Mutagenetix > Incidental Mutation

Incidental Mutation 'R0068:Or13f5'

17185

Institutional Source

Beutler Lab

Gene Symbol

Or13f5

Ensembl Gene

ENSMUSG00000089717

Gene Name

olfactory receptor family 13 subfamily F member 5

Synonyms

GA_x6K02T2N78B-7168533-7167574, Olfr275, MOR262-2

MMRRC Submission

038359-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R0068 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

52825399-52826358 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 52825503 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 35 (Y35*)

Ref Sequence

ENSEMBL: ENSMUSP00000092700 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095085]

AlphaFold

Q7TS18

Predicted Effect

probably null
Transcript: ENSMUST00000095085
AA Change: Y35*

SMART Domains

Protein: ENSMUSP00000092700
Gene: ENSMUSG00000089717
AA Change: Y35*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	308	9.8e-54	PFAM
Pfam:7tm_1	41	290	6.2e-20	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000120435

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135738

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219705

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 89.9%
3x: 97.6%
10x: 82.1%
20x: 74.0%

Validation Efficiency

94% (83/88)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	T	C	11: 110,036,405 (GRCm39)	N568S	probably damaging	Het
Aldoart2	G	T	12: 55,612,233 (GRCm39)	E53*	probably null	Het
Ankra2	C	T	13: 98,409,891 (GRCm39)	Q137*	probably null	Het
Arpc1a	C	T	5: 145,028,054 (GRCm39)	T21I	possibly damaging	Het
Arvcf	T	C	16: 18,214,819 (GRCm39)		probably benign	Het
Ash1l	C	A	3: 88,914,624 (GRCm39)	S1751R	probably benign	Het
Bltp1	A	G	3: 37,006,370 (GRCm39)	T1675A	probably benign	Het
Bsn	C	A	9: 107,989,336 (GRCm39)	G2139C	probably damaging	Het
Cbl	A	T	9: 44,065,491 (GRCm39)	S22T	probably damaging	Het
Ccdc148	T	C	2: 58,717,629 (GRCm39)	E530G	probably benign	Het
Cct3	A	G	3: 88,225,772 (GRCm39)	D365G	probably benign	Het
Cep85	A	T	4: 133,881,606 (GRCm39)	H332Q	probably benign	Het
Cwf19l1	A	T	19: 44,119,938 (GRCm39)	Y68N	probably damaging	Het
Dlc1	T	A	8: 37,404,875 (GRCm39)	M305L	probably benign	Het
Dnm1l	C	A	16: 16,141,883 (GRCm39)	G288C	probably damaging	Het
Exoc7	T	C	11: 116,195,732 (GRCm39)	Y83C	probably damaging	Het
Fignl2	A	T	15: 100,952,129 (GRCm39)	I51N	probably damaging	Het
Flnb	A	G	14: 7,915,290 (GRCm38)	N1474D	possibly damaging	Het
Ghrhr	C	T	6: 55,357,849 (GRCm39)		probably benign	Het
Gucy1b1	T	C	3: 81,942,185 (GRCm39)	T525A	probably benign	Het
Hhip	T	G	8: 80,715,885 (GRCm39)	D557A	probably damaging	Het
Hps5	A	G	7: 46,426,466 (GRCm39)		probably benign	Het
Igsf10	A	T	3: 59,238,045 (GRCm39)	V712D	probably damaging	Het
Irf6	G	T	1: 192,848,067 (GRCm39)		probably benign	Het
Itpr3	T	C	17: 27,323,034 (GRCm39)		probably benign	Het
Jag2	A	G	12: 112,878,813 (GRCm39)		probably benign	Het
Kansl1l	A	G	1: 66,760,047 (GRCm39)	V911A	probably benign	Het
Kdm3b	C	T	18: 34,957,827 (GRCm39)	T1064I	probably benign	Het
Lrriq1	T	A	10: 102,899,279 (GRCm39)	Q1654L	probably benign	Het
Ltbp1	A	G	17: 75,666,404 (GRCm39)	T1366A	probably damaging	Het
Mroh1	A	G	15: 76,330,892 (GRCm39)		probably benign	Het
Napb	G	A	2: 148,540,843 (GRCm39)		probably benign	Het
Nebl	T	A	2: 17,439,782 (GRCm39)	R164*	probably null	Het
Npc1	G	C	18: 12,341,424 (GRCm39)	P532A	probably benign	Het
Nrp2	G	T	1: 62,784,536 (GRCm39)	K228N	possibly damaging	Het
Plekhg1	A	T	10: 3,890,502 (GRCm39)	Y386F	probably damaging	Het
Pmfbp1	G	C	8: 110,269,011 (GRCm39)		probably benign	Het
Poln	T	C	5: 34,234,432 (GRCm39)		probably benign	Het
Polr1c	A	G	17: 46,555,829 (GRCm39)	V200A	probably benign	Het
Ppil1	A	T	17: 29,471,230 (GRCm39)	F92I	probably damaging	Het
Ptchd3	T	G	11: 121,733,798 (GRCm39)	L896R	probably damaging	Het
Rev3l	A	G	10: 39,700,827 (GRCm39)	N1775D	possibly damaging	Het
Robo4	G	A	9: 37,315,773 (GRCm39)	R342Q	probably benign	Het
Rusc2	T	C	4: 43,424,100 (GRCm39)		probably benign	Het
S100pbp	T	C	4: 129,038,249 (GRCm39)		probably benign	Het
Slc25a48	T	C	13: 56,599,024 (GRCm39)	V118A	probably damaging	Het
Slc38a10	T	C	11: 120,025,679 (GRCm39)	D219G	probably damaging	Het
Slc38a2	C	T	15: 96,589,173 (GRCm39)		probably null	Het
Slc39a12	A	G	2: 14,440,489 (GRCm39)	E480G	probably benign	Het
Tab2	C	A	10: 7,795,441 (GRCm39)	R347L	probably damaging	Het
Tas2r123	T	C	6: 132,824,955 (GRCm39)	I284T	possibly damaging	Het
Tex9	A	G	9: 72,394,051 (GRCm39)		probably benign	Het
Tifab	A	G	13: 56,324,218 (GRCm39)	L75P	probably damaging	Het
Tmc5	T	A	7: 118,233,460 (GRCm39)	D91E	probably benign	Het
Tnks1bp1	T	A	2: 84,892,696 (GRCm39)	D212E	probably benign	Het
Ugcg	A	G	4: 59,217,130 (GRCm39)	D218G	probably benign	Het
Zfp451	A	T	1: 33,816,706 (GRCm39)	L198I	probably damaging	Het

Other mutations in Or13f5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01108:Or13f5	APN	4	52,825,727 (GRCm39)	missense	probably damaging	1.00
IGL01758:Or13f5	APN	4	52,825,468 (GRCm39)	nonsense	probably null
IGL01925:Or13f5	APN	4	52,825,910 (GRCm39)	missense	probably benign	0.00
IGL02525:Or13f5	APN	4	52,825,616 (GRCm39)	missense	probably damaging	1.00
IGL02536:Or13f5	APN	4	52,825,817 (GRCm39)	missense	possibly damaging	0.95
IGL02829:Or13f5	APN	4	52,826,027 (GRCm39)	missense	probably damaging	0.98
R0068:Or13f5	UTSW	4	52,825,503 (GRCm39)	nonsense	probably null
R0190:Or13f5	UTSW	4	52,825,613 (GRCm39)	missense	probably damaging	0.97
R4376:Or13f5	UTSW	4	52,826,195 (GRCm39)	missense	possibly damaging	0.81
R4617:Or13f5	UTSW	4	52,825,399 (GRCm39)	start codon destroyed	probably benign	0.35
R4658:Or13f5	UTSW	4	52,826,240 (GRCm39)	missense	probably damaging	0.99
R4828:Or13f5	UTSW	4	52,826,138 (GRCm39)	missense	probably damaging	1.00
R4850:Or13f5	UTSW	4	52,825,450 (GRCm39)	missense	possibly damaging	0.94
R6194:Or13f5	UTSW	4	52,825,779 (GRCm39)	nonsense	probably null
R6401:Or13f5	UTSW	4	52,826,242 (GRCm39)	missense	probably damaging	1.00
R6842:Or13f5	UTSW	4	52,825,576 (GRCm39)	missense	probably damaging	1.00
R7033:Or13f5	UTSW	4	52,826,089 (GRCm39)	missense	probably benign
R7998:Or13f5	UTSW	4	52,825,970 (GRCm39)	missense	possibly damaging	0.89
R8101:Or13f5	UTSW	4	52,825,849 (GRCm39)	missense	probably benign	0.03
R9655:Or13f5	UTSW	4	52,825,526 (GRCm39)	missense	probably benign

Protein Function and Prediction

The function of Olfr275 is unknown.

Posted On

2013-01-20