Incidental Mutation 'R1541:Cwf19l2'
ID 171740
Institutional Source Beutler Lab
Gene Symbol Cwf19l2
Ensembl Gene ENSMUSG00000025898
Gene Name CWF19 like cell cycle control factor 2
Synonyms 3230401L03Rik
MMRRC Submission 039580-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.934) question?
Stock # R1541 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 3403592-3479236 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 3456760 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 698 (S698T)
Ref Sequence ENSEMBL: ENSMUSP00000027027 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027027]
AlphaFold Q8BG79
Predicted Effect probably damaging
Transcript: ENSMUST00000027027
AA Change: S698T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027027
Gene: ENSMUSG00000025898
AA Change: S698T

DomainStartEndE-ValueType
low complexity region 64 114 N/A INTRINSIC
coiled coil region 165 196 N/A INTRINSIC
low complexity region 403 418 N/A INTRINSIC
coiled coil region 496 524 N/A INTRINSIC
Pfam:CwfJ_C_1 655 779 1.8e-40 PFAM
Pfam:CwfJ_C_2 788 882 4.6e-34 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acod1 A G 14: 103,286,769 (GRCm39) D24G probably damaging Het
Angptl2 G A 2: 33,136,177 (GRCm39) R454H probably benign Het
Atat1 T A 17: 36,215,223 (GRCm39) N181I probably damaging Het
Atp6v0d2 A C 4: 19,910,645 (GRCm39) F82V probably damaging Het
Calhm4 T C 10: 33,917,659 (GRCm39) H264R probably benign Het
Casp3 A G 8: 47,087,369 (GRCm39) I105M probably benign Het
Ccdc33 T A 9: 58,024,749 (GRCm39) D159V probably damaging Het
Cd163 A C 6: 124,304,920 (GRCm39) D1099A probably benign Het
Cep128 A T 12: 91,315,555 (GRCm39) S110R probably damaging Het
Cfap43 A T 19: 47,752,291 (GRCm39) probably null Het
Cfap58 T C 19: 47,971,969 (GRCm39) I633T probably damaging Het
Clvs1 A G 4: 9,281,814 (GRCm39) H86R probably benign Het
Comt T C 16: 18,230,565 (GRCm39) K48R probably benign Het
Crip2 T C 12: 113,108,586 (GRCm39) V64A possibly damaging Het
Cstdc5 T A 16: 36,187,863 (GRCm39) M1L probably damaging Het
Dis3l T C 9: 64,214,771 (GRCm39) I933V probably benign Het
Dnah8 C A 17: 30,966,221 (GRCm39) N2470K probably damaging Het
Dstn T C 2: 143,780,408 (GRCm39) V36A possibly damaging Het
Dtx1 T A 5: 120,848,411 (GRCm39) probably benign Het
Dzip1 G A 14: 119,116,890 (GRCm39) S782L probably damaging Het
Ece1 T A 4: 137,675,971 (GRCm39) probably null Het
Erich1 A G 8: 14,080,688 (GRCm39) I277T probably damaging Het
Gbp4 T A 5: 105,266,275 (GRCm39) M589L probably benign Het
Grip1 T C 10: 119,836,448 (GRCm39) I440T probably damaging Het
Helz C T 11: 107,560,874 (GRCm39) S1311L probably benign Het
Herc2 A T 7: 55,785,405 (GRCm39) I1552F probably damaging Het
Kif13a T C 13: 46,962,689 (GRCm39) T459A probably benign Het
Knop1 G A 7: 118,455,009 (GRCm39) probably benign Het
Llgl2 C A 11: 115,743,947 (GRCm39) T758K probably benign Het
Lonrf2 G A 1: 38,852,357 (GRCm39) P165S probably benign Het
Lrrc71 T C 3: 87,649,148 (GRCm39) D340G possibly damaging Het
Luzp1 A G 4: 136,270,636 (GRCm39) D953G probably damaging Het
Mst1r T C 9: 107,794,562 (GRCm39) V1247A probably damaging Het
Ncoa4 A T 14: 31,898,845 (GRCm39) K555M probably damaging Het
Ncoa6 A T 2: 155,257,224 (GRCm39) L773Q probably benign Het
Ndc1 C T 4: 107,228,485 (GRCm39) Q70* probably null Het
Nfe2l3 C T 6: 51,434,585 (GRCm39) L382F probably damaging Het
Nlrp4b C A 7: 10,458,979 (GRCm39) T399N possibly damaging Het
Nsmce2 T A 15: 59,473,234 (GRCm39) D250E probably damaging Het
Nudt14 A T 12: 112,898,548 (GRCm39) L184Q probably damaging Het
Ogdhl G A 14: 32,062,624 (GRCm39) R570H possibly damaging Het
Or5p56 T C 7: 107,590,048 (GRCm39) F159L probably benign Het
Pira13 T C 7: 3,819,988 (GRCm39) D525G probably damaging Het
Plag1 A G 4: 3,904,085 (GRCm39) S369P probably benign Het
Ranbp2 A T 10: 58,318,916 (GRCm39) T2476S possibly damaging Het
Rnmt T C 18: 68,440,853 (GRCm39) L172P probably damaging Het
Sec24a T A 11: 51,634,623 (GRCm39) H101L probably benign Het
Sirpd T A 3: 15,385,744 (GRCm39) T53S possibly damaging Het
Srm A G 4: 148,677,881 (GRCm39) D173G probably damaging Het
Srp54b A G 12: 55,302,844 (GRCm39) D380G probably benign Het
Svs5 C T 2: 164,078,929 (GRCm39) R326Q possibly damaging Het
Tent4b T C 8: 88,972,227 (GRCm39) V222A probably damaging Het
Tfap2b C T 1: 19,304,294 (GRCm39) T350M probably damaging Het
Tie1 A T 4: 118,341,070 (GRCm39) C304S probably damaging Het
Tsc2 G T 17: 24,850,950 (GRCm39) T36N probably damaging Het
Wdhd1 A T 14: 47,505,649 (GRCm39) Y274* probably null Het
Wdr37 T C 13: 8,870,574 (GRCm39) T373A probably benign Het
Xirp2 A T 2: 67,342,634 (GRCm39) N1625I possibly damaging Het
Ythdf1 A C 2: 180,560,936 (GRCm39) S35A probably damaging Het
Zfp462 A G 4: 55,008,928 (GRCm39) N298S possibly damaging Het
Zfp541 T A 7: 15,812,437 (GRCm39) D363E probably benign Het
Zgpat A G 2: 181,020,658 (GRCm39) D277G probably benign Het
Znfx1 A T 2: 166,898,110 (GRCm39) N271K probably damaging Het
Other mutations in Cwf19l2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00227:Cwf19l2 APN 9 3,409,990 (GRCm39) missense probably benign 0.01
IGL00573:Cwf19l2 APN 9 3,450,161 (GRCm39) splice site probably benign
IGL00757:Cwf19l2 APN 9 3,460,054 (GRCm39) missense probably damaging 1.00
IGL00803:Cwf19l2 APN 9 3,430,810 (GRCm39) missense probably benign 0.41
IGL01916:Cwf19l2 APN 9 3,477,869 (GRCm39) missense possibly damaging 0.82
IGL02315:Cwf19l2 APN 9 3,410,030 (GRCm39) missense probably damaging 1.00
IGL02419:Cwf19l2 APN 9 3,418,777 (GRCm39) critical splice donor site probably null
IGL02427:Cwf19l2 APN 9 3,456,817 (GRCm39) missense probably benign 0.00
IGL03026:Cwf19l2 APN 9 3,428,777 (GRCm39) missense probably benign 0.28
IGL03028:Cwf19l2 APN 9 3,430,622 (GRCm39) missense probably benign 0.26
IGL03199:Cwf19l2 APN 9 3,477,830 (GRCm39) missense probably damaging 1.00
R0015:Cwf19l2 UTSW 9 3,454,666 (GRCm39) missense probably benign 0.00
R0015:Cwf19l2 UTSW 9 3,454,666 (GRCm39) missense probably benign 0.00
R0532:Cwf19l2 UTSW 9 3,431,057 (GRCm39) missense probably benign 0.38
R0724:Cwf19l2 UTSW 9 3,421,377 (GRCm39) critical splice donor site probably null
R0924:Cwf19l2 UTSW 9 3,441,047 (GRCm39) splice site probably benign
R0947:Cwf19l2 UTSW 9 3,421,286 (GRCm39) missense probably benign 0.16
R1210:Cwf19l2 UTSW 9 3,430,810 (GRCm39) missense probably benign 0.00
R1393:Cwf19l2 UTSW 9 3,456,818 (GRCm39) missense probably benign 0.01
R1594:Cwf19l2 UTSW 9 3,430,973 (GRCm39) missense probably benign
R1870:Cwf19l2 UTSW 9 3,458,802 (GRCm39) missense possibly damaging 0.56
R1950:Cwf19l2 UTSW 9 3,418,674 (GRCm39) missense probably benign
R1996:Cwf19l2 UTSW 9 3,417,947 (GRCm39) missense probably benign 0.01
R2005:Cwf19l2 UTSW 9 3,430,720 (GRCm39) missense possibly damaging 0.92
R2246:Cwf19l2 UTSW 9 3,430,661 (GRCm39) missense probably benign 0.16
R2420:Cwf19l2 UTSW 9 3,411,341 (GRCm39) missense possibly damaging 0.80
R3051:Cwf19l2 UTSW 9 3,410,006 (GRCm39) missense probably benign 0.05
R3738:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R3915:Cwf19l2 UTSW 9 3,456,776 (GRCm39) missense probably damaging 1.00
R4034:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R4035:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R4323:Cwf19l2 UTSW 9 3,430,452 (GRCm39) missense probably damaging 0.99
R4328:Cwf19l2 UTSW 9 3,458,878 (GRCm39) missense probably damaging 1.00
R4329:Cwf19l2 UTSW 9 3,458,878 (GRCm39) missense probably damaging 1.00
R4692:Cwf19l2 UTSW 9 3,428,709 (GRCm39) missense probably damaging 1.00
R4775:Cwf19l2 UTSW 9 3,430,973 (GRCm39) missense probably benign
R4779:Cwf19l2 UTSW 9 3,410,035 (GRCm39) missense possibly damaging 0.95
R4822:Cwf19l2 UTSW 9 3,458,839 (GRCm39) missense probably damaging 1.00
R4833:Cwf19l2 UTSW 9 3,430,783 (GRCm39) missense probably benign 0.28
R5110:Cwf19l2 UTSW 9 3,450,012 (GRCm39) critical splice acceptor site probably null
R5120:Cwf19l2 UTSW 9 3,418,761 (GRCm39) nonsense probably null
R5164:Cwf19l2 UTSW 9 3,475,511 (GRCm39) missense probably damaging 1.00
R5440:Cwf19l2 UTSW 9 3,475,549 (GRCm39) missense probably damaging 1.00
R5567:Cwf19l2 UTSW 9 3,456,831 (GRCm39) missense probably damaging 1.00
R5594:Cwf19l2 UTSW 9 3,418,773 (GRCm39) missense probably benign 0.42
R5960:Cwf19l2 UTSW 9 3,411,404 (GRCm39) missense probably benign 0.43
R6222:Cwf19l2 UTSW 9 3,454,569 (GRCm39) nonsense probably null
R6259:Cwf19l2 UTSW 9 3,458,879 (GRCm39) missense probably damaging 1.00
R6688:Cwf19l2 UTSW 9 3,450,015 (GRCm39) missense probably benign 0.00
R6983:Cwf19l2 UTSW 9 3,477,817 (GRCm39) missense probably damaging 1.00
R7063:Cwf19l2 UTSW 9 3,430,532 (GRCm39) missense probably benign 0.03
R7506:Cwf19l2 UTSW 9 3,456,775 (GRCm39) missense probably damaging 1.00
R7733:Cwf19l2 UTSW 9 3,450,066 (GRCm39) missense probably benign 0.19
R7846:Cwf19l2 UTSW 9 3,477,889 (GRCm39) missense probably damaging 1.00
R7900:Cwf19l2 UTSW 9 3,460,107 (GRCm39) missense probably damaging 1.00
R8510:Cwf19l2 UTSW 9 3,454,732 (GRCm39) missense possibly damaging 0.89
R8709:Cwf19l2 UTSW 9 3,430,723 (GRCm39) missense probably benign 0.26
R8900:Cwf19l2 UTSW 9 3,447,245 (GRCm39) missense probably benign 0.01
R9031:Cwf19l2 UTSW 9 3,417,942 (GRCm39) missense probably benign 0.00
R9373:Cwf19l2 UTSW 9 3,454,718 (GRCm39) missense probably damaging 0.99
R9701:Cwf19l2 UTSW 9 3,430,454 (GRCm39) missense probably damaging 1.00
T0722:Cwf19l2 UTSW 9 3,456,755 (GRCm39) missense probably benign 0.00
X0003:Cwf19l2 UTSW 9 3,456,755 (GRCm39) missense probably benign 0.00
X0020:Cwf19l2 UTSW 9 3,418,662 (GRCm39) missense probably damaging 1.00
Z1177:Cwf19l2 UTSW 9 3,428,782 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- agggtaGCTTGGAATTGGACCTGA -3'
(R):5'- GGAACCTCACGCCACAGCTTTT -3'

Sequencing Primer
(F):5'- GTTCCCTCAGATAAAAATCAAGTGAC -3'
(R):5'- CTGAAACTTCCTTCTTGGATACAG -3'
Posted On 2014-04-13