Mutagenetix > Incidental Mutations

Incidental Mutation 'R1635:Kmt2a'

173082

Institutional Source

Beutler Lab

Gene Symbol

Kmt2a

Ensembl Gene

ENSMUSG00000002028

Gene Name

lysine (K)-specific methyltransferase 2A

Synonyms

Mll1, HTRX1, ALL-1, Cxxc7, trithorax Drosophila, Mll, All1

Accession Numbers

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

R1635 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

44803355-44881296 bp(-) (GRCm38)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

A to T at 44824369 bp

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000002095] [ENSMUST00000114689]

Predicted Effect

unknown
Transcript: ENSMUST00000002095
AA Change: N2034K

SMART Domains

Protein: ENSMUSP00000002095
Gene: ENSMUSG00000002028
AA Change: N2034K

Domain	Start	End	E-Value	Type
low complexity region	14	29	N/A	INTRINSIC
low complexity region	41	102	N/A	INTRINSIC
PDB:3U88\|N	103	151	6e-15	PDB
AT_hook	171	183	2.12e2	SMART
AT_hook	217	229	4.68e1	SMART
AT_hook	298	310	2.8e0	SMART
coiled coil region	366	394	N/A	INTRINSIC
low complexity region	450	489	N/A	INTRINSIC
low complexity region	524	535	N/A	INTRINSIC
low complexity region	544	574	N/A	INTRINSIC
low complexity region	589	601	N/A	INTRINSIC
low complexity region	660	674	N/A	INTRINSIC
low complexity region	717	732	N/A	INTRINSIC
low complexity region	760	790	N/A	INTRINSIC
low complexity region	866	892	N/A	INTRINSIC
low complexity region	989	1005	N/A	INTRINSIC
Pfam:zf-CXXC	1144	1191	1.1e-15	PFAM
low complexity region	1204	1233	N/A	INTRINSIC
low complexity region	1236	1283	N/A	INTRINSIC
low complexity region	1295	1316	N/A	INTRINSIC
low complexity region	1323	1345	N/A	INTRINSIC
low complexity region	1353	1366	N/A	INTRINSIC
PHD	1432	1479	5.57e-3	SMART
PHD	1480	1530	1.17e-10	SMART
PHD	1567	1624	7.94e-8	SMART
BROMO	1632	1766	2.24e-10	SMART
low complexity region	1816	1850	N/A	INTRINSIC
PHD	1931	1977	1.74e-4	SMART
low complexity region	1990	2001	N/A	INTRINSIC
FYRN	2029	2072	2.33e-20	SMART
low complexity region	2180	2194	N/A	INTRINSIC
low complexity region	2215	2227	N/A	INTRINSIC
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2789	2800	N/A	INTRINSIC
low complexity region	2824	2833	N/A	INTRINSIC
low complexity region	2856	2878	N/A	INTRINSIC
low complexity region	2902	2909	N/A	INTRINSIC
low complexity region	3115	3141	N/A	INTRINSIC
low complexity region	3164	3175	N/A	INTRINSIC
low complexity region	3228	3239	N/A	INTRINSIC
low complexity region	3299	3312	N/A	INTRINSIC
low complexity region	3342	3351	N/A	INTRINSIC
low complexity region	3405	3419	N/A	INTRINSIC
low complexity region	3498	3526	N/A	INTRINSIC
low complexity region	3620	3633	N/A	INTRINSIC
FYRC	3662	3747	8.54e-37	SMART
SET	3823	3945	6.09e-45	SMART
PostSET	3947	3963	1.65e-4	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000114689
AA Change: N2037K

SMART Domains

Protein: ENSMUSP00000110337
Gene: ENSMUSG00000002028
AA Change: N2037K

Domain	Start	End	E-Value	Type
low complexity region	14	29	N/A	INTRINSIC
low complexity region	41	102	N/A	INTRINSIC
PDB:3U88\|N	103	151	6e-15	PDB
AT_hook	171	183	2.12e2	SMART
AT_hook	217	229	4.68e1	SMART
AT_hook	298	310	2.8e0	SMART
coiled coil region	366	394	N/A	INTRINSIC
low complexity region	450	489	N/A	INTRINSIC
low complexity region	524	535	N/A	INTRINSIC
low complexity region	544	574	N/A	INTRINSIC
low complexity region	589	601	N/A	INTRINSIC
low complexity region	660	674	N/A	INTRINSIC
low complexity region	717	732	N/A	INTRINSIC
low complexity region	760	790	N/A	INTRINSIC
low complexity region	866	892	N/A	INTRINSIC
low complexity region	989	1005	N/A	INTRINSIC
Pfam:zf-CXXC	1144	1191	1.1e-15	PFAM
low complexity region	1204	1233	N/A	INTRINSIC
low complexity region	1236	1283	N/A	INTRINSIC
low complexity region	1295	1316	N/A	INTRINSIC
low complexity region	1323	1345	N/A	INTRINSIC
low complexity region	1353	1366	N/A	INTRINSIC
PHD	1432	1479	5.57e-3	SMART
PHD	1480	1530	1.17e-10	SMART
PHD	1567	1627	9.12e-8	SMART
BROMO	1635	1769	2.24e-10	SMART
low complexity region	1819	1853	N/A	INTRINSIC
PHD	1934	1980	1.74e-4	SMART
low complexity region	1993	2004	N/A	INTRINSIC
FYRN	2032	2075	2.33e-20	SMART
low complexity region	2183	2197	N/A	INTRINSIC
low complexity region	2218	2230	N/A	INTRINSIC
low complexity region	2610	2621	N/A	INTRINSIC
low complexity region	2792	2803	N/A	INTRINSIC
low complexity region	2827	2836	N/A	INTRINSIC
low complexity region	2859	2881	N/A	INTRINSIC
low complexity region	2905	2912	N/A	INTRINSIC
low complexity region	3118	3144	N/A	INTRINSIC
low complexity region	3167	3178	N/A	INTRINSIC
low complexity region	3231	3242	N/A	INTRINSIC
low complexity region	3302	3315	N/A	INTRINSIC
low complexity region	3345	3354	N/A	INTRINSIC
low complexity region	3408	3422	N/A	INTRINSIC
low complexity region	3501	3529	N/A	INTRINSIC
low complexity region	3623	3636	N/A	INTRINSIC
FYRC	3665	3750	8.54e-37	SMART
SET	3826	3948	6.09e-45	SMART
PostSET	3950	3966	1.65e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000138119

Predicted Effect

probably benign
Transcript: ENSMUST00000152241

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.0%
20x: 91.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
PHENOTYPE: Homozygotes for targeted null mutations die at embryonic day 11.5-14.5 with edematous bodies, petechiae, and hematopoietic insufficiency. Heterozygotes show reduced growth, hematopoietic abnormalities, and homeotic transformations of the axial skeleton. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 95 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca2	A	T	2: 25,444,856	I1947F	probably benign	Het
Adgrd1	G	T	5: 129,128,907	V182F	probably damaging	Het
Agmat	A	G	4: 141,747,069	D87G	probably damaging	Het
AI182371	T	C	2: 35,088,737		probably null	Het
Anapc1	G	T	2: 128,628,532	H1559Q	probably damaging	Het
Ankar	T	C	1: 72,650,138	Y1278C	probably damaging	Het
Arhgef2	A	T	3: 88,639,321		probably null	Het
Arsi	G	A	18: 60,916,651	G202E	probably benign	Het
Banp	A	T	8: 122,001,011	I130F	probably damaging	Het
C130050O18Rik	G	T	5: 139,414,493	R100S	probably benign	Het
Carmil3	A	G	14: 55,496,282	T374A	possibly damaging	Het
Cc2d2a	T	A	5: 43,722,470	W1076R	probably damaging	Het
Cdc34	T	G	10: 79,688,054	S235A	probably benign	Het
Cdh8	G	T	8: 99,031,024	H647Q	probably damaging	Het
Cdk1	A	T	10: 69,338,547	L282Q	probably damaging	Het
Ceacam3	A	G	7: 17,159,977	D471G	probably damaging	Het
Cltc	A	T	11: 86,757,279	I4N	probably benign	Het
Cntfr	T	A	4: 41,658,816	E305V	probably damaging	Het
Cwh43	T	A	5: 73,434,310	I496N	probably damaging	Het
Cyp2f2	A	G	7: 27,129,724	N218S	probably benign	Het
D16Ertd472e	A	G	16: 78,546,504		probably null	Het
Dab2	A	G	15: 6,429,870	Q400R	possibly damaging	Het
Dapl1	A	T	2: 59,496,562	I51F	probably benign	Het
Drc7	G	A	8: 95,074,332		probably null	Het
Etl4	A	G	2: 20,806,408	T1101A	probably damaging	Het
Fam83c	C	A	2: 155,830,051	R488M	possibly damaging	Het
Fam96b	A	T	8: 104,640,988	I108N	possibly damaging	Het
Fbxo42	A	G	4: 141,200,529	T707A	probably damaging	Het
Fcmr	A	T	1: 130,876,185		probably null	Het
Fer1l6	G	C	15: 58,647,081	K1687N	probably damaging	Het
Fgd4	G	A	16: 16,475,029	R275*	probably null	Het
Fxr2	G	A	11: 69,641,313	C87Y	possibly damaging	Het
Gja4	A	T	4: 127,312,679	I97N	probably damaging	Het
Gm136	A	G	4: 34,750,919		probably null	Het
Gm14496	A	G	2: 182,001,044	D836G	possibly damaging	Het
Gm8882	A	G	6: 132,363,006		probably null	Het
Grm3	T	A	5: 9,511,520	T777S	probably damaging	Het
Guca2b	A	G	4: 119,657,715	Y50H	probably damaging	Het
Herc2	C	T	7: 56,136,667	P1587S	probably benign	Het
Hmcn1	C	T	1: 150,669,558	S2766N	probably benign	Het
Idi2	T	A	13: 8,959,419	I224K	probably damaging	Het
Lonp2	A	T	8: 86,713,450	M693L	possibly damaging	Het
Megf8	G	T	7: 25,346,747	M1525I	possibly damaging	Het
Mgme1	T	C	2: 144,279,098	V276A	possibly damaging	Het
Mief2	G	T	11: 60,731,408	W268L	probably damaging	Het
Mpped1	C	T	15: 83,791,990		probably benign	Het
Mreg	T	C	1: 72,192,197	N34S	probably benign	Het
Myf6	T	C	10: 107,494,673	Y11C	probably damaging	Het
Myh9	C	A	15: 77,771,167	Q1196H	probably benign	Het
Myh9	A	T	15: 77,775,899	D56E	probably benign	Het
Myo5c	A	T	9: 75,277,075	R949S	probably benign	Het
Ncapg2	TAA	TA	12: 116,434,685		probably null	Het
Nfx1	T	A	4: 40,977,004	V226E	probably benign	Het
Nlrp10	T	A	7: 108,924,530	K581M	possibly damaging	Het
Nmd3	T	G	3: 69,739,984	I273S	probably benign	Het
Olfr1264	A	T	2: 90,021,970	I32N	possibly damaging	Het
P4hb	T	C	11: 120,571,616	E88G	probably damaging	Het
Pcnx3	A	T	19: 5,665,745	H1444Q	probably benign	Het
Pdia4	A	T	6: 47,799,199	F421L	possibly damaging	Het
Picalm	T	A	7: 90,191,251	S538T	probably damaging	Het
Ppp2r2b	T	A	18: 43,059,210	I11F	probably benign	Het
Ptk7	C	T	17: 46,573,534	E757K	possibly damaging	Het
Rbm22	T	G	18: 60,561,268	C24W	probably damaging	Het
Rev3l	A	G	10: 39,806,662	D288G	probably damaging	Het
Rgs18	T	A	1: 144,754,053	H156L	probably benign	Het
Rnf213	A	G	11: 119,442,579	I2871M	probably damaging	Het
Rrm2b	A	T	15: 37,945,084	M137K	probably damaging	Het
Rrp12	A	T	19: 41,868,785	D1183E	probably benign	Het
Sacs	G	A	14: 61,203,828	V1108M	probably damaging	Het
Scube2	A	T	7: 109,843,214	D270E	possibly damaging	Het
Serpina3a	T	A	12: 104,116,478	F170Y	probably damaging	Het
Serpinb3b	T	C	1: 107,154,673	E287G	probably benign	Het
Slamf8	C	T	1: 172,584,619	V130M	probably damaging	Het
Slc5a3	T	C	16: 92,077,396	S114P	possibly damaging	Het
Sos1	T	A	17: 80,422,679		probably null	Het
Sox10	A	T	15: 79,156,460	D293E	probably damaging	Het
Sphk1	A	G	11: 116,535,770	D177G	probably damaging	Het
Sphkap	T	G	1: 83,278,400	M543L	probably benign	Het
Syt13	A	T	2: 92,953,415	K343N	probably damaging	Het
Tatdn3	A	G	1: 191,060,176	M34T	probably benign	Het
Timd4	T	G	11: 46,842,162	V305G	possibly damaging	Het
Tnnc2	T	C	2: 164,777,592	I111V	probably benign	Het
Togaram2	C	T	17: 71,697,851	P301L	probably benign	Het
Trpc3	T	C	3: 36,640,627	N726S	probably damaging	Het
Tspear	T	A	10: 77,870,419	L341H	possibly damaging	Het
Ugt1a5	T	A	1: 88,166,083		probably benign	Het
Ulk3	A	T	9: 57,593,160		probably null	Het
Unc5d	T	A	8: 28,760,749	I297L	probably benign	Het
Usp20	A	G	2: 31,018,818	I804V	probably benign	Het
Usp22	G	T	11: 61,161,318	C278*	probably null	Het
Usp53	A	T	3: 122,934,223	N903K	probably benign	Het
V1rd19	T	C	7: 24,003,387	F93L	probably benign	Het
Zdbf2	T	A	1: 63,304,334	V624E	possibly damaging	Het
Zfyve16	A	T	13: 92,509,020	S1073T	probably damaging	Het
Zkscan8	T	C	13: 21,526,595	H115R	possibly damaging	Het

Other mutations in Kmt2a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00492:Kmt2a	APN	9	44807934	unclassified	probably benign
IGL00667:Kmt2a	APN	9	44824386	utr 3 prime	probably benign
IGL00828:Kmt2a	APN	9	44820776	unclassified	probably benign
IGL01080:Kmt2a	APN	9	44809092	missense	unknown
IGL01131:Kmt2a	APN	9	44821170	unclassified	probably benign
IGL01294:Kmt2a	APN	9	44820297	unclassified	probably benign
IGL01432:Kmt2a	APN	9	44809096	missense	unknown
IGL01646:Kmt2a	APN	9	44825484	utr 3 prime	probably benign
IGL01777:Kmt2a	APN	9	44849005	missense	probably damaging	0.99
IGL01944:Kmt2a	APN	9	44849767	missense	probably damaging	1.00
IGL02125:Kmt2a	APN	9	44848686	missense	probably damaging	1.00
IGL02207:Kmt2a	APN	9	44847682	missense	probably damaging	0.98
IGL02424:Kmt2a	APN	9	44824635	utr 3 prime	probably benign
IGL02499:Kmt2a	APN	9	44830509	splice site	probably benign
IGL02574:Kmt2a	APN	9	44830513	splice site	probably benign
IGL02711:Kmt2a	APN	9	44824523	splice site	probably benign
IGL02828:Kmt2a	APN	9	44821947	unclassified	probably benign
IGL03012:Kmt2a	APN	9	44810966	unclassified	probably benign
IGL03242:Kmt2a	APN	9	44848392	missense	probably damaging	0.99
IGL03294:Kmt2a	APN	9	44820565	unclassified	probably benign
IGL03326:Kmt2a	APN	9	44818747	nonsense	probably null
Chromas	UTSW	9	44820342	unclassified	probably benign
Heteros	UTSW	9	44828811	nonsense	probably null
Pyknos	UTSW	9	44826828	utr 3 prime	probably benign
Skies	UTSW	9	44829261	utr 3 prime	probably benign
spacious	UTSW	9	44847645	missense	probably benign	0.03
PIT4402001:Kmt2a	UTSW	9	44841062	missense	unknown
R0076:Kmt2a	UTSW	9	44830059	utr 3 prime	probably benign
R0076:Kmt2a	UTSW	9	44830059	utr 3 prime	probably benign
R0180:Kmt2a	UTSW	9	44826851	utr 3 prime	probably benign
R0363:Kmt2a	UTSW	9	44809713	critical splice donor site	probably null
R0411:Kmt2a	UTSW	9	44819964	unclassified	probably benign
R0555:Kmt2a	UTSW	9	44847571	missense	probably damaging	1.00
R0587:Kmt2a	UTSW	9	44847534	missense	probably damaging	0.99
R0865:Kmt2a	UTSW	9	44818770	unclassified	probably benign
R0988:Kmt2a	UTSW	9	44848549	missense	probably benign	0.03
R1006:Kmt2a	UTSW	9	44847696	missense	probably damaging	0.99
R1108:Kmt2a	UTSW	9	44849062	missense	probably damaging	1.00
R1292:Kmt2a	UTSW	9	44814694	utr 3 prime	probably benign
R1322:Kmt2a	UTSW	9	44821121	unclassified	probably benign
R1476:Kmt2a	UTSW	9	44824635	utr 3 prime	probably benign
R1485:Kmt2a	UTSW	9	44826928	utr 3 prime	probably benign
R1487:Kmt2a	UTSW	9	44833990	utr 3 prime	probably benign
R1493:Kmt2a	UTSW	9	44846905	missense	probably damaging	1.00
R1499:Kmt2a	UTSW	9	44848266	missense	probably benign	0.36
R1507:Kmt2a	UTSW	9	44818403	unclassified	probably benign
R1603:Kmt2a	UTSW	9	44841561	unclassified	probably null
R1662:Kmt2a	UTSW	9	44836670	utr 3 prime	probably benign
R1711:Kmt2a	UTSW	9	44841621	missense	unknown
R1785:Kmt2a	UTSW	9	44819675	unclassified	probably benign
R1786:Kmt2a	UTSW	9	44819675	unclassified	probably benign
R1919:Kmt2a	UTSW	9	44820345	unclassified	probably benign
R1964:Kmt2a	UTSW	9	44820644	missense	probably benign	0.23
R1965:Kmt2a	UTSW	9	44821460	unclassified	probably benign
R2029:Kmt2a	UTSW	9	44818450	missense	probably benign	0.23
R2054:Kmt2a	UTSW	9	44823374	utr 3 prime	probably benign
R2259:Kmt2a	UTSW	9	44881142	unclassified	probably benign
R2382:Kmt2a	UTSW	9	44820910	unclassified	probably benign
R2483:Kmt2a	UTSW	9	44848966	missense	probably damaging	0.99
R3033:Kmt2a	UTSW	9	44821863	unclassified	probably benign
R3423:Kmt2a	UTSW	9	44820097	unclassified	probably benign
R3428:Kmt2a	UTSW	9	44848119	missense	probably benign	0.06
R3605:Kmt2a	UTSW	9	44849196	missense	probably damaging	1.00
R3607:Kmt2a	UTSW	9	44849196	missense	probably damaging	1.00
R3611:Kmt2a	UTSW	9	44822466	unclassified	probably benign
R3623:Kmt2a	UTSW	9	44848966	missense	probably damaging	0.99
R3745:Kmt2a	UTSW	9	44831340	utr 3 prime	probably benign
R3806:Kmt2a	UTSW	9	44820356	unclassified	probably benign
R3841:Kmt2a	UTSW	9	44831291	utr 3 prime	probably benign
R3855:Kmt2a	UTSW	9	44830499	utr 3 prime	probably benign
R4027:Kmt2a	UTSW	9	44836693	utr 3 prime	probably benign
R4124:Kmt2a	UTSW	9	44819796	unclassified	probably benign
R4177:Kmt2a	UTSW	9	44820983	unclassified	probably benign
R4296:Kmt2a	UTSW	9	44821175	unclassified	probably benign
R4414:Kmt2a	UTSW	9	44809780	unclassified	probably benign
R4461:Kmt2a	UTSW	9	44848966	missense	probably damaging	0.99
R4668:Kmt2a	UTSW	9	44824572	utr 3 prime	probably benign
R4761:Kmt2a	UTSW	9	44849124	missense	probably damaging	1.00
R4812:Kmt2a	UTSW	9	44831354	utr 3 prime	probably benign
R4815:Kmt2a	UTSW	9	44821256	unclassified	probably benign
R4817:Kmt2a	UTSW	9	44821466	unclassified	probably benign
R4888:Kmt2a	UTSW	9	44821680	unclassified	probably benign
R4958:Kmt2a	UTSW	9	44848467	missense	probably damaging	1.00
R5055:Kmt2a	UTSW	9	44818352	unclassified	probably benign
R5065:Kmt2a	UTSW	9	44842700	unclassified	probably benign
R5185:Kmt2a	UTSW	9	44820246	unclassified	probably benign
R5358:Kmt2a	UTSW	9	44819274	unclassified	probably benign
R5411:Kmt2a	UTSW	9	44848485	missense	probably damaging	1.00
R5420:Kmt2a	UTSW	9	44848336	missense	probably damaging	1.00
R5483:Kmt2a	UTSW	9	44824624	utr 3 prime	probably benign
R5487:Kmt2a	UTSW	9	44821975	unclassified	probably benign
R5488:Kmt2a	UTSW	9	44841038	utr 3 prime	probably benign
R5489:Kmt2a	UTSW	9	44841038	utr 3 prime	probably benign
R5538:Kmt2a	UTSW	9	44820342	unclassified	probably benign
R5576:Kmt2a	UTSW	9	44842634	missense	possibly damaging	0.94
R5631:Kmt2a	UTSW	9	44820688	unclassified	probably benign
R5781:Kmt2a	UTSW	9	44847842	nonsense	probably null
R5789:Kmt2a	UTSW	9	44819904	unclassified	probably benign
R5932:Kmt2a	UTSW	9	44820647	unclassified	probably benign
R6027:Kmt2a	UTSW	9	44819290	unclassified	probably benign
R6191:Kmt2a	UTSW	9	44826828	utr 3 prime	probably benign
R6239:Kmt2a	UTSW	9	44819796	unclassified	probably benign
R6291:Kmt2a	UTSW	9	44832874	utr 3 prime	probably benign
R6344:Kmt2a	UTSW	9	44821859	unclassified	probably benign
R6611:Kmt2a	UTSW	9	44849272	missense	probably damaging	0.98
R6641:Kmt2a	UTSW	9	44819835	unclassified	probably benign
R6651:Kmt2a	UTSW	9	44828811	nonsense	probably null
R6825:Kmt2a	UTSW	9	44818407	unclassified	probably benign
R6853:Kmt2a	UTSW	9	44818407	unclassified	probably benign
R6897:Kmt2a	UTSW	9	44847645	missense	probably benign	0.03
R6930:Kmt2a	UTSW	9	44842665	unclassified	probably benign
R6932:Kmt2a	UTSW	9	44829261	utr 3 prime	probably benign
R6957:Kmt2a	UTSW	9	44820022	unclassified	probably benign
R7170:Kmt2a	UTSW	9	44810721	missense	unknown
R7202:Kmt2a	UTSW	9	44847715	missense	probably benign	0.03
R7481:Kmt2a	UTSW	9	44809071	missense	unknown
R7538:Kmt2a	UTSW	9	44847744	missense	probably damaging	0.99
R7597:Kmt2a	UTSW	9	44831353	missense	unknown
R7741:Kmt2a	UTSW	9	44808062	missense	unknown
R7767:Kmt2a	UTSW	9	44818998	missense	unknown
R7768:Kmt2a	UTSW	9	44820603	missense	unknown
X0021:Kmt2a	UTSW	9	44831235	utr 3 prime	probably benign
X0025:Kmt2a	UTSW	9	44825392	nonsense	probably null
X0026:Kmt2a	UTSW	9	44820906	unclassified	probably benign
X0027:Kmt2a	UTSW	9	44880896	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- GGGGACTGGATCTTACATTGTCAGC -3'
(R):5'- ACATGATGATAGGTAGGACCCAGGC -3'

Sequencing Primer
(F):5'- aatcccagcactcacgac -3'
(R):5'- CTTCCTTAATGGGGAGGGTCTATT -3'

Posted On

2014-04-24