Mutagenetix > Incidental Mutation

Incidental Mutation 'R1632:Mslnl'

172878

Institutional Source

Beutler Lab

Gene Symbol

Mslnl

Ensembl Gene

ENSMUSG00000041062

Gene Name

mesothelin-like

Synonyms

MMRRC Submission

039669-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1632 (G1)

Quality Score

203

Status

Not validated

Chromosome

Chromosomal Location

25736040-25748330 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 25742934 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 128 (V128M)

Ref Sequence

ENSEMBL: ENSMUSP00000049020 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047098]

AlphaFold

Q8C160

Predicted Effect

probably damaging
Transcript: ENSMUST00000047098
AA Change: V128M

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000049020
Gene: ENSMUSG00000041062
AA Change: V128M

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:Mesothelin	29	589	2.8e-70	PFAM
low complexity region	633	653	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000102319

Meta Mutation Damage Score

0.2148

Coding Region Coverage

1x: 99.1%
3x: 98.2%
10x: 95.8%
20x: 90.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810046K07Rik	T	C	9: 51,290,402	D118G	probably damaging	Het
AF529169	T	A	9: 89,602,360	H328L	probably damaging	Het
Alkbh2	C	T	5: 114,124,226	E148K	probably damaging	Het
Arhgap28	A	T	17: 67,849,074	Y696N	probably damaging	Het
C77080	A	G	4: 129,222,666	M735T	possibly damaging	Het
Cachd1	A	G	4: 100,966,972	T537A	probably benign	Het
Capn15	A	T	17: 25,960,665	F841Y	probably damaging	Het
Card10	G	A	15: 78,791,220	R396*	probably null	Het
Chd9	A	T	8: 90,956,707	K592*	probably null	Het
Cyp2j8	T	A	4: 96,447,324	H411L	probably benign	Het
Dhcr24	G	T	4: 106,585,951	M394I	probably benign	Het
Dhrs3	T	C	4: 144,893,546	V11A	probably benign	Het
Dync1li2	A	T	8: 104,437,491	I134N	probably damaging	Het
Enpp4	G	T	17: 44,099,653	S344Y	probably damaging	Het
Ephb3	T	C	16: 21,212,937	S14P	probably benign	Het
Fancm	T	G	12: 65,130,331	I1983S	probably damaging	Het
Fndc1	T	C	17: 7,773,200	T555A	unknown	Het
Gemin4	A	T	11: 76,210,989	M982K	probably benign	Het
Gtpbp2	A	G	17: 46,168,592	R590G	probably benign	Het
H2-M3	G	A	17: 37,271,163	R170H	probably benign	Het
Hoxa13	G	T	6: 52,259,937	N278K	probably damaging	Het
Hspb3	A	G	13: 113,663,053	V147A	probably benign	Het
Il6st	G	T	13: 112,504,332	D820Y	possibly damaging	Het
Kdm7a	A	G	6: 39,152,898	V448A	probably benign	Het
Kmt2b	T	C	7: 30,583,962	D991G	probably damaging	Het
Kri1	T	C	9: 21,282,211	D140G	possibly damaging	Het
Limk2	A	G	11: 3,346,250	L399P	probably damaging	Het
Lrrc9	T	A	12: 72,460,020		probably null	Het
Map2	C	T	1: 66,415,086	T1045M	possibly damaging	Het
Map4k5	T	C	12: 69,828,047	I321V	probably benign	Het
Mpp5	T	A	12: 78,797,038	Y5*	probably null	Het
Myh7b	A	G	2: 155,620,525	S383G	probably benign	Het
Nostrin	A	G	2: 69,175,734	K254R	probably benign	Het
Nphp1	G	T	2: 127,770,392	P212T	probably benign	Het
Olfr988	A	T	2: 85,353,242	M228K	possibly damaging	Het
Pclo	A	C	5: 14,680,003		probably benign	Het
Phf19	G	A	2: 34,911,619	R60W	probably damaging	Het
Psg18	G	A	7: 18,350,899	P91S	probably benign	Het
Rttn	C	T	18: 89,009,336	T525I	probably benign	Het
Ryr1	T	C	7: 29,094,261	M1268V	probably benign	Het
Slc25a2	T	C	18: 37,637,687	E263G	possibly damaging	Het
Slc32a1	C	T	2: 158,613,890	A155V	possibly damaging	Het
Slc6a19	A	T	13: 73,689,908		probably null	Het
Socs4	A	G	14: 47,289,577		probably benign	Het
Tas2r118	A	G	6: 23,969,261	I267T	probably benign	Het
Tpte	G	A	8: 22,349,347	C470Y	probably damaging	Het
Usp17la	A	T	7: 104,860,911	H241L	probably benign	Het
Vmn2r72	T	A	7: 85,751,792	I140F	probably benign	Het
Zfp329	T	C	7: 12,810,949	D216G	possibly damaging	Het

Other mutations in Mslnl

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01621:Mslnl	APN	17	25743667	unclassified	probably benign
IGL01629:Mslnl	APN	17	25744775	missense	possibly damaging	0.95
IGL02084:Mslnl	APN	17	25746151	missense	probably benign	0.07
IGL02408:Mslnl	APN	17	25747998	missense	possibly damaging	0.80
IGL02726:Mslnl	APN	17	25744103	critical splice donor site	probably null
IGL03387:Mslnl	APN	17	25744077	missense	probably benign	0.06
R0561:Mslnl	UTSW	17	25743203	nonsense	probably null
R0881:Mslnl	UTSW	17	25742965	missense	possibly damaging	0.82
R1295:Mslnl	UTSW	17	25743240	missense	probably damaging	1.00
R1296:Mslnl	UTSW	17	25743240	missense	probably damaging	1.00
R1582:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1629:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1630:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1631:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1794:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1850:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1866:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1876:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1914:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2166:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2241:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2243:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2247:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2282:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2284:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2852:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2867:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2867:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2877:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2878:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2919:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2920:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3026:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3405:Mslnl	UTSW	17	25746181	missense	probably damaging	1.00
R3406:Mslnl	UTSW	17	25746181	missense	probably damaging	1.00
R3411:Mslnl	UTSW	17	25744517	missense	probably benign	0.05
R3434:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3546:Mslnl	UTSW	17	25744969	missense	probably damaging	0.98
R3612:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3729:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3730:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3802:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3804:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3894:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3895:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4454:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4455:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4456:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4457:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4561:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4562:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4564:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4600:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4601:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4610:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4704:Mslnl	UTSW	17	25738978	missense	possibly damaging	0.73
R5155:Mslnl	UTSW	17	25738968	nonsense	probably null
R5257:Mslnl	UTSW	17	25746165	missense	probably benign	0.00
R5456:Mslnl	UTSW	17	25743159	missense	probably damaging	0.98
R5645:Mslnl	UTSW	17	25737842	missense	possibly damaging	0.95
R6007:Mslnl	UTSW	17	25746775	missense	probably benign	0.00
R6083:Mslnl	UTSW	17	25737902	missense	possibly damaging	0.83
R6142:Mslnl	UTSW	17	25744557	missense	probably damaging	1.00
R6761:Mslnl	UTSW	17	25746073	missense	probably damaging	1.00
R7058:Mslnl	UTSW	17	25743212	missense	probably benign	0.03
R7156:Mslnl	UTSW	17	25743210	missense	probably benign	0.20
R7467:Mslnl	UTSW	17	25736921	start codon destroyed	probably benign	0.33
R7687:Mslnl	UTSW	17	25743183	missense	probably damaging	0.97
R7807:Mslnl	UTSW	17	25746777	missense	probably benign	0.03
R8682:Mslnl	UTSW	17	25746988	missense	probably benign
R8735:Mslnl	UTSW	17	25745088	missense	probably benign	0.09
R8742:Mslnl	UTSW	17	25745073	missense	probably damaging	1.00
R9208:Mslnl	UTSW	17	25742720	missense	possibly damaging	0.94
R9264:Mslnl	UTSW	17	25742532	intron	probably benign
RF007:Mslnl	UTSW	17	25743228	missense	possibly damaging	0.87

Predicted Primers

PCR Primer
(F):5'- CTTTTCTACGAGTGAGTGCCCCTG -3'
(R):5'- GCAGTCACAATTTGTGCTGCCTC -3'

Sequencing Primer
(F):5'- TGCCCCTGCCATCAGAAG -3'
(R):5'- TCTGAAGCACTGAGCTGTAGG -3'

Posted On

2014-04-24