Incidental Mutation 'R1580:Kif15'
ID 171362
Institutional Source Beutler Lab
Gene Symbol Kif15
Ensembl Gene ENSMUSG00000036768
Gene Name kinesin family member 15
Synonyms N-10 kinesin, 3930402I10Rik, 3110023M17Rik, HKLP2, Knsl7
MMRRC Submission 039617-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1580 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 122780146-122847798 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 122789021 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 71 (V71A)
Ref Sequence ENSEMBL: ENSMUSP00000149737 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040717] [ENSMUST00000213745] [ENSMUST00000214652] [ENSMUST00000216388] [ENSMUST00000217401]
AlphaFold Q6P9L6
Predicted Effect probably benign
Transcript: ENSMUST00000040717
AA Change: V71A

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000035490
Gene: ENSMUSG00000036768
AA Change: V71A

DomainStartEndE-ValueType
KISc 24 371 2.86e-179 SMART
Pfam:Kinesin-relat_1 463 551 6.6e-26 PFAM
coiled coil region 579 643 N/A INTRINSIC
coiled coil region 706 1037 N/A INTRINSIC
coiled coil region 1065 1133 N/A INTRINSIC
Pfam:HMMR_C 1265 1387 3.5e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213745
AA Change: V71A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000214652
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214921
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215176
Predicted Effect probably benign
Transcript: ENSMUST00000216388
Predicted Effect probably benign
Transcript: ENSMUST00000217401
AA Change: V71A

PolyPhen 2 Score 0.215 (Sensitivity: 0.92; Specificity: 0.88)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.4%
  • 20x: 89.8%
Validation Efficiency 96% (43/45)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 C T 1: 71,305,124 (GRCm39) V2044I possibly damaging Het
Adgrv1 A G 13: 81,614,279 (GRCm39) probably null Het
Arhgef38 T C 3: 132,839,465 (GRCm39) Q526R probably benign Het
Atp2c2 A G 8: 120,479,726 (GRCm39) N752D probably benign Het
Atp6v0a1 T C 11: 100,920,030 (GRCm39) I221T probably damaging Het
Atp8b5 T C 4: 43,355,673 (GRCm39) V551A possibly damaging Het
B3galnt1 A G 3: 69,483,040 (GRCm39) S74P possibly damaging Het
Bcl2l13 A G 6: 120,842,675 (GRCm39) I123V probably benign Het
Brms1l A T 12: 55,915,007 (GRCm39) K305N probably damaging Het
Ccdc82 C T 9: 13,252,385 (GRCm39) R226C probably damaging Het
Chst9 T G 18: 15,586,122 (GRCm39) K147T probably benign Het
Clec16a A G 16: 10,413,762 (GRCm39) R390G probably damaging Het
Clec5a G T 6: 40,562,153 (GRCm39) H4N probably benign Het
Csmd1 T A 8: 15,975,299 (GRCm39) Q2970L probably damaging Het
Cyp2a4 T C 7: 26,007,076 (GRCm39) I61T possibly damaging Het
Cyp3a16 T A 5: 145,378,884 (GRCm39) K379I possibly damaging Het
Cyp3a16 T C 5: 145,378,885 (GRCm39) K379E probably damaging Het
Dok2 A G 14: 71,014,397 (GRCm39) D195G probably benign Het
Emilin1 A G 5: 31,074,764 (GRCm39) E335G probably damaging Het
Gm7361 G T 5: 26,462,768 (GRCm39) L3F probably damaging Het
Haus1 T C 18: 77,854,620 (GRCm39) D50G probably damaging Het
Igf1r T C 7: 67,857,617 (GRCm39) V1099A probably benign Het
Klk10 C T 7: 43,432,286 (GRCm39) A73V probably damaging Het
Lins1 C A 7: 66,364,239 (GRCm39) D711E probably benign Het
Mbtps1 C T 8: 120,265,639 (GRCm39) V303I possibly damaging Het
Mest G A 6: 30,745,822 (GRCm39) probably benign Het
Nup214 C T 2: 31,924,478 (GRCm39) S1669F probably damaging Het
Or14c43 A G 7: 86,114,658 (GRCm39) E13G probably benign Het
Or6c210 G T 10: 129,496,184 (GRCm39) V170F probably benign Het
Rfwd3 C T 8: 112,014,874 (GRCm39) R326Q probably damaging Het
Rtf2 A G 2: 172,287,285 (GRCm39) D68G probably damaging Het
Sbspon C A 1: 15,962,692 (GRCm39) C62F probably damaging Het
Spata31f3 T C 4: 42,874,020 (GRCm39) probably null Het
Spg7 T A 8: 123,816,977 (GRCm39) probably benign Het
Trabd2b T C 4: 114,437,531 (GRCm39) V236A possibly damaging Het
Vmn2r10 A T 5: 109,154,117 (GRCm39) N62K possibly damaging Het
Vmn2r45 T G 7: 8,474,746 (GRCm39) S761R possibly damaging Het
Zfp580 C T 7: 5,056,284 (GRCm39) R215C probably damaging Het
Zfpm2 A G 15: 40,966,605 (GRCm39) D898G possibly damaging Het
Other mutations in Kif15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01459:Kif15 APN 9 122,804,820 (GRCm39) missense probably damaging 1.00
IGL01577:Kif15 APN 9 122,825,399 (GRCm39) missense probably benign 0.06
IGL01647:Kif15 APN 9 122,792,536 (GRCm39) intron probably benign
IGL01921:Kif15 APN 9 122,808,569 (GRCm39) missense probably damaging 1.00
IGL02040:Kif15 APN 9 122,846,450 (GRCm39) missense probably damaging 0.99
IGL02191:Kif15 APN 9 122,804,744 (GRCm39) missense probably damaging 1.00
IGL02218:Kif15 APN 9 122,824,892 (GRCm39) splice site probably benign
IGL02537:Kif15 APN 9 122,822,914 (GRCm39) missense probably benign 0.08
IGL02814:Kif15 APN 9 122,832,705 (GRCm39) missense possibly damaging 0.83
PIT4480001:Kif15 UTSW 9 122,840,608 (GRCm39) missense probably benign
R0034:Kif15 UTSW 9 122,828,350 (GRCm39) missense possibly damaging 0.47
R0458:Kif15 UTSW 9 122,838,424 (GRCm39) missense probably benign
R0526:Kif15 UTSW 9 122,826,862 (GRCm39) missense probably damaging 0.96
R0533:Kif15 UTSW 9 122,838,498 (GRCm39) unclassified probably benign
R0726:Kif15 UTSW 9 122,788,993 (GRCm39) missense probably benign 0.21
R1597:Kif15 UTSW 9 122,823,074 (GRCm39) missense probably benign 0.22
R2096:Kif15 UTSW 9 122,815,252 (GRCm39) missense probably damaging 1.00
R3125:Kif15 UTSW 9 122,817,026 (GRCm39) missense probably damaging 0.99
R3176:Kif15 UTSW 9 122,816,905 (GRCm39) splice site probably benign
R4088:Kif15 UTSW 9 122,815,254 (GRCm39) missense probably benign 0.29
R4308:Kif15 UTSW 9 122,843,047 (GRCm39) missense probably benign 0.00
R4597:Kif15 UTSW 9 122,822,914 (GRCm39) missense probably benign 0.08
R4705:Kif15 UTSW 9 122,789,058 (GRCm39) splice site probably null
R4832:Kif15 UTSW 9 122,831,191 (GRCm39) splice site probably null
R5100:Kif15 UTSW 9 122,821,059 (GRCm39) missense probably damaging 0.98
R5126:Kif15 UTSW 9 122,804,823 (GRCm39) missense probably damaging 1.00
R5180:Kif15 UTSW 9 122,828,275 (GRCm39) missense probably damaging 0.99
R5247:Kif15 UTSW 9 122,815,507 (GRCm39) missense possibly damaging 0.65
R5376:Kif15 UTSW 9 122,823,036 (GRCm39) missense probably benign 0.04
R5392:Kif15 UTSW 9 122,825,360 (GRCm39) missense probably damaging 0.99
R5422:Kif15 UTSW 9 122,813,954 (GRCm39) splice site probably null
R5562:Kif15 UTSW 9 122,807,081 (GRCm39) missense probably damaging 1.00
R5663:Kif15 UTSW 9 122,820,916 (GRCm39) splice site probably null
R5767:Kif15 UTSW 9 122,843,039 (GRCm39) missense possibly damaging 0.78
R5927:Kif15 UTSW 9 122,846,326 (GRCm39) missense probably benign 0.00
R6049:Kif15 UTSW 9 122,840,687 (GRCm39) missense probably damaging 0.98
R6435:Kif15 UTSW 9 122,815,556 (GRCm39) missense probably damaging 1.00
R7040:Kif15 UTSW 9 122,840,679 (GRCm39) missense possibly damaging 0.67
R7158:Kif15 UTSW 9 122,828,379 (GRCm39) missense probably benign
R7163:Kif15 UTSW 9 122,846,722 (GRCm39) missense probably damaging 1.00
R7197:Kif15 UTSW 9 122,838,991 (GRCm39) critical splice donor site probably null
R7318:Kif15 UTSW 9 122,817,014 (GRCm39) missense probably damaging 1.00
R7360:Kif15 UTSW 9 122,820,202 (GRCm39) missense probably benign
R8039:Kif15 UTSW 9 122,836,490 (GRCm39) missense possibly damaging 0.82
R8228:Kif15 UTSW 9 122,821,041 (GRCm39) missense possibly damaging 0.82
R8549:Kif15 UTSW 9 122,815,236 (GRCm39) missense probably benign
R9001:Kif15 UTSW 9 122,826,855 (GRCm39) missense probably benign 0.00
R9031:Kif15 UTSW 9 122,846,492 (GRCm39) intron probably benign
R9044:Kif15 UTSW 9 122,840,781 (GRCm39) missense probably benign 0.01
R9063:Kif15 UTSW 9 122,833,706 (GRCm39) missense probably damaging 1.00
R9306:Kif15 UTSW 9 122,807,056 (GRCm39) missense probably damaging 1.00
R9490:Kif15 UTSW 9 122,788,203 (GRCm39) missense probably benign 0.10
R9554:Kif15 UTSW 9 122,828,585 (GRCm39) missense probably damaging 1.00
R9682:Kif15 UTSW 9 122,815,712 (GRCm39) missense probably damaging 0.98
R9752:Kif15 UTSW 9 122,824,890 (GRCm39) critical splice donor site probably null
Z1177:Kif15 UTSW 9 122,780,116 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- ACAGGCAAGCTGAGATTCTGGTG -3'
(R):5'- ATTCACACAGTGGCAAGACTGAGG -3'

Sequencing Primer
(F):5'- AGCTTCTTTCCCCAGGAAAC -3'
(R):5'- AACCTGGAGACTTGCTCATGTC -3'
Posted On 2014-04-13