Incidental Mutation 'R1633:Cep162'
ID 172924
Institutional Source Beutler Lab
Gene Symbol Cep162
Ensembl Gene ENSMUSG00000056919
Gene Name centrosomal protein 162
Synonyms 4922501C03Rik
MMRRC Submission 039670-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R1633 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 87071630-87137589 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87085736 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 1196 (E1196G)
Ref Sequence ENSEMBL: ENSMUSP00000091319 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093802]
AlphaFold Q6ZQ06
Predicted Effect probably benign
Transcript: ENSMUST00000093802
AA Change: E1196G

PolyPhen 2 Score 0.232 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000091319
Gene: ENSMUSG00000056919
AA Change: E1196G

DomainStartEndE-ValueType
low complexity region 198 208 N/A INTRINSIC
low complexity region 528 539 N/A INTRINSIC
coiled coil region 630 674 N/A INTRINSIC
coiled coil region 695 899 N/A INTRINSIC
coiled coil region 953 1124 N/A INTRINSIC
coiled coil region 1235 1386 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139301
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157106
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 93.9%
  • 20x: 83.9%
Validation Efficiency 94% (68/72)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acmsd C T 1: 127,681,592 (GRCm39) A185V probably benign Het
Acsl6 T C 11: 54,219,224 (GRCm39) probably benign Het
Arel1 A G 12: 84,973,057 (GRCm39) F580S probably damaging Het
Arhgef19 T C 4: 140,965,871 (GRCm39) probably benign Het
Bpifb3 T A 2: 153,764,504 (GRCm39) L132Q probably damaging Het
Cacna2d1 T A 5: 16,525,114 (GRCm39) D516E probably damaging Het
Ccar1 T C 10: 62,586,793 (GRCm39) R882G unknown Het
Cpt1b T C 15: 89,303,018 (GRCm39) T649A probably damaging Het
Cttnbp2 A T 6: 18,435,166 (GRCm39) S231T probably damaging Het
Dock8 A G 19: 25,028,927 (GRCm39) T44A probably benign Het
Edrf1 T C 7: 133,253,869 (GRCm39) S536P probably damaging Het
Eif5 T A 12: 111,506,721 (GRCm39) N104K probably damaging Het
Enpp3 T C 10: 24,671,680 (GRCm39) Y438C probably damaging Het
Ess2 A G 16: 17,727,831 (GRCm39) V116A probably benign Het
Galnt4 T C 10: 98,945,814 (GRCm39) V513A possibly damaging Het
Gdpd5 T C 7: 99,097,720 (GRCm39) I172T probably benign Het
Ggt7 C T 2: 155,344,608 (GRCm39) G245D probably damaging Het
Gm5884 A T 6: 128,623,028 (GRCm39) noncoding transcript Het
Herc2 G A 7: 55,879,117 (GRCm39) G4669R probably null Het
Hydin T A 8: 111,233,614 (GRCm39) D1817E probably benign Het
Igf2r A C 17: 12,945,196 (GRCm39) N359K probably benign Het
Itgb4 T C 11: 115,898,586 (GRCm39) F1722L probably damaging Het
Itih3 T A 14: 30,639,355 (GRCm39) E406V possibly damaging Het
Lamc2 A T 1: 153,017,444 (GRCm39) C514* probably null Het
Mepe G T 5: 104,485,540 (GRCm39) V227F probably benign Het
Nadk C T 4: 155,661,642 (GRCm39) T56I probably damaging Het
Nedd4 G A 9: 72,578,539 (GRCm39) V84I possibly damaging Het
Nipal3 C A 4: 135,174,659 (GRCm39) R364L probably benign Het
Nkx2-9 T C 12: 56,659,766 (GRCm39) R27G probably benign Het
Noc2l T A 4: 156,329,750 (GRCm39) S600T probably benign Het
Or1l4b T A 2: 37,036,983 (GRCm39) I253N probably damaging Het
Or1o3 T A 17: 37,574,553 (GRCm39) M1L probably benign Het
Or2c1 A C 16: 3,657,396 (GRCm39) K186N probably damaging Het
Pax6 A T 2: 105,522,063 (GRCm39) E240V probably damaging Het
Pdilt T G 7: 119,087,217 (GRCm39) T478P probably damaging Het
Phldb1 T A 9: 44,629,619 (GRCm39) I25F probably damaging Het
Rad50 C T 11: 53,583,686 (GRCm39) R365Q probably benign Het
Rdh10 A G 1: 16,198,420 (GRCm39) E186G possibly damaging Het
Rdh12 A T 12: 79,265,498 (GRCm39) E224V probably damaging Het
Reck T C 4: 43,922,964 (GRCm39) V413A possibly damaging Het
Scn8a A G 15: 100,927,696 (GRCm39) I1392V probably benign Het
Simc1 G A 13: 54,673,044 (GRCm39) G464D probably benign Het
Srf A T 17: 46,862,534 (GRCm39) V318E probably damaging Het
Stab1 T C 14: 30,872,337 (GRCm39) probably null Het
Stk3 T C 15: 34,959,206 (GRCm39) D322G probably damaging Het
Stxbp4 A G 11: 90,430,986 (GRCm39) probably benign Het
Sult2a1 A G 7: 13,535,351 (GRCm39) I234T probably benign Het
Syne1 A G 10: 5,299,388 (GRCm39) F956L probably damaging Het
Tasor2 A T 13: 3,631,771 (GRCm39) I910N possibly damaging Het
Thsd7a G T 6: 12,471,103 (GRCm39) S505* probably null Het
Tmem63a T A 1: 180,776,391 (GRCm39) V67E probably damaging Het
Tram2 A T 1: 21,074,146 (GRCm39) V264E probably damaging Het
Trpv5 A T 6: 41,652,854 (GRCm39) C106* probably null Het
Tspyl5 T A 15: 33,686,791 (GRCm39) K385* probably null Het
Vezt T A 10: 93,820,138 (GRCm39) Q409L probably damaging Het
Vmn2r79 T C 7: 86,687,042 (GRCm39) C808R possibly damaging Het
Wdfy3 A C 5: 102,129,414 (GRCm39) V4G probably damaging Het
Wdr95 A T 5: 149,516,637 (GRCm39) I493F probably damaging Het
Zfhx4 A T 3: 5,465,473 (GRCm39) N1877I probably damaging Het
Zfp180 A G 7: 23,804,226 (GRCm39) D215G probably benign Het
Zfp442 A T 2: 150,250,260 (GRCm39) Y490* probably null Het
Zfp804b A G 5: 7,229,513 (GRCm39) probably benign Het
Other mutations in Cep162
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Cep162 APN 9 87,109,220 (GRCm39) missense probably benign 0.24
IGL00584:Cep162 APN 9 87,103,143 (GRCm39) splice site probably benign
IGL01387:Cep162 APN 9 87,093,864 (GRCm39) missense probably benign 0.08
IGL01862:Cep162 APN 9 87,135,986 (GRCm39) missense possibly damaging 0.90
IGL02304:Cep162 APN 9 87,109,200 (GRCm39) splice site probably benign
IGL02558:Cep162 APN 9 87,107,779 (GRCm39) missense probably benign
IGL02558:Cep162 APN 9 87,107,786 (GRCm39) missense probably benign 0.04
IGL02602:Cep162 APN 9 87,128,206 (GRCm39) missense probably benign 0.19
IGL02636:Cep162 APN 9 87,130,432 (GRCm39) missense possibly damaging 0.90
IGL02680:Cep162 APN 9 87,128,797 (GRCm39) missense possibly damaging 0.64
IGL03195:Cep162 APN 9 87,107,839 (GRCm39) missense probably benign 0.00
circus UTSW 9 87,088,915 (GRCm39) missense probably damaging 1.00
moscow UTSW 9 87,075,750 (GRCm39) missense probably damaging 1.00
smiley UTSW 9 87,099,134 (GRCm39) nonsense probably null
PIT4378001:Cep162 UTSW 9 87,099,198 (GRCm39) missense probably benign 0.01
PIT4431001:Cep162 UTSW 9 87,126,398 (GRCm39) missense probably benign 0.00
PIT4434001:Cep162 UTSW 9 87,075,701 (GRCm39) missense probably damaging 1.00
R0060:Cep162 UTSW 9 87,119,878 (GRCm39) splice site probably benign
R0218:Cep162 UTSW 9 87,093,862 (GRCm39) missense possibly damaging 0.73
R0366:Cep162 UTSW 9 87,102,537 (GRCm39) missense probably damaging 0.96
R0468:Cep162 UTSW 9 87,075,750 (GRCm39) missense probably damaging 1.00
R0764:Cep162 UTSW 9 87,083,798 (GRCm39) missense probably damaging 1.00
R1386:Cep162 UTSW 9 87,103,255 (GRCm39) missense probably benign
R1614:Cep162 UTSW 9 87,094,985 (GRCm39) missense probably damaging 1.00
R1831:Cep162 UTSW 9 87,088,985 (GRCm39) missense probably damaging 1.00
R1847:Cep162 UTSW 9 87,086,133 (GRCm39) missense probably benign 0.06
R1941:Cep162 UTSW 9 87,082,048 (GRCm39) missense probably benign 0.14
R2228:Cep162 UTSW 9 87,126,384 (GRCm39) missense probably benign 0.05
R2256:Cep162 UTSW 9 87,088,967 (GRCm39) missense probably damaging 1.00
R2257:Cep162 UTSW 9 87,088,967 (GRCm39) missense probably damaging 1.00
R2936:Cep162 UTSW 9 87,109,467 (GRCm39) missense probably benign
R3005:Cep162 UTSW 9 87,114,113 (GRCm39) missense probably benign 0.00
R3508:Cep162 UTSW 9 87,114,030 (GRCm39) critical splice donor site probably null
R3689:Cep162 UTSW 9 87,107,747 (GRCm39) nonsense probably null
R3743:Cep162 UTSW 9 87,099,230 (GRCm39) splice site probably benign
R4118:Cep162 UTSW 9 87,086,229 (GRCm39) missense probably benign 0.30
R4380:Cep162 UTSW 9 87,082,056 (GRCm39) missense probably damaging 0.99
R4450:Cep162 UTSW 9 87,107,861 (GRCm39) missense probably damaging 1.00
R4540:Cep162 UTSW 9 87,094,992 (GRCm39) missense probably damaging 1.00
R4598:Cep162 UTSW 9 87,085,848 (GRCm39) missense possibly damaging 0.95
R4700:Cep162 UTSW 9 87,088,915 (GRCm39) missense probably damaging 1.00
R4941:Cep162 UTSW 9 87,108,022 (GRCm39) intron probably benign
R5356:Cep162 UTSW 9 87,088,948 (GRCm39) missense probably damaging 1.00
R5468:Cep162 UTSW 9 87,109,290 (GRCm39) missense probably benign 0.00
R5579:Cep162 UTSW 9 87,085,724 (GRCm39) missense probably benign 0.26
R5859:Cep162 UTSW 9 87,086,145 (GRCm39) missense probably damaging 1.00
R6114:Cep162 UTSW 9 87,085,763 (GRCm39) missense probably benign
R6143:Cep162 UTSW 9 87,094,904 (GRCm39) critical splice donor site probably null
R6422:Cep162 UTSW 9 87,114,069 (GRCm39) missense possibly damaging 0.92
R6517:Cep162 UTSW 9 87,104,227 (GRCm39) missense probably damaging 0.99
R6576:Cep162 UTSW 9 87,099,198 (GRCm39) missense probably benign 0.01
R6782:Cep162 UTSW 9 87,093,737 (GRCm39) missense probably benign 0.07
R6867:Cep162 UTSW 9 87,099,134 (GRCm39) nonsense probably null
R7293:Cep162 UTSW 9 87,085,836 (GRCm39) missense probably benign 0.01
R7355:Cep162 UTSW 9 87,136,008 (GRCm39) nonsense probably null
R7391:Cep162 UTSW 9 87,130,547 (GRCm39) nonsense probably null
R7426:Cep162 UTSW 9 87,074,819 (GRCm39) missense probably damaging 1.00
R7593:Cep162 UTSW 9 87,086,250 (GRCm39) missense probably benign 0.40
R7710:Cep162 UTSW 9 87,114,172 (GRCm39) missense probably damaging 1.00
R7841:Cep162 UTSW 9 87,126,369 (GRCm39) missense probably benign 0.00
R7949:Cep162 UTSW 9 87,088,901 (GRCm39) missense probably benign 0.04
R8351:Cep162 UTSW 9 87,074,903 (GRCm39) nonsense probably null
R8451:Cep162 UTSW 9 87,074,903 (GRCm39) nonsense probably null
R8552:Cep162 UTSW 9 87,126,361 (GRCm39) missense probably benign 0.34
R8755:Cep162 UTSW 9 87,114,064 (GRCm39) missense probably benign 0.02
R8762:Cep162 UTSW 9 87,109,314 (GRCm39) missense probably benign 0.00
R9640:Cep162 UTSW 9 87,126,352 (GRCm39) missense probably benign 0.06
X0063:Cep162 UTSW 9 87,104,095 (GRCm39) critical splice donor site probably null
Z1177:Cep162 UTSW 9 87,082,033 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TGGCAGTTGGAATCAGCAGCAG -3'
(R):5'- GGGAATGCTTTCCCTGAAACCCTG -3'

Sequencing Primer
(F):5'- gggacttctgagcctcctg -3'
(R):5'- CTGGATGGCAAACTGTATCAC -3'
Posted On 2014-04-24