|Institutional Source||Beutler Lab|
|Gene Name||dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R1650 (G1)|
|Chromosomal Location||126876020-126921839 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 126899829 bp|
|Amino Acid Change||Lysine to Glutamic Acid at position 62 (K62E)|
|Ref Sequence||ENSEMBL: ENSMUSP00000077606 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000078521]|
|Predicted Effect||noncoding transcript
|Predicted Effect||probably benign
AA Change: K62E
PolyPhen 2 Score 0.285 (Sensitivity: 0.91; Specificity: 0.88)
AA Change: K62E
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||99% (86/87)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
PHENOTYPE: Contrary to expectation, homozygous null males are fertile and do not exhibit any obvious dysfunction in spermatogenesis, sperm motility and fertilization. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Dyrk4||
(F):5'- TGCACTGAAAATGTGGAGAAGTTCCTC -3'
(R):5'- TGACCCAGAACTCCTGTCTCAGTTATC -3'
(F):5'- AGAAGTTCCTCCATATTCCTGAACG -3'
(R):5'- cattcatacattcaccgagcac -3'