Incidental Mutation 'R0109:Miox'
ID 17409
Institutional Source Beutler Lab
Gene Symbol Miox
Ensembl Gene ENSMUSG00000022613
Gene Name myo-inositol oxygenase
Synonyms RSOR, C85427, 0610009I10Rik, Aldrl6
MMRRC Submission 038395-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.158) question?
Stock # R0109 (G1)
Quality Score
Status Validated
Chromosome 15
Chromosomal Location 89218676-89221210 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 89219784 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 91 (V91I)
Ref Sequence ENSEMBL: ENSMUSP00000023282 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023282] [ENSMUST00000162756]
AlphaFold Q9QXN5
PDB Structure Crystal structure of mouse myo-inositol oxygenase in complex with substrate [X-RAY DIFFRACTION]
Crystal structure of Mouse Myo-inositol oxygenase (re-refined) [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000023282
AA Change: V91I

PolyPhen 2 Score 0.172 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000023282
Gene: ENSMUSG00000022613
AA Change: V91I

DomainStartEndE-ValueType
Pfam:MIOX 31 285 2.1e-125 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159381
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160491
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161437
Predicted Effect probably benign
Transcript: ENSMUST00000162033
SMART Domains Protein: ENSMUSP00000123732
Gene: ENSMUSG00000022613

DomainStartEndE-ValueType
Pfam:MIOX 1 53 7.2e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162756
SMART Domains Protein: ENSMUSP00000125302
Gene: ENSMUSG00000022613

DomainStartEndE-ValueType
Pfam:DUF706 40 128 8.7e-30 PFAM
Meta Mutation Damage Score 0.1386 question?
Coding Region Coverage
  • 1x: 90.6%
  • 3x: 88.5%
  • 10x: 83.8%
  • 20x: 77.5%
Validation Efficiency 90% (95/106)
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m C A 6: 121,636,262 (GRCm39) H710Q probably benign Het
Abca14 A T 7: 119,917,985 (GRCm39) K1496* probably null Het
Anapc1 C A 2: 128,476,613 (GRCm39) R1335L probably damaging Het
Arhgef10l A T 4: 140,305,605 (GRCm39) S203T probably benign Het
Astn1 C T 1: 158,491,674 (GRCm39) T41I possibly damaging Het
Atrnl1 T A 19: 57,743,949 (GRCm39) Y1184N possibly damaging Het
Avil A G 10: 126,849,513 (GRCm39) N603S probably benign Het
Brca1 T C 11: 101,421,916 (GRCm39) D149G possibly damaging Het
Car14 C A 3: 95,806,763 (GRCm39) A234S probably benign Het
Cep164 A C 9: 45,682,885 (GRCm39) L935R probably damaging Het
Cps1 T C 1: 67,268,577 (GRCm39) V1435A possibly damaging Het
Csmd2 T G 4: 128,438,536 (GRCm39) S3038R probably benign Het
Cyp2j6 A T 4: 96,406,394 (GRCm39) I459N probably damaging Het
Cyth1 T C 11: 118,073,132 (GRCm39) E242G probably damaging Het
Dclk3 T G 9: 111,296,738 (GRCm39) L94R possibly damaging Het
Disp2 T C 2: 118,622,297 (GRCm39) S1010P probably damaging Het
Dlec1 G A 9: 118,934,892 (GRCm39) R145H probably damaging Het
Dsg3 T C 18: 20,673,191 (GRCm39) V954A probably damaging Het
Dync2h1 T A 9: 7,111,487 (GRCm39) D309V probably damaging Het
Fam13b A G 18: 34,584,361 (GRCm39) I601T probably benign Het
Fgd5 T A 6: 91,965,216 (GRCm39) M325K possibly damaging Het
Frmpd1 A T 4: 45,279,340 (GRCm39) E688D probably benign Het
Gabrb1 C T 5: 72,279,289 (GRCm39) probably benign Het
Gm6590 A T 6: 130,461,869 (GRCm39) noncoding transcript Het
Gse1 T A 8: 121,294,524 (GRCm39) S284T probably damaging Het
Ipo13 C T 4: 117,762,213 (GRCm39) R387Q possibly damaging Het
Kctd16 A G 18: 40,392,204 (GRCm39) E264G probably benign Het
Krt73 A T 15: 101,704,830 (GRCm39) L352* probably null Het
Mapk15 A T 15: 75,867,926 (GRCm39) K153* probably null Het
Mcemp1 C A 8: 3,717,055 (GRCm39) Y65* probably null Het
Mcoln2 C G 3: 145,881,473 (GRCm39) R210G probably damaging Het
Myh7b A G 2: 155,453,594 (GRCm39) E6G possibly damaging Het
Ncapg A G 5: 45,851,090 (GRCm39) probably null Het
Nfyb G A 10: 82,590,836 (GRCm39) A65V possibly damaging Het
Or4a69 A G 2: 89,313,147 (GRCm39) F111L probably benign Het
Or52d1 T C 7: 103,755,812 (GRCm39) S109P probably damaging Het
Or5b94 C A 19: 12,652,224 (GRCm39) F218L probably benign Het
Osbp2 A C 11: 3,661,791 (GRCm39) S754A probably benign Het
Pard3 C T 8: 128,125,147 (GRCm39) R712C probably damaging Het
Parp9 T C 16: 35,768,711 (GRCm39) I64T probably damaging Het
Pcm1 T A 8: 41,710,974 (GRCm39) H81Q possibly damaging Het
Pcnt G A 10: 76,225,030 (GRCm39) P1825S probably benign Het
Pfkfb4 T C 9: 108,827,957 (GRCm39) V43A probably benign Het
Pgap1 A T 1: 54,533,984 (GRCm39) V643E probably damaging Het
Pip5k1a T C 3: 94,972,753 (GRCm39) T433A probably benign Het
Pip5k1b T A 19: 24,356,411 (GRCm39) M176L probably benign Het
Polg2 T C 11: 106,667,958 (GRCm39) probably benign Het
Pomp T A 5: 147,812,323 (GRCm39) H136Q probably benign Het
Ppfia4 A T 1: 134,251,955 (GRCm39) probably null Het
Prdx2 G A 8: 85,696,880 (GRCm39) G4S probably benign Het
Rbm28 C T 6: 29,160,104 (GRCm39) G70D probably benign Het
Rdh10 T A 1: 16,176,489 (GRCm39) I83N probably damaging Het
Rin3 A G 12: 102,279,340 (GRCm39) I50V possibly damaging Het
Rnf122 T C 8: 31,614,877 (GRCm39) probably benign Het
Sik2 A G 9: 50,810,775 (GRCm39) M447T possibly damaging Het
Sla2 A G 2: 156,725,507 (GRCm39) probably null Het
Slc51a T A 16: 32,296,425 (GRCm39) I192L probably benign Het
Sorcs1 T C 19: 50,367,329 (GRCm39) probably benign Het
Spata16 T A 3: 26,967,416 (GRCm39) F389I probably damaging Het
Srebf1 G A 11: 60,092,630 (GRCm39) A793V probably benign Het
Tbc1d9b T C 11: 50,049,261 (GRCm39) V736A probably benign Het
Tbx15 C A 3: 99,259,182 (GRCm39) T351N possibly damaging Het
Tep1 A G 14: 51,089,373 (GRCm39) probably null Het
Tmed11 T A 5: 108,925,278 (GRCm39) D178V probably damaging Het
Traf7 A G 17: 24,732,900 (GRCm39) F110L probably benign Het
Ubqlnl C T 7: 103,799,399 (GRCm39) V33M probably damaging Het
Vcan A T 13: 89,826,192 (GRCm39) probably null Het
Vmn1r194 A G 13: 22,429,217 (GRCm39) Y278C probably damaging Het
Vmn1r46 T C 6: 89,954,044 (GRCm39) F298L probably benign Het
Vps13b A G 15: 35,572,265 (GRCm39) T961A probably benign Het
Wdr48 G A 9: 119,747,634 (GRCm39) probably benign Het
Wwp1 G A 4: 19,641,725 (GRCm39) probably benign Het
Zfp1001 A T 2: 150,165,761 (GRCm39) probably benign Het
Zfp217 C T 2: 169,957,382 (GRCm39) A539T probably benign Het
Zfp839 G A 12: 110,827,308 (GRCm39) E400K possibly damaging Het
Other mutations in Miox
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03070:Miox APN 15 89,220,287 (GRCm39) missense possibly damaging 0.48
R0001:Miox UTSW 15 89,220,477 (GRCm39) missense possibly damaging 0.48
R0011:Miox UTSW 15 89,220,477 (GRCm39) missense possibly damaging 0.48
R0011:Miox UTSW 15 89,220,477 (GRCm39) missense possibly damaging 0.48
R0039:Miox UTSW 15 89,220,477 (GRCm39) missense possibly damaging 0.48
R0043:Miox UTSW 15 89,220,477 (GRCm39) missense possibly damaging 0.48
R0079:Miox UTSW 15 89,220,477 (GRCm39) missense possibly damaging 0.48
R0081:Miox UTSW 15 89,220,477 (GRCm39) missense possibly damaging 0.48
R0109:Miox UTSW 15 89,219,784 (GRCm39) missense probably benign 0.17
R0134:Miox UTSW 15 89,218,657 (GRCm39) unclassified probably benign
R0166:Miox UTSW 15 89,220,477 (GRCm39) missense possibly damaging 0.48
R0172:Miox UTSW 15 89,220,477 (GRCm39) missense possibly damaging 0.48
R0173:Miox UTSW 15 89,220,477 (GRCm39) missense possibly damaging 0.48
R0225:Miox UTSW 15 89,218,657 (GRCm39) unclassified probably benign
R0284:Miox UTSW 15 89,220,477 (GRCm39) missense possibly damaging 0.48
R0285:Miox UTSW 15 89,220,477 (GRCm39) missense possibly damaging 0.48
R0288:Miox UTSW 15 89,220,477 (GRCm39) missense possibly damaging 0.48
R0681:Miox UTSW 15 89,220,477 (GRCm39) missense possibly damaging 0.48
R1383:Miox UTSW 15 89,219,245 (GRCm39) missense probably damaging 1.00
R4620:Miox UTSW 15 89,220,324 (GRCm39) missense probably benign 0.43
R5016:Miox UTSW 15 89,219,767 (GRCm39) missense probably null 1.00
R5110:Miox UTSW 15 89,219,759 (GRCm39) missense probably benign
R5393:Miox UTSW 15 89,220,450 (GRCm39) nonsense probably null
R6136:Miox UTSW 15 89,219,524 (GRCm39) missense probably damaging 1.00
R6339:Miox UTSW 15 89,219,702 (GRCm39) nonsense probably null
R7309:Miox UTSW 15 89,220,252 (GRCm39) missense probably damaging 1.00
R7402:Miox UTSW 15 89,219,206 (GRCm39) missense probably benign 0.01
R7891:Miox UTSW 15 89,220,742 (GRCm39) missense probably benign 0.10
R7913:Miox UTSW 15 89,220,785 (GRCm39) missense probably damaging 0.99
R9136:Miox UTSW 15 89,220,740 (GRCm39) missense probably damaging 1.00
R9660:Miox UTSW 15 89,218,703 (GRCm39) unclassified probably benign
R9711:Miox UTSW 15 89,220,785 (GRCm39) missense probably damaging 0.99
R9728:Miox UTSW 15 89,218,703 (GRCm39) unclassified probably benign
Z1177:Miox UTSW 15 89,219,847 (GRCm39) missense probably damaging 1.00
Posted On 2013-01-31