Vmn2r45	UTSW	7	8,483,278 (GRCm38)	missense	probably damaging	0.98
R4381:Vmn2r45	UTSW	7	8,471,913 (GRCm38)	nonsense	probably null
R4618:Vmn2r45	UTSW	7	8,483,437 (GRCm38)	missense	probably benign	0.00
R4624:Vmn2r45	UTSW	7	8,481,342 (GRCm38)	missense	probably damaging	1.00
R4704:Vmn2r45	UTSW	7	8,483,536 (GRCm38)	nonsense	probably null
R4735:Vmn2r45	UTSW	7	8,483,473 (GRCm38)	missense	probably damaging	1.00
R4868:Vmn2r45	UTSW	7	8,481,481 (GRCm38)	missense	probably benign	0.06
R4983:Vmn2r45	UTSW	7	8,483,117 (GRCm38)	missense	probably damaging	0.99
R5246:Vmn2r45	UTSW	7	8,483,252 (GRCm38)	missense	probably benign	0.00
R5430:Vmn2r45	UTSW	7	8,483,334 (GRCm38)	nonsense	probably null
R5504:Vmn2r45	UTSW	7	8,483,177 (GRCm38)	missense	probably benign	0.03
R5511:Vmn2r45	UTSW	7	8,471,833 (GRCm38)	missense	probably benign	0.19
R5745:Vmn2r45	UTSW	7	8,483,075 (GRCm38)	missense	probably benign	0.00
R5814:Vmn2r45	UTSW	7	8,471,476 (GRCm38)	missense	probably benign	0.00
R6223:Vmn2r45	UTSW	7	8,483,302 (GRCm38)	missense	probably benign
R6267:Vmn2r45	UTSW	7	8,472,208 (GRCm38)	missense	probably benign	0.26
R6623:Vmn2r45	UTSW	7	8,471,501 (GRCm38)	missense	probably benign	0.09
R6999:Vmn2r45	UTSW	7	8,483,220 (GRCm38)	missense	probably benign
R7242:Vmn2r45	UTSW	7	8,485,613 (GRCm38)	nonsense	probably null
R7491:Vmn2r45	UTSW	7	8,481,343 (GRCm38)	missense	probably benign	0.27
R7620:Vmn2r45	UTSW	7	8,483,223 (GRCm38)	nonsense	probably null
R7719:Vmn2r45	UTSW	7	8,483,461 (GRCm38)	missense	probably damaging	0.99
R7720:Vmn2r45	UTSW	7	8,483,461 (GRCm38)	missense	probably damaging	0.99
R7853:Vmn2r45	UTSW	7	8,482,988 (GRCm38)	missense	possibly damaging	0.90
R7873:Vmn2r45	UTSW	7	8,483,075 (GRCm38)	missense	probably benign	0.00
R7882:Vmn2r45	UTSW	7	8,483,410 (GRCm38)	missense	possibly damaging	0.82
R7927:Vmn2r45	UTSW	7	8,483,514 (GRCm38)	missense	probably benign
R8684:Vmn2r45	UTSW	7	8,483,512 (GRCm38)	missense	probably damaging	0.99
R8780:Vmn2r45	UTSW	7	8,481,372 (GRCm38)	missense	possibly damaging	0.94
R8811:Vmn2r45	UTSW	7	8,471,882 (GRCm38)	missense	probably damaging	1.00
R8893:Vmn2r45	UTSW	7	8,485,620 (GRCm38)	missense	probably damaging	1.00
R9043:Vmn2r45	UTSW	7	8,471,905 (GRCm38)	missense	possibly damaging	0.92
R9208:Vmn2r45	UTSW	7	8,483,299 (GRCm38)	missense	probably damaging	1.00
R9327:Vmn2r45	UTSW	7	8,471,533 (GRCm38)	missense	probably damaging	1.00
R9586:Vmn2r45	UTSW	7	8,483,051 (GRCm38)	missense	probably benign	0.01
R9599:Vmn2r45	UTSW	7	8,475,458 (GRCm38)	critical splice acceptor site	probably null
U24488:Vmn2r45	UTSW	7	8,472,362 (GRCm38)	missense	probably damaging	1.00
Z1088:Vmn2r45	UTSW	7	8,471,485 (GRCm38)	missense	probably benign	0.16

Predicted Primers

PCR Primer
(F):5'- CACAGCAACCATGTGTTTGCCC -3'
(R):5'- ACAGTCACTGTGGTTCTGGCTTTC -3'

Sequencing Primer
(F):5'- CCATGTGTTTGCCCTTGGTG -3'
(R):5'- GGCTTTCAAAGTCACAGACC -3'

Posted On

2014-04-13