Incidental Mutation 'R1631:Or10a3b'
ID 172794
Institutional Source Beutler Lab
Gene Symbol Or10a3b
Ensembl Gene ENSMUSG00000062434
Gene Name olfactory receptor family 10 subfamily A member 3B
Synonyms GA_x6K02T2PBJ9-11176324-11175380, MOR268-2, Olfr516
MMRRC Submission 039668-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.181) question?
Stock # R1631 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 108444271-108445215 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 108445064 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Arginine at position 51 (L51R)
Ref Sequence ENSEMBL: ENSMUSP00000150359 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071410] [ENSMUST00000216092] [ENSMUST00000217279]
AlphaFold Q8VFZ5
Predicted Effect probably damaging
Transcript: ENSMUST00000071410
AA Change: L51R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000071358
Gene: ENSMUSG00000062434
AA Change: L51R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.2e-60 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.9e-5 PFAM
Pfam:7tm_1 41 290 9.2e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208389
Predicted Effect probably damaging
Transcript: ENSMUST00000216092
AA Change: L51R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217279
AA Change: L51R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 93.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts10 T A 17: 33,756,316 (GRCm39) S320T probably benign Het
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
Als2 T C 1: 59,257,226 (GRCm39) E12G probably benign Het
Arhgef10 A T 8: 14,997,157 (GRCm39) D321V probably damaging Het
Atp8a1 T G 5: 67,906,395 (GRCm39) probably null Het
Avil A G 10: 126,846,494 (GRCm39) probably null Het
C2cd3 G A 7: 100,021,704 (GRCm39) probably null Het
Cdhr18 C T 14: 13,829,796 (GRCm38) E649K probably damaging Het
Col18a1 G A 10: 76,895,131 (GRCm39) P1177S probably damaging Het
Copb2 T A 9: 98,462,213 (GRCm39) F428L probably benign Het
Cpa1 A G 6: 30,640,923 (GRCm39) E138G probably damaging Het
Ctsm T C 13: 61,686,249 (GRCm39) I12V possibly damaging Het
Dctn1 A G 6: 83,174,578 (GRCm39) Q967R possibly damaging Het
Dok2 T C 14: 71,014,393 (GRCm39) Y194H probably damaging Het
Ezh2 C T 6: 47,554,592 (GRCm39) M1I probably null Het
Fkbp8 T A 8: 70,984,282 (GRCm39) L210Q probably damaging Het
Fpr1 T A 17: 18,097,263 (GRCm39) Q242L probably benign Het
Gal3st2b T A 1: 93,868,505 (GRCm39) D243E probably damaging Het
Gm5422 A G 10: 31,125,802 (GRCm39) noncoding transcript Het
Gucy1a2 A G 9: 3,533,052 (GRCm39) N84D probably damaging Het
Hsd3b5 A C 3: 98,529,393 (GRCm39) V79G probably damaging Het
Htr6 A T 4: 138,788,804 (GRCm39) V417E probably benign Het
Ifnar2 G A 16: 91,188,755 (GRCm39) V79I probably benign Het
Ighv10-1 T C 12: 114,443,102 (GRCm39) probably benign Het
Itpr2 A G 6: 146,081,788 (GRCm39) F182L probably damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lama3 A G 18: 12,540,551 (GRCm39) Y285C probably damaging Het
Lamc2 C A 1: 153,034,680 (GRCm39) V108L possibly damaging Het
Lrrc14b A G 13: 74,509,373 (GRCm39) probably null Het
Magi3 T C 3: 103,958,493 (GRCm39) T531A probably benign Het
Mapre2 A G 18: 23,966,011 (GRCm39) Y32C probably damaging Het
Med1 C T 11: 98,046,452 (GRCm39) probably benign Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Nt5el C A 13: 105,218,749 (GRCm39) Q28K probably benign Het
Or51h1 A G 7: 102,308,408 (GRCm39) I127V probably damaging Het
Or5h23 G A 16: 58,906,408 (GRCm39) T146I probably benign Het
Or7a35 A T 10: 78,853,239 (GRCm39) I28L probably benign Het
Pde1b A G 15: 103,430,099 (GRCm39) T143A probably damaging Het
Pkhd1 T C 1: 20,593,121 (GRCm39) D1664G probably benign Het
Plod3 C T 5: 137,017,847 (GRCm39) R208W probably damaging Het
Pstk G A 7: 130,986,271 (GRCm39) A277T possibly damaging Het
Qrich1 T C 9: 108,411,684 (GRCm39) V403A probably damaging Het
Rad21 C A 15: 51,833,436 (GRCm39) V348F probably damaging Het
Sacs T A 14: 61,448,181 (GRCm39) L3409* probably null Het
Setd4 T A 16: 93,390,136 (GRCm39) K98* probably null Het
Skint5 A G 4: 113,341,123 (GRCm39) V1385A probably benign Het
Stam C A 2: 14,151,059 (GRCm39) S472* probably null Het
Stx2 A G 5: 129,069,289 (GRCm39) F141L probably damaging Het
Tia1 A G 6: 86,397,330 (GRCm39) D101G probably damaging Het
Ttc21a T A 9: 119,783,228 (GRCm39) probably null Het
Usp34 T A 11: 23,410,651 (GRCm39) N2700K probably damaging Het
Other mutations in Or10a3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01540:Or10a3b APN 7 108,444,887 (GRCm39) missense probably damaging 0.99
R0583:Or10a3b UTSW 7 108,444,621 (GRCm39) missense possibly damaging 0.87
R0939:Or10a3b UTSW 7 108,444,440 (GRCm39) missense probably damaging 1.00
R1037:Or10a3b UTSW 7 108,445,191 (GRCm39) missense probably benign 0.04
R1691:Or10a3b UTSW 7 108,444,348 (GRCm39) missense possibly damaging 0.60
R5153:Or10a3b UTSW 7 108,444,906 (GRCm39) missense probably benign 0.03
R6114:Or10a3b UTSW 7 108,444,593 (GRCm39) missense possibly damaging 0.53
R6305:Or10a3b UTSW 7 108,444,761 (GRCm39) missense possibly damaging 0.87
R6808:Or10a3b UTSW 7 108,444,747 (GRCm39) missense probably benign 0.01
R6896:Or10a3b UTSW 7 108,444,750 (GRCm39) missense probably benign
R7544:Or10a3b UTSW 7 108,444,528 (GRCm39) missense probably benign 0.39
R8998:Or10a3b UTSW 7 108,445,017 (GRCm39) missense probably benign 0.22
Predicted Primers PCR Primer
(F):5'- GCAAATCGATCATAAGCCATTGCCC -3'
(R):5'- TGAACTCAGCTCCTGCTCTGTGAC -3'

Sequencing Primer
(F):5'- TAAGCCATTGCCCCCAGG -3'
(R):5'- TGTACTGTGTCCCTAAGACCAAC -3'
Posted On 2014-04-24