Mutagenetix > Incidental Mutation

Incidental Mutation 'R1580:Vmn2r45'

171350

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r45

Ensembl Gene

ENSMUSG00000090662

Gene Name

vomeronasal 2, receptor 45

Synonyms

MMRRC Submission

039617-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

R1580 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

8474468-8491958 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 8474746 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 761 (S761R)

Ref Sequence

ENSEMBL: ENSMUSP00000129466 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164845]

AlphaFold

L7N2B5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000164845
AA Change: S761R

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000129466
Gene: ENSMUSG00000090662
AA Change: S761R

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	154	469	4.5e-26	PFAM
Pfam:NCD3G	512	565	6.4e-21	PFAM
Pfam:7tm_3	598	833	2.1e-54	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.0%
3x: 98.0%
10x: 95.4%
20x: 89.8%

Validation Efficiency

96% (43/45)

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	C	T	1: 71,305,124 (GRCm39)	V2044I	possibly damaging	Het
Adgrv1	A	G	13: 81,614,279 (GRCm39)		probably null	Het
Arhgef38	T	C	3: 132,839,465 (GRCm39)	Q526R	probably benign	Het
Atp2c2	A	G	8: 120,479,726 (GRCm39)	N752D	probably benign	Het
Atp6v0a1	T	C	11: 100,920,030 (GRCm39)	I221T	probably damaging	Het
Atp8b5	T	C	4: 43,355,673 (GRCm39)	V551A	possibly damaging	Het
B3galnt1	A	G	3: 69,483,040 (GRCm39)	S74P	possibly damaging	Het
Bcl2l13	A	G	6: 120,842,675 (GRCm39)	I123V	probably benign	Het
Brms1l	A	T	12: 55,915,007 (GRCm39)	K305N	probably damaging	Het
Ccdc82	C	T	9: 13,252,385 (GRCm39)	R226C	probably damaging	Het
Chst9	T	G	18: 15,586,122 (GRCm39)	K147T	probably benign	Het
Clec16a	A	G	16: 10,413,762 (GRCm39)	R390G	probably damaging	Het
Clec5a	G	T	6: 40,562,153 (GRCm39)	H4N	probably benign	Het
Csmd1	T	A	8: 15,975,299 (GRCm39)	Q2970L	probably damaging	Het
Cyp2a4	T	C	7: 26,007,076 (GRCm39)	I61T	possibly damaging	Het
Cyp3a16	T	A	5: 145,378,884 (GRCm39)	K379I	possibly damaging	Het
Cyp3a16	T	C	5: 145,378,885 (GRCm39)	K379E	probably damaging	Het
Dok2	A	G	14: 71,014,397 (GRCm39)	D195G	probably benign	Het
Emilin1	A	G	5: 31,074,764 (GRCm39)	E335G	probably damaging	Het
Gm7361	G	T	5: 26,462,768 (GRCm39)	L3F	probably damaging	Het
Haus1	T	C	18: 77,854,620 (GRCm39)	D50G	probably damaging	Het
Igf1r	T	C	7: 67,857,617 (GRCm39)	V1099A	probably benign	Het
Kif15	T	C	9: 122,789,021 (GRCm39)	V71A	probably benign	Het
Klk10	C	T	7: 43,432,286 (GRCm39)	A73V	probably damaging	Het
Lins1	C	A	7: 66,364,239 (GRCm39)	D711E	probably benign	Het
Mbtps1	C	T	8: 120,265,639 (GRCm39)	V303I	possibly damaging	Het
Mest	G	A	6: 30,745,822 (GRCm39)		probably benign	Het
Nup214	C	T	2: 31,924,478 (GRCm39)	S1669F	probably damaging	Het
Or14c43	A	G	7: 86,114,658 (GRCm39)	E13G	probably benign	Het
Or6c210	G	T	10: 129,496,184 (GRCm39)	V170F	probably benign	Het
Rfwd3	C	T	8: 112,014,874 (GRCm39)	R326Q	probably damaging	Het
Rtf2	A	G	2: 172,287,285 (GRCm39)	D68G	probably damaging	Het
Sbspon	C	A	1: 15,962,692 (GRCm39)	C62F	probably damaging	Het
Spata31f3	T	C	4: 42,874,020 (GRCm39)		probably null	Het
Spg7	T	A	8: 123,816,977 (GRCm39)		probably benign	Het
Trabd2b	T	C	4: 114,437,531 (GRCm39)	V236A	possibly damaging	Het
Vmn2r10	A	T	5: 109,154,117 (GRCm39)	N62K	possibly damaging	Het
Zfp580	C	T	7: 5,056,284 (GRCm39)	R215C	probably damaging	Het
Zfpm2	A	G	15: 40,966,605 (GRCm39)	D898G	possibly damaging	Het

Other mutations in Vmn2r45

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01287:Vmn2r45	APN	7	8,488,622 (GRCm39)	missense	probably benign	0.00
IGL01322:Vmn2r45	APN	7	8,484,332 (GRCm39)	missense	possibly damaging	0.49
IGL01402:Vmn2r45	APN	7	8,484,467 (GRCm39)	missense	probably damaging	0.98
IGL01404:Vmn2r45	APN	7	8,484,467 (GRCm39)	missense	probably damaging	0.98
IGL01529:Vmn2r45	APN	7	8,486,493 (GRCm39)	missense	probably benign
IGL01596:Vmn2r45	APN	7	8,486,272 (GRCm39)	missense	probably damaging	0.98
IGL01646:Vmn2r45	APN	7	8,486,337 (GRCm39)	missense	probably benign	0.18
IGL01819:Vmn2r45	APN	7	8,488,556 (GRCm39)	missense	probably benign	0.00
IGL02096:Vmn2r45	APN	7	8,484,443 (GRCm39)	missense	probably damaging	0.99
IGL02130:Vmn2r45	APN	7	8,486,556 (GRCm39)	missense	possibly damaging	0.46
IGL02409:Vmn2r45	APN	7	8,488,727 (GRCm39)	missense	probably benign	0.03
IGL02517:Vmn2r45	APN	7	8,486,185 (GRCm39)	nonsense	probably null
IGL02633:Vmn2r45	APN	7	8,488,728 (GRCm39)	missense	probably benign	0.01
IGL02940:Vmn2r45	APN	7	8,475,369 (GRCm39)	missense	probably damaging	0.99
IGL03281:Vmn2r45	APN	7	8,486,603 (GRCm39)	missense	probably damaging	1.00
IGL03358:Vmn2r45	APN	7	8,474,715 (GRCm39)	missense	probably damaging	1.00
BB004:Vmn2r45	UTSW	7	8,486,513 (GRCm39)	missense	probably benign
BB014:Vmn2r45	UTSW	7	8,486,513 (GRCm39)	missense	probably benign
R0382:Vmn2r45	UTSW	7	8,486,098 (GRCm39)	missense	probably benign	0.06
R0532:Vmn2r45	UTSW	7	8,474,820 (GRCm39)	missense	probably damaging	0.99
R0932:Vmn2r45	UTSW	7	8,478,380 (GRCm39)	missense	probably damaging	1.00
R1125:Vmn2r45	UTSW	7	8,488,542 (GRCm39)	missense	probably benign	0.00
R1817:Vmn2r45	UTSW	7	8,475,372 (GRCm39)	missense	probably damaging	1.00
R1996:Vmn2r45	UTSW	7	8,475,024 (GRCm39)	missense	probably damaging	1.00
R2050:Vmn2r45	UTSW	7	8,475,021 (GRCm39)	missense	probably damaging	1.00
R2284:Vmn2r45	UTSW	7	8,488,765 (GRCm39)	missense	probably benign	0.02
R4019:Vmn2r45	UTSW	7	8,474,580 (GRCm39)	nonsense	probably null
R4227:Vmn2r45	UTSW	7	8,486,277 (GRCm39)	missense	probably damaging	0.98
R4381:Vmn2r45	UTSW	7	8,474,912 (GRCm39)	nonsense	probably null
R4618:Vmn2r45	UTSW	7	8,486,436 (GRCm39)	missense	probably benign	0.00
R4624:Vmn2r45	UTSW	7	8,484,341 (GRCm39)	missense	probably damaging	1.00
R4704:Vmn2r45	UTSW	7	8,486,535 (GRCm39)	nonsense	probably null
R4735:Vmn2r45	UTSW	7	8,486,472 (GRCm39)	missense	probably damaging	1.00
R4868:Vmn2r45	UTSW	7	8,484,480 (GRCm39)	missense	probably benign	0.06
R4983:Vmn2r45	UTSW	7	8,486,116 (GRCm39)	missense	probably damaging	0.99
R5246:Vmn2r45	UTSW	7	8,486,251 (GRCm39)	missense	probably benign	0.00
R5430:Vmn2r45	UTSW	7	8,486,333 (GRCm39)	nonsense	probably null
R5504:Vmn2r45	UTSW	7	8,486,176 (GRCm39)	missense	probably benign	0.03
R5511:Vmn2r45	UTSW	7	8,474,832 (GRCm39)	missense	probably benign	0.19
R5745:Vmn2r45	UTSW	7	8,486,074 (GRCm39)	missense	probably benign	0.00
R5814:Vmn2r45	UTSW	7	8,474,475 (GRCm39)	missense	probably benign	0.00
R6223:Vmn2r45	UTSW	7	8,486,301 (GRCm39)	missense	probably benign
R6267:Vmn2r45	UTSW	7	8,475,207 (GRCm39)	missense	probably benign	0.26
R6623:Vmn2r45	UTSW	7	8,474,500 (GRCm39)	missense	probably benign	0.09
R6999:Vmn2r45	UTSW	7	8,486,219 (GRCm39)	missense	probably benign
R7242:Vmn2r45	UTSW	7	8,488,612 (GRCm39)	nonsense	probably null
R7491:Vmn2r45	UTSW	7	8,484,342 (GRCm39)	missense	probably benign	0.27
R7620:Vmn2r45	UTSW	7	8,486,222 (GRCm39)	nonsense	probably null
R7719:Vmn2r45	UTSW	7	8,486,460 (GRCm39)	missense	probably damaging	0.99
R7720:Vmn2r45	UTSW	7	8,486,460 (GRCm39)	missense	probably damaging	0.99
R7853:Vmn2r45	UTSW	7	8,485,987 (GRCm39)	missense	possibly damaging	0.90
R7873:Vmn2r45	UTSW	7	8,486,074 (GRCm39)	missense	probably benign	0.00
R7882:Vmn2r45	UTSW	7	8,486,409 (GRCm39)	missense	possibly damaging	0.82
R7927:Vmn2r45	UTSW	7	8,486,513 (GRCm39)	missense	probably benign
R8684:Vmn2r45	UTSW	7	8,486,511 (GRCm39)	missense	probably damaging	0.99
R8780:Vmn2r45	UTSW	7	8,484,371 (GRCm39)	missense	possibly damaging	0.94
R8811:Vmn2r45	UTSW	7	8,474,881 (GRCm39)	missense	probably damaging	1.00
R8893:Vmn2r45	UTSW	7	8,488,619 (GRCm39)	missense	probably damaging	1.00
R9043:Vmn2r45	UTSW	7	8,474,904 (GRCm39)	missense	possibly damaging	0.92
R9208:Vmn2r45	UTSW	7	8,486,298 (GRCm39)	missense	probably damaging	1.00
R9327:Vmn2r45	UTSW	7	8,474,532 (GRCm39)	missense	probably damaging	1.00
R9586:Vmn2r45	UTSW	7	8,486,050 (GRCm39)	missense	probably benign	0.01
R9599:Vmn2r45	UTSW	7	8,478,457 (GRCm39)	critical splice acceptor site	probably null
U24488:Vmn2r45	UTSW	7	8,475,361 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r45	UTSW	7	8,474,484 (GRCm39)	missense	probably benign	0.16

Predicted Primers

PCR Primer
(F):5'- CACAGCAACCATGTGTTTGCCC -3'
(R):5'- ACAGTCACTGTGGTTCTGGCTTTC -3'

Sequencing Primer
(F):5'- CCATGTGTTTGCCCTTGGTG -3'
(R):5'- GGCTTTCAAAGTCACAGACC -3'

Posted On

2014-04-13