Incidental Mutation 'R1639:Zfp947'
ID 173405
Institutional Source Beutler Lab
Gene Symbol Zfp947
Ensembl Gene ENSMUSG00000063383
Gene Name zinc finger protein 947
Synonyms Gm4769
MMRRC Submission 039675-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R1639 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 22363336-22385153 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 22365074 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 200 (K200R)
Ref Sequence ENSEMBL: ENSMUSP00000079137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080249]
AlphaFold Q8BIQ6
Predicted Effect probably benign
Transcript: ENSMUST00000080249
AA Change: K200R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000079137
Gene: ENSMUSG00000063383
AA Change: K200R

DomainStartEndE-ValueType
KRAB 13 73 9.26e-19 SMART
ZnF_C2H2 183 205 7.05e-1 SMART
ZnF_C2H2 211 233 1.5e-4 SMART
ZnF_C2H2 239 261 7.67e-2 SMART
ZnF_C2H2 267 289 2.79e-4 SMART
ZnF_C2H2 295 317 5.59e-4 SMART
ZnF_C2H2 323 345 4.24e-4 SMART
ZnF_C2H2 351 373 3.21e-4 SMART
ZnF_C2H2 379 401 5.99e-4 SMART
ZnF_C2H2 407 429 8.02e-5 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.5%
  • 20x: 89.7%
Validation Efficiency 96% (66/69)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss2 C A 2: 155,398,828 (GRCm39) T425N probably benign Het
Adam18 T A 8: 25,142,168 (GRCm39) I203L probably benign Het
Amigo2 A G 15: 97,143,879 (GRCm39) M181T probably benign Het
Anks1 T A 17: 28,277,280 (GRCm39) I1045N probably damaging Het
Ap3d1 C T 10: 80,565,844 (GRCm39) V108I probably damaging Het
Arl8a C T 1: 135,080,561 (GRCm39) R57* probably null Het
Atp12a A T 14: 56,621,525 (GRCm39) D720V possibly damaging Het
Brpf3 T C 17: 29,043,042 (GRCm39) probably null Het
C2 T C 17: 35,091,379 (GRCm39) K95E probably benign Het
Cdk19 T C 10: 40,352,965 (GRCm39) probably null Het
Cebpz T A 17: 79,242,035 (GRCm39) I540L possibly damaging Het
Cep128 A G 12: 91,333,142 (GRCm39) V41A probably damaging Het
Cog7 T C 7: 121,580,642 (GRCm39) E56G probably damaging Het
Cylc2 T C 4: 51,228,310 (GRCm39) V127A probably benign Het
Cyp2b23 A G 7: 26,385,842 (GRCm39) V5A possibly damaging Het
Cyp8b1 A G 9: 121,743,956 (GRCm39) Y459H probably benign Het
Dbpht2 A G 12: 74,345,932 (GRCm39) noncoding transcript Het
Ddx24 T C 12: 103,377,578 (GRCm39) probably null Het
Dgki C T 6: 36,914,299 (GRCm39) C757Y probably damaging Het
Eef2k T A 7: 120,485,051 (GRCm39) L306H probably damaging Het
Ephb2 T C 4: 136,421,216 (GRCm39) N378S probably benign Het
Espl1 C T 15: 102,229,149 (GRCm39) T1767I probably damaging Het
Fbn2 C A 18: 58,191,534 (GRCm39) A1530S probably benign Het
Fndc11 A G 2: 180,863,374 (GRCm39) S60G possibly damaging Het
Glb1l G T 1: 75,176,245 (GRCm39) Q612K probably benign Het
Gpsm1 A G 2: 26,235,199 (GRCm39) E371G probably damaging Het
Gtpbp2 G A 17: 46,476,697 (GRCm39) probably null Het
Itch A G 2: 155,020,945 (GRCm39) probably null Het
Itga2 T C 13: 114,993,832 (GRCm39) T774A probably benign Het
Kit A G 5: 75,813,467 (GRCm39) I881V probably damaging Het
Lpar5 T C 6: 125,058,564 (GRCm39) L95P probably damaging Het
Lrp6 T C 6: 134,430,529 (GRCm39) T1511A possibly damaging Het
Mgat4c T C 10: 102,214,142 (GRCm39) Y42H probably damaging Het
Mpp3 G T 11: 101,914,268 (GRCm39) T109K probably damaging Het
Msantd4 A G 9: 4,385,199 (GRCm39) E308G probably damaging Het
Mug1 T C 6: 121,857,530 (GRCm39) S1085P probably damaging Het
Myo5b A G 18: 74,840,987 (GRCm39) H956R probably benign Het
Ncoa7 A C 10: 30,577,988 (GRCm39) L132R probably damaging Het
Ndufc1 T C 3: 51,315,664 (GRCm39) T25A probably benign Het
Or4a81 T C 2: 89,619,589 (GRCm39) T36A probably damaging Het
Pkhd1l1 G A 15: 44,404,351 (GRCm39) V2327M probably damaging Het
Ppp1r9b T C 11: 94,887,436 (GRCm39) Y59H probably damaging Het
Sema4c A T 1: 36,592,615 (GRCm39) F152I probably benign Het
Slit2 A T 5: 48,416,996 (GRCm39) Y1016F probably damaging Het
Spata31d1c T A 13: 65,183,853 (GRCm39) V465D probably benign Het
Ssc5d T C 7: 4,931,416 (GRCm39) C208R probably damaging Het
Stambpl1 T G 19: 34,213,707 (GRCm39) V312G probably benign Het
Stim1 T A 7: 102,003,748 (GRCm39) D60E probably benign Het
Syt13 T A 2: 92,776,316 (GRCm39) V201D probably benign Het
Tcaim G A 9: 122,647,838 (GRCm39) probably null Het
Tex15 T C 8: 34,060,845 (GRCm39) S366P possibly damaging Het
Tex56 T C 13: 35,128,233 (GRCm39) I150T possibly damaging Het
Tpte G A 8: 22,810,913 (GRCm39) R190H probably benign Het
Vmn1r4 T C 6: 56,934,060 (GRCm39) V188A probably damaging Het
Vmn2r88 A G 14: 51,654,244 (GRCm39) D542G probably damaging Het
Vps33b T A 7: 79,934,101 (GRCm39) I257N probably damaging Het
Wwox G T 8: 115,172,118 (GRCm39) G71* probably null Het
Zc3h11a G T 1: 133,552,446 (GRCm39) Q554K probably benign Het
Zscan12 T A 13: 21,553,156 (GRCm39) C327S probably damaging Het
Other mutations in Zfp947
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02092:Zfp947 APN 17 22,366,477 (GRCm39) missense probably damaging 1.00
IGL02592:Zfp947 APN 17 22,365,233 (GRCm39) missense possibly damaging 0.95
deformity UTSW 17 22,364,594 (GRCm39) missense probably damaging 1.00
Gnarled UTSW 17 22,365,165 (GRCm39) missense probably benign 0.00
R0070:Zfp947 UTSW 17 22,365,165 (GRCm39) missense probably benign 0.00
R1519:Zfp947 UTSW 17 22,365,273 (GRCm39) missense probably benign 0.02
R1521:Zfp947 UTSW 17 22,364,813 (GRCm39) missense probably benign 0.00
R1721:Zfp947 UTSW 17 22,365,184 (GRCm39) missense probably benign
R1801:Zfp947 UTSW 17 22,365,443 (GRCm39) missense probably benign
R2264:Zfp947 UTSW 17 22,364,919 (GRCm39) missense probably benign
R3943:Zfp947 UTSW 17 22,364,801 (GRCm39) missense probably damaging 1.00
R4561:Zfp947 UTSW 17 22,365,124 (GRCm39) nonsense probably null
R4562:Zfp947 UTSW 17 22,365,124 (GRCm39) nonsense probably null
R4943:Zfp947 UTSW 17 22,364,813 (GRCm39) missense probably benign
R5688:Zfp947 UTSW 17 22,365,066 (GRCm39) missense probably benign 0.00
R6037:Zfp947 UTSW 17 22,366,415 (GRCm39) missense probably damaging 0.99
R6037:Zfp947 UTSW 17 22,366,415 (GRCm39) missense probably damaging 0.99
R6414:Zfp947 UTSW 17 22,365,395 (GRCm39) missense probably damaging 0.98
R6786:Zfp947 UTSW 17 22,364,750 (GRCm39) missense probably benign 0.01
R6993:Zfp947 UTSW 17 22,364,961 (GRCm39) missense probably benign 0.11
R7556:Zfp947 UTSW 17 22,364,597 (GRCm39) missense probably benign
R8224:Zfp947 UTSW 17 22,364,363 (GRCm39) missense probably benign
R8398:Zfp947 UTSW 17 22,365,102 (GRCm39) missense probably benign 0.03
R8670:Zfp947 UTSW 17 22,364,687 (GRCm39) missense probably benign 0.09
R8871:Zfp947 UTSW 17 22,364,695 (GRCm39) missense probably benign 0.13
R9000:Zfp947 UTSW 17 22,365,161 (GRCm39) missense probably benign 0.12
R9099:Zfp947 UTSW 17 22,364,855 (GRCm39) missense probably benign 0.00
R9180:Zfp947 UTSW 17 22,364,386 (GRCm39) missense probably damaging 1.00
R9287:Zfp947 UTSW 17 22,364,594 (GRCm39) missense probably damaging 1.00
R9371:Zfp947 UTSW 17 22,364,384 (GRCm39) missense possibly damaging 0.63
R9507:Zfp947 UTSW 17 22,364,582 (GRCm39) missense probably benign 0.00
R9738:Zfp947 UTSW 17 22,365,341 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- aagatcaccAACTTGAATGAAACAtttctcac -3'
(R):5'- TGTTGAATCATCAAACCTAAGCAGACATGAA -3'

Sequencing Primer
(F):5'- aaggatttgccacattcactac -3'
(R):5'- GTGCTCTACCATTAGTCGAAATC -3'
Posted On 2014-04-24