Incidental Mutation 'R1548:Zfp142'
| ID |
172299 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp142
|
| Ensembl Gene |
ENSMUSG00000026135 |
| Gene Name |
zinc finger protein 142 |
| Synonyms |
9330177B18Rik |
| MMRRC Submission |
039587-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1548 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
74605490-74627308 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 74609263 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Asparagine
at position 1408
(H1408N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109366
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027315]
[ENSMUST00000027362]
[ENSMUST00000066986]
[ENSMUST00000067916]
[ENSMUST00000113737]
[ENSMUST00000113747]
[ENSMUST00000113749]
[ENSMUST00000156613]
[ENSMUST00000127921]
[ENSMUST00000113750]
[ENSMUST00000141412]
[ENSMUST00000152707]
|
| AlphaFold |
G5E869 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000027315
AA Change: H1511N
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000027315
Gene: ENSMUSG00000026135
AA Change: H1511N
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
103 |
127 |
1.16e1 |
SMART |
|
ZnF_C2H2
|
164 |
186 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
193 |
218 |
7.78e-3 |
SMART |
|
ZnF_C2H2
|
223 |
247 |
2.29e0 |
SMART |
|
ZnF_C2H2
|
250 |
272 |
9.96e-1 |
SMART |
|
low complexity region
|
317 |
329 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
363 |
385 |
9.96e-1 |
SMART |
|
ZnF_C2H2
|
391 |
411 |
1.26e1 |
SMART |
|
ZnF_C2H2
|
419 |
442 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
453 |
475 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
486 |
511 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
516 |
540 |
4.81e0 |
SMART |
|
ZnF_C2H2
|
543 |
566 |
7.05e-1 |
SMART |
|
ZnF_C2H2
|
572 |
595 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
601 |
623 |
1.56e-2 |
SMART |
|
ZnF_C2H2
|
629 |
651 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
657 |
679 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
685 |
707 |
9.44e-2 |
SMART |
|
ZnF_C2H2
|
712 |
735 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
744 |
767 |
1.31e0 |
SMART |
|
ZnF_C2H2
|
773 |
796 |
2.63e0 |
SMART |
|
low complexity region
|
903 |
919 |
N/A |
INTRINSIC |
|
low complexity region
|
953 |
969 |
N/A |
INTRINSIC |
|
low complexity region
|
996 |
1007 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1039 |
1059 |
2.01e1 |
SMART |
|
ZnF_C2H2
|
1069 |
1089 |
1.91e1 |
SMART |
|
low complexity region
|
1147 |
1160 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1187 |
1207 |
2.7e2 |
SMART |
|
low complexity region
|
1209 |
1222 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1265 |
1285 |
3.56e1 |
SMART |
|
ZnF_C2H2
|
1295 |
1318 |
4.98e-1 |
SMART |
|
ZnF_C2H2
|
1331 |
1354 |
2.49e-1 |
SMART |
|
ZnF_C2H2
|
1360 |
1382 |
1.03e-2 |
SMART |
|
ZnF_C2H2
|
1388 |
1411 |
5.72e-1 |
SMART |
|
ZnF_C2H2
|
1417 |
1440 |
6.75e0 |
SMART |
|
ZnF_C2H2
|
1446 |
1469 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
1488 |
1511 |
1.64e-1 |
SMART |
|
ZnF_C2H2
|
1514 |
1536 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
1540 |
1563 |
4.05e-1 |
SMART |
|
ZnF_C2H2
|
1580 |
1602 |
4.45e0 |
SMART |
|
ZnF_C2H2
|
1608 |
1630 |
8.81e-2 |
SMART |
|
ZnF_C2H2
|
1636 |
1658 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
1664 |
1686 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
1692 |
1715 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
1721 |
1743 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
1749 |
1771 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
1777 |
1799 |
3.52e-1 |
SMART |
|
low complexity region
|
1829 |
1838 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000027362
|
| SMART Domains |
Protein: ENSMUSP00000027362
Gene: ENSMUSG00000026173
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
17 |
126 |
2.6e-12 |
SMART |
|
EFh
|
138 |
166 |
9.97e-1 |
SMART |
|
EFh
|
174 |
202 |
1.83e1 |
SMART |
|
EFh
|
207 |
234 |
4.45e1 |
SMART |
|
PLCXc
|
290 |
435 |
2.03e-79 |
SMART |
|
low complexity region
|
441 |
459 |
N/A |
INTRINSIC |
|
PLCYc
|
538 |
654 |
1.26e-75 |
SMART |
|
C2
|
673 |
779 |
5.68e-20 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000066986
AA Change: H1310N
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000065149
Gene: ENSMUSG00000026135
AA Change: H1310N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
116 |
128 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
162 |
184 |
9.96e-1 |
SMART |
|
ZnF_C2H2
|
190 |
210 |
1.26e1 |
SMART |
|
ZnF_C2H2
|
218 |
241 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
252 |
274 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
285 |
310 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
315 |
339 |
4.81e0 |
SMART |
|
ZnF_C2H2
|
342 |
365 |
7.05e-1 |
SMART |
|
ZnF_C2H2
|
371 |
394 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
400 |
422 |
1.56e-2 |
SMART |
|
ZnF_C2H2
|
428 |
450 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
456 |
478 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
484 |
506 |
9.44e-2 |
SMART |
|
ZnF_C2H2
|
511 |
534 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
543 |
566 |
1.31e0 |
SMART |
|
ZnF_C2H2
|
572 |
595 |
2.63e0 |
SMART |
|
low complexity region
|
702 |
718 |
N/A |
INTRINSIC |
|
low complexity region
|
752 |
768 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
806 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
838 |
858 |
2.01e1 |
SMART |
|
ZnF_C2H2
|
868 |
888 |
1.91e1 |
SMART |
|
low complexity region
|
946 |
959 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
986 |
1006 |
2.7e2 |
SMART |
|
low complexity region
|
1008 |
1021 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1064 |
1084 |
3.56e1 |
SMART |
|
ZnF_C2H2
|
1094 |
1117 |
4.98e-1 |
SMART |
|
ZnF_C2H2
|
1130 |
1153 |
2.49e-1 |
SMART |
|
ZnF_C2H2
|
1159 |
1181 |
1.03e-2 |
SMART |
|
ZnF_C2H2
|
1187 |
1210 |
5.72e-1 |
SMART |
|
ZnF_C2H2
|
1216 |
1239 |
6.75e0 |
SMART |
|
ZnF_C2H2
|
1245 |
1268 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
1287 |
1310 |
1.64e-1 |
SMART |
|
ZnF_C2H2
|
1313 |
1335 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
1339 |
1362 |
4.05e-1 |
SMART |
|
ZnF_C2H2
|
1379 |
1401 |
4.45e0 |
SMART |
|
ZnF_C2H2
|
1407 |
1429 |
8.81e-2 |
SMART |
|
ZnF_C2H2
|
1435 |
1457 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
1463 |
1485 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
1491 |
1514 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
1520 |
1542 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
1548 |
1570 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
1576 |
1598 |
3.52e-1 |
SMART |
|
low complexity region
|
1628 |
1637 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000067916
|
| SMART Domains |
Protein: ENSMUSP00000064413
Gene: ENSMUSG00000026173
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
17 |
126 |
2.6e-12 |
SMART |
|
EFh
|
138 |
166 |
9.97e-1 |
SMART |
|
EFh
|
174 |
202 |
1.83e1 |
SMART |
|
EFh
|
207 |
234 |
4.45e1 |
SMART |
|
PLCXc
|
290 |
435 |
2.03e-79 |
SMART |
|
low complexity region
|
441 |
459 |
N/A |
INTRINSIC |
|
PLCYc
|
506 |
622 |
1.26e-75 |
SMART |
|
C2
|
641 |
747 |
5.68e-20 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113737
AA Change: H1408N
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000109366
Gene: ENSMUSG00000026135
AA Change: H1408N
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
93 |
115 |
9.81e1 |
SMART |
|
ZnF_C2H2
|
120 |
144 |
2.29e0 |
SMART |
|
ZnF_C2H2
|
147 |
169 |
9.96e-1 |
SMART |
|
low complexity region
|
214 |
226 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
260 |
282 |
9.96e-1 |
SMART |
|
ZnF_C2H2
|
288 |
308 |
1.26e1 |
SMART |
|
ZnF_C2H2
|
316 |
339 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
350 |
372 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
383 |
408 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
413 |
437 |
4.81e0 |
SMART |
|
ZnF_C2H2
|
440 |
463 |
7.05e-1 |
SMART |
|
ZnF_C2H2
|
469 |
492 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
498 |
520 |
1.56e-2 |
SMART |
|
ZnF_C2H2
|
526 |
548 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
554 |
576 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
582 |
604 |
9.44e-2 |
SMART |
|
ZnF_C2H2
|
609 |
632 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
641 |
664 |
1.31e0 |
SMART |
|
ZnF_C2H2
|
670 |
693 |
2.63e0 |
SMART |
|
low complexity region
|
800 |
816 |
N/A |
INTRINSIC |
|
low complexity region
|
850 |
866 |
N/A |
INTRINSIC |
|
low complexity region
|
893 |
904 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
936 |
956 |
2.01e1 |
SMART |
|
ZnF_C2H2
|
966 |
986 |
1.91e1 |
SMART |
|
low complexity region
|
1044 |
1057 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1084 |
1104 |
2.7e2 |
SMART |
|
low complexity region
|
1106 |
1119 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1162 |
1182 |
3.56e1 |
SMART |
|
ZnF_C2H2
|
1192 |
1215 |
4.98e-1 |
SMART |
|
ZnF_C2H2
|
1228 |
1251 |
2.49e-1 |
SMART |
|
ZnF_C2H2
|
1257 |
1279 |
1.03e-2 |
SMART |
|
ZnF_C2H2
|
1285 |
1308 |
5.72e-1 |
SMART |
|
ZnF_C2H2
|
1314 |
1337 |
6.75e0 |
SMART |
|
ZnF_C2H2
|
1343 |
1366 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
1385 |
1408 |
1.64e-1 |
SMART |
|
ZnF_C2H2
|
1411 |
1433 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
1437 |
1460 |
4.05e-1 |
SMART |
|
ZnF_C2H2
|
1477 |
1499 |
4.45e0 |
SMART |
|
ZnF_C2H2
|
1505 |
1527 |
8.81e-2 |
SMART |
|
ZnF_C2H2
|
1533 |
1555 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
1561 |
1583 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
1589 |
1612 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
1618 |
1640 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
1646 |
1668 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
1674 |
1696 |
3.52e-1 |
SMART |
|
low complexity region
|
1726 |
1735 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113747
|
| SMART Domains |
Protein: ENSMUSP00000109376
Gene: ENSMUSG00000026173
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
17 |
126 |
2.6e-12 |
SMART |
|
EFh
|
138 |
166 |
9.97e-1 |
SMART |
|
EFh
|
174 |
202 |
1.83e1 |
SMART |
|
EFh
|
207 |
234 |
4.45e1 |
SMART |
|
PLCXc
|
290 |
435 |
2.03e-79 |
SMART |
|
low complexity region
|
441 |
459 |
N/A |
INTRINSIC |
|
PLCYc
|
506 |
622 |
1.26e-75 |
SMART |
|
C2
|
641 |
747 |
5.68e-20 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113749
|
| SMART Domains |
Protein: ENSMUSP00000109378
Gene: ENSMUSG00000026173
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
17 |
126 |
2.6e-12 |
SMART |
|
EFh
|
138 |
166 |
9.97e-1 |
SMART |
|
EFh
|
174 |
202 |
1.83e1 |
SMART |
|
EFh
|
207 |
234 |
4.45e1 |
SMART |
|
PLCXc
|
290 |
435 |
2.03e-79 |
SMART |
|
low complexity region
|
441 |
459 |
N/A |
INTRINSIC |
|
PLCYc
|
538 |
654 |
1.26e-75 |
SMART |
|
C2
|
673 |
779 |
5.68e-20 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000135111
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000189956
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156613
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000127921
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113750
|
| SMART Domains |
Protein: ENSMUSP00000109379
Gene: ENSMUSG00000026173
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
17 |
126 |
2.6e-12 |
SMART |
|
EFh
|
138 |
166 |
9.97e-1 |
SMART |
|
EFh
|
174 |
202 |
1.83e1 |
SMART |
|
EFh
|
207 |
234 |
4.45e1 |
SMART |
|
PLCXc
|
290 |
435 |
2.03e-79 |
SMART |
|
low complexity region
|
441 |
459 |
N/A |
INTRINSIC |
|
PLCYc
|
506 |
622 |
1.26e-75 |
SMART |
|
C2
|
641 |
747 |
7.16e-17 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141412
|
| SMART Domains |
Protein: ENSMUSP00000115322
Gene: ENSMUSG00000026173
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
17 |
126 |
2.6e-12 |
SMART |
|
EFh
|
138 |
166 |
9.97e-1 |
SMART |
|
EFh
|
174 |
202 |
1.83e1 |
SMART |
|
EFh
|
207 |
234 |
4.45e1 |
SMART |
|
PLCXc
|
290 |
435 |
2.03e-79 |
SMART |
|
low complexity region
|
441 |
459 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152707
|
| SMART Domains |
Protein: ENSMUSP00000121732
Gene: ENSMUSG00000026173
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
17 |
126 |
2.6e-12 |
SMART |
|
EFh
|
138 |
166 |
9.97e-1 |
SMART |
|
EFh
|
174 |
202 |
1.83e1 |
SMART |
|
EFh
|
207 |
234 |
4.45e1 |
SMART |
|
PLCXc
|
290 |
435 |
2.03e-79 |
SMART |
|
low complexity region
|
441 |
459 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1461 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 95.9%
- 20x: 91.3%
|
| Validation Efficiency |
99% (69/70) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31 C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 65 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A830018L16Rik |
A |
T |
1: 11,588,818 (GRCm39) |
R78S |
probably damaging |
Het |
| Acad10 |
G |
C |
5: 121,764,104 (GRCm39) |
|
probably benign |
Het |
| Acad10 |
G |
T |
5: 121,764,103 (GRCm39) |
|
probably benign |
Het |
| Ang2 |
C |
A |
14: 51,432,990 (GRCm39) |
E131* |
probably null |
Het |
| Ankfn1 |
T |
C |
11: 89,417,367 (GRCm39) |
N82D |
probably damaging |
Het |
| Anks1b |
T |
C |
10: 89,885,847 (GRCm39) |
I181T |
possibly damaging |
Het |
| Bcl2l12 |
C |
G |
7: 44,642,242 (GRCm39) |
G215R |
probably damaging |
Het |
| Bnc2 |
A |
G |
4: 84,194,194 (GRCm39) |
Y1044H |
probably damaging |
Het |
| Cacna1s |
T |
C |
1: 136,038,675 (GRCm39) |
F1172S |
probably damaging |
Het |
| Cct8 |
A |
G |
16: 87,282,472 (GRCm39) |
I482T |
probably damaging |
Het |
| Cfap74 |
C |
T |
4: 155,518,502 (GRCm39) |
T580I |
probably benign |
Het |
| Cib1 |
A |
T |
7: 79,878,162 (GRCm39) |
Y105* |
probably null |
Het |
| Cpa1 |
G |
A |
6: 30,642,334 (GRCm39) |
G245D |
probably damaging |
Het |
| Csmd3 |
A |
G |
15: 47,845,371 (GRCm39) |
V801A |
possibly damaging |
Het |
| Ddx10 |
T |
C |
9: 53,060,861 (GRCm39) |
|
probably null |
Het |
| Ddx4 |
T |
C |
13: 112,736,531 (GRCm39) |
N613S |
probably damaging |
Het |
| Drd3 |
A |
G |
16: 43,641,704 (GRCm39) |
D340G |
probably benign |
Het |
| E2f4 |
A |
G |
8: 106,031,320 (GRCm39) |
*411W |
probably null |
Het |
| Fmnl2 |
A |
G |
2: 52,995,549 (GRCm39) |
E424G |
probably damaging |
Het |
| Foxp1 |
A |
T |
6: 98,922,381 (GRCm39) |
I450N |
probably damaging |
Het |
| Ftdc1 |
A |
T |
16: 58,436,202 (GRCm39) |
D40E |
probably benign |
Het |
| Gpr19 |
A |
G |
6: 134,847,047 (GRCm39) |
F175S |
possibly damaging |
Het |
| Gpr21 |
C |
T |
2: 37,408,084 (GRCm39) |
T210M |
probably damaging |
Het |
| Grhl2 |
C |
T |
15: 37,336,567 (GRCm39) |
A488V |
probably benign |
Het |
| Hif3a |
T |
C |
7: 16,778,328 (GRCm39) |
T435A |
probably benign |
Het |
| Hoxb4 |
C |
T |
11: 96,209,725 (GRCm39) |
R44* |
probably null |
Het |
| Ifi47 |
A |
G |
11: 48,986,698 (GRCm39) |
D155G |
probably damaging |
Het |
| Igdcc4 |
T |
C |
9: 65,042,509 (GRCm39) |
L142P |
probably benign |
Het |
| Ints6 |
G |
A |
14: 62,951,141 (GRCm39) |
P296L |
probably damaging |
Het |
| Itga3 |
A |
G |
11: 94,937,745 (GRCm39) |
|
probably null |
Het |
| Klra3 |
G |
C |
6: 130,310,107 (GRCm39) |
R138G |
probably benign |
Het |
| Krtap20-1 |
G |
A |
16: 88,812,277 (GRCm39) |
|
probably benign |
Het |
| Lgals12 |
A |
T |
19: 7,581,677 (GRCm39) |
H50Q |
probably benign |
Het |
| Lrp12 |
A |
G |
15: 39,735,902 (GRCm39) |
S696P |
probably damaging |
Het |
| Lrp6 |
G |
A |
6: 134,436,392 (GRCm39) |
T1258I |
possibly damaging |
Het |
| Meis2 |
C |
T |
2: 115,889,183 (GRCm39) |
D190N |
probably damaging |
Het |
| Mir100hg |
T |
C |
9: 41,492,672 (GRCm39) |
L116P |
probably damaging |
Het |
| Mon2 |
C |
T |
10: 122,871,912 (GRCm39) |
|
probably benign |
Het |
| Muc6 |
A |
G |
7: 141,238,368 (GRCm39) |
|
probably benign |
Het |
| Muc6 |
G |
T |
7: 141,218,685 (GRCm39) |
T1996N |
possibly damaging |
Het |
| Myo15a |
A |
G |
11: 60,379,064 (GRCm39) |
H1394R |
probably damaging |
Het |
| Myo5a |
A |
T |
9: 75,079,028 (GRCm39) |
I929F |
probably damaging |
Het |
| Nek6 |
T |
A |
2: 38,458,907 (GRCm39) |
Y141N |
probably damaging |
Het |
| Notch4 |
T |
A |
17: 34,787,396 (GRCm39) |
C319S |
probably damaging |
Het |
| Nwd2 |
A |
T |
5: 63,957,525 (GRCm39) |
D285V |
probably benign |
Het |
| Olfml1 |
T |
C |
7: 107,189,582 (GRCm39) |
S216P |
possibly damaging |
Het |
| Pabpc1l |
G |
T |
2: 163,879,091 (GRCm39) |
V313F |
possibly damaging |
Het |
| Pfkfb2 |
G |
T |
1: 130,625,820 (GRCm39) |
H453Q |
probably benign |
Het |
| Pigt |
C |
T |
2: 164,343,439 (GRCm39) |
T305I |
probably benign |
Het |
| Plxnb1 |
C |
T |
9: 108,929,968 (GRCm39) |
L275F |
possibly damaging |
Het |
| Ppm1d |
C |
T |
11: 85,230,431 (GRCm39) |
R350C |
probably damaging |
Het |
| Prss1l |
G |
T |
6: 41,372,945 (GRCm39) |
L72F |
probably damaging |
Het |
| Rassf1 |
C |
A |
9: 107,429,045 (GRCm39) |
P84T |
probably benign |
Het |
| Rgl3 |
G |
T |
9: 21,892,002 (GRCm39) |
R361S |
probably benign |
Het |
| Rnf213 |
G |
A |
11: 119,333,533 (GRCm39) |
R2914H |
probably damaging |
Het |
| Ryr2 |
A |
T |
13: 11,569,435 (GRCm39) |
C4956* |
probably null |
Het |
| Scaper |
C |
T |
9: 55,723,954 (GRCm39) |
R668H |
probably damaging |
Het |
| Spata6 |
T |
C |
4: 111,636,203 (GRCm39) |
F165L |
probably benign |
Het |
| Tcirg1 |
A |
T |
19: 3,946,845 (GRCm39) |
W694R |
probably benign |
Het |
| Tmem245 |
A |
T |
4: 56,906,233 (GRCm39) |
Y160* |
probably null |
Het |
| Tshr |
T |
C |
12: 91,500,805 (GRCm39) |
Y279H |
probably damaging |
Het |
| Ttf1 |
A |
C |
2: 28,955,150 (GRCm39) |
K171N |
probably damaging |
Het |
| Ubap2 |
C |
T |
4: 41,199,872 (GRCm39) |
A752T |
probably benign |
Het |
| Ugcg |
C |
T |
4: 59,207,798 (GRCm39) |
P46S |
probably benign |
Het |
| Xdh |
A |
G |
17: 74,220,896 (GRCm39) |
V611A |
probably damaging |
Het |
|
| Other mutations in Zfp142 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00581:Zfp142
|
APN |
1 |
74,606,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00711:Zfp142
|
APN |
1 |
74,611,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01391:Zfp142
|
APN |
1 |
74,618,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01808:Zfp142
|
APN |
1 |
74,615,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02074:Zfp142
|
APN |
1 |
74,609,022 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02134:Zfp142
|
APN |
1 |
74,609,022 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02567:Zfp142
|
APN |
1 |
74,617,309 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02567:Zfp142
|
APN |
1 |
74,617,306 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02567:Zfp142
|
APN |
1 |
74,617,308 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02669:Zfp142
|
APN |
1 |
74,610,432 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL02694:Zfp142
|
APN |
1 |
74,609,307 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02884:Zfp142
|
APN |
1 |
74,611,142 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03000:Zfp142
|
APN |
1 |
74,612,777 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03080:Zfp142
|
APN |
1 |
74,610,368 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03238:Zfp142
|
APN |
1 |
74,615,437 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL03277:Zfp142
|
APN |
1 |
74,610,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4402001:Zfp142
|
UTSW |
1 |
74,618,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0124:Zfp142
|
UTSW |
1 |
74,607,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0256:Zfp142
|
UTSW |
1 |
74,617,317 (GRCm39) |
missense |
probably benign |
|
|
R0267:Zfp142
|
UTSW |
1 |
74,615,223 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0306:Zfp142
|
UTSW |
1 |
74,609,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0321:Zfp142
|
UTSW |
1 |
74,608,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0466:Zfp142
|
UTSW |
1 |
74,624,570 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0513:Zfp142
|
UTSW |
1 |
74,610,714 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1084:Zfp142
|
UTSW |
1 |
74,610,985 (GRCm39) |
missense |
probably benign |
|
|
R1534:Zfp142
|
UTSW |
1 |
74,611,247 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1623:Zfp142
|
UTSW |
1 |
74,610,934 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1628:Zfp142
|
UTSW |
1 |
74,611,047 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1710:Zfp142
|
UTSW |
1 |
74,611,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1722:Zfp142
|
UTSW |
1 |
74,608,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1770:Zfp142
|
UTSW |
1 |
74,618,790 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2042:Zfp142
|
UTSW |
1 |
74,609,778 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2112:Zfp142
|
UTSW |
1 |
74,612,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2249:Zfp142
|
UTSW |
1 |
74,606,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4393:Zfp142
|
UTSW |
1 |
74,611,219 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4700:Zfp142
|
UTSW |
1 |
74,609,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4750:Zfp142
|
UTSW |
1 |
74,611,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4763:Zfp142
|
UTSW |
1 |
74,615,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5208:Zfp142
|
UTSW |
1 |
74,610,027 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5233:Zfp142
|
UTSW |
1 |
74,624,608 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5585:Zfp142
|
UTSW |
1 |
74,617,404 (GRCm39) |
nonsense |
probably null |
|
|
R6192:Zfp142
|
UTSW |
1 |
74,609,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6461:Zfp142
|
UTSW |
1 |
74,606,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6482:Zfp142
|
UTSW |
1 |
74,609,376 (GRCm39) |
splice site |
probably null |
|
|
R7320:Zfp142
|
UTSW |
1 |
74,609,167 (GRCm39) |
nonsense |
probably null |
|
|
R7438:Zfp142
|
UTSW |
1 |
74,624,679 (GRCm39) |
missense |
probably benign |
|
|
R7528:Zfp142
|
UTSW |
1 |
74,610,061 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7600:Zfp142
|
UTSW |
1 |
74,612,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8007:Zfp142
|
UTSW |
1 |
74,610,655 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8681:Zfp142
|
UTSW |
1 |
74,610,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8772:Zfp142
|
UTSW |
1 |
74,610,825 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9058:Zfp142
|
UTSW |
1 |
74,608,955 (GRCm39) |
nonsense |
probably null |
|
|
R9233:Zfp142
|
UTSW |
1 |
74,610,288 (GRCm39) |
missense |
probably benign |
|
|
R9281:Zfp142
|
UTSW |
1 |
74,607,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9302:Zfp142
|
UTSW |
1 |
74,606,302 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9454:Zfp142
|
UTSW |
1 |
74,609,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9569:Zfp142
|
UTSW |
1 |
74,615,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9595:Zfp142
|
UTSW |
1 |
74,611,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9680:Zfp142
|
UTSW |
1 |
74,610,933 (GRCm39) |
missense |
probably benign |
0.16 |
|
Z1177:Zfp142
|
UTSW |
1 |
74,609,325 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGATGGCGACATGCAAAGTCAC -3'
(R):5'- GCCCAGTTTAGCTCAGAAACAGCAC -3'
Sequencing Primer
(F):5'- CAGCATCCCCATCTGAGG -3'
(R):5'- GTTTAGCTCAGAAACAGCACTCAAG -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation