Incidental Mutation 'R1635:Dab2'
| ID |
173111 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dab2
|
| Ensembl Gene |
ENSMUSG00000022150 |
| Gene Name |
disabled 2, mitogen-responsive phosphoprotein |
| Synonyms |
5730435J12Rik, D15Wsu122e, D630005B22Rik, p96 |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.917)
|
| Stock # |
R1635 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
6329269-6470193 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 6459351 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Arginine
at position 400
(Q400R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106292
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000078019]
[ENSMUST00000080880]
[ENSMUST00000110663]
[ENSMUST00000110664]
[ENSMUST00000160134]
[ENSMUST00000161040]
[ENSMUST00000161812]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000078019
|
| SMART Domains |
Protein: ENSMUSP00000077166
Gene: ENSMUSG00000022150
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
PTB
|
45 |
179 |
1.16e-27 |
SMART |
|
low complexity region
|
270 |
288 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
306 |
N/A |
INTRINSIC |
|
low complexity region
|
335 |
355 |
N/A |
INTRINSIC |
|
low complexity region
|
378 |
394 |
N/A |
INTRINSIC |
|
PDB:3H8D|H
|
465 |
493 |
2e-12 |
PDB |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000080880
AA Change: Q421R
PolyPhen 2
Score 0.777 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000079689
Gene: ENSMUSG00000022150
AA Change: Q421R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
PTB
|
45 |
179 |
1.16e-27 |
SMART |
|
low complexity region
|
488 |
506 |
N/A |
INTRINSIC |
|
low complexity region
|
510 |
524 |
N/A |
INTRINSIC |
|
low complexity region
|
553 |
573 |
N/A |
INTRINSIC |
|
low complexity region
|
596 |
612 |
N/A |
INTRINSIC |
|
PDB:3H8D|H
|
683 |
711 |
3e-12 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110663
|
| SMART Domains |
Protein: ENSMUSP00000106291
Gene: ENSMUSG00000022150
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
PTB
|
45 |
179 |
1.16e-27 |
SMART |
|
low complexity region
|
270 |
288 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
306 |
N/A |
INTRINSIC |
|
low complexity region
|
335 |
355 |
N/A |
INTRINSIC |
|
low complexity region
|
378 |
394 |
N/A |
INTRINSIC |
|
PDB:3H8D|H
|
465 |
493 |
2e-12 |
PDB |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000110664
AA Change: Q400R
PolyPhen 2
Score 0.795 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000106292
Gene: ENSMUSG00000022150
AA Change: Q400R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
PTB
|
45 |
179 |
1.16e-27 |
SMART |
|
low complexity region
|
467 |
485 |
N/A |
INTRINSIC |
|
low complexity region
|
489 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
532 |
552 |
N/A |
INTRINSIC |
|
low complexity region
|
575 |
591 |
N/A |
INTRINSIC |
|
PDB:3H8D|H
|
662 |
690 |
3e-12 |
PDB |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159552
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160134
|
| SMART Domains |
Protein: ENSMUSP00000125021
Gene: ENSMUSG00000022150
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
PTB
|
45 |
179 |
1.16e-27 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161040
|
| SMART Domains |
Protein: ENSMUSP00000124478
Gene: ENSMUSG00000022150
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
PTB
|
45 |
179 |
1.16e-27 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000163082
AA Change: Q288R
|
| SMART Domains |
Protein: ENSMUSP00000124996
Gene: ENSMUSG00000022150
AA Change: Q288R
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:PTB
|
2 |
59 |
1e-33 |
BLAST |
|
PDB:1P3R|C
|
2 |
59 |
2e-34 |
PDB |
|
SCOP:d1ddma_
|
3 |
59 |
9e-12 |
SMART |
|
low complexity region
|
60 |
79 |
N/A |
INTRINSIC |
|
low complexity region
|
356 |
374 |
N/A |
INTRINSIC |
|
low complexity region
|
378 |
392 |
N/A |
INTRINSIC |
|
low complexity region
|
421 |
441 |
N/A |
INTRINSIC |
|
low complexity region
|
464 |
480 |
N/A |
INTRINSIC |
|
PDB:3H8D|H
|
551 |
579 |
3e-12 |
PDB |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161558
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161812
|
| SMART Domains |
Protein: ENSMUSP00000124589
Gene: ENSMUSG00000022150
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
PTB
|
45 |
179 |
1.16e-27 |
SMART |
|
low complexity region
|
249 |
267 |
N/A |
INTRINSIC |
|
low complexity region
|
271 |
285 |
N/A |
INTRINSIC |
|
low complexity region
|
314 |
334 |
N/A |
INTRINSIC |
|
low complexity region
|
357 |
373 |
N/A |
INTRINSIC |
|
PDB:3H8D|H
|
444 |
472 |
2e-12 |
PDB |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.0%
- 20x: 91.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous null mutants exhibit abnormal primitive endoderm structure and/or function, lack a proamniotic cavity and die prior to embryonic day 9.5. A conditional mutant survives, but shows kidney proximal tubule abnormality. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(4) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(1) |
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca2 |
A |
T |
2: 25,334,868 (GRCm39) |
I1947F |
probably benign |
Het |
| Adgrd1 |
G |
T |
5: 129,205,971 (GRCm39) |
V182F |
probably damaging |
Het |
| Agmat |
A |
G |
4: 141,474,380 (GRCm39) |
D87G |
probably damaging |
Het |
| AI182371 |
T |
C |
2: 34,978,749 (GRCm39) |
|
probably null |
Het |
| Anapc1 |
G |
T |
2: 128,470,452 (GRCm39) |
H1559Q |
probably damaging |
Het |
| Ankar |
T |
C |
1: 72,689,297 (GRCm39) |
Y1278C |
probably damaging |
Het |
| Arhgef2 |
A |
T |
3: 88,546,628 (GRCm39) |
|
probably null |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| Banp |
A |
T |
8: 122,727,750 (GRCm39) |
I130F |
probably damaging |
Het |
| C130050O18Rik |
G |
T |
5: 139,400,248 (GRCm39) |
R100S |
probably benign |
Het |
| Carmil3 |
A |
G |
14: 55,733,739 (GRCm39) |
T374A |
possibly damaging |
Het |
| Cc2d2a |
T |
A |
5: 43,879,812 (GRCm39) |
W1076R |
probably damaging |
Het |
| Cdc34 |
T |
G |
10: 79,523,888 (GRCm39) |
S235A |
probably benign |
Het |
| Cdh8 |
G |
T |
8: 99,757,656 (GRCm39) |
H647Q |
probably damaging |
Het |
| Cdk1 |
A |
T |
10: 69,174,377 (GRCm39) |
L282Q |
probably damaging |
Het |
| Ceacam3 |
A |
G |
7: 16,893,902 (GRCm39) |
D471G |
probably damaging |
Het |
| Ciao2b |
A |
T |
8: 105,367,620 (GRCm39) |
I108N |
possibly damaging |
Het |
| Cltc |
A |
T |
11: 86,648,105 (GRCm39) |
I4N |
probably benign |
Het |
| Cntfr |
T |
A |
4: 41,658,816 (GRCm39) |
E305V |
probably damaging |
Het |
| Cwh43 |
T |
A |
5: 73,591,653 (GRCm39) |
I496N |
probably damaging |
Het |
| Cyp2f2 |
A |
G |
7: 26,829,149 (GRCm39) |
N218S |
probably benign |
Het |
| D16Ertd472e |
A |
G |
16: 78,343,392 (GRCm39) |
|
probably null |
Het |
| Dapl1 |
A |
T |
2: 59,326,906 (GRCm39) |
I51F |
probably benign |
Het |
| Drc7 |
G |
A |
8: 95,800,960 (GRCm39) |
|
probably null |
Het |
| Etl4 |
A |
G |
2: 20,811,219 (GRCm39) |
T1101A |
probably damaging |
Het |
| Fam83c |
C |
A |
2: 155,671,971 (GRCm39) |
R488M |
possibly damaging |
Het |
| Fbxo42 |
A |
G |
4: 140,927,840 (GRCm39) |
T707A |
probably damaging |
Het |
| Fcmr |
A |
T |
1: 130,803,922 (GRCm39) |
|
probably null |
Het |
| Fer1l6 |
G |
C |
15: 58,518,930 (GRCm39) |
K1687N |
probably damaging |
Het |
| Fgd4 |
G |
A |
16: 16,292,893 (GRCm39) |
R275* |
probably null |
Het |
| Fxr2 |
G |
A |
11: 69,532,139 (GRCm39) |
C87Y |
possibly damaging |
Het |
| Gja4 |
A |
T |
4: 127,206,472 (GRCm39) |
I97N |
probably damaging |
Het |
| Gm136 |
A |
G |
4: 34,750,919 (GRCm39) |
|
probably null |
Het |
| Gm14496 |
A |
G |
2: 181,642,837 (GRCm39) |
D836G |
possibly damaging |
Het |
| Grm3 |
T |
A |
5: 9,561,520 (GRCm39) |
T777S |
probably damaging |
Het |
| Guca2b |
A |
G |
4: 119,514,912 (GRCm39) |
Y50H |
probably damaging |
Het |
| Herc2 |
C |
T |
7: 55,786,415 (GRCm39) |
P1587S |
probably benign |
Het |
| Hmcn1 |
C |
T |
1: 150,545,309 (GRCm39) |
S2766N |
probably benign |
Het |
| Idi2 |
T |
A |
13: 9,009,455 (GRCm39) |
I224K |
probably damaging |
Het |
| Kmt2a |
A |
T |
9: 44,735,666 (GRCm39) |
|
probably benign |
Het |
| Lonp2 |
A |
T |
8: 87,440,078 (GRCm39) |
M693L |
possibly damaging |
Het |
| Megf8 |
G |
T |
7: 25,046,172 (GRCm39) |
M1525I |
possibly damaging |
Het |
| Mgme1 |
T |
C |
2: 144,121,018 (GRCm39) |
V276A |
possibly damaging |
Het |
| Mief2 |
G |
T |
11: 60,622,234 (GRCm39) |
W268L |
probably damaging |
Het |
| Mpped1 |
C |
T |
15: 83,676,191 (GRCm39) |
|
probably benign |
Het |
| Mreg |
T |
C |
1: 72,231,356 (GRCm39) |
N34S |
probably benign |
Het |
| Myf6 |
T |
C |
10: 107,330,534 (GRCm39) |
Y11C |
probably damaging |
Het |
| Myh9 |
C |
A |
15: 77,655,367 (GRCm39) |
Q1196H |
probably benign |
Het |
| Myh9 |
A |
T |
15: 77,660,099 (GRCm39) |
D56E |
probably benign |
Het |
| Myo5c |
A |
T |
9: 75,184,357 (GRCm39) |
R949S |
probably benign |
Het |
| Ncapg2 |
TAA |
TA |
12: 116,398,305 (GRCm39) |
|
probably null |
Het |
| Nfx1 |
T |
A |
4: 40,977,004 (GRCm39) |
V226E |
probably benign |
Het |
| Nlrp10 |
T |
A |
7: 108,523,737 (GRCm39) |
K581M |
possibly damaging |
Het |
| Nmd3 |
T |
G |
3: 69,647,317 (GRCm39) |
I273S |
probably benign |
Het |
| Or4c3 |
A |
T |
2: 89,852,314 (GRCm39) |
I32N |
possibly damaging |
Het |
| P4hb |
T |
C |
11: 120,462,442 (GRCm39) |
E88G |
probably damaging |
Het |
| Pcnx3 |
A |
T |
19: 5,715,773 (GRCm39) |
H1444Q |
probably benign |
Het |
| Pdia4 |
A |
T |
6: 47,776,133 (GRCm39) |
F421L |
possibly damaging |
Het |
| Picalm |
T |
A |
7: 89,840,459 (GRCm39) |
S538T |
probably damaging |
Het |
| Ppp2r2b |
T |
A |
18: 43,192,275 (GRCm39) |
I11F |
probably benign |
Het |
| Prb1c |
A |
G |
6: 132,339,969 (GRCm39) |
|
probably null |
Het |
| Ptk7 |
C |
T |
17: 46,884,460 (GRCm39) |
E757K |
possibly damaging |
Het |
| Rbm22 |
T |
G |
18: 60,694,340 (GRCm39) |
C24W |
probably damaging |
Het |
| Rev3l |
A |
G |
10: 39,682,658 (GRCm39) |
D288G |
probably damaging |
Het |
| Rgs18 |
T |
A |
1: 144,629,791 (GRCm39) |
H156L |
probably benign |
Het |
| Rnf213 |
A |
G |
11: 119,333,405 (GRCm39) |
I2871M |
probably damaging |
Het |
| Rrm2b |
A |
T |
15: 37,945,328 (GRCm39) |
M137K |
probably damaging |
Het |
| Rrp12 |
A |
T |
19: 41,857,224 (GRCm39) |
D1183E |
probably benign |
Het |
| Sacs |
G |
A |
14: 61,441,277 (GRCm39) |
V1108M |
probably damaging |
Het |
| Scube2 |
A |
T |
7: 109,442,421 (GRCm39) |
D270E |
possibly damaging |
Het |
| Serpina3a |
T |
A |
12: 104,082,737 (GRCm39) |
F170Y |
probably damaging |
Het |
| Serpinb3b |
T |
C |
1: 107,082,403 (GRCm39) |
E287G |
probably benign |
Het |
| Slamf8 |
C |
T |
1: 172,412,186 (GRCm39) |
V130M |
probably damaging |
Het |
| Slc5a3 |
T |
C |
16: 91,874,284 (GRCm39) |
S114P |
possibly damaging |
Het |
| Sos1 |
T |
A |
17: 80,730,108 (GRCm39) |
|
probably null |
Het |
| Sox10 |
A |
T |
15: 79,040,660 (GRCm39) |
D293E |
probably damaging |
Het |
| Sphk1 |
A |
G |
11: 116,426,596 (GRCm39) |
D177G |
probably damaging |
Het |
| Sphkap |
T |
G |
1: 83,256,121 (GRCm39) |
M543L |
probably benign |
Het |
| Syt13 |
A |
T |
2: 92,783,760 (GRCm39) |
K343N |
probably damaging |
Het |
| Tatdn3 |
A |
G |
1: 190,792,373 (GRCm39) |
M34T |
probably benign |
Het |
| Timd4 |
T |
G |
11: 46,732,989 (GRCm39) |
V305G |
possibly damaging |
Het |
| Tnnc2 |
T |
C |
2: 164,619,512 (GRCm39) |
I111V |
probably benign |
Het |
| Togaram2 |
C |
T |
17: 72,004,846 (GRCm39) |
P301L |
probably benign |
Het |
| Trpc3 |
T |
C |
3: 36,694,776 (GRCm39) |
N726S |
probably damaging |
Het |
| Tspear |
T |
A |
10: 77,706,253 (GRCm39) |
L341H |
possibly damaging |
Het |
| Ugt1a5 |
T |
A |
1: 88,093,805 (GRCm39) |
|
probably benign |
Het |
| Ulk3 |
A |
T |
9: 57,500,443 (GRCm39) |
|
probably null |
Het |
| Unc5d |
T |
A |
8: 29,250,777 (GRCm39) |
I297L |
probably benign |
Het |
| Usp20 |
A |
G |
2: 30,908,830 (GRCm39) |
I804V |
probably benign |
Het |
| Usp22 |
G |
T |
11: 61,052,144 (GRCm39) |
C278* |
probably null |
Het |
| Usp53 |
A |
T |
3: 122,727,872 (GRCm39) |
N903K |
probably benign |
Het |
| V1rd19 |
T |
C |
7: 23,702,812 (GRCm39) |
F93L |
probably benign |
Het |
| Zdbf2 |
T |
A |
1: 63,343,493 (GRCm39) |
V624E |
possibly damaging |
Het |
| Zfyve16 |
A |
T |
13: 92,645,528 (GRCm39) |
S1073T |
probably damaging |
Het |
| Zkscan8 |
T |
C |
13: 21,710,765 (GRCm39) |
H115R |
possibly damaging |
Het |
|
| Other mutations in Dab2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00586:Dab2
|
APN |
15 |
6,459,306 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00731:Dab2
|
APN |
15 |
6,465,191 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02382:Dab2
|
APN |
15 |
6,466,468 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL02598:Dab2
|
APN |
15 |
6,458,847 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03054:Dab2
|
APN |
15 |
6,447,707 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03093:Dab2
|
APN |
15 |
6,465,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03369:Dab2
|
APN |
15 |
6,464,790 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL03372:Dab2
|
APN |
15 |
6,459,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0157:Dab2
|
UTSW |
15 |
6,459,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0326:Dab2
|
UTSW |
15 |
6,447,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0488:Dab2
|
UTSW |
15 |
6,454,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0552:Dab2
|
UTSW |
15 |
6,464,895 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0938:Dab2
|
UTSW |
15 |
6,464,865 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1433:Dab2
|
UTSW |
15 |
6,459,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1713:Dab2
|
UTSW |
15 |
6,459,182 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1757:Dab2
|
UTSW |
15 |
6,359,933 (GRCm39) |
intron |
probably benign |
|
|
R1800:Dab2
|
UTSW |
15 |
6,464,948 (GRCm39) |
missense |
probably benign |
|
|
R1837:Dab2
|
UTSW |
15 |
6,365,957 (GRCm39) |
intron |
probably benign |
|
|
R1999:Dab2
|
UTSW |
15 |
6,446,398 (GRCm39) |
missense |
probably benign |
0.32 |
|
R2050:Dab2
|
UTSW |
15 |
6,464,696 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R2117:Dab2
|
UTSW |
15 |
6,465,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2129:Dab2
|
UTSW |
15 |
6,365,864 (GRCm39) |
nonsense |
probably null |
|
|
R2150:Dab2
|
UTSW |
15 |
6,446,398 (GRCm39) |
missense |
probably benign |
0.32 |
|
R2329:Dab2
|
UTSW |
15 |
6,459,044 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2338:Dab2
|
UTSW |
15 |
6,464,733 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R2680:Dab2
|
UTSW |
15 |
6,466,474 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3978:Dab2
|
UTSW |
15 |
6,464,644 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3979:Dab2
|
UTSW |
15 |
6,464,644 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3980:Dab2
|
UTSW |
15 |
6,464,644 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4551:Dab2
|
UTSW |
15 |
6,464,775 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4795:Dab2
|
UTSW |
15 |
6,459,092 (GRCm39) |
missense |
probably benign |
0.16 |
|
R4829:Dab2
|
UTSW |
15 |
6,454,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4830:Dab2
|
UTSW |
15 |
6,457,008 (GRCm39) |
missense |
probably benign |
|
|
R4832:Dab2
|
UTSW |
15 |
6,366,080 (GRCm39) |
splice site |
probably null |
|
|
R5168:Dab2
|
UTSW |
15 |
6,365,924 (GRCm39) |
intron |
probably benign |
|
|
R5620:Dab2
|
UTSW |
15 |
6,447,796 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5996:Dab2
|
UTSW |
15 |
6,464,792 (GRCm39) |
nonsense |
probably null |
|
|
R6159:Dab2
|
UTSW |
15 |
6,465,941 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6998:Dab2
|
UTSW |
15 |
6,454,130 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7002:Dab2
|
UTSW |
15 |
6,464,846 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7040:Dab2
|
UTSW |
15 |
6,451,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7138:Dab2
|
UTSW |
15 |
6,458,780 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7448:Dab2
|
UTSW |
15 |
6,451,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7548:Dab2
|
UTSW |
15 |
6,459,399 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8062:Dab2
|
UTSW |
15 |
6,456,822 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8124:Dab2
|
UTSW |
15 |
6,458,878 (GRCm39) |
nonsense |
probably null |
|
|
R8164:Dab2
|
UTSW |
15 |
6,460,449 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8171:Dab2
|
UTSW |
15 |
6,453,407 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8230:Dab2
|
UTSW |
15 |
6,451,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8372:Dab2
|
UTSW |
15 |
6,446,406 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8427:Dab2
|
UTSW |
15 |
6,458,840 (GRCm39) |
nonsense |
probably null |
|
|
R8919:Dab2
|
UTSW |
15 |
6,465,271 (GRCm39) |
missense |
|
|
|
R9363:Dab2
|
UTSW |
15 |
6,460,481 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9461:Dab2
|
UTSW |
15 |
6,460,435 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9532:Dab2
|
UTSW |
15 |
6,451,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9779:Dab2
|
UTSW |
15 |
6,460,525 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCTCTCTAACCGGACTGGCAAAC -3'
(R):5'- TTTCCTGAAGGACCGATGTGCCTC -3'
Sequencing Primer
(F):5'- TGGCAAACCGGAAGCTC -3'
(R):5'- GACCGATGTGCCTCATCCC -3'
|
| Posted On |
2014-04-24 |
Incidental Mutation