Incidental Mutation 'R1636:Tex15'
ID 173167
Institutional Source Beutler Lab
Gene Symbol Tex15
Ensembl Gene ENSMUSG00000009628
Gene Name testis expressed gene 15
Synonyms 2210014E14Rik
MMRRC Submission 039672-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.292) question?
Stock # R1636 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 34006766-34075610 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to G at 34066415 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 1948 (Y1948*)
Ref Sequence ENSEMBL: ENSMUSP00000009772 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009772] [ENSMUST00000124496] [ENSMUST00000124501]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000009772
AA Change: Y1948*
SMART Domains Protein: ENSMUSP00000009772
Gene: ENSMUSG00000009628
AA Change: Y1948*

DomainStartEndE-ValueType
low complexity region 262 274 N/A INTRINSIC
low complexity region 302 313 N/A INTRINSIC
low complexity region 524 536 N/A INTRINSIC
low complexity region 665 674 N/A INTRINSIC
low complexity region 713 725 N/A INTRINSIC
low complexity region 946 961 N/A INTRINSIC
low complexity region 1497 1508 N/A INTRINSIC
Pfam:TEX15 1572 1788 1.3e-109 PFAM
Pfam:TEX15 1901 2119 1.1e-16 PFAM
low complexity region 2758 2770 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124496
SMART Domains Protein: ENSMUSP00000120744
Gene: ENSMUSG00000009628

DomainStartEndE-ValueType
Pfam:DUF3715 89 251 1.6e-58 PFAM
low complexity region 536 548 N/A INTRINSIC
low complexity region 576 587 N/A INTRINSIC
low complexity region 798 810 N/A INTRINSIC
low complexity region 939 948 N/A INTRINSIC
low complexity region 987 999 N/A INTRINSIC
low complexity region 1220 1235 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124501
SMART Domains Protein: ENSMUSP00000138070
Gene: ENSMUSG00000009628

DomainStartEndE-ValueType
Pfam:DUF3715 96 251 2.4e-52 PFAM
Meta Mutation Damage Score 0.9754 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.4%
  • 20x: 86.1%
Validation Efficiency 96% (85/89)
MGI Phenotype PHENOTYPE: Male mice are infertile due to arrest of meiosis stemming from failure to repair double-strand breaks. However, female mice are fertile. [provided by MGI curators]
Allele List at MGI

All alleles(4) : Targeted(3) Gene trapped(1)

Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m C A 6: 121,631,571 (GRCm39) L623M probably benign Het
Abca7 A G 10: 79,844,832 (GRCm39) H1518R probably benign Het
Adam4 A G 12: 81,466,464 (GRCm39) L719S probably damaging Het
Adprm T C 11: 66,932,549 (GRCm39) Y120C possibly damaging Het
Arhgap25 T A 6: 87,472,923 (GRCm39) Y78F probably damaging Het
Asap1 G A 15: 63,995,761 (GRCm39) P665L probably damaging Het
Bank1 T C 3: 135,788,987 (GRCm39) K637R probably damaging Het
Bcr T A 10: 74,966,898 (GRCm39) L502M probably damaging Het
Brwd1 A G 16: 95,860,841 (GRCm39) L315P probably damaging Het
Btbd7 A T 12: 102,760,110 (GRCm39) Y613N probably damaging Het
Cdca7l G A 12: 117,840,663 (GRCm39) R395H probably damaging Het
Cftr T A 6: 18,226,156 (GRCm39) I368K probably damaging Het
D6Wsu163e T C 6: 126,923,564 (GRCm39) V150A possibly damaging Het
Ddx52 A G 11: 83,846,169 (GRCm39) T470A probably damaging Het
Def6 A G 17: 28,442,892 (GRCm39) E316G possibly damaging Het
Dip2a A T 10: 76,157,412 (GRCm39) N64K probably benign Het
Dlgap4 G T 2: 156,587,997 (GRCm39) E631* probably null Het
Dner T C 1: 84,563,051 (GRCm39) K190E possibly damaging Het
Eif2b4 T A 5: 31,349,610 (GRCm39) probably null Het
Eif3a A T 19: 60,770,343 (GRCm39) D119E possibly damaging Het
Ercc2 C T 7: 19,121,049 (GRCm39) T276M possibly damaging Het
Exoc1 A G 5: 76,715,965 (GRCm39) K830R probably benign Het
F2r G T 13: 95,740,400 (GRCm39) Y378* probably null Het
Fam186a G A 15: 99,839,539 (GRCm39) T2235I unknown Het
Fmo3 T G 1: 162,781,994 (GRCm39) K453T probably benign Het
Fzd3 A T 14: 65,490,555 (GRCm39) D9E probably benign Het
Galns A G 8: 123,330,955 (GRCm39) probably benign Het
Gm1818 T C 12: 48,602,550 (GRCm39) noncoding transcript Het
Gm9955 C A 18: 24,842,287 (GRCm39) probably benign Het
Immp2l T C 12: 41,750,470 (GRCm39) V113A probably damaging Het
Iyd T A 10: 3,495,588 (GRCm39) M82K possibly damaging Het
Kif21a A T 15: 90,869,008 (GRCm39) probably benign Het
Lipf A G 19: 33,953,935 (GRCm39) D342G probably damaging Het
Lmbrd1 C A 1: 24,786,011 (GRCm39) Y435* probably null Het
Mpped1 C T 15: 83,676,191 (GRCm39) probably benign Het
Mtrf1l A G 10: 5,763,265 (GRCm39) S355P probably damaging Het
Ndn C T 7: 61,998,256 (GRCm39) P34L probably benign Het
Neo1 T C 9: 58,820,560 (GRCm39) S788G probably damaging Het
Nfx1 T G 4: 41,016,072 (GRCm39) probably null Het
Nlrp4c T C 7: 6,069,737 (GRCm39) V546A possibly damaging Het
Nwd2 G A 5: 63,964,900 (GRCm39) V1495M probably damaging Het
Oaf T A 9: 43,150,621 (GRCm39) I84F probably benign Het
Obscn A G 11: 59,013,463 (GRCm39) F1153S probably damaging Het
Ofcc1 A T 13: 40,333,904 (GRCm39) C396S possibly damaging Het
Omg A G 11: 79,393,166 (GRCm39) S231P probably benign Het
Or51a7 T G 7: 102,614,898 (GRCm39) I197S possibly damaging Het
Or8g35 T C 9: 39,381,215 (GRCm39) D269G probably benign Het
Pdcl3 A G 1: 39,034,016 (GRCm39) T53A possibly damaging Het
Pik3r2 A T 8: 71,224,542 (GRCm39) H244Q probably benign Het
Pinx1 A T 14: 64,103,586 (GRCm39) H55L probably damaging Het
Pwwp2b T A 7: 138,834,758 (GRCm39) H66Q probably benign Het
Rell2 A G 18: 38,091,132 (GRCm39) D99G probably damaging Het
Reln G A 5: 22,203,681 (GRCm39) A1191V probably damaging Het
Rprm T C 2: 53,975,316 (GRCm39) M1V probably null Het
Sav1 A C 12: 70,031,269 (GRCm39) H84Q probably benign Het
Scamp5 T C 9: 57,358,692 (GRCm39) D28G possibly damaging Het
Selenbp2 G A 3: 94,604,122 (GRCm39) G9D probably damaging Het
Sh3tc2 T C 18: 62,122,792 (GRCm39) W518R probably damaging Het
Slc10a6 A T 5: 103,777,012 (GRCm39) N29K probably benign Het
Spindoc C A 19: 7,351,922 (GRCm39) D142Y probably damaging Het
Spink12 T A 18: 44,240,795 (GRCm39) D60E probably benign Het
Sugt1 A G 14: 79,825,422 (GRCm39) I23V probably benign Het
Syne2 T C 12: 76,051,506 (GRCm39) C4079R probably benign Het
Thoc2l T A 5: 104,668,616 (GRCm39) M1046K probably damaging Het
Tln2 T C 9: 67,213,814 (GRCm39) E321G probably damaging Het
Tmem198b A G 10: 128,638,065 (GRCm39) L166P probably damaging Het
Tspear T A 10: 77,706,253 (GRCm39) L341H possibly damaging Het
Ttn T A 2: 76,730,566 (GRCm39) probably benign Het
Unc13a G A 8: 72,106,034 (GRCm39) T690I probably damaging Het
Ush2a T C 1: 188,198,373 (GRCm39) I1479T possibly damaging Het
Vcan G A 13: 89,851,786 (GRCm39) T1058I possibly damaging Het
Vmn1r84 T C 7: 12,096,522 (GRCm39) Q45R probably benign Het
Vmn2r111 T C 17: 22,790,380 (GRCm39) N209D probably damaging Het
Wbp1l A G 19: 46,632,883 (GRCm39) Y40C probably damaging Het
Wdr72 A T 9: 74,086,907 (GRCm39) H625L probably benign Het
Zeb2 T C 2: 44,892,623 (GRCm39) Y195C probably damaging Het
Zkscan6 C T 11: 65,705,256 (GRCm39) probably benign Het
Zmym6 C A 4: 127,017,560 (GRCm39) H1022N probably damaging Het
Other mutations in Tex15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00639:Tex15 APN 8 34,065,339 (GRCm39) missense probably benign 0.18
IGL00705:Tex15 APN 8 34,071,620 (GRCm39) missense probably damaging 1.00
IGL00820:Tex15 APN 8 34,069,034 (GRCm39) splice site probably benign
IGL01288:Tex15 APN 8 34,061,412 (GRCm39) missense probably benign 0.02
IGL01328:Tex15 APN 8 34,061,424 (GRCm39) nonsense probably null
IGL01359:Tex15 APN 8 34,071,926 (GRCm39) missense probably damaging 0.99
IGL01603:Tex15 APN 8 34,063,575 (GRCm39) missense possibly damaging 0.93
IGL01861:Tex15 APN 8 34,060,717 (GRCm39) missense probably damaging 1.00
IGL02052:Tex15 APN 8 34,072,493 (GRCm39) missense probably benign 0.28
IGL02560:Tex15 APN 8 34,071,779 (GRCm39) missense probably benign 0.00
IGL02677:Tex15 APN 8 34,061,108 (GRCm39) missense probably benign 0.03
IGL02739:Tex15 APN 8 34,071,721 (GRCm39) missense possibly damaging 0.68
Big_gulp UTSW 8 34,071,762 (GRCm39) missense probably damaging 1.00
P0005:Tex15 UTSW 8 34,060,896 (GRCm39) missense probably benign 0.00
P0037:Tex15 UTSW 8 34,071,608 (GRCm39) missense probably benign 0.00
PIT4377001:Tex15 UTSW 8 34,061,129 (GRCm39) missense probably damaging 1.00
R0056:Tex15 UTSW 8 34,072,055 (GRCm39) missense probably benign 0.00
R0056:Tex15 UTSW 8 34,072,055 (GRCm39) missense probably benign 0.00
R0058:Tex15 UTSW 8 34,071,530 (GRCm39) splice site probably benign
R0058:Tex15 UTSW 8 34,071,530 (GRCm39) splice site probably benign
R0595:Tex15 UTSW 8 34,062,645 (GRCm39) missense probably damaging 1.00
R0646:Tex15 UTSW 8 34,072,354 (GRCm39) missense possibly damaging 0.83
R0688:Tex15 UTSW 8 34,063,528 (GRCm39) missense probably damaging 1.00
R0842:Tex15 UTSW 8 34,061,575 (GRCm39) missense possibly damaging 0.95
R0987:Tex15 UTSW 8 34,066,875 (GRCm39) missense probably damaging 1.00
R1084:Tex15 UTSW 8 34,067,032 (GRCm39) missense probably benign 0.28
R1183:Tex15 UTSW 8 34,064,893 (GRCm39) missense probably benign 0.35
R1186:Tex15 UTSW 8 34,061,661 (GRCm39) missense probably benign 0.19
R1378:Tex15 UTSW 8 34,065,244 (GRCm39) missense probably damaging 0.99
R1500:Tex15 UTSW 8 34,065,120 (GRCm39) missense probably damaging 0.96
R1508:Tex15 UTSW 8 34,066,880 (GRCm39) missense probably damaging 1.00
R1597:Tex15 UTSW 8 34,061,511 (GRCm39) missense probably damaging 0.96
R1639:Tex15 UTSW 8 34,060,845 (GRCm39) missense possibly damaging 0.94
R1809:Tex15 UTSW 8 34,064,262 (GRCm39) missense probably benign
R1843:Tex15 UTSW 8 34,066,682 (GRCm39) missense probably benign 0.27
R2029:Tex15 UTSW 8 34,061,302 (GRCm39) missense probably damaging 0.99
R2228:Tex15 UTSW 8 34,061,265 (GRCm39) missense probably benign 0.05
R2229:Tex15 UTSW 8 34,061,265 (GRCm39) missense probably benign 0.05
R2245:Tex15 UTSW 8 34,061,524 (GRCm39) missense possibly damaging 0.77
R2246:Tex15 UTSW 8 34,072,540 (GRCm39) missense possibly damaging 0.49
R2880:Tex15 UTSW 8 34,064,935 (GRCm39) nonsense probably null
R2881:Tex15 UTSW 8 34,064,935 (GRCm39) nonsense probably null
R2882:Tex15 UTSW 8 34,064,935 (GRCm39) nonsense probably null
R3001:Tex15 UTSW 8 34,064,556 (GRCm39) missense probably benign 0.15
R3002:Tex15 UTSW 8 34,064,556 (GRCm39) missense probably benign 0.15
R3020:Tex15 UTSW 8 34,066,698 (GRCm39) missense probably damaging 1.00
R3084:Tex15 UTSW 8 34,064,913 (GRCm39) missense probably benign 0.11
R3085:Tex15 UTSW 8 34,064,913 (GRCm39) missense probably benign 0.11
R3701:Tex15 UTSW 8 34,064,194 (GRCm39) missense probably benign 0.00
R3702:Tex15 UTSW 8 34,064,194 (GRCm39) missense probably benign 0.00
R3752:Tex15 UTSW 8 34,061,443 (GRCm39) missense probably benign
R4162:Tex15 UTSW 8 34,071,586 (GRCm39) missense probably damaging 1.00
R4231:Tex15 UTSW 8 34,062,165 (GRCm39) missense probably damaging 0.99
R4589:Tex15 UTSW 8 34,047,401 (GRCm39) missense probably damaging 1.00
R4707:Tex15 UTSW 8 34,072,525 (GRCm39) missense probably benign 0.00
R4773:Tex15 UTSW 8 34,072,760 (GRCm39) missense probably benign 0.42
R4967:Tex15 UTSW 8 34,064,498 (GRCm39) missense probably benign 0.34
R5063:Tex15 UTSW 8 34,072,638 (GRCm39) missense possibly damaging 0.59
R5121:Tex15 UTSW 8 34,061,794 (GRCm39) missense probably damaging 1.00
R5147:Tex15 UTSW 8 34,062,340 (GRCm39) nonsense probably null
R5166:Tex15 UTSW 8 34,066,420 (GRCm39) missense probably benign 0.07
R5173:Tex15 UTSW 8 34,061,768 (GRCm39) missense possibly damaging 0.73
R5439:Tex15 UTSW 8 34,064,199 (GRCm39) missense possibly damaging 0.93
R5537:Tex15 UTSW 8 34,061,641 (GRCm39) missense probably damaging 1.00
R5580:Tex15 UTSW 8 34,062,457 (GRCm39) missense probably damaging 1.00
R5588:Tex15 UTSW 8 34,067,215 (GRCm39) missense probably damaging 1.00
R5696:Tex15 UTSW 8 34,063,220 (GRCm39) missense probably benign 0.01
R5734:Tex15 UTSW 8 34,036,364 (GRCm39) missense probably benign 0.01
R5756:Tex15 UTSW 8 34,065,861 (GRCm39) missense probably benign 0.17
R5823:Tex15 UTSW 8 34,060,962 (GRCm39) missense possibly damaging 0.67
R6126:Tex15 UTSW 8 34,063,591 (GRCm39) missense probably benign 0.19
R6129:Tex15 UTSW 8 34,064,158 (GRCm39) missense possibly damaging 0.90
R6276:Tex15 UTSW 8 34,067,217 (GRCm39) missense possibly damaging 0.93
R6374:Tex15 UTSW 8 34,065,940 (GRCm39) missense probably damaging 1.00
R6430:Tex15 UTSW 8 34,061,329 (GRCm39) missense probably benign 0.01
R6452:Tex15 UTSW 8 34,062,844 (GRCm39) missense probably damaging 1.00
R6471:Tex15 UTSW 8 34,071,762 (GRCm39) missense probably damaging 1.00
R6700:Tex15 UTSW 8 34,064,917 (GRCm39) missense possibly damaging 0.93
R6918:Tex15 UTSW 8 34,063,212 (GRCm39) missense probably benign 0.27
R6958:Tex15 UTSW 8 34,060,899 (GRCm39) missense probably benign 0.01
R6970:Tex15 UTSW 8 34,047,456 (GRCm39) missense probably benign 0.03
R7059:Tex15 UTSW 8 34,064,758 (GRCm39) missense possibly damaging 0.57
R7069:Tex15 UTSW 8 34,060,748 (GRCm39) missense probably benign
R7072:Tex15 UTSW 8 34,065,459 (GRCm39) missense possibly damaging 0.85
R7212:Tex15 UTSW 8 34,063,023 (GRCm39) missense probably damaging 1.00
R7212:Tex15 UTSW 8 34,060,854 (GRCm39) nonsense probably null
R7216:Tex15 UTSW 8 34,063,014 (GRCm39) missense possibly damaging 0.93
R7219:Tex15 UTSW 8 34,036,268 (GRCm39) missense probably benign 0.40
R7313:Tex15 UTSW 8 34,064,845 (GRCm39) missense possibly damaging 0.82
R7315:Tex15 UTSW 8 34,071,544 (GRCm39) missense probably benign 0.01
R7444:Tex15 UTSW 8 34,066,590 (GRCm39) missense possibly damaging 0.92
R7455:Tex15 UTSW 8 34,067,025 (GRCm39) missense possibly damaging 0.91
R7643:Tex15 UTSW 8 34,065,148 (GRCm39) missense probably damaging 1.00
R7644:Tex15 UTSW 8 34,064,445 (GRCm39) missense probably benign 0.01
R7724:Tex15 UTSW 8 34,036,291 (GRCm39) missense possibly damaging 0.60
R7779:Tex15 UTSW 8 34,065,309 (GRCm39) missense probably damaging 1.00
R7798:Tex15 UTSW 8 34,071,875 (GRCm39) missense possibly damaging 0.69
R7816:Tex15 UTSW 8 34,071,683 (GRCm39) missense probably benign 0.14
R7820:Tex15 UTSW 8 34,065,090 (GRCm39) missense probably damaging 0.98
R8041:Tex15 UTSW 8 34,065,874 (GRCm39) missense probably damaging 1.00
R8150:Tex15 UTSW 8 34,063,534 (GRCm39) missense probably benign 0.06
R8152:Tex15 UTSW 8 34,062,921 (GRCm39) missense possibly damaging 0.82
R8237:Tex15 UTSW 8 34,067,427 (GRCm39) missense possibly damaging 0.72
R8250:Tex15 UTSW 8 34,055,233 (GRCm39) missense probably null 0.27
R8264:Tex15 UTSW 8 34,072,390 (GRCm39) missense probably benign 0.18
R8279:Tex15 UTSW 8 34,061,765 (GRCm39) missense probably damaging 0.96
R8353:Tex15 UTSW 8 34,066,899 (GRCm39) nonsense probably null
R8388:Tex15 UTSW 8 34,065,237 (GRCm39) missense probably benign 0.00
R8432:Tex15 UTSW 8 34,066,572 (GRCm39) missense probably damaging 0.99
R8453:Tex15 UTSW 8 34,066,899 (GRCm39) nonsense probably null
R8489:Tex15 UTSW 8 34,067,574 (GRCm39) missense probably benign 0.02
R8670:Tex15 UTSW 8 34,064,746 (GRCm39) missense probably benign 0.19
R8703:Tex15 UTSW 8 34,062,724 (GRCm39) missense probably benign 0.00
R8871:Tex15 UTSW 8 34,066,992 (GRCm39) missense possibly damaging 0.62
R8945:Tex15 UTSW 8 34,064,724 (GRCm39) missense probably benign 0.00
R9104:Tex15 UTSW 8 34,060,950 (GRCm39) missense possibly damaging 0.86
R9132:Tex15 UTSW 8 34,067,554 (GRCm39) missense possibly damaging 0.84
R9207:Tex15 UTSW 8 34,065,784 (GRCm39) missense probably damaging 1.00
R9210:Tex15 UTSW 8 34,064,319 (GRCm39) missense possibly damaging 0.91
R9330:Tex15 UTSW 8 34,065,143 (GRCm39) missense probably benign 0.01
R9354:Tex15 UTSW 8 34,063,344 (GRCm39) missense possibly damaging 0.86
R9365:Tex15 UTSW 8 34,064,564 (GRCm39) missense possibly damaging 0.56
R9440:Tex15 UTSW 8 34,072,273 (GRCm39) missense possibly damaging 0.90
R9534:Tex15 UTSW 8 34,060,999 (GRCm39) missense probably benign 0.45
R9570:Tex15 UTSW 8 34,067,309 (GRCm39) missense probably damaging 0.96
R9574:Tex15 UTSW 8 34,064,509 (GRCm39) missense probably benign 0.09
R9618:Tex15 UTSW 8 34,062,397 (GRCm39) missense probably benign 0.35
R9655:Tex15 UTSW 8 34,066,784 (GRCm39) nonsense probably null
R9786:Tex15 UTSW 8 34,062,457 (GRCm39) missense probably damaging 1.00
R9798:Tex15 UTSW 8 34,062,721 (GRCm39) missense probably damaging 0.98
RF005:Tex15 UTSW 8 34,066,705 (GRCm39) missense probably benign 0.05
X0020:Tex15 UTSW 8 34,066,607 (GRCm39) missense probably benign 0.03
X0065:Tex15 UTSW 8 34,065,545 (GRCm39) nonsense probably null
Z1088:Tex15 UTSW 8 34,061,343 (GRCm39) missense possibly damaging 0.89
Z1088:Tex15 UTSW 8 34,064,898 (GRCm39) missense probably benign
Z1088:Tex15 UTSW 8 34,061,838 (GRCm39) missense possibly damaging 0.68
Z1176:Tex15 UTSW 8 34,064,754 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- TTTCTACCCTGGTTTTCAAGGACGAC -3'
(R):5'- TGTACATCTGAGAGTGAGGCCCTG -3'

Sequencing Primer
(F):5'- ACTTTGGAGATAGTTTAGGAGACC -3'
(R):5'- AGAGTGAGGCCCTGTAACTCC -3'
Posted On 2014-04-24