Incidental Mutation 'R1626:Vmn2r2'
ID |
172478 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r2
|
Ensembl Gene |
ENSMUSG00000043897 |
Gene Name |
vomeronasal 2, receptor 2 |
Synonyms |
|
MMRRC Submission |
039663-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.108)
|
Stock # |
R1626 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
3 |
Chromosomal Location |
64022699-64049349 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 64041921 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Phenylalanine
at position 265
(I265F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000135110
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077958]
[ENSMUST00000177151]
|
AlphaFold |
L7N2E9 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000077958
AA Change: I181F
PolyPhen 2
Score 0.607 (Sensitivity: 0.87; Specificity: 0.91)
|
SMART Domains |
Protein: ENSMUSP00000077109 Gene: ENSMUSG00000043897 AA Change: I181F
Domain | Start | End | E-Value | Type |
Pfam:ANF_receptor
|
1 |
416 |
4.5e-80 |
PFAM |
Pfam:NCD3G
|
458 |
511 |
8.3e-18 |
PFAM |
Pfam:7tm_3
|
542 |
779 |
1.3e-75 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000177151
AA Change: I265F
PolyPhen 2
Score 0.607 (Sensitivity: 0.87; Specificity: 0.91)
|
SMART Domains |
Protein: ENSMUSP00000135110 Gene: ENSMUSG00000043897 AA Change: I265F
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
83 |
500 |
1.6e-84 |
PFAM |
Pfam:NCD3G
|
542 |
595 |
2.6e-17 |
PFAM |
Pfam:7tm_3
|
628 |
862 |
1.9e-47 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.5%
- 20x: 90.1%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 54 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700020N01Rik |
T |
C |
10: 21,497,571 (GRCm39) |
Y71H |
possibly damaging |
Het |
Acsl6 |
C |
A |
11: 54,242,872 (GRCm39) |
P628T |
probably damaging |
Het |
Ak7 |
A |
G |
12: 105,734,807 (GRCm39) |
D591G |
probably benign |
Het |
Anxa5 |
T |
C |
3: 36,516,130 (GRCm39) |
D66G |
probably damaging |
Het |
Cacna1b |
G |
A |
2: 24,496,721 (GRCm39) |
T2283I |
probably damaging |
Het |
Cand1 |
A |
T |
10: 119,045,919 (GRCm39) |
D995E |
possibly damaging |
Het |
Cblc |
G |
T |
7: 19,530,427 (GRCm39) |
A94E |
probably damaging |
Het |
Cd48 |
G |
A |
1: 171,509,687 (GRCm39) |
C9Y |
probably benign |
Het |
Chd9 |
A |
G |
8: 91,721,224 (GRCm39) |
K1004R |
probably benign |
Het |
Cilk1 |
A |
G |
9: 78,057,919 (GRCm39) |
Y156C |
probably damaging |
Het |
Cldn1 |
T |
C |
16: 26,190,202 (GRCm39) |
T59A |
probably damaging |
Het |
Col11a1 |
G |
A |
3: 113,925,218 (GRCm39) |
G17D |
probably damaging |
Het |
Cpeb1 |
A |
G |
7: 81,085,995 (GRCm39) |
V49A |
probably damaging |
Het |
Cyp4b1 |
G |
T |
4: 115,498,855 (GRCm39) |
P109Q |
probably damaging |
Het |
Dhrs7b |
T |
A |
11: 60,735,082 (GRCm39) |
F23I |
possibly damaging |
Het |
Dnah9 |
C |
A |
11: 65,976,093 (GRCm39) |
A1319S |
probably benign |
Het |
Egf |
A |
T |
3: 129,479,864 (GRCm39) |
V553D |
possibly damaging |
Het |
Fbn1 |
T |
C |
2: 125,183,199 (GRCm39) |
D1760G |
probably damaging |
Het |
Fbxo31 |
A |
G |
8: 122,286,745 (GRCm39) |
F178L |
probably damaging |
Het |
Fstl4 |
C |
A |
11: 52,891,117 (GRCm39) |
S85* |
probably null |
Het |
Gfm1 |
A |
G |
3: 67,345,977 (GRCm39) |
Y225C |
probably damaging |
Het |
Gm10797 |
A |
T |
10: 67,408,453 (GRCm39) |
|
noncoding transcript |
Het |
H3c8 |
G |
A |
13: 23,719,721 (GRCm39) |
V36M |
probably damaging |
Het |
Heatr4 |
T |
A |
12: 84,020,495 (GRCm39) |
I499L |
probably benign |
Het |
Igfn1 |
A |
T |
1: 135,896,705 (GRCm39) |
M1287K |
probably benign |
Het |
Inpp5b |
C |
A |
4: 124,677,696 (GRCm39) |
D385E |
probably damaging |
Het |
Lrrc9 |
A |
G |
12: 72,542,435 (GRCm39) |
|
probably null |
Het |
Ltb4r1 |
A |
G |
14: 56,004,699 (GRCm39) |
M1V |
probably null |
Het |
Macf1 |
T |
C |
4: 123,365,327 (GRCm39) |
I3145V |
probably benign |
Het |
Man2a2 |
T |
C |
7: 80,017,450 (GRCm39) |
N277S |
probably damaging |
Het |
Megf6 |
G |
T |
4: 154,261,578 (GRCm39) |
V68L |
probably benign |
Het |
Mgat4e |
A |
G |
1: 134,469,016 (GRCm39) |
Y343H |
probably benign |
Het |
Noxred1 |
T |
C |
12: 87,268,029 (GRCm39) |
*367W |
probably null |
Het |
Nup58 |
A |
T |
14: 60,480,076 (GRCm39) |
L190* |
probably null |
Het |
Olfml2a |
G |
T |
2: 38,841,275 (GRCm39) |
K270N |
probably damaging |
Het |
Or5c1 |
A |
G |
2: 37,222,774 (GRCm39) |
|
probably null |
Het |
Or7g32 |
A |
G |
9: 19,389,495 (GRCm39) |
L14P |
probably damaging |
Het |
Phgdh |
G |
T |
3: 98,223,725 (GRCm39) |
Q359K |
probably benign |
Het |
Plpp5 |
G |
T |
8: 26,212,604 (GRCm39) |
C200F |
possibly damaging |
Het |
Pole |
A |
C |
5: 110,441,235 (GRCm39) |
I230L |
probably benign |
Het |
Prtg |
A |
T |
9: 72,752,193 (GRCm39) |
D193V |
probably damaging |
Het |
Ptgs2 |
G |
A |
1: 149,979,619 (GRCm39) |
|
probably null |
Het |
Ptprz1 |
A |
T |
6: 23,001,573 (GRCm39) |
Q1221L |
probably benign |
Het |
Rufy2 |
T |
C |
10: 62,831,151 (GRCm39) |
I204T |
probably benign |
Het |
Rybp |
A |
G |
6: 100,209,919 (GRCm39) |
S115P |
possibly damaging |
Het |
Samd13 |
A |
G |
3: 146,368,481 (GRCm39) |
V37A |
probably benign |
Het |
Secisbp2l |
T |
G |
2: 125,617,606 (GRCm39) |
K24Q |
probably damaging |
Het |
Sorbs2 |
A |
G |
8: 46,222,891 (GRCm39) |
Y198C |
probably damaging |
Het |
Svil |
T |
G |
18: 5,117,099 (GRCm39) |
|
probably null |
Het |
Ttc24 |
G |
T |
3: 87,977,366 (GRCm39) |
R127S |
probably benign |
Het |
Ttn |
C |
T |
2: 76,588,888 (GRCm39) |
V21394M |
probably damaging |
Het |
Tubal3 |
G |
T |
13: 3,982,841 (GRCm39) |
C207F |
probably damaging |
Het |
Vmn2r16 |
A |
T |
5: 109,511,443 (GRCm39) |
D550V |
probably damaging |
Het |
Zfp507 |
T |
C |
7: 35,494,858 (GRCm39) |
K62E |
probably damaging |
Het |
|
Other mutations in Vmn2r2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00326:Vmn2r2
|
APN |
3 |
64,041,319 (GRCm39) |
splice site |
probably benign |
|
IGL00980:Vmn2r2
|
APN |
3 |
64,024,601 (GRCm39) |
missense |
probably benign |
0.11 |
IGL01389:Vmn2r2
|
APN |
3 |
64,024,430 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL01804:Vmn2r2
|
APN |
3 |
64,041,677 (GRCm39) |
missense |
possibly damaging |
0.91 |
IGL02750:Vmn2r2
|
APN |
3 |
64,024,823 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02829:Vmn2r2
|
APN |
3 |
64,026,172 (GRCm39) |
splice site |
probably benign |
|
IGL03036:Vmn2r2
|
APN |
3 |
64,024,321 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03174:Vmn2r2
|
APN |
3 |
64,024,544 (GRCm39) |
nonsense |
probably null |
|
PIT4151001:Vmn2r2
|
UTSW |
3 |
64,024,334 (GRCm39) |
missense |
possibly damaging |
0.67 |
R0029:Vmn2r2
|
UTSW |
3 |
64,024,365 (GRCm39) |
missense |
probably benign |
0.00 |
R0310:Vmn2r2
|
UTSW |
3 |
64,042,039 (GRCm39) |
missense |
probably damaging |
1.00 |
R0357:Vmn2r2
|
UTSW |
3 |
64,041,320 (GRCm39) |
splice site |
probably null |
|
R0637:Vmn2r2
|
UTSW |
3 |
64,033,999 (GRCm39) |
missense |
probably benign |
0.00 |
R1662:Vmn2r2
|
UTSW |
3 |
64,024,551 (GRCm39) |
missense |
probably benign |
0.00 |
R1710:Vmn2r2
|
UTSW |
3 |
64,024,820 (GRCm39) |
missense |
probably benign |
0.19 |
R1797:Vmn2r2
|
UTSW |
3 |
64,042,128 (GRCm39) |
missense |
probably benign |
0.00 |
R1862:Vmn2r2
|
UTSW |
3 |
64,041,942 (GRCm39) |
missense |
possibly damaging |
0.79 |
R1971:Vmn2r2
|
UTSW |
3 |
64,034,121 (GRCm39) |
missense |
probably damaging |
1.00 |
R2051:Vmn2r2
|
UTSW |
3 |
64,024,766 (GRCm39) |
missense |
possibly damaging |
0.77 |
R2099:Vmn2r2
|
UTSW |
3 |
64,024,474 (GRCm39) |
missense |
probably damaging |
1.00 |
R2275:Vmn2r2
|
UTSW |
3 |
64,023,930 (GRCm39) |
missense |
probably benign |
0.00 |
R3078:Vmn2r2
|
UTSW |
3 |
64,042,053 (GRCm39) |
missense |
probably benign |
0.22 |
R3418:Vmn2r2
|
UTSW |
3 |
64,024,320 (GRCm39) |
missense |
probably benign |
0.00 |
R3419:Vmn2r2
|
UTSW |
3 |
64,024,320 (GRCm39) |
missense |
probably benign |
0.00 |
R3959:Vmn2r2
|
UTSW |
3 |
64,047,947 (GRCm39) |
missense |
probably benign |
|
R4230:Vmn2r2
|
UTSW |
3 |
64,041,912 (GRCm39) |
missense |
probably benign |
0.00 |
R4258:Vmn2r2
|
UTSW |
3 |
64,042,118 (GRCm39) |
missense |
probably damaging |
1.00 |
R4810:Vmn2r2
|
UTSW |
3 |
64,044,883 (GRCm39) |
missense |
probably damaging |
1.00 |
R4822:Vmn2r2
|
UTSW |
3 |
64,041,960 (GRCm39) |
missense |
probably damaging |
0.99 |
R4919:Vmn2r2
|
UTSW |
3 |
64,024,578 (GRCm39) |
missense |
possibly damaging |
0.56 |
R4925:Vmn2r2
|
UTSW |
3 |
64,044,892 (GRCm39) |
start codon destroyed |
probably null |
0.03 |
R4954:Vmn2r2
|
UTSW |
3 |
64,047,905 (GRCm39) |
missense |
probably benign |
0.00 |
R5071:Vmn2r2
|
UTSW |
3 |
64,024,321 (GRCm39) |
missense |
probably benign |
0.01 |
R5315:Vmn2r2
|
UTSW |
3 |
64,024,377 (GRCm39) |
missense |
probably benign |
0.37 |
R5450:Vmn2r2
|
UTSW |
3 |
64,034,011 (GRCm39) |
missense |
probably benign |
|
R5577:Vmn2r2
|
UTSW |
3 |
64,024,416 (GRCm39) |
missense |
probably benign |
0.00 |
R5595:Vmn2r2
|
UTSW |
3 |
64,034,036 (GRCm39) |
missense |
possibly damaging |
0.74 |
R5727:Vmn2r2
|
UTSW |
3 |
64,024,608 (GRCm39) |
missense |
probably benign |
0.41 |
R5810:Vmn2r2
|
UTSW |
3 |
64,024,815 (GRCm39) |
missense |
probably damaging |
1.00 |
R5919:Vmn2r2
|
UTSW |
3 |
64,044,723 (GRCm39) |
missense |
probably benign |
0.39 |
R6052:Vmn2r2
|
UTSW |
3 |
64,024,782 (GRCm39) |
missense |
possibly damaging |
0.56 |
R6084:Vmn2r2
|
UTSW |
3 |
64,024,467 (GRCm39) |
missense |
probably benign |
0.01 |
R6299:Vmn2r2
|
UTSW |
3 |
64,024,074 (GRCm39) |
nonsense |
probably null |
|
R6762:Vmn2r2
|
UTSW |
3 |
64,041,870 (GRCm39) |
missense |
probably damaging |
1.00 |
R6858:Vmn2r2
|
UTSW |
3 |
64,044,915 (GRCm39) |
missense |
probably damaging |
1.00 |
R6889:Vmn2r2
|
UTSW |
3 |
64,024,688 (GRCm39) |
missense |
probably damaging |
0.99 |
R6990:Vmn2r2
|
UTSW |
3 |
64,024,608 (GRCm39) |
missense |
probably benign |
0.02 |
R7195:Vmn2r2
|
UTSW |
3 |
64,023,900 (GRCm39) |
missense |
probably benign |
0.01 |
R7269:Vmn2r2
|
UTSW |
3 |
64,033,998 (GRCm39) |
missense |
probably benign |
0.32 |
R7699:Vmn2r2
|
UTSW |
3 |
64,024,536 (GRCm39) |
missense |
possibly damaging |
0.69 |
R7717:Vmn2r2
|
UTSW |
3 |
64,042,019 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7798:Vmn2r2
|
UTSW |
3 |
64,041,518 (GRCm39) |
missense |
possibly damaging |
0.60 |
R7914:Vmn2r2
|
UTSW |
3 |
64,041,526 (GRCm39) |
missense |
probably benign |
0.20 |
R7974:Vmn2r2
|
UTSW |
3 |
64,024,808 (GRCm39) |
missense |
probably damaging |
0.99 |
R8394:Vmn2r2
|
UTSW |
3 |
64,044,858 (GRCm39) |
missense |
probably damaging |
1.00 |
R8478:Vmn2r2
|
UTSW |
3 |
64,024,257 (GRCm39) |
missense |
possibly damaging |
0.87 |
R8731:Vmn2r2
|
UTSW |
3 |
64,024,404 (GRCm39) |
missense |
probably benign |
0.16 |
R9035:Vmn2r2
|
UTSW |
3 |
64,024,172 (GRCm39) |
missense |
probably damaging |
1.00 |
R9182:Vmn2r2
|
UTSW |
3 |
64,044,802 (GRCm39) |
missense |
probably damaging |
1.00 |
R9225:Vmn2r2
|
UTSW |
3 |
64,034,021 (GRCm39) |
missense |
probably benign |
0.00 |
R9266:Vmn2r2
|
UTSW |
3 |
64,024,057 (GRCm39) |
missense |
probably damaging |
0.98 |
R9427:Vmn2r2
|
UTSW |
3 |
64,041,945 (GRCm39) |
missense |
probably damaging |
1.00 |
R9659:Vmn2r2
|
UTSW |
3 |
64,041,942 (GRCm39) |
missense |
possibly damaging |
0.79 |
R9666:Vmn2r2
|
UTSW |
3 |
64,023,870 (GRCm39) |
missense |
probably benign |
0.08 |
R9771:Vmn2r2
|
UTSW |
3 |
64,042,079 (GRCm39) |
missense |
possibly damaging |
0.88 |
R9788:Vmn2r2
|
UTSW |
3 |
64,041,942 (GRCm39) |
missense |
possibly damaging |
0.79 |
X0024:Vmn2r2
|
UTSW |
3 |
64,044,707 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- TGTTGGGCCAGGTACAGTTAAAAGC -3'
(R):5'- TCTGAGGGCATGGTGAGTCTTATCC -3'
Sequencing Primer
(F):5'- GCAGTTTGCCAGAATTCAATGG -3'
(R):5'- GCATGGTGAGTCTTATCCAACAC -3'
|
Posted On |
2014-04-24 |