Incidental Mutation 'R1616:Magi2'
| ID |
174238 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Magi2
|
| Ensembl Gene |
ENSMUSG00000040003 |
| Gene Name |
membrane associated guanylate kinase, WW and PDZ domain containing 2 |
| Synonyms |
Acvrinp1, Magi-2, S-SCAM |
| MMRRC Submission |
039653-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1616 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
19432034-20909790 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 20814324 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Lysine
at position 1075
(T1075K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000142764
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000088516]
[ENSMUST00000101558]
[ENSMUST00000115267]
[ENSMUST00000197354]
[ENSMUST00000197443]
[ENSMUST00000197553]
[ENSMUST00000208219]
|
| AlphaFold |
Q9WVQ1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000088516
AA Change: T1089K
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000085872
Gene: ENSMUSG00000040003
AA Change: T1089K
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
101 |
5.26e-9 |
SMART |
|
GuKc
|
107 |
290 |
2.76e-45 |
SMART |
|
WW
|
302 |
334 |
7.43e-12 |
SMART |
|
WW
|
348 |
380 |
2.4e-6 |
SMART |
|
PDZ
|
433 |
509 |
3.51e-19 |
SMART |
|
PDZ
|
612 |
682 |
2.3e-14 |
SMART |
|
PDZ
|
785 |
861 |
4.04e-19 |
SMART |
|
low complexity region
|
893 |
907 |
N/A |
INTRINSIC |
|
PDZ
|
928 |
1009 |
5.05e-20 |
SMART |
|
low complexity region
|
1052 |
1063 |
N/A |
INTRINSIC |
|
PDZ
|
1147 |
1221 |
3.88e-21 |
SMART |
|
low complexity region
|
1257 |
1270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000101558
AA Change: T912K
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000099094
Gene: ENSMUSG00000040003
AA Change: T912K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
66 |
74 |
N/A |
INTRINSIC |
|
WW
|
139 |
171 |
7.43e-12 |
SMART |
|
WW
|
185 |
217 |
2.4e-6 |
SMART |
|
PDZ
|
270 |
346 |
3.51e-19 |
SMART |
|
PDZ
|
449 |
519 |
2.3e-14 |
SMART |
|
PDZ
|
608 |
684 |
4.04e-19 |
SMART |
|
low complexity region
|
716 |
730 |
N/A |
INTRINSIC |
|
PDZ
|
751 |
832 |
5.05e-20 |
SMART |
|
low complexity region
|
875 |
886 |
N/A |
INTRINSIC |
|
PDZ
|
970 |
1044 |
3.88e-21 |
SMART |
|
low complexity region
|
1080 |
1093 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115267
AA Change: T926K
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000110922
Gene: ENSMUSG00000040003
AA Change: T926K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
66 |
74 |
N/A |
INTRINSIC |
|
WW
|
139 |
171 |
7.43e-12 |
SMART |
|
WW
|
185 |
217 |
2.4e-6 |
SMART |
|
PDZ
|
270 |
346 |
3.51e-19 |
SMART |
|
PDZ
|
449 |
519 |
2.3e-14 |
SMART |
|
PDZ
|
622 |
698 |
4.04e-19 |
SMART |
|
low complexity region
|
730 |
744 |
N/A |
INTRINSIC |
|
PDZ
|
765 |
846 |
5.05e-20 |
SMART |
|
low complexity region
|
889 |
900 |
N/A |
INTRINSIC |
|
PDZ
|
984 |
1058 |
3.88e-21 |
SMART |
|
low complexity region
|
1094 |
1107 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000197354
AA Change: T1089K
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000142576
Gene: ENSMUSG00000040003
AA Change: T1089K
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
101 |
2.5e-11 |
SMART |
|
GuKc
|
107 |
290 |
1.4e-47 |
SMART |
|
WW
|
302 |
334 |
4.3e-14 |
SMART |
|
WW
|
348 |
380 |
1.4e-8 |
SMART |
|
PDZ
|
433 |
509 |
1.7e-21 |
SMART |
|
PDZ
|
612 |
682 |
1.1e-16 |
SMART |
|
PDZ
|
785 |
861 |
2e-21 |
SMART |
|
low complexity region
|
893 |
907 |
N/A |
INTRINSIC |
|
PDZ
|
928 |
1009 |
2.4e-22 |
SMART |
|
low complexity region
|
1052 |
1063 |
N/A |
INTRINSIC |
|
PDZ
|
1147 |
1221 |
1.9e-23 |
SMART |
|
low complexity region
|
1255 |
1269 |
N/A |
INTRINSIC |
|
low complexity region
|
1304 |
1319 |
N/A |
INTRINSIC |
|
low complexity region
|
1344 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1384 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000197443
AA Change: T1075K
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000142764
Gene: ENSMUSG00000040003
AA Change: T1075K
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
101 |
2.5e-11 |
SMART |
|
GuKc
|
107 |
290 |
1.4e-47 |
SMART |
|
WW
|
302 |
334 |
4.3e-14 |
SMART |
|
WW
|
348 |
380 |
1.4e-8 |
SMART |
|
PDZ
|
433 |
509 |
1.7e-21 |
SMART |
|
PDZ
|
612 |
682 |
1.1e-16 |
SMART |
|
PDZ
|
771 |
847 |
2e-21 |
SMART |
|
low complexity region
|
879 |
893 |
N/A |
INTRINSIC |
|
PDZ
|
914 |
995 |
2.4e-22 |
SMART |
|
low complexity region
|
1038 |
1049 |
N/A |
INTRINSIC |
|
PDZ
|
1133 |
1207 |
1.9e-23 |
SMART |
|
low complexity region
|
1241 |
1255 |
N/A |
INTRINSIC |
|
low complexity region
|
1290 |
1305 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1349 |
N/A |
INTRINSIC |
|
low complexity region
|
1354 |
1370 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197553
AA Change: T699K
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000199514
AA Change: T29K
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000208219
AA Change: T683K
PolyPhen 2
Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
|
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.8%
- 10x: 94.3%
- 20x: 85.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a null allele show neonatal death and hippocampal neurons with altered dendritic spine morphology. Homozygotes for a different null allele die neonatally due to anuria and podocyte anomalies. Mice lacking all three isoforms develop proteinuria, podocytopathy and die of renal failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933406P04Rik |
T |
C |
10: 20,187,087 (GRCm39) |
|
probably benign |
Het |
| A1cf |
A |
G |
19: 31,912,175 (GRCm39) |
E430G |
probably damaging |
Het |
| Aacs |
T |
A |
5: 125,561,590 (GRCm39) |
|
probably null |
Het |
| Acot12 |
G |
A |
13: 91,920,886 (GRCm39) |
V331I |
probably benign |
Het |
| Acp7 |
A |
G |
7: 28,310,503 (GRCm39) |
W445R |
probably damaging |
Het |
| Actl11 |
C |
A |
9: 107,809,135 (GRCm39) |
Q1153K |
probably benign |
Het |
| Actr8 |
A |
G |
14: 29,704,601 (GRCm39) |
T34A |
possibly damaging |
Het |
| Ahnak |
A |
G |
19: 8,986,351 (GRCm39) |
D2545G |
possibly damaging |
Het |
| Ap5z1 |
A |
G |
5: 142,457,991 (GRCm39) |
Y388C |
probably benign |
Het |
| Apol7a |
C |
T |
15: 77,273,806 (GRCm39) |
G219S |
probably damaging |
Het |
| Arid1b |
T |
A |
17: 5,389,569 (GRCm39) |
I1705N |
probably damaging |
Het |
| Bod1l |
T |
C |
5: 41,966,058 (GRCm39) |
Q2669R |
probably benign |
Het |
| Braf |
A |
T |
6: 39,620,067 (GRCm39) |
S504T |
probably benign |
Het |
| Cbl |
A |
T |
9: 44,064,197 (GRCm39) |
Y780N |
probably damaging |
Het |
| Cd86 |
T |
C |
16: 36,449,338 (GRCm39) |
I20V |
probably benign |
Het |
| Cep290 |
T |
G |
10: 100,404,698 (GRCm39) |
D2353E |
probably benign |
Het |
| Ckmt2 |
G |
A |
13: 92,007,328 (GRCm39) |
R289C |
probably benign |
Het |
| Col3a1 |
T |
C |
1: 45,367,648 (GRCm39) |
|
probably null |
Het |
| Cyp4f16 |
T |
A |
17: 32,761,942 (GRCm39) |
Y163* |
probably null |
Het |
| Dimt1 |
T |
C |
13: 107,089,958 (GRCm39) |
V227A |
possibly damaging |
Het |
| Dnah6 |
A |
T |
6: 73,077,095 (GRCm39) |
M2338K |
probably benign |
Het |
| Dock4 |
T |
G |
12: 40,719,044 (GRCm39) |
I274S |
probably damaging |
Het |
| Enthd1 |
T |
C |
15: 80,336,586 (GRCm39) |
D616G |
probably damaging |
Het |
| Fignl2 |
T |
C |
15: 100,951,997 (GRCm39) |
E95G |
probably damaging |
Het |
| Foxn1 |
A |
G |
11: 78,249,692 (GRCm39) |
M611T |
probably benign |
Het |
| Foxs1 |
T |
C |
2: 152,774,559 (GRCm39) |
S165G |
probably benign |
Het |
| Fzd3 |
G |
T |
14: 65,472,956 (GRCm39) |
Q271K |
probably benign |
Het |
| Hadhb |
A |
T |
5: 30,371,713 (GRCm39) |
I55F |
probably damaging |
Het |
| Hipk3 |
G |
A |
2: 104,264,090 (GRCm39) |
Q824* |
probably null |
Het |
| Hps1 |
G |
A |
19: 42,755,624 (GRCm39) |
R201W |
probably damaging |
Het |
| Kif21b |
T |
C |
1: 136,099,423 (GRCm39) |
S1477P |
probably damaging |
Het |
| Kif26a |
A |
T |
12: 112,123,680 (GRCm39) |
|
probably null |
Het |
| Krt90 |
T |
C |
15: 101,469,026 (GRCm39) |
E172G |
possibly damaging |
Het |
| Lama4 |
T |
G |
10: 38,951,446 (GRCm39) |
F1064V |
probably damaging |
Het |
| Leng9 |
A |
G |
7: 4,151,902 (GRCm39) |
V258A |
probably benign |
Het |
| Lgi2 |
A |
C |
5: 52,703,980 (GRCm39) |
V217G |
probably benign |
Het |
| Lpgat1 |
T |
C |
1: 191,495,741 (GRCm39) |
I310T |
possibly damaging |
Het |
| Ltbp3 |
A |
G |
19: 5,796,995 (GRCm39) |
Y374C |
probably damaging |
Het |
| Man2c1 |
T |
C |
9: 57,042,793 (GRCm39) |
I221T |
probably benign |
Het |
| Mydgf |
A |
G |
17: 56,486,415 (GRCm39) |
M72T |
possibly damaging |
Het |
| Myo1b |
T |
C |
1: 51,815,474 (GRCm39) |
N624S |
probably damaging |
Het |
| Myo5c |
T |
A |
9: 75,203,299 (GRCm39) |
M1465K |
probably damaging |
Het |
| Nek4 |
A |
T |
14: 30,709,094 (GRCm39) |
D716V |
probably damaging |
Het |
| Nfxl1 |
T |
A |
5: 72,686,380 (GRCm39) |
Q607L |
probably benign |
Het |
| Nlrp9c |
A |
T |
7: 26,083,862 (GRCm39) |
D572E |
probably benign |
Het |
| Nop14 |
G |
T |
5: 34,807,757 (GRCm39) |
Q402K |
possibly damaging |
Het |
| Npy5r |
C |
G |
8: 67,134,052 (GRCm39) |
C247S |
probably damaging |
Het |
| Nrap |
T |
A |
19: 56,378,255 (GRCm39) |
I19F |
probably damaging |
Het |
| Or4c102 |
A |
G |
2: 88,422,352 (GRCm39) |
D68G |
probably damaging |
Het |
| Or51t4 |
T |
A |
7: 102,597,721 (GRCm39) |
N16K |
probably damaging |
Het |
| Or6z3 |
T |
G |
7: 6,463,744 (GRCm39) |
S79A |
probably damaging |
Het |
| Pcdh9 |
A |
T |
14: 94,124,405 (GRCm39) |
Y588* |
probably null |
Het |
| Ppp1r12a |
A |
G |
10: 108,096,728 (GRCm39) |
E183G |
probably damaging |
Het |
| Ppp2r2b |
T |
A |
18: 42,821,375 (GRCm39) |
H261L |
probably benign |
Het |
| Ptch1 |
G |
T |
13: 63,687,656 (GRCm39) |
T374K |
possibly damaging |
Het |
| Ptpn13 |
A |
T |
5: 103,713,103 (GRCm39) |
N1742I |
possibly damaging |
Het |
| Rab33a |
C |
T |
X: 47,608,521 (GRCm39) |
S15L |
probably benign |
Het |
| Ralb |
T |
C |
1: 119,405,744 (GRCm39) |
Y75C |
probably damaging |
Het |
| Rassf7 |
T |
A |
7: 140,796,645 (GRCm39) |
V2D |
probably damaging |
Het |
| Rbm10 |
A |
G |
X: 20,512,230 (GRCm39) |
N397S |
probably benign |
Het |
| Rbm15 |
T |
C |
3: 107,238,197 (GRCm39) |
T734A |
probably benign |
Het |
| Rbm8a |
G |
T |
3: 96,539,046 (GRCm39) |
|
probably benign |
Het |
| Rock2 |
T |
C |
12: 17,022,986 (GRCm39) |
I1095T |
probably benign |
Het |
| Rxfp3 |
T |
A |
15: 11,036,389 (GRCm39) |
T328S |
probably damaging |
Het |
| Sec31a |
T |
A |
5: 100,534,054 (GRCm39) |
K505N |
possibly damaging |
Het |
| Selenof |
A |
G |
3: 144,302,642 (GRCm39) |
*122W |
probably null |
Het |
| Sh3pxd2b |
T |
C |
11: 32,331,441 (GRCm39) |
M55T |
possibly damaging |
Het |
| Slc15a2 |
T |
C |
16: 36,574,843 (GRCm39) |
D522G |
probably benign |
Het |
| Slc2a1 |
T |
C |
4: 118,993,503 (GRCm39) |
F447L |
probably damaging |
Het |
| Slc45a2 |
T |
A |
15: 11,022,214 (GRCm39) |
C319S |
probably null |
Het |
| Smad4 |
T |
C |
18: 73,773,333 (GRCm39) |
D551G |
probably benign |
Het |
| Smarcc2 |
A |
G |
10: 128,318,662 (GRCm39) |
Y648C |
probably damaging |
Het |
| Snrnp40 |
C |
G |
4: 130,271,836 (GRCm39) |
|
probably null |
Het |
| Stab2 |
A |
T |
10: 86,721,582 (GRCm39) |
|
probably null |
Het |
| Tanc1 |
A |
G |
2: 59,615,731 (GRCm39) |
D246G |
probably damaging |
Het |
| Tekt3 |
T |
G |
11: 62,978,024 (GRCm39) |
|
probably null |
Het |
| Them5 |
G |
A |
3: 94,253,567 (GRCm39) |
|
probably null |
Het |
| Tlr4 |
T |
A |
4: 66,757,717 (GRCm39) |
F170Y |
probably damaging |
Het |
| Tmem214 |
T |
G |
5: 31,028,907 (GRCm39) |
Y165* |
probably null |
Het |
| Tmem94 |
T |
C |
11: 115,686,971 (GRCm39) |
|
probably null |
Het |
| Tom1l1 |
A |
G |
11: 90,547,177 (GRCm39) |
L301S |
possibly damaging |
Het |
| Trpm3 |
A |
G |
19: 22,960,076 (GRCm39) |
E1237G |
probably damaging |
Het |
| Ube2d1 |
C |
A |
10: 71,092,523 (GRCm39) |
C107F |
probably damaging |
Het |
| Ugt3a1 |
C |
T |
15: 9,306,330 (GRCm39) |
R160* |
probably null |
Het |
| Vcan |
G |
A |
13: 89,853,782 (GRCm39) |
P393S |
probably damaging |
Het |
| Virma |
T |
C |
4: 11,544,954 (GRCm39) |
F1638L |
probably damaging |
Het |
| Vmn1r31 |
G |
A |
6: 58,449,043 (GRCm39) |
T274I |
probably damaging |
Het |
| Xylt2 |
C |
T |
11: 94,559,035 (GRCm39) |
S445N |
probably damaging |
Het |
| Zfp457 |
A |
G |
13: 67,444,375 (GRCm39) |
F43L |
possibly damaging |
Het |
| Zfp879 |
T |
A |
11: 50,723,473 (GRCm39) |
M455L |
probably benign |
Het |
|
| Other mutations in Magi2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00908:Magi2
|
APN |
5 |
20,596,299 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02120:Magi2
|
APN |
5 |
20,433,451 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02341:Magi2
|
APN |
5 |
20,671,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02411:Magi2
|
APN |
5 |
19,883,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02657:Magi2
|
APN |
5 |
19,432,581 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02976:Magi2
|
APN |
5 |
20,739,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03105:Magi2
|
APN |
5 |
20,748,616 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03246:Magi2
|
APN |
5 |
20,563,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03329:Magi2
|
APN |
5 |
20,671,126 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
LCD18:Magi2
|
UTSW |
5 |
20,159,509 (GRCm39) |
intron |
probably benign |
|
|
PIT4519001:Magi2
|
UTSW |
5 |
20,866,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0009:Magi2
|
UTSW |
5 |
20,816,053 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0009:Magi2
|
UTSW |
5 |
20,816,053 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0352:Magi2
|
UTSW |
5 |
20,270,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0362:Magi2
|
UTSW |
5 |
19,432,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0496:Magi2
|
UTSW |
5 |
20,866,357 (GRCm39) |
splice site |
probably benign |
|
|
R1103:Magi2
|
UTSW |
5 |
20,816,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1435:Magi2
|
UTSW |
5 |
20,563,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1583:Magi2
|
UTSW |
5 |
19,432,330 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1643:Magi2
|
UTSW |
5 |
20,910,504 (GRCm39) |
unclassified |
probably benign |
|
|
R1707:Magi2
|
UTSW |
5 |
20,420,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1833:Magi2
|
UTSW |
5 |
19,432,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1837:Magi2
|
UTSW |
5 |
20,670,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Magi2
|
UTSW |
5 |
20,670,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1839:Magi2
|
UTSW |
5 |
20,670,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1847:Magi2
|
UTSW |
5 |
20,807,458 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2223:Magi2
|
UTSW |
5 |
20,670,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2496:Magi2
|
UTSW |
5 |
19,883,750 (GRCm39) |
missense |
probably benign |
0.42 |
|
R2504:Magi2
|
UTSW |
5 |
20,563,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2848:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R2879:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R2935:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R2936:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R3694:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R3783:Magi2
|
UTSW |
5 |
20,670,907 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3786:Magi2
|
UTSW |
5 |
20,670,907 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3787:Magi2
|
UTSW |
5 |
20,670,907 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3837:Magi2
|
UTSW |
5 |
20,420,466 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4151:Magi2
|
UTSW |
5 |
19,432,290 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4721:Magi2
|
UTSW |
5 |
20,739,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5005:Magi2
|
UTSW |
5 |
20,739,444 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5012:Magi2
|
UTSW |
5 |
20,670,618 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5193:Magi2
|
UTSW |
5 |
20,563,970 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5298:Magi2
|
UTSW |
5 |
20,774,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5372:Magi2
|
UTSW |
5 |
20,907,108 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5580:Magi2
|
UTSW |
5 |
20,420,422 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5806:Magi2
|
UTSW |
5 |
20,856,202 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5924:Magi2
|
UTSW |
5 |
20,816,067 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5992:Magi2
|
UTSW |
5 |
19,432,289 (GRCm39) |
start codon destroyed |
probably null |
0.42 |
|
R6014:Magi2
|
UTSW |
5 |
20,816,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6073:Magi2
|
UTSW |
5 |
20,774,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6500:Magi2
|
UTSW |
5 |
20,807,345 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6664:Magi2
|
UTSW |
5 |
20,907,395 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7229:Magi2
|
UTSW |
5 |
20,670,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7344:Magi2
|
UTSW |
5 |
20,755,238 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7448:Magi2
|
UTSW |
5 |
20,563,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7605:Magi2
|
UTSW |
5 |
20,433,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7712:Magi2
|
UTSW |
5 |
20,755,280 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7808:Magi2
|
UTSW |
5 |
20,670,838 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7955:Magi2
|
UTSW |
5 |
20,594,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8134:Magi2
|
UTSW |
5 |
20,596,392 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8134:Magi2
|
UTSW |
5 |
20,596,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8253:Magi2
|
UTSW |
5 |
20,814,305 (GRCm39) |
missense |
probably benign |
0.44 |
|
R8481:Magi2
|
UTSW |
5 |
20,594,152 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8553:Magi2
|
UTSW |
5 |
20,856,198 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8751:Magi2
|
UTSW |
5 |
20,739,462 (GRCm39) |
missense |
probably benign |
|
|
R8766:Magi2
|
UTSW |
5 |
20,400,123 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8851:Magi2
|
UTSW |
5 |
20,270,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8876:Magi2
|
UTSW |
5 |
20,856,190 (GRCm39) |
nonsense |
probably null |
|
|
R9120:Magi2
|
UTSW |
5 |
20,733,305 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9335:Magi2
|
UTSW |
5 |
20,866,263 (GRCm39) |
missense |
|
|
|
R9367:Magi2
|
UTSW |
5 |
20,766,308 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9454:Magi2
|
UTSW |
5 |
20,671,176 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9474:Magi2
|
UTSW |
5 |
20,400,019 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9577:Magi2
|
UTSW |
5 |
20,814,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9673:Magi2
|
UTSW |
5 |
20,670,582 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9696:Magi2
|
UTSW |
5 |
20,670,864 (GRCm39) |
missense |
probably benign |
0.35 |
|
X0065:Magi2
|
UTSW |
5 |
20,774,176 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1176:Magi2
|
UTSW |
5 |
20,907,107 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1177:Magi2
|
UTSW |
5 |
20,907,410 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CAGGAGACCTTTTCCACAAGATTCCAG -3'
(R):5'- TGGTGACCCCATGATCTTCAGCAG -3'
Sequencing Primer
(F):5'- TGTGTCGATTTCTTAACAAGCC -3'
(R):5'- TGTAGTCTGACAGAGGGTACTG -3'
|
| Posted On |
2014-04-24 |
Incidental Mutation