Incidental Mutation 'R0056:Lyplal1'
ID17317
Institutional Source Beutler Lab
Gene Symbol Lyplal1
Ensembl Gene ENSMUSG00000039246
Gene Namelysophospholipase-like 1
SynonymsQ96AVO
MMRRC Submission 038350-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R0056 (G1)
Quality Score
Status Validated
Chromosome1
Chromosomal Location186087731-186117310 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 186088566 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 228 (T228I)
Ref Sequence ENSEMBL: ENSMUSP00000048229 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045388]
Predicted Effect probably benign
Transcript: ENSMUST00000045388
AA Change: T228I

PolyPhen 2 Score 0.360 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000048229
Gene: ENSMUSG00000039246
AA Change: T228I

DomainStartEndE-ValueType
Pfam:Esterase 3 213 3.6e-8 PFAM
Pfam:Abhydrolase_2 11 230 1.5e-44 PFAM
Pfam:Abhydrolase_5 24 213 1.5e-13 PFAM
Pfam:Abhydrolase_3 89 167 1.5e-6 PFAM
Pfam:DLH 89 224 2.3e-6 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195481
Meta Mutation Damage Score 0.0820 question?
Coding Region Coverage
  • 1x: 89.2%
  • 3x: 86.3%
  • 10x: 78.7%
  • 20x: 65.9%
Validation Efficiency 89% (66/74)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankfn1 A G 11: 89,391,676 S1061P possibly damaging Het
Atp9b A G 18: 80,765,803 S634P probably damaging Het
Bche A T 3: 73,701,321 N257K possibly damaging Het
Bms1 A T 6: 118,405,229 D449E probably benign Het
C630050I24Rik G T 8: 107,119,394 V59F unknown Het
Camkk2 C T 5: 122,742,198 E452K probably damaging Het
Ccdc121 T C 1: 181,510,553 Y278C probably damaging Het
Chd9 A G 8: 90,933,537 H375R possibly damaging Het
Entpd7 T A 19: 43,725,294 V364E probably benign Het
Epb41l3 A T 17: 69,253,397 D313V probably damaging Het
Etv6 G T 6: 134,248,534 E154* probably null Het
Fshr T G 17: 88,988,457 H274P probably damaging Het
G3bp1 A G 11: 55,498,041 N360D probably benign Het
Gdf11 C T 10: 128,886,425 R187H probably benign Het
Gm5346 A T 8: 43,625,503 C561* probably null Het
Gpihbp1 T A 15: 75,597,133 I52N probably damaging Het
H1foo G T 6: 115,946,973 probably benign Het
Htt T C 5: 34,826,078 probably benign Het
Iqcm A G 8: 75,753,386 Q324R probably benign Het
Kcng3 A G 17: 83,587,756 L427P probably damaging Het
Klk7 T C 7: 43,812,010 L17P possibly damaging Het
Klrd1 G A 6: 129,593,775 V50I probably benign Het
Lama5 A T 2: 180,187,106 probably benign Het
Lamtor3 T A 3: 137,926,950 probably benign Het
Mapk6 A G 9: 75,388,816 Y467H possibly damaging Het
March6 T C 15: 31,467,734 T776A possibly damaging Het
Mogat1 T G 1: 78,523,770 M157R probably damaging Het
Morc2b T A 17: 33,138,759 Q13L possibly damaging Het
Myo1h C T 5: 114,330,212 T356I probably damaging Het
Ncoa2 C A 1: 117,516,497 probably null Het
Nobox A G 6: 43,304,919 C407R probably benign Het
Nupl1 A G 14: 60,239,475 probably null Het
Olfr684 A G 7: 105,157,122 S187P probably benign Het
Otoa A G 7: 121,131,347 Y590C probably benign Het
Pelp1 A T 11: 70,393,832 V1070E unknown Het
Pglyrp3 G T 3: 92,025,804 probably benign Het
Plpp2 A G 10: 79,527,229 F189S probably damaging Het
Polr2b T C 5: 77,334,535 I640T possibly damaging Het
Ryr2 T A 13: 11,669,038 T3047S probably damaging Het
Snx25 A T 8: 46,038,513 W847R probably damaging Het
Son T C 16: 91,678,155 Y454H possibly damaging Het
Sos1 A T 17: 80,413,621 N923K probably damaging Het
Tex15 A G 8: 33,582,027 H2534R probably benign Het
Ticam2 G T 18: 46,560,334 Q229K possibly damaging Het
Tnfaip3 A T 10: 19,005,293 V342E probably damaging Het
Traf6 A G 2: 101,697,151 I415M possibly damaging Het
Trpm1 A G 7: 64,243,586 D1062G probably damaging Het
Wdr59 C T 8: 111,480,607 probably benign Het
Other mutations in Lyplal1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0166:Lyplal1 UTSW 1 186088746 missense probably benign 0.00
R1169:Lyplal1 UTSW 1 186114334 missense probably benign 0.08
R1840:Lyplal1 UTSW 1 186100217 missense probably damaging 1.00
R3498:Lyplal1 UTSW 1 186088660 missense possibly damaging 0.95
R3499:Lyplal1 UTSW 1 186088660 missense possibly damaging 0.95
R4128:Lyplal1 UTSW 1 186089539 missense possibly damaging 0.94
R4613:Lyplal1 UTSW 1 186088752 missense probably benign
R6447:Lyplal1 UTSW 1 186089442 critical splice donor site probably null
R7102:Lyplal1 UTSW 1 186100327 missense probably damaging 1.00
Posted On2013-01-20