Incidental Mutation 'R1540:Ptgfrn'
ID 171640
Institutional Source Beutler Lab
Gene Symbol Ptgfrn
Ensembl Gene ENSMUSG00000027864
Gene Name prostaglandin F2 receptor negative regulator
Synonyms 4833445A08Rik, CD9P-1
MMRRC Submission 039579-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1540 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 100947548-101017594 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 100967970 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 541 (I541T)
Ref Sequence ENSEMBL: ENSMUSP00000099755 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102694]
AlphaFold Q9WV91
Predicted Effect probably benign
Transcript: ENSMUST00000102694
AA Change: I541T

PolyPhen 2 Score 0.406 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000099755
Gene: ENSMUSG00000027864
AA Change: I541T

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IGv 38 121 3.01e-7 SMART
IG 154 264 1.54e-4 SMART
IG 284 390 1.11e-5 SMART
IG 414 532 1.72e-2 SMART
IG 556 676 9.71e-2 SMART
IG 696 822 5.21e-2 SMART
transmembrane domain 831 853 N/A INTRINSIC
low complexity region 862 872 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198037
Meta Mutation Damage Score 0.1666 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 93.0%
Validation Efficiency 96% (72/75)
MGI Phenotype PHENOTYPE: Homozygous mice for a null gene trap mutation exhibit a decreased depressive-like response during tail suspension testing when compared with their wild-type littermates, [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agl A G 3: 116,574,384 (GRCm39) C767R probably benign Het
Anpep C T 7: 79,488,004 (GRCm39) E518K probably benign Het
Ap3d1 A T 10: 80,551,775 (GRCm39) I644N probably benign Het
Asb16 A G 11: 102,163,402 (GRCm39) I131V probably benign Het
Atp6v0a2 C A 5: 124,784,638 (GRCm39) A307D probably damaging Het
C1qtnf1 C T 11: 118,338,749 (GRCm39) H140Y probably benign Het
Cacna1g T A 11: 94,347,865 (GRCm39) D741V probably damaging Het
Caprin2 T A 6: 148,777,969 (GRCm39) T211S probably benign Het
Carmil1 T C 13: 24,283,037 (GRCm39) E89G possibly damaging Het
Casz1 T A 4: 149,027,357 (GRCm39) probably benign Het
Catsperb G A 12: 101,378,589 (GRCm39) R30Q probably benign Het
Ccdc102a A T 8: 95,634,341 (GRCm39) probably null Het
Ccdc110 G T 8: 46,395,362 (GRCm39) E418* probably null Het
Ccdc90b C T 7: 92,231,024 (GRCm39) A210V probably benign Het
Cdadc1 G T 14: 59,823,532 (GRCm39) A320E probably damaging Het
Cdadc1 T A 14: 59,823,541 (GRCm39) Q317L probably damaging Het
Cep170 C A 1: 176,567,498 (GRCm39) W1396L probably damaging Het
Col4a6 T C X: 140,010,854 (GRCm39) T129A probably damaging Het
Ctcfl C T 2: 172,954,141 (GRCm39) D319N probably benign Het
Dclk1 T C 3: 55,385,244 (GRCm39) S45P probably damaging Het
Efcab3 T C 11: 104,999,726 (GRCm39) I5581T probably benign Het
Evi2 T C 11: 79,406,412 (GRCm39) I388V probably benign Het
Fbxl5 A T 5: 43,915,978 (GRCm39) V435E possibly damaging Het
Fig4 A T 10: 41,064,582 (GRCm39) M887K possibly damaging Het
Glt8d1 G A 14: 30,733,549 (GRCm39) V345I probably benign Het
Gm5709 T C 3: 59,526,073 (GRCm39) noncoding transcript Het
Hsp90b1 A G 10: 86,529,906 (GRCm39) F264L probably damaging Het
Id3 A G 4: 135,871,250 (GRCm39) S21G possibly damaging Het
Ighe T A 12: 113,235,066 (GRCm39) N365Y unknown Het
Il17rd T G 14: 26,821,915 (GRCm39) M403R probably damaging Het
Ints10 A G 8: 69,249,365 (GRCm39) probably benign Het
Kcnc4 T A 3: 107,352,743 (GRCm39) probably null Het
Kctd19 A G 8: 106,114,511 (GRCm39) S517P probably damaging Het
Lama5 A G 2: 179,821,944 (GRCm39) F2964L probably benign Het
Lin54 A T 5: 100,628,109 (GRCm39) N31K probably damaging Het
Lrrc8e A G 8: 4,284,990 (GRCm39) K405R probably benign Het
Lyst T A 13: 13,809,686 (GRCm39) M452K possibly damaging Het
Mroh7 A G 4: 106,560,273 (GRCm39) L677P probably benign Het
Mrps27 T A 13: 99,541,558 (GRCm39) F221I probably benign Het
Nhlrc1 C T 13: 47,167,820 (GRCm39) V146M probably damaging Het
Nlrp9b T A 7: 19,782,772 (GRCm39) C895* probably null Het
Nod1 T C 6: 54,920,960 (GRCm39) T453A probably benign Het
Nodal T C 10: 61,258,764 (GRCm39) V67A probably damaging Het
Ntsr1 T C 2: 180,184,440 (GRCm39) L381P probably damaging Het
Or13c25 T C 4: 52,910,996 (GRCm39) D266G probably benign Het
Or2b2b T A 13: 21,858,700 (GRCm39) Q138L probably benign Het
Or9e1 T A 11: 58,732,477 (GRCm39) M179K probably benign Het
P2ry14 T A 3: 59,022,686 (GRCm39) K267M probably benign Het
Pcdh1 T C 18: 38,322,779 (GRCm39) N1018S probably benign Het
Pkn3 G A 2: 29,974,703 (GRCm39) V406I probably damaging Het
Prkcb C T 7: 122,226,916 (GRCm39) T634I probably damaging Het
Psme2b T A 11: 48,836,209 (GRCm39) probably null Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Ralgapb T C 2: 158,307,746 (GRCm39) V684A probably benign Het
Rbbp5 C T 1: 132,422,020 (GRCm39) R307* probably null Het
Rcor1 T A 12: 111,070,037 (GRCm39) probably benign Het
Rlbp1 C T 7: 79,029,808 (GRCm39) A142T probably damaging Het
Rps6ka2 A G 17: 7,560,305 (GRCm39) E581G probably null Het
Sars1 A T 3: 108,340,461 (GRCm39) V155E probably benign Het
Sec31a G C 5: 100,523,178 (GRCm39) P569A probably damaging Het
Selenof A T 3: 144,300,685 (GRCm39) K111* probably null Het
Serpinb7 C T 1: 107,355,998 (GRCm39) A7V possibly damaging Het
Smc4 T A 3: 68,924,105 (GRCm39) Y298N probably damaging Het
Snrpa1 T A 7: 65,720,409 (GRCm39) I204N probably damaging Het
Spry4 T G 18: 38,734,740 (GRCm39) probably benign Het
Tcea2 A G 2: 181,328,751 (GRCm39) N261S possibly damaging Het
Tmem59l A G 8: 70,937,804 (GRCm39) F192S probably benign Het
Tnr T A 1: 159,677,675 (GRCm39) I20N probably damaging Het
Ttll5 C T 12: 85,938,982 (GRCm39) Q427* probably null Het
Vps45 C T 3: 95,955,658 (GRCm39) A111T probably damaging Het
Zfp395 T C 14: 65,630,523 (GRCm39) S358P probably benign Het
Zfp438 A G 18: 5,210,740 (GRCm39) V766A probably benign Het
Other mutations in Ptgfrn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00949:Ptgfrn APN 3 100,980,161 (GRCm39) missense probably benign 0.01
IGL01710:Ptgfrn APN 3 100,980,404 (GRCm39) missense probably damaging 0.98
IGL02557:Ptgfrn APN 3 100,967,952 (GRCm39) critical splice donor site probably null
IGL02740:Ptgfrn APN 3 100,980,253 (GRCm39) missense possibly damaging 0.84
IGL02817:Ptgfrn APN 3 100,968,068 (GRCm39) missense probably benign
IGL02948:Ptgfrn APN 3 100,980,135 (GRCm39) missense probably benign 0.21
R1563:Ptgfrn UTSW 3 100,967,967 (GRCm39) missense possibly damaging 0.67
R1730:Ptgfrn UTSW 3 100,963,758 (GRCm39) missense possibly damaging 0.71
R1766:Ptgfrn UTSW 3 100,957,438 (GRCm39) missense probably benign 0.00
R1783:Ptgfrn UTSW 3 100,963,758 (GRCm39) missense possibly damaging 0.71
R1918:Ptgfrn UTSW 3 100,963,623 (GRCm39) missense probably benign
R2113:Ptgfrn UTSW 3 100,984,625 (GRCm39) missense probably benign 0.00
R2290:Ptgfrn UTSW 3 100,984,677 (GRCm39) missense possibly damaging 0.77
R3522:Ptgfrn UTSW 3 100,950,718 (GRCm39) missense probably damaging 1.00
R5223:Ptgfrn UTSW 3 100,952,909 (GRCm39) missense probably benign 0.13
R5600:Ptgfrn UTSW 3 100,963,566 (GRCm39) missense probably damaging 0.99
R5642:Ptgfrn UTSW 3 100,950,678 (GRCm39) missense probably damaging 1.00
R5927:Ptgfrn UTSW 3 100,967,968 (GRCm39) missense possibly damaging 0.92
R5984:Ptgfrn UTSW 3 100,957,459 (GRCm39) missense probably damaging 0.99
R6124:Ptgfrn UTSW 3 100,980,405 (GRCm39) missense probably damaging 0.98
R6331:Ptgfrn UTSW 3 100,952,936 (GRCm39) missense possibly damaging 0.64
R6363:Ptgfrn UTSW 3 100,952,894 (GRCm39) missense possibly damaging 0.93
R6473:Ptgfrn UTSW 3 100,952,955 (GRCm39) missense probably damaging 1.00
R6856:Ptgfrn UTSW 3 100,952,762 (GRCm39) missense probably damaging 1.00
R7151:Ptgfrn UTSW 3 100,987,511 (GRCm39) nonsense probably null
R7313:Ptgfrn UTSW 3 100,980,363 (GRCm39) missense possibly damaging 0.84
R7361:Ptgfrn UTSW 3 100,984,760 (GRCm39) missense probably benign 0.03
R7806:Ptgfrn UTSW 3 100,984,448 (GRCm39) missense possibly damaging 0.50
R7823:Ptgfrn UTSW 3 100,950,725 (GRCm39) missense probably damaging 1.00
R7841:Ptgfrn UTSW 3 100,968,126 (GRCm39) missense probably damaging 0.98
R8093:Ptgfrn UTSW 3 100,980,257 (GRCm39) missense probably benign 0.09
R8093:Ptgfrn UTSW 3 100,963,753 (GRCm39) missense probably benign 0.19
R8490:Ptgfrn UTSW 3 100,963,686 (GRCm39) missense probably damaging 0.99
R8856:Ptgfrn UTSW 3 100,963,927 (GRCm39) missense possibly damaging 0.86
Z1088:Ptgfrn UTSW 3 100,963,753 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGTGGTTCCAGTTCCCTAGTGTATGA -3'
(R):5'- ACCAGGTCTACCTGAACGCTTCTAA -3'

Sequencing Primer
(F):5'- CAGTTCCCTAGTGTATGAGCACAG -3'
(R):5'- GGTACTATAGAATGACCCGTCGC -3'
Posted On 2014-04-13