Incidental Mutation 'R1581:Wars1'
ID 171427
Institutional Source Beutler Lab
Gene Symbol Wars1
Ensembl Gene ENSMUSG00000021266
Gene Name tryptophanyl-tRNA synthetase1
Synonyms Wars
MMRRC Submission 039618-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1581 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 108825956-108860095 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 108841635 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 171 (E171*)
Ref Sequence ENSEMBL: ENSMUSP00000125320 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109848] [ENSMUST00000160477] [ENSMUST00000161154] [ENSMUST00000161410] [ENSMUST00000162748]
AlphaFold P32921
Predicted Effect probably null
Transcript: ENSMUST00000109848
AA Change: E171*
SMART Domains Protein: ENSMUSP00000105474
Gene: ENSMUSG00000021266
AA Change: E171*

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 447 5.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000160477
Predicted Effect probably null
Transcript: ENSMUST00000161154
AA Change: E171*
SMART Domains Protein: ENSMUSP00000124625
Gene: ENSMUSG00000021266
AA Change: E171*

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 446 1.4e-22 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000161410
AA Change: E171*
SMART Domains Protein: ENSMUSP00000125320
Gene: ENSMUSG00000021266
AA Change: E171*

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 447 5.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000162748
SMART Domains Protein: ENSMUSP00000125102
Gene: ENSMUSG00000021266

DomainStartEndE-ValueType
PDB:2QUK|A 4 37 1e-8 PDB
SCOP:d1fyja_ 14 37 8e-7 SMART
Blast:WHEP 16 37 3e-7 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162952
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221779
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.2%
  • 20x: 92.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd2 T C 15: 91,063,347 (GRCm39) E447G probably benign Het
Actn4 T C 7: 28,598,071 (GRCm39) T510A probably benign Het
Adgrb3 A G 1: 25,133,153 (GRCm39) M1311T possibly damaging Het
Arfgef1 C T 1: 10,270,103 (GRCm39) A349T probably benign Het
Auh G A 13: 52,989,532 (GRCm39) P308L probably benign Het
Bicdl1 G T 5: 115,789,326 (GRCm39) probably benign Het
Bmyc T C 2: 25,597,346 (GRCm39) S137P probably damaging Het
Camsap3 C T 8: 3,654,708 (GRCm39) R782C probably damaging Het
Casc3 C T 11: 98,713,644 (GRCm39) T292I possibly damaging Het
Chmp7 C T 14: 69,956,899 (GRCm39) M336I probably benign Het
Cibar1 T A 4: 12,155,745 (GRCm39) probably null Het
Cnnm2 A G 19: 46,751,562 (GRCm39) T451A probably damaging Het
Eed T C 7: 89,629,676 (GRCm39) K20E possibly damaging Het
Eps15 T A 4: 109,220,383 (GRCm39) M180K probably benign Het
Esr1 T C 10: 4,947,905 (GRCm39) I486T probably damaging Het
Etnppl A G 3: 130,422,393 (GRCm39) I207V possibly damaging Het
Fancg G A 4: 43,007,039 (GRCm39) P246L probably damaging Het
Fcrl1 G A 3: 87,293,030 (GRCm39) C249Y possibly damaging Het
Foxred2 A G 15: 77,839,961 (GRCm39) F110L possibly damaging Het
Fsip2 A T 2: 82,816,626 (GRCm39) N4120Y probably damaging Het
Gm4884 C T 7: 40,693,255 (GRCm39) S408L probably benign Het
Gm9476 T C 10: 100,142,474 (GRCm39) noncoding transcript Het
Gria1 T C 11: 57,127,836 (GRCm39) probably null Het
H6pd T A 4: 150,066,971 (GRCm39) I472F possibly damaging Het
Hydin A T 8: 111,137,092 (GRCm39) M632L probably benign Het
Hyou1 C T 9: 44,300,167 (GRCm39) P819S probably damaging Het
Il6st A G 13: 112,618,075 (GRCm39) E163G probably damaging Het
Kcnk1 T C 8: 126,722,278 (GRCm39) V27A possibly damaging Het
Kdelr3 T C 15: 79,407,114 (GRCm39) probably null Het
Klk1b22 A G 7: 43,765,399 (GRCm39) N117S possibly damaging Het
Klrh1 T C 6: 129,752,796 (GRCm39) D3G probably benign Het
Lpp C A 16: 24,500,591 (GRCm39) C134* probably null Het
Lrrc37a G A 11: 103,347,843 (GRCm39) R2951* probably null Het
Luzp2 T A 7: 54,899,238 (GRCm39) D285E possibly damaging Het
Ly75 C T 2: 60,158,237 (GRCm39) R1016H probably damaging Het
Mesp2 T A 7: 79,462,289 (GRCm39) S282T possibly damaging Het
Nav3 T C 10: 109,659,289 (GRCm39) D776G probably damaging Het
Nr2e1 T C 10: 42,443,964 (GRCm39) T253A probably benign Het
Nup214 C T 2: 31,924,478 (GRCm39) S1669F probably damaging Het
Or1r1 A T 11: 73,875,347 (GRCm39) L29H probably damaging Het
Padi6 T C 4: 140,463,147 (GRCm39) Y146C probably damaging Het
Pank4 C T 4: 155,059,108 (GRCm39) R414W probably damaging Het
Pclo T G 5: 14,571,296 (GRCm39) I227S probably benign Het
Plppr4 A G 3: 117,121,915 (GRCm39) V221A possibly damaging Het
Pradc1 G A 6: 85,425,568 (GRCm39) R25C probably damaging Het
Rfwd3 C T 8: 112,014,874 (GRCm39) R326Q probably damaging Het
Rnd2 A G 11: 101,362,022 (GRCm39) T192A probably benign Het
Rtbdn A G 8: 85,681,695 (GRCm39) E131G probably benign Het
Ryr2 A G 13: 11,809,449 (GRCm39) V792A probably benign Het
Sacs G T 14: 61,451,128 (GRCm39) Q4391H probably damaging Het
Scd2 A G 19: 44,286,538 (GRCm39) S123G probably benign Het
Septin9 A G 11: 117,181,421 (GRCm39) R74G probably damaging Het
Sipa1l2 T A 8: 126,218,356 (GRCm39) Q327L probably damaging Het
Skor1 T C 9: 63,053,505 (GRCm39) T127A probably damaging Het
Sphk2 A G 7: 45,362,920 (GRCm39) V57A probably damaging Het
Tfec A T 6: 16,844,243 (GRCm39) D101E probably damaging Het
Tmem43 T A 6: 91,455,717 (GRCm39) H109Q probably benign Het
Tmem67 C A 4: 12,047,814 (GRCm39) S839I probably damaging Het
Trpv5 T C 6: 41,630,074 (GRCm39) Y672C probably damaging Het
Ttc39d A C 17: 80,523,913 (GRCm39) S191R probably benign Het
Ttll1 C T 15: 83,380,478 (GRCm39) V296M probably damaging Het
Upp2 A C 2: 58,664,177 (GRCm39) K130T possibly damaging Het
Vmn2r5 A G 3: 64,398,640 (GRCm39) C780R probably damaging Het
Zeb2 A T 2: 44,887,012 (GRCm39) S637T probably damaging Het
Zfp27 T A 7: 29,595,549 (GRCm39) T139S possibly damaging Het
Zfp941 A T 7: 140,392,033 (GRCm39) L442Q probably benign Het
Other mutations in Wars1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01961:Wars1 APN 12 108,832,096 (GRCm39) missense probably damaging 1.00
IGL02327:Wars1 APN 12 108,832,227 (GRCm39) critical splice acceptor site probably null
IGL02864:Wars1 APN 12 108,848,791 (GRCm39) missense probably benign
IGL02962:Wars1 APN 12 108,841,706 (GRCm39) missense probably damaging 0.99
R0271:Wars1 UTSW 12 108,841,119 (GRCm39) missense probably benign
R0485:Wars1 UTSW 12 108,841,083 (GRCm39) missense probably damaging 1.00
R0669:Wars1 UTSW 12 108,831,944 (GRCm39) missense probably benign 0.00
R1144:Wars1 UTSW 12 108,854,291 (GRCm39) nonsense probably null
R1730:Wars1 UTSW 12 108,841,667 (GRCm39) missense probably damaging 1.00
R1783:Wars1 UTSW 12 108,841,667 (GRCm39) missense probably damaging 1.00
R1990:Wars1 UTSW 12 108,854,359 (GRCm39) missense possibly damaging 0.94
R5382:Wars1 UTSW 12 108,848,706 (GRCm39) missense probably benign
R5703:Wars1 UTSW 12 108,841,047 (GRCm39) missense probably damaging 1.00
R6299:Wars1 UTSW 12 108,827,309 (GRCm39) missense probably benign 0.00
R7186:Wars1 UTSW 12 108,846,982 (GRCm39) missense probably damaging 0.99
R7508:Wars1 UTSW 12 108,848,801 (GRCm39) missense probably benign 0.01
R7919:Wars1 UTSW 12 108,847,030 (GRCm39) missense probably benign 0.11
R8530:Wars1 UTSW 12 108,848,818 (GRCm39) missense probably damaging 0.99
R9132:Wars1 UTSW 12 108,827,199 (GRCm39) missense probably benign 0.41
Predicted Primers PCR Primer
(F):5'- GCAAAACACACGAGTGACTGCCTG -3'
(R):5'- TGGTCATCGTCTGTGGCATTCACC -3'

Sequencing Primer
(F):5'- CCAGGAAGAATGCCACTTTGTATG -3'
(R):5'- GTGGCATTCACCTCCCC -3'
Posted On 2014-04-13