Incidental Mutation 'R1580:Klk10'
ID 171352
Institutional Source Beutler Lab
Gene Symbol Klk10
Ensembl Gene ENSMUSG00000030693
Gene Name kallikrein related-peptidase 10
Synonyms 2300002A13Rik, PRSSL1, NES1
MMRRC Submission 039617-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R1580 (G1)
Quality Score 217
Status Validated
Chromosome 7
Chromosomal Location 43430478-43434834 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 43432286 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 73 (A73V)
Ref Sequence ENSEMBL: ENSMUSP00000014058 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000014058] [ENSMUST00000080211] [ENSMUST00000171458]
AlphaFold Q99M20
Predicted Effect probably damaging
Transcript: ENSMUST00000014058
AA Change: A73V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000014058
Gene: ENSMUSG00000030693
AA Change: A73V

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
Tryp_SPc 46 271 1.35e-71 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000080211
SMART Domains Protein: ENSMUSP00000079101
Gene: ENSMUSG00000067616

DomainStartEndE-ValueType
low complexity region 22 37 N/A INTRINSIC
Tryp_SPc 47 269 5.14e-95 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000171458
SMART Domains Protein: ENSMUSP00000132721
Gene: ENSMUSG00000067616

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Tryp_SPc 20 242 5.14e-95 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181454
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205415
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205566
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206165
Meta Mutation Damage Score 0.6850 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.4%
  • 20x: 89.8%
Validation Efficiency 96% (43/45)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 C T 1: 71,305,124 (GRCm39) V2044I possibly damaging Het
Adgrv1 A G 13: 81,614,279 (GRCm39) probably null Het
Arhgef38 T C 3: 132,839,465 (GRCm39) Q526R probably benign Het
Atp2c2 A G 8: 120,479,726 (GRCm39) N752D probably benign Het
Atp6v0a1 T C 11: 100,920,030 (GRCm39) I221T probably damaging Het
Atp8b5 T C 4: 43,355,673 (GRCm39) V551A possibly damaging Het
B3galnt1 A G 3: 69,483,040 (GRCm39) S74P possibly damaging Het
Bcl2l13 A G 6: 120,842,675 (GRCm39) I123V probably benign Het
Brms1l A T 12: 55,915,007 (GRCm39) K305N probably damaging Het
Ccdc82 C T 9: 13,252,385 (GRCm39) R226C probably damaging Het
Chst9 T G 18: 15,586,122 (GRCm39) K147T probably benign Het
Clec16a A G 16: 10,413,762 (GRCm39) R390G probably damaging Het
Clec5a G T 6: 40,562,153 (GRCm39) H4N probably benign Het
Csmd1 T A 8: 15,975,299 (GRCm39) Q2970L probably damaging Het
Cyp2a4 T C 7: 26,007,076 (GRCm39) I61T possibly damaging Het
Cyp3a16 T A 5: 145,378,884 (GRCm39) K379I possibly damaging Het
Cyp3a16 T C 5: 145,378,885 (GRCm39) K379E probably damaging Het
Dok2 A G 14: 71,014,397 (GRCm39) D195G probably benign Het
Emilin1 A G 5: 31,074,764 (GRCm39) E335G probably damaging Het
Gm7361 G T 5: 26,462,768 (GRCm39) L3F probably damaging Het
Haus1 T C 18: 77,854,620 (GRCm39) D50G probably damaging Het
Igf1r T C 7: 67,857,617 (GRCm39) V1099A probably benign Het
Kif15 T C 9: 122,789,021 (GRCm39) V71A probably benign Het
Lins1 C A 7: 66,364,239 (GRCm39) D711E probably benign Het
Mbtps1 C T 8: 120,265,639 (GRCm39) V303I possibly damaging Het
Mest G A 6: 30,745,822 (GRCm39) probably benign Het
Nup214 C T 2: 31,924,478 (GRCm39) S1669F probably damaging Het
Or14c43 A G 7: 86,114,658 (GRCm39) E13G probably benign Het
Or6c210 G T 10: 129,496,184 (GRCm39) V170F probably benign Het
Rfwd3 C T 8: 112,014,874 (GRCm39) R326Q probably damaging Het
Rtf2 A G 2: 172,287,285 (GRCm39) D68G probably damaging Het
Sbspon C A 1: 15,962,692 (GRCm39) C62F probably damaging Het
Spata31f3 T C 4: 42,874,020 (GRCm39) probably null Het
Spg7 T A 8: 123,816,977 (GRCm39) probably benign Het
Trabd2b T C 4: 114,437,531 (GRCm39) V236A possibly damaging Het
Vmn2r10 A T 5: 109,154,117 (GRCm39) N62K possibly damaging Het
Vmn2r45 T G 7: 8,474,746 (GRCm39) S761R possibly damaging Het
Zfp580 C T 7: 5,056,284 (GRCm39) R215C probably damaging Het
Zfpm2 A G 15: 40,966,605 (GRCm39) D898G possibly damaging Het
Other mutations in Klk10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01488:Klk10 APN 7 43,434,400 (GRCm39) missense probably damaging 1.00
IGL01657:Klk10 APN 7 43,431,013 (GRCm39) missense possibly damaging 0.49
IGL02049:Klk10 APN 7 43,433,882 (GRCm39) splice site probably benign
IGL02725:Klk10 APN 7 43,431,044 (GRCm39) missense probably damaging 1.00
IGL03382:Klk10 APN 7 43,433,883 (GRCm39) splice site probably benign
R0433:Klk10 UTSW 7 43,430,989 (GRCm39) missense possibly damaging 0.51
R1521:Klk10 UTSW 7 43,432,304 (GRCm39) missense probably benign 0.00
R4825:Klk10 UTSW 7 43,433,022 (GRCm39) missense probably damaging 1.00
R5969:Klk10 UTSW 7 43,434,409 (GRCm39) missense probably damaging 1.00
R6437:Klk10 UTSW 7 43,432,241 (GRCm39) missense probably benign 0.04
R6641:Klk10 UTSW 7 43,434,324 (GRCm39) missense possibly damaging 0.94
R7589:Klk10 UTSW 7 43,433,051 (GRCm39) missense probably benign 0.00
R7599:Klk10 UTSW 7 43,433,851 (GRCm39) missense probably benign 0.03
R7902:Klk10 UTSW 7 43,432,942 (GRCm39) missense probably benign 0.34
R8519:Klk10 UTSW 7 43,432,239 (GRCm39) nonsense probably null
R9560:Klk10 UTSW 7 43,433,746 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TATTAACCCGGAACCGTGACTTGGC -3'
(R):5'- TGCGTTGCAGGCATATGAGGAG -3'

Sequencing Primer
(F):5'- CTGGGCGAAACCTGATCC -3'
(R):5'- GGTCTTAAATACAACATGCCCTGG -3'
Posted On 2014-04-13