Incidental Mutation 'R0057:Olfr1022'
ID17271
Institutional Source Beutler Lab
Gene Symbol Olfr1022
Ensembl Gene ENSMUSG00000057761
Gene Nameolfactory receptor 1022
SynonymsGA_x6K02T2Q125-47347069-47348016, MOR196-1
MMRRC Submission 038351-MU
Accession Numbers

Ncbi RefSeq: NM_146589.2; MGI: 3030856

Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #R0057 (G1)
Quality Score
Status Validated
Chromosome2
Chromosomal Location85868594-85869541 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 85869253 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 220 (Y220*)
Ref Sequence ENSEMBL: ENSMUSP00000059312 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054736] [ENSMUST00000121914]
Predicted Effect probably null
Transcript: ENSMUST00000054736
AA Change: Y220*
SMART Domains Protein: ENSMUSP00000059312
Gene: ENSMUSG00000057761
AA Change: Y220*

DomainStartEndE-ValueType
Pfam:7tm_4 31 312 4.8e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 304 8e-6 PFAM
Pfam:7tm_1 41 290 9.8e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000121914
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 90.1%
  • 3x: 87.8%
  • 10x: 82.7%
  • 20x: 75.7%
Validation Efficiency 89% (65/73)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b A T 11: 109,941,559 F1309L possibly damaging Het
Abcc6 C T 7: 46,020,143 A163T probably benign Het
Adam23 T A 1: 63,570,919 H693Q probably damaging Het
Afg3l2 A G 18: 67,423,086 F392L probably damaging Het
Ak9 A T 10: 41,392,728 T1055S probably benign Het
Ap5z1 T C 5: 142,470,389 probably benign Het
Arhgef10l A G 4: 140,611,218 probably benign Het
Bloc1s6 T A 2: 122,744,221 probably benign Het
Caskin1 A G 17: 24,504,896 N886S probably damaging Het
Celsr1 A C 15: 86,030,762 S1003R probably benign Het
Ctse G T 1: 131,663,371 D97Y probably damaging Het
Cux1 T A 5: 136,256,282 I505F probably damaging Het
Dcaf11 T C 14: 55,569,310 V490A probably benign Het
Dscam A C 16: 96,673,736 W1209G probably damaging Het
Emc8 A G 8: 120,659,083 probably benign Het
Entpd6 A G 2: 150,758,828 K152R probably null Het
Eps8l2 C T 7: 141,342,971 T49I probably benign Het
Fuk C T 8: 110,893,768 probably benign Het
Gm12251 C A 11: 58,393,041 probably benign Het
Gna11 A G 10: 81,530,940 M312T probably benign Het
Hacd2 T A 16: 35,075,627 V105D probably damaging Het
Il17a T A 1: 20,733,657 I92N probably damaging Het
Ino80 G A 2: 119,382,960 R1249C probably damaging Het
Irak4 A C 15: 94,553,872 R115S probably benign Het
Jarid2 C T 13: 44,884,856 H77Y probably damaging Het
Kcnk6 A T 7: 29,225,663 L176Q probably damaging Het
Kmt2b A T 7: 30,576,792 probably benign Het
Kremen2 A C 17: 23,743,228 I210S possibly damaging Het
Ldah T C 12: 8,238,432 probably benign Het
Lgals9 A T 11: 78,971,436 probably benign Het
Mfsd13a C T 19: 46,366,504 T40I probably benign Het
Msh4 C T 3: 153,869,681 A686T probably benign Het
Mycbp2 T C 14: 103,152,142 N3411D probably damaging Het
Myt1l A G 12: 29,842,612 probably null Het
Nmbr A G 10: 14,760,524 N79S probably damaging Het
Npsr1 A T 9: 24,300,427 I84F probably damaging Het
Olfr1346 T C 7: 6,474,680 L190P probably damaging Het
Olfr648 G T 7: 104,180,329 H26Q probably benign Het
Prlr A G 15: 10,328,423 Y328C probably damaging Het
Rasal3 A G 17: 32,391,383 S977P probably benign Het
Ros1 C T 10: 52,180,191 V68I probably benign Het
RP24-170A20.3 T A 10: 39,891,097 probably benign Het
Shmt2 G A 10: 127,521,048 T31M possibly damaging Het
Snapc1 C T 12: 73,975,032 R81C probably damaging Het
Snrnp200 C G 2: 127,237,907 L1899V probably damaging Het
Snrnp48 T A 13: 38,216,380 C154* probably null Het
Tdrd6 G A 17: 43,617,161 probably benign Het
Tmem175 C T 5: 108,639,562 H92Y probably damaging Het
Tom1l1 G A 11: 90,685,149 probably benign Het
Top3a C T 11: 60,740,684 A951T probably benign Het
Tram2 C T 1: 21,006,154 R184Q probably damaging Het
Trpc4ap T C 2: 155,640,486 E528G possibly damaging Het
Vwa7 G A 17: 35,024,547 S710N possibly damaging Het
Zfa-ps A T 10: 52,545,106 noncoding transcript Het
Zfp770 T A 2: 114,197,232 R119* probably null Het
Other mutations in Olfr1022
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02701:Olfr1022 APN 2 85869458 missense probably benign 0.22
IGL03265:Olfr1022 APN 2 85869150 missense possibly damaging 0.80
PIT4366001:Olfr1022 UTSW 2 85868882 missense probably damaging 1.00
R0057:Olfr1022 UTSW 2 85869253 nonsense probably null
R0554:Olfr1022 UTSW 2 85869519 missense probably benign 0.00
R3873:Olfr1022 UTSW 2 85868962 nonsense probably null
R3913:Olfr1022 UTSW 2 85868771 missense probably damaging 1.00
R4698:Olfr1022 UTSW 2 85869252 missense possibly damaging 0.90
R5628:Olfr1022 UTSW 2 85868805 missense probably damaging 0.99
R6467:Olfr1022 UTSW 2 85869370 nonsense probably null
R6947:Olfr1022 UTSW 2 85868927 missense probably benign 0.01
R7092:Olfr1022 UTSW 2 85868607 missense probably damaging 1.00
R7351:Olfr1022 UTSW 2 85864071 unclassified probably benign
R7574:Olfr1022 UTSW 2 85869006 missense probably benign 0.03
Protein Function and Prediction

Olfr1022 is a member of the olfactory receptor gene family; the function of Olfr1022 is unknown.

Posted On2013-01-20
Science WriterAnne Murray