Incidental Mutation 'R1645:Ccny'
ID 173846
Institutional Source Beutler Lab
Gene Symbol Ccny
Ensembl Gene ENSMUSG00000024286
Gene Name cyclin Y
Synonyms 1700025H17Rik, 4631402G10Rik, 5730405I09Rik, 3110050L10Rik
MMRRC Submission 039681-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.234) question?
Stock # R1645 (G1)
Quality Score 225
Status Not validated
Chromosome 18
Chromosomal Location 9312304-9450154 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 9345199 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 192 (T192A)
Ref Sequence ENSEMBL: ENSMUSP00000050001 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053917]
AlphaFold Q8BGU5
Predicted Effect probably damaging
Transcript: ENSMUST00000053917
AA Change: T192A

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000050001
Gene: ENSMUSG00000024286
AA Change: T192A

DomainStartEndE-ValueType
CYCLIN 173 258 1.36e-7 SMART
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.3%
  • 20x: 89.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired adipogenesis and lipid production. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 A G 3: 121,948,926 (GRCm39) M1732V probably benign Het
Acvr1 A T 2: 58,352,911 (GRCm39) C350S probably damaging Het
Adgrl2 A T 3: 148,571,244 (GRCm39) V130D probably damaging Het
Anapc1 A G 2: 128,500,166 (GRCm39) probably null Het
Asap1 A T 15: 63,961,324 (GRCm39) V1116E probably damaging Het
Bcas1 T A 2: 170,229,087 (GRCm39) D308V probably damaging Het
Brca1 G A 11: 101,400,879 (GRCm39) H1468Y probably benign Het
C2cd5 A G 6: 142,995,852 (GRCm39) C421R probably damaging Het
C4b A G 17: 34,959,571 (GRCm39) S363P probably damaging Het
Camk2b A T 11: 5,922,719 (GRCm39) C484S probably damaging Het
Cby2 C A 14: 75,821,089 (GRCm39) R212L probably benign Het
Chl1 G T 6: 103,660,141 (GRCm39) A356S probably benign Het
Dst T A 1: 34,264,803 (GRCm39) Y4850N probably damaging Het
Dyrk4 C A 6: 126,871,756 (GRCm39) E171* probably null Het
Entrep3 C A 3: 89,094,154 (GRCm39) D322E possibly damaging Het
Ephb1 A G 9: 101,804,758 (GRCm39) Y928H probably damaging Het
Fam114a2 A T 11: 57,390,621 (GRCm39) N304K probably benign Het
Fras1 A T 5: 96,848,445 (GRCm39) D1820V possibly damaging Het
Gabbr2 A T 4: 46,664,963 (GRCm39) probably null Het
Gm6358 T C 16: 88,937,967 (GRCm39) W69R unknown Het
Ikbkb C A 8: 23,181,082 (GRCm39) S127I probably damaging Het
Impa1 A T 3: 10,393,501 (GRCm39) M48K possibly damaging Het
Klra2 A T 6: 131,220,857 (GRCm39) probably null Het
Lama1 A T 17: 68,044,677 (GRCm39) Y192F probably benign Het
Lama2 T A 10: 27,244,981 (GRCm39) T267S probably damaging Het
Mroh7 G A 4: 106,577,865 (GRCm39) T271I probably benign Het
Myo9b A G 8: 71,775,622 (GRCm39) E348G probably damaging Het
Nrp2 C T 1: 62,824,283 (GRCm39) P796L probably damaging Het
Ntn4 C T 10: 93,543,215 (GRCm39) R314W probably damaging Het
Or10al4 A T 17: 38,037,229 (GRCm39) T114S probably benign Het
Or51i1 A G 7: 103,671,210 (GRCm39) F105S probably damaging Het
Or9k7 T A 10: 130,046,081 (GRCm39) D306V probably damaging Het
P3h2 T A 16: 25,815,982 (GRCm39) H177L probably damaging Het
Pcdhb16 T C 18: 37,612,423 (GRCm39) I461T probably benign Het
Pdlim3 A G 8: 46,349,785 (GRCm39) I32V probably benign Het
Pigu A C 2: 155,170,598 (GRCm39) Y143* probably null Het
Prkd3 A C 17: 79,263,949 (GRCm39) probably null Het
Psrc1 C T 3: 108,292,554 (GRCm39) R116W probably damaging Het
Rab5b A G 10: 128,522,695 (GRCm39) S29P possibly damaging Het
Rbm26 A G 14: 105,388,253 (GRCm39) V403A probably damaging Het
Rbm47 G T 5: 66,184,481 (GRCm39) R41S probably benign Het
Rngtt A G 4: 33,362,939 (GRCm39) I364M probably damaging Het
Ryr2 A T 13: 11,733,368 (GRCm39) C2271* probably null Het
Shcbp1 T A 8: 4,799,645 (GRCm39) Q277L probably benign Het
Sntg1 T C 1: 8,874,155 (GRCm39) T5A probably benign Het
Snx24 T C 18: 53,522,634 (GRCm39) F163S probably benign Het
Srp72 T C 5: 77,146,125 (GRCm39) V581A probably benign Het
Srrt T A 5: 137,300,401 (GRCm39) K59* probably null Het
Tnrc6b A G 15: 80,767,159 (GRCm39) T975A probably damaging Het
Vmn1r174 G A 7: 23,453,777 (GRCm39) V148I possibly damaging Het
Vmn2r115 T A 17: 23,565,192 (GRCm39) C360S possibly damaging Het
Vwa8 A T 14: 79,420,427 (GRCm39) Q1709H probably damaging Het
Wdr11 A G 7: 129,215,613 (GRCm39) T526A probably benign Het
Zfp532 C A 18: 65,820,335 (GRCm39) N973K probably benign Het
Other mutations in Ccny
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00863:Ccny APN 18 9,345,444 (GRCm39) missense probably benign 0.18
IGL01986:Ccny APN 18 9,377,817 (GRCm39) missense probably damaging 1.00
IGL03000:Ccny APN 18 9,353,489 (GRCm39) missense probably benign 0.12
IGL03257:Ccny APN 18 9,386,747 (GRCm39) missense possibly damaging 0.84
R0015:Ccny UTSW 18 9,316,682 (GRCm39) splice site probably benign
R0015:Ccny UTSW 18 9,316,682 (GRCm39) splice site probably benign
R0372:Ccny UTSW 18 9,345,201 (GRCm39) missense probably damaging 1.00
R0440:Ccny UTSW 18 9,332,917 (GRCm39) missense probably benign 0.21
R2044:Ccny UTSW 18 9,449,644 (GRCm39) missense probably damaging 1.00
R2405:Ccny UTSW 18 9,353,480 (GRCm39) missense probably benign 0.08
R3847:Ccny UTSW 18 9,449,641 (GRCm39) missense probably benign 0.37
R3864:Ccny UTSW 18 9,449,604 (GRCm39) missense probably damaging 1.00
R4198:Ccny UTSW 18 9,332,928 (GRCm39) missense probably damaging 0.96
R4964:Ccny UTSW 18 9,449,516 (GRCm39) critical splice donor site probably null
R6474:Ccny UTSW 18 9,345,427 (GRCm39) missense probably damaging 1.00
R7858:Ccny UTSW 18 9,386,782 (GRCm39) missense probably damaging 0.99
R8889:Ccny UTSW 18 9,345,235 (GRCm39) missense probably damaging 1.00
R8892:Ccny UTSW 18 9,345,235 (GRCm39) missense probably damaging 1.00
R9004:Ccny UTSW 18 9,332,883 (GRCm39) missense possibly damaging 0.74
X0050:Ccny UTSW 18 9,332,874 (GRCm39) missense possibly damaging 0.87
Z1177:Ccny UTSW 18 9,353,494 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GGCTTTGAGTGGGACTTCACAGATG -3'
(R):5'- TTTCCTTACCAGGGACCCAGATGG -3'

Sequencing Primer
(F):5'- CTTCACAGATGATTTTAGAAGGGGAC -3'
(R):5'- CCCAGATGGAAGGATGCTCTTAG -3'
Posted On 2014-04-24