Incidental Mutation 'R1642:Plpp2'
ID 173611
Institutional Source Beutler Lab
Gene Symbol Plpp2
Ensembl Gene ENSMUSG00000052151
Gene Name phospholipid phosphatase 2
Synonyms Lpp2, Ppap2c
MMRRC Submission 039678-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1642 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 79362258-79369621 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 79366518 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 42 (V42A)
Ref Sequence ENSEMBL: ENSMUSP00000133247 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063879] [ENSMUST00000165233] [ENSMUST00000166804] [ENSMUST00000218241]
AlphaFold Q9DAX2
Predicted Effect probably damaging
Transcript: ENSMUST00000063879
AA Change: V98A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000069670
Gene: ENSMUSG00000052151
AA Change: V98A

DomainStartEndE-ValueType
low complexity region 6 20 N/A INTRINSIC
Blast:acidPPc 21 70 6e-9 BLAST
acidPPc 99 239 1.42e-41 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000163602
Predicted Effect silent
Transcript: ENSMUST00000165233
SMART Domains Protein: ENSMUSP00000127000
Gene: ENSMUSG00000052151

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000166804
AA Change: V42A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000133247
Gene: ENSMUSG00000052151
AA Change: V42A

DomainStartEndE-ValueType
transmembrane domain 4 23 N/A INTRINSIC
acidPPc 43 183 1.42e-41 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184212
Predicted Effect probably benign
Transcript: ENSMUST00000218241
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.4%
  • 20x: 89.7%
Validation Efficiency
MGI Phenotype FUNCTION: The protein encoded by this gene is a lipid phosphate phosphohydrolase. It is an integral membrane protein that catalyzes the conversion of phosphatidic acid to diacylglycerol and inorganic phosphate. The transcript is expressed at high levels in lung, liver, and kidney and at low levels in brain and heart. Null mutant mice are viable and fertile and display no overt phenotypic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for disruptions in this gene display a normal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057J18Rik A G 10: 28,862,233 (GRCm39) V19A probably benign Het
6820408C15Rik T C 2: 152,282,774 (GRCm39) Y210H probably damaging Het
Aars1 T A 8: 111,769,882 (GRCm39) I327N possibly damaging Het
Abca6 T A 11: 110,109,107 (GRCm39) N688Y possibly damaging Het
Ablim3 T C 18: 61,947,382 (GRCm39) K457R probably benign Het
Acsm2 A T 7: 119,162,860 (GRCm39) N45Y probably damaging Het
Agxt2 T C 15: 10,373,917 (GRCm39) S108P probably damaging Het
Akr1cl A T 1: 65,060,588 (GRCm39) M174K probably benign Het
Armh4 T C 14: 50,005,867 (GRCm39) probably null Het
Bfsp1 G A 2: 143,683,683 (GRCm39) R214W probably damaging Het
Cby3 A G 11: 50,250,343 (GRCm39) D183G probably damaging Het
Clip2 T C 5: 134,532,107 (GRCm39) D566G possibly damaging Het
Colgalt1 A G 8: 72,073,401 (GRCm39) I341V probably benign Het
Cyp2c38 T A 19: 39,390,153 (GRCm39) D349V probably damaging Het
Cyp3a16 T A 5: 145,406,399 (GRCm39) I18F unknown Het
Degs2 C T 12: 108,658,451 (GRCm39) C176Y probably benign Het
Dhx16 A T 17: 36,201,957 (GRCm39) T995S probably damaging Het
Dicer1 A T 12: 104,679,415 (GRCm39) C521S probably damaging Het
Dop1b T C 16: 93,559,203 (GRCm39) S532P probably benign Het
Dpysl4 T G 7: 138,670,254 (GRCm39) M124R probably damaging Het
Eml6 A G 11: 29,727,001 (GRCm39) probably null Het
Erbb4 A T 1: 68,370,393 (GRCm39) V395D probably damaging Het
Esf1 T C 2: 140,000,406 (GRCm39) D460G possibly damaging Het
F830045P16Rik G A 2: 129,305,634 (GRCm39) H247Y probably benign Het
Fsbp T A 4: 11,583,965 (GRCm39) S221R probably benign Het
Fstl5 T A 3: 76,317,929 (GRCm39) N198K possibly damaging Het
Gemin5 G T 11: 58,029,906 (GRCm39) H855Q probably damaging Het
Gjd3 T C 11: 98,873,535 (GRCm39) E103G probably benign Het
I0C0044D17Rik A G 4: 98,708,471 (GRCm39) probably benign Het
Iqca1l C A 5: 24,757,686 (GRCm39) R177L probably damaging Het
Itgb4 A T 11: 115,898,183 (GRCm39) R1646W probably damaging Het
Klri2 A T 6: 129,715,837 (GRCm39) C121S probably benign Het
Lamc3 A G 2: 31,806,008 (GRCm39) Y703C probably damaging Het
Lrrc10 A G 10: 116,881,788 (GRCm39) N154S probably damaging Het
Lrriq1 A G 10: 103,050,317 (GRCm39) F812L probably benign Het
Naip2 C T 13: 100,298,489 (GRCm39) A516T possibly damaging Het
Nav1 T C 1: 135,380,010 (GRCm39) Y1564C probably damaging Het
Ndufc1 T C 3: 51,315,664 (GRCm39) T25A probably benign Het
Neurl4 A G 11: 69,794,485 (GRCm39) M23V probably benign Het
Nnt A G 13: 119,541,086 (GRCm39) probably null Het
Nolc1 G C 19: 46,067,461 (GRCm39) probably null Het
Nrg1 A T 8: 32,314,536 (GRCm39) M289K probably benign Het
Oas3 G T 5: 120,915,639 (GRCm39) H17Q possibly damaging Het
Or10h1 A G 17: 33,418,430 (GRCm39) Y132C probably damaging Het
Or2z2 A G 11: 58,346,664 (GRCm39) I37T probably benign Het
Or5m5 A G 2: 85,814,201 (GRCm39) K6E probably benign Het
Or8g36 C T 9: 39,422,650 (GRCm39) R122H possibly damaging Het
Parp9 T C 16: 35,788,067 (GRCm39) Y612H probably benign Het
Pcdh1 A T 18: 38,332,283 (GRCm39) M240K possibly damaging Het
Pcdhb9 A G 18: 37,533,987 (GRCm39) probably benign Het
Ppic C T 18: 53,540,134 (GRCm39) V172M probably damaging Het
Ppp1r9b A G 11: 94,892,150 (GRCm39) silent Het
Prop1 A G 11: 50,844,152 (GRCm39) V27A possibly damaging Het
Psmc5 A G 11: 106,153,242 (GRCm39) T295A probably benign Het
Rpa1 A G 11: 75,203,517 (GRCm39) probably null Het
Rrp12 A G 19: 41,860,176 (GRCm39) F1016L probably damaging Het
Scn2a A T 2: 65,514,041 (GRCm39) I242F probably damaging Het
Slco1a6 T A 6: 142,032,160 (GRCm39) H655L probably benign Het
Sp140 G A 1: 85,538,545 (GRCm39) probably null Het
Syne1 A G 10: 5,298,694 (GRCm39) I1071T possibly damaging Het
Tbc1d9b A G 11: 50,040,659 (GRCm39) D392G probably damaging Het
Tcaim G A 9: 122,647,838 (GRCm39) probably null Het
Tgm3 T A 2: 129,889,702 (GRCm39) V632E probably damaging Het
Triobp C A 15: 78,886,348 (GRCm39) R1830S probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Vps8 A G 16: 21,400,329 (GRCm39) T1266A probably benign Het
Znfx1 T C 2: 166,880,930 (GRCm39) I285V possibly damaging Het
Other mutations in Plpp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01321:Plpp2 APN 10 79,363,327 (GRCm39) missense probably damaging 1.00
IGL03327:Plpp2 APN 10 79,366,818 (GRCm39) splice site probably null
Trust UTSW 10 79,366,763 (GRCm39) missense probably damaging 1.00
R0009:Plpp2 UTSW 10 79,363,078 (GRCm39) missense probably benign 0.01
R0056:Plpp2 UTSW 10 79,363,063 (GRCm39) missense probably damaging 0.99
R0097:Plpp2 UTSW 10 79,366,371 (GRCm39) missense possibly damaging 0.50
R0311:Plpp2 UTSW 10 79,363,414 (GRCm39) missense probably damaging 0.97
R0840:Plpp2 UTSW 10 79,363,378 (GRCm39) missense probably benign 0.16
R1406:Plpp2 UTSW 10 79,366,611 (GRCm39) splice site probably benign
R3436:Plpp2 UTSW 10 79,363,647 (GRCm39) critical splice donor site probably null
R3437:Plpp2 UTSW 10 79,363,647 (GRCm39) critical splice donor site probably null
R4400:Plpp2 UTSW 10 79,363,327 (GRCm39) missense possibly damaging 0.88
R4521:Plpp2 UTSW 10 79,366,459 (GRCm39) missense probably damaging 1.00
R4873:Plpp2 UTSW 10 79,366,763 (GRCm39) missense probably damaging 1.00
R4875:Plpp2 UTSW 10 79,366,763 (GRCm39) missense probably damaging 1.00
R5114:Plpp2 UTSW 10 79,362,973 (GRCm39) missense probably benign 0.41
R6970:Plpp2 UTSW 10 79,366,380 (GRCm39) missense possibly damaging 0.90
R7383:Plpp2 UTSW 10 79,366,841 (GRCm39) missense probably null 0.99
R7902:Plpp2 UTSW 10 79,363,378 (GRCm39) missense possibly damaging 0.91
R7953:Plpp2 UTSW 10 79,366,374 (GRCm39) missense possibly damaging 0.89
R8237:Plpp2 UTSW 10 79,363,294 (GRCm39) missense possibly damaging 0.94
R9218:Plpp2 UTSW 10 79,366,501 (GRCm39) missense probably damaging 1.00
R9452:Plpp2 UTSW 10 79,363,702 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGACAGATTTTCTCCATCCACCAGG -3'
(R):5'- ACTCATGGCTGGGGTCATCATCAC -3'

Sequencing Primer
(F):5'- TGCAGCAGATACTCACCTGG -3'
(R):5'- TGGGGTCATCATCACAGCTAC -3'
Posted On 2014-04-24