Mutagenetix > Incidental Mutation

Incidental Mutation 'R1645:Vmn2r115'

173840

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r115

Ensembl Gene

ENSMUSG00000091076

Gene Name

vomeronasal 2, receptor 115

Synonyms

V2Rp4, EG638102

MMRRC Submission

039681-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

R1645 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23562951-23579102 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 23565192 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 360 (C360S)

Ref Sequence

ENSEMBL: ENSMUSP00000131447 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168175]

AlphaFold

E9Q0E7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000168175
AA Change: C360S

PolyPhen 2 Score 0.688 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000131447
Gene: ENSMUSG00000091076
AA Change: C360S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	1.4e-28	PFAM
Pfam:NCD3G	512	565	2.9e-20	PFAM
Pfam:7tm_3	598	833	5e-55	PFAM

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.3%
20x: 89.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	A	G	3: 121,948,926 (GRCm39)	M1732V	probably benign	Het
Acvr1	A	T	2: 58,352,911 (GRCm39)	C350S	probably damaging	Het
Adgrl2	A	T	3: 148,571,244 (GRCm39)	V130D	probably damaging	Het
Anapc1	A	G	2: 128,500,166 (GRCm39)		probably null	Het
Asap1	A	T	15: 63,961,324 (GRCm39)	V1116E	probably damaging	Het
Bcas1	T	A	2: 170,229,087 (GRCm39)	D308V	probably damaging	Het
Brca1	G	A	11: 101,400,879 (GRCm39)	H1468Y	probably benign	Het
C2cd5	A	G	6: 142,995,852 (GRCm39)	C421R	probably damaging	Het
C4b	A	G	17: 34,959,571 (GRCm39)	S363P	probably damaging	Het
Camk2b	A	T	11: 5,922,719 (GRCm39)	C484S	probably damaging	Het
Cby2	C	A	14: 75,821,089 (GRCm39)	R212L	probably benign	Het
Ccny	T	C	18: 9,345,199 (GRCm39)	T192A	probably damaging	Het
Chl1	G	T	6: 103,660,141 (GRCm39)	A356S	probably benign	Het
Dst	T	A	1: 34,264,803 (GRCm39)	Y4850N	probably damaging	Het
Dyrk4	C	A	6: 126,871,756 (GRCm39)	E171*	probably null	Het
Entrep3	C	A	3: 89,094,154 (GRCm39)	D322E	possibly damaging	Het
Ephb1	A	G	9: 101,804,758 (GRCm39)	Y928H	probably damaging	Het
Fam114a2	A	T	11: 57,390,621 (GRCm39)	N304K	probably benign	Het
Fras1	A	T	5: 96,848,445 (GRCm39)	D1820V	possibly damaging	Het
Gabbr2	A	T	4: 46,664,963 (GRCm39)		probably null	Het
Gm6358	T	C	16: 88,937,967 (GRCm39)	W69R	unknown	Het
Ikbkb	C	A	8: 23,181,082 (GRCm39)	S127I	probably damaging	Het
Impa1	A	T	3: 10,393,501 (GRCm39)	M48K	possibly damaging	Het
Klra2	A	T	6: 131,220,857 (GRCm39)		probably null	Het
Lama1	A	T	17: 68,044,677 (GRCm39)	Y192F	probably benign	Het
Lama2	T	A	10: 27,244,981 (GRCm39)	T267S	probably damaging	Het
Mroh7	G	A	4: 106,577,865 (GRCm39)	T271I	probably benign	Het
Myo9b	A	G	8: 71,775,622 (GRCm39)	E348G	probably damaging	Het
Nrp2	C	T	1: 62,824,283 (GRCm39)	P796L	probably damaging	Het
Ntn4	C	T	10: 93,543,215 (GRCm39)	R314W	probably damaging	Het
Or10al4	A	T	17: 38,037,229 (GRCm39)	T114S	probably benign	Het
Or51i1	A	G	7: 103,671,210 (GRCm39)	F105S	probably damaging	Het
Or9k7	T	A	10: 130,046,081 (GRCm39)	D306V	probably damaging	Het
P3h2	T	A	16: 25,815,982 (GRCm39)	H177L	probably damaging	Het
Pcdhb16	T	C	18: 37,612,423 (GRCm39)	I461T	probably benign	Het
Pdlim3	A	G	8: 46,349,785 (GRCm39)	I32V	probably benign	Het
Pigu	A	C	2: 155,170,598 (GRCm39)	Y143*	probably null	Het
Prkd3	A	C	17: 79,263,949 (GRCm39)		probably null	Het
Psrc1	C	T	3: 108,292,554 (GRCm39)	R116W	probably damaging	Het
Rab5b	A	G	10: 128,522,695 (GRCm39)	S29P	possibly damaging	Het
Rbm26	A	G	14: 105,388,253 (GRCm39)	V403A	probably damaging	Het
Rbm47	G	T	5: 66,184,481 (GRCm39)	R41S	probably benign	Het
Rngtt	A	G	4: 33,362,939 (GRCm39)	I364M	probably damaging	Het
Ryr2	A	T	13: 11,733,368 (GRCm39)	C2271*	probably null	Het
Shcbp1	T	A	8: 4,799,645 (GRCm39)	Q277L	probably benign	Het
Sntg1	T	C	1: 8,874,155 (GRCm39)	T5A	probably benign	Het
Snx24	T	C	18: 53,522,634 (GRCm39)	F163S	probably benign	Het
Srp72	T	C	5: 77,146,125 (GRCm39)	V581A	probably benign	Het
Srrt	T	A	5: 137,300,401 (GRCm39)	K59*	probably null	Het
Tnrc6b	A	G	15: 80,767,159 (GRCm39)	T975A	probably damaging	Het
Vmn1r174	G	A	7: 23,453,777 (GRCm39)	V148I	possibly damaging	Het
Vwa8	A	T	14: 79,420,427 (GRCm39)	Q1709H	probably damaging	Het
Wdr11	A	G	7: 129,215,613 (GRCm39)	T526A	probably benign	Het
Zfp532	C	A	18: 65,820,335 (GRCm39)	N973K	probably benign	Het

Other mutations in Vmn2r115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r115	APN	17	23,575,934 (GRCm39)	missense	probably benign	0.00
IGL00990:Vmn2r115	APN	17	23,565,345 (GRCm39)	nonsense	probably null
IGL00990:Vmn2r115	APN	17	23,578,371 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,565,135 (GRCm39)	missense	probably benign	0.03
IGL00990:Vmn2r115	APN	17	23,565,252 (GRCm39)	missense	probably benign	0.14
IGL00990:Vmn2r115	APN	17	23,565,313 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,578,323 (GRCm39)	missense	probably benign	0.22
IGL00990:Vmn2r115	APN	17	23,565,150 (GRCm39)	missense	probably benign	0.00
IGL00990:Vmn2r115	APN	17	23,565,180 (GRCm39)	missense	possibly damaging	0.90
IGL00990:Vmn2r115	APN	17	23,567,008 (GRCm39)	nonsense	probably null
IGL00990:Vmn2r115	APN	17	23,578,798 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,578,753 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,565,238 (GRCm39)	missense	probably benign	0.19
IGL00990:Vmn2r115	APN	17	23,565,346 (GRCm39)	missense	probably benign	0.30
IGL01073:Vmn2r115	APN	17	23,564,971 (GRCm39)	missense	probably benign	0.12
IGL01101:Vmn2r115	APN	17	23,564,971 (GRCm39)	missense	probably benign	0.12
IGL01300:Vmn2r115	APN	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
IGL01415:Vmn2r115	APN	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
IGL02309:Vmn2r115	APN	17	23,564,113 (GRCm39)	missense	probably benign	0.01
IGL02863:Vmn2r115	APN	17	23,578,257 (GRCm39)	missense	probably damaging	0.97
R0023:Vmn2r115	UTSW	17	23,565,252 (GRCm39)	missense	probably benign	0.14
R0197:Vmn2r115	UTSW	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
R0361:Vmn2r115	UTSW	17	23,564,196 (GRCm39)	missense	probably benign	0.11
R0601:Vmn2r115	UTSW	17	23,579,074 (GRCm39)	missense	probably null	0.51
R0676:Vmn2r115	UTSW	17	23,565,238 (GRCm39)	missense	probably benign	0.19
R0685:Vmn2r115	UTSW	17	23,578,249 (GRCm39)	missense	probably benign
R0865:Vmn2r115	UTSW	17	23,565,382 (GRCm39)	missense	possibly damaging	0.65
R1124:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1145:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1146:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1207:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1266:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1318:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1367:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1376:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1376:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1420:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1469:Vmn2r115	UTSW	17	23,564,992 (GRCm39)	missense	probably damaging	0.99
R1469:Vmn2r115	UTSW	17	23,564,992 (GRCm39)	missense	probably damaging	0.99
R1604:Vmn2r115	UTSW	17	23,564,245 (GRCm39)	missense	probably benign	0.12
R1646:Vmn2r115	UTSW	17	23,578,513 (GRCm39)	missense	probably damaging	1.00
R1650:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1678:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1716:Vmn2r115	UTSW	17	23,566,795 (GRCm39)	missense	probably benign
R1846:Vmn2r115	UTSW	17	23,578,357 (GRCm39)	missense	probably damaging	1.00
R1847:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1885:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1887:Vmn2r115	UTSW	17	23,565,007 (GRCm39)	missense	possibly damaging	0.91
R1937:Vmn2r115	UTSW	17	23,578,388 (GRCm39)	missense	probably damaging	1.00
R2007:Vmn2r115	UTSW	17	23,566,927 (GRCm39)	missense	possibly damaging	0.94
R2120:Vmn2r115	UTSW	17	23,578,297 (GRCm39)	missense	probably damaging	1.00
R3161:Vmn2r115	UTSW	17	23,575,998 (GRCm39)	missense	possibly damaging	0.82
R3780:Vmn2r115	UTSW	17	23,564,146 (GRCm39)	missense	probably damaging	1.00
R3806:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R3982:Vmn2r115	UTSW	17	23,578,948 (GRCm39)	missense	probably damaging	1.00
R4019:Vmn2r115	UTSW	17	23,579,017 (GRCm39)	missense	probably damaging	1.00
R4039:Vmn2r115	UTSW	17	23,564,077 (GRCm39)	missense	probably benign	0.26
R4087:Vmn2r115	UTSW	17	23,565,358 (GRCm39)	missense	probably benign	0.35
R4089:Vmn2r115	UTSW	17	23,565,358 (GRCm39)	missense	probably benign	0.35
R4379:Vmn2r115	UTSW	17	23,564,197 (GRCm39)	missense	possibly damaging	0.95
R4417:Vmn2r115	UTSW	17	23,564,854 (GRCm39)	missense	probably benign	0.02
R4601:Vmn2r115	UTSW	17	23,565,373 (GRCm39)	missense	probably benign	0.01
R4874:Vmn2r115	UTSW	17	23,578,825 (GRCm39)	missense	probably damaging	1.00
R5466:Vmn2r115	UTSW	17	23,579,030 (GRCm39)	missense	probably damaging	1.00
R5613:Vmn2r115	UTSW	17	23,564,307 (GRCm39)	missense	probably benign
R5821:Vmn2r115	UTSW	17	23,566,937 (GRCm39)	missense	probably damaging	0.99
R6120:Vmn2r115	UTSW	17	23,565,003 (GRCm39)	missense	probably damaging	1.00
R6193:Vmn2r115	UTSW	17	23,575,983 (GRCm39)	missense	probably benign	0.01
R6213:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R6290:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R6319:Vmn2r115	UTSW	17	23,566,877 (GRCm39)	missense	possibly damaging	0.70
R6495:Vmn2r115	UTSW	17	23,578,572 (GRCm39)	missense	probably benign	0.02
R6599:Vmn2r115	UTSW	17	23,565,006 (GRCm39)	missense	probably benign	0.00
R6764:Vmn2r115	UTSW	17	23,565,046 (GRCm39)	missense	probably damaging	1.00
R6970:Vmn2r115	UTSW	17	23,564,989 (GRCm39)	missense	probably benign	0.23
R7023:Vmn2r115	UTSW	17	23,578,785 (GRCm39)	missense	probably damaging	1.00
R7236:Vmn2r115	UTSW	17	23,578,576 (GRCm39)	missense	probably benign	0.01
R7353:Vmn2r115	UTSW	17	23,564,887 (GRCm39)	missense	possibly damaging	0.65
R7483:Vmn2r115	UTSW	17	23,565,371 (GRCm39)	missense	possibly damaging	0.95
R7743:Vmn2r115	UTSW	17	23,564,772 (GRCm39)	nonsense	probably null
R8005:Vmn2r115	UTSW	17	23,563,124 (GRCm39)	nonsense	probably null
R8191:Vmn2r115	UTSW	17	23,578,530 (GRCm39)	missense	probably damaging	1.00
R8544:Vmn2r115	UTSW	17	23,564,773 (GRCm39)	missense	possibly damaging	0.88
R8890:Vmn2r115	UTSW	17	23,578,497 (GRCm39)	missense	probably damaging	0.98
R9098:Vmn2r115	UTSW	17	23,564,803 (GRCm39)	missense	probably benign
R9114:Vmn2r115	UTSW	17	23,564,307 (GRCm39)	missense	probably benign
R9189:Vmn2r115	UTSW	17	23,564,784 (GRCm39)	missense	probably damaging	1.00
R9351:Vmn2r115	UTSW	17	23,578,482 (GRCm39)	missense	probably benign	0.05
R9397:Vmn2r115	UTSW	17	23,564,152 (GRCm39)	nonsense	probably null
R9410:Vmn2r115	UTSW	17	23,578,915 (GRCm39)	missense	possibly damaging	0.67
R9593:Vmn2r115	UTSW	17	23,578,184 (GRCm39)	missense	probably damaging	0.99
V5622:Vmn2r115	UTSW	17	23,578,333 (GRCm39)	missense	probably benign
V5622:Vmn2r115	UTSW	17	23,565,201 (GRCm39)	missense	probably damaging	1.00
X0023:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
X0033:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign

Predicted Primers

PCR Primer
(F):5'- TCACTACCTCACAGTGGAATGTCAGTC -3'
(R):5'- AGGTCTACATGGACAGATTCTGCCTC -3'

Sequencing Primer
(F):5'- TGTCAGTCCTGGTATGAAAGAC -3'
(R):5'- GTCCTTGGGCAGATTATCAAAC -3'

Posted On

2014-04-24