Mutagenetix > Incidental Mutation

Incidental Mutation 'R0057:Or5m10b'

17271

Institutional Source

Beutler Lab

Gene Symbol

Or5m10b

Ensembl Gene

ENSMUSG00000057761

Gene Name

olfactory receptor family 5 subfamily M member 10B

Synonyms

GA_x6K02T2Q125-47347069-47348016, Olfr1022, MOR196-1

MMRRC Submission

038351-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R0057 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

85698938-85699885 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 85699597 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 220 (Y220*)

Ref Sequence

ENSEMBL: ENSMUSP00000059312 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054736] [ENSMUST00000121914]

AlphaFold

L7MTT3

Predicted Effect

probably null
Transcript: ENSMUST00000054736
AA Change: Y220*

SMART Domains

Protein: ENSMUSP00000059312
Gene: ENSMUSG00000057761
AA Change: Y220*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	312	4.8e-51	PFAM
Pfam:7TM_GPCR_Srsx	35	304	8e-6	PFAM
Pfam:7tm_1	41	290	9.8e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000121914

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 90.1%
3x: 87.8%
10x: 82.7%
20x: 75.7%

Validation Efficiency

89% (65/73)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8b	A	T	11: 109,832,385 (GRCm39)	F1309L	possibly damaging	Het
Abcc6	C	T	7: 45,669,567 (GRCm39)	A163T	probably benign	Het
Adam23	T	A	1: 63,610,078 (GRCm39)	H693Q	probably damaging	Het
Afg3l2	A	G	18: 67,556,156 (GRCm39)	F392L	probably damaging	Het
Ak9	A	T	10: 41,268,724 (GRCm39)	T1055S	probably benign	Het
Ap5z1	T	C	5: 142,456,144 (GRCm39)		probably benign	Het
Arhgef10l	A	G	4: 140,338,529 (GRCm39)		probably benign	Het
Bloc1s6	T	A	2: 122,586,141 (GRCm39)		probably benign	Het
Caskin1	A	G	17: 24,723,870 (GRCm39)	N886S	probably damaging	Het
Celsr1	A	C	15: 85,914,963 (GRCm39)	S1003R	probably benign	Het
Ctse	G	T	1: 131,591,109 (GRCm39)	D97Y	probably damaging	Het
Cux1	T	A	5: 136,285,136 (GRCm39)	I505F	probably damaging	Het
Dcaf11	T	C	14: 55,806,767 (GRCm39)	V490A	probably benign	Het
Dscam	A	C	16: 96,474,936 (GRCm39)	W1209G	probably damaging	Het
Emc8	A	G	8: 121,385,822 (GRCm39)		probably benign	Het
Entpd6	A	G	2: 150,600,748 (GRCm39)	K152R	probably null	Het
Eps8l2	C	T	7: 140,922,884 (GRCm39)	T49I	probably benign	Het
Fcsk	C	T	8: 111,620,400 (GRCm39)		probably benign	Het
Gm12251	C	A	11: 58,283,867 (GRCm39)		probably benign	Het
Gna11	A	G	10: 81,366,774 (GRCm39)	M312T	probably benign	Het
Hacd2	T	A	16: 34,895,997 (GRCm39)	V105D	probably damaging	Het
Il17a	T	A	1: 20,803,881 (GRCm39)	I92N	probably damaging	Het
Ino80	G	A	2: 119,213,441 (GRCm39)	R1249C	probably damaging	Het
Irak4	A	C	15: 94,451,753 (GRCm39)	R115S	probably benign	Het
Jarid2	C	T	13: 45,038,332 (GRCm39)	H77Y	probably damaging	Het
Kcnk6	A	T	7: 28,925,088 (GRCm39)	L176Q	probably damaging	Het
Kmt2b	A	T	7: 30,276,217 (GRCm39)		probably benign	Het
Kremen2	A	C	17: 23,962,202 (GRCm39)	I210S	possibly damaging	Het
Ldah	T	C	12: 8,288,432 (GRCm39)		probably benign	Het
Lgals9	A	T	11: 78,862,262 (GRCm39)		probably benign	Het
Mfsd13a	C	T	19: 46,354,943 (GRCm39)	T40I	probably benign	Het
Mfsd4b4	T	A	10: 39,891,097 (GRCm38)		probably benign	Het
Msh4	C	T	3: 153,575,318 (GRCm39)	A686T	probably benign	Het
Mycbp2	T	C	14: 103,389,578 (GRCm39)	N3411D	probably damaging	Het
Myt1l	A	G	12: 29,892,611 (GRCm39)		probably null	Het
Nmbr	A	G	10: 14,636,268 (GRCm39)	N79S	probably damaging	Het
Npsr1	A	T	9: 24,211,723 (GRCm39)	I84F	probably damaging	Het
Or52h1	G	T	7: 103,829,536 (GRCm39)	H26Q	probably benign	Het
Or6z5	T	C	7: 6,477,679 (GRCm39)	L190P	probably damaging	Het
Prlr	A	G	15: 10,328,509 (GRCm39)	Y328C	probably damaging	Het
Rasal3	A	G	17: 32,610,357 (GRCm39)	S977P	probably benign	Het
Ros1	C	T	10: 52,056,287 (GRCm39)	V68I	probably benign	Het
Shmt2	G	A	10: 127,356,917 (GRCm39)	T31M	possibly damaging	Het
Snapc1	C	T	12: 74,021,806 (GRCm39)	R81C	probably damaging	Het
Snrnp200	C	G	2: 127,079,827 (GRCm39)	L1899V	probably damaging	Het
Snrnp48	T	A	13: 38,400,356 (GRCm39)	C154*	probably null	Het
Tdrd6	G	A	17: 43,928,052 (GRCm39)		probably benign	Het
Tmem175	C	T	5: 108,787,428 (GRCm39)	H92Y	probably damaging	Het
Tom1l1	G	A	11: 90,575,975 (GRCm39)		probably benign	Het
Top3a	C	T	11: 60,631,510 (GRCm39)	A951T	probably benign	Het
Tram2	C	T	1: 21,076,378 (GRCm39)	R184Q	probably damaging	Het
Trpc4ap	T	C	2: 155,482,406 (GRCm39)	E528G	possibly damaging	Het
Vwa7	G	A	17: 35,243,523 (GRCm39)	S710N	possibly damaging	Het
Zfa-ps	A	T	10: 52,421,202 (GRCm39)		noncoding transcript	Het
Zfp770	T	A	2: 114,027,713 (GRCm39)	R119*	probably null	Het

Other mutations in Or5m10b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02701:Or5m10b	APN	2	85,699,802 (GRCm39)	missense	probably benign	0.22
IGL03265:Or5m10b	APN	2	85,699,494 (GRCm39)	missense	possibly damaging	0.80
PIT4366001:Or5m10b	UTSW	2	85,699,226 (GRCm39)	missense	probably damaging	1.00
R0057:Or5m10b	UTSW	2	85,699,597 (GRCm39)	nonsense	probably null
R0554:Or5m10b	UTSW	2	85,699,863 (GRCm39)	missense	probably benign	0.00
R3873:Or5m10b	UTSW	2	85,699,306 (GRCm39)	nonsense	probably null
R3913:Or5m10b	UTSW	2	85,699,115 (GRCm39)	missense	probably damaging	1.00
R4698:Or5m10b	UTSW	2	85,699,596 (GRCm39)	missense	possibly damaging	0.90
R5628:Or5m10b	UTSW	2	85,699,149 (GRCm39)	missense	probably damaging	0.99
R6467:Or5m10b	UTSW	2	85,699,714 (GRCm39)	nonsense	probably null
R6947:Or5m10b	UTSW	2	85,699,271 (GRCm39)	missense	probably benign	0.01
R7092:Or5m10b	UTSW	2	85,698,951 (GRCm39)	missense	probably damaging	1.00
R7351:Or5m10b	UTSW	2	85,694,415 (GRCm39)	unclassified	probably benign
R7574:Or5m10b	UTSW	2	85,699,350 (GRCm39)	missense	probably benign	0.03
R8430:Or5m10b	UTSW	2	85,699,526 (GRCm39)	missense	probably benign	0.00
R8771:Or5m10b	UTSW	2	85,699,712 (GRCm39)	missense	probably damaging	0.99
R8969:Or5m10b	UTSW	2	85,699,832 (GRCm39)	missense	probably benign	0.19
R9101:Or5m10b	UTSW	2	85,694,523 (GRCm39)	unclassified	probably benign
R9630:Or5m10b	UTSW	2	85,699,493 (GRCm39)	missense	probably benign	0.00
R9649:Or5m10b	UTSW	2	85,699,819 (GRCm39)	missense	probably damaging	1.00
R9649:Or5m10b	UTSW	2	85,699,278 (GRCm39)	missense	possibly damaging	0.96

Protein Function and Prediction

Olfr1022 is a member of the olfactory receptor gene family; the function of Olfr1022 is unknown.

Posted On

2013-01-20

Science Writer

Anne Murray