Mutagenetix > Incidental Mutations

Incidental Mutation 'R1620:Gm10037'

174630

Institutional Source

Beutler Lab

Gene Symbol

Gm10037

Ensembl Gene

ENSMUSG00000058246

Gene Name

predicted gene 10037

Synonyms

EG328280

MMRRC Submission

039657-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.083) question?

Stock #

R1620 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

67831106-67844035 bp(+) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

T to C at 67842990 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000156286 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060609] [ENSMUST00000221266] [ENSMUST00000221620] [ENSMUST00000222626] [ENSMUST00000231606]

Predicted Effect

probably benign
Transcript: ENSMUST00000060609

SMART Domains

Protein: ENSMUSP00000051123
Gene: ENSMUSG00000058246

Domain	Start	End	E-Value	Type
KRAB	2	61	1.42e-28	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000221266

Predicted Effect

probably benign
Transcript: ENSMUST00000221620

Predicted Effect

probably benign
Transcript: ENSMUST00000222626

Predicted Effect

probably benign
Transcript: ENSMUST00000231606

Coding Region Coverage

1x: 99.1%
3x: 98.1%
10x: 95.6%
20x: 90.1%

Validation Efficiency

95% (58/61)

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp2c2	T	C	8: 119,749,126	V586A	probably benign	Het
Atp8a2	T	A	14: 59,791,183	H945L	probably benign	Het
Bfar	G	T	16: 13,688,846	V187F	probably damaging	Het
C130026I21Rik	A	G	1: 85,254,186		probably benign	Het
Capn2	A	T	1: 182,517,137	I73N	probably damaging	Het
Cfc1	C	A	1: 34,536,473	A76E	possibly damaging	Het
Chl1	T	C	6: 103,690,242	F398L	probably benign	Het
Cyp2u1	A	G	3: 131,302,701	S143P	probably damaging	Het
Dlgap4	T	A	2: 156,749,136	Y57*	probably null	Het
Epha4	T	A	1: 77,374,926	R897S	probably benign	Het
Fscn2	A	T	11: 120,366,685	T291S	probably damaging	Het
Gga1	G	A	15: 78,888,470	S267N	probably damaging	Het
Gigyf2	A	G	1: 87,449,128	T1287A	probably damaging	Het
Gm10845	C	A	14: 79,863,229		noncoding transcript	Het
Gm11559	T	A	11: 99,865,056	L177Q	unknown	Het
Itga9	A	G	9: 118,843,502	T195A	probably benign	Het
Lama1	A	G	17: 67,767,033	T935A	probably benign	Het
Lrrk1	G	T	7: 66,381,538	T4K	probably benign	Het
Lrrn1	G	A	6: 107,568,366	C375Y	probably damaging	Het
Maip1	T	C	1: 57,409,985		probably null	Het
Mecom	A	T	3: 29,987,088	I119N	probably damaging	Het
Mrpl2	G	A	17: 46,647,499	R69H	probably benign	Het
Muc16	A	G	9: 18,510,477	V8246A	possibly damaging	Het
Myh3	C	T	11: 67,088,736		probably benign	Het
Myocd	A	G	11: 65,196,394	S236P	probably damaging	Het
Myot	A	T	18: 44,337,058	Q34L	possibly damaging	Het
Nlrp5	A	G	7: 23,418,639	D596G	probably damaging	Het
Npas2	T	C	1: 39,333,912	S415P	possibly damaging	Het
Obox2	A	G	7: 15,397,041	E66G	probably benign	Het
Olfr1312	G	T	2: 112,042,246	T262K	probably benign	Het
Pcdh9	G	A	14: 93,888,305	P143L	probably damaging	Het
Phactr1	G	T	13: 43,094,897	V356L	probably damaging	Het
Pparg	A	T	6: 115,473,281	I414L	probably benign	Het
Rapgef6	A	T	11: 54,626,594	I371L	possibly damaging	Het
Rc3h1	T	C	1: 160,954,973	V674A	probably benign	Het
Rps6ka4	T	C	19: 6,838,149	Y159C	probably damaging	Het
Sf3b6	T	C	12: 4,826,808	I67T	possibly damaging	Het
Spata17	T	C	1: 187,183,215		probably benign	Het
Ston1	A	G	17: 88,635,816	T217A	probably benign	Het
Tank	A	G	2: 61,650,098	D326G	possibly damaging	Het
Tbc1d9	T	A	8: 83,249,595	N594K	probably damaging	Het
Tfpi2	T	A	6: 3,965,507	T102S	probably benign	Het
Ulk4	T	G	9: 121,204,805	E589D	possibly damaging	Het
Usp40	A	T	1: 87,994,225	H305Q	probably damaging	Het
Vmn1r170	A	G	7: 23,606,329	K52R	probably benign	Het
Vmn1r194	A	G	13: 22,244,963	D250G	probably damaging	Het
Wdr6	A	T	9: 108,574,655	D676E	possibly damaging	Het
Xirp2	T	A	2: 67,510,835	V1140E	probably damaging	Het

Other mutations in Gm10037

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0308:Gm10037	UTSW	13	67843113	intron	probably benign
R1777:Gm10037	UTSW	13	67833865	missense	probably benign	0.28
R6818:Gm10037	UTSW	13	67833867	missense	possibly damaging	0.86
R7136:Gm10037	UTSW	13	67842992	splice site	probably null

Predicted Primers

PCR Primer
(F):5'- ACTCCTGGAACAGACAGAGCAGATG -3'
(R):5'- AGCACCTGGACTTCTTTCTTGGGC -3'

Sequencing Primer
(F):5'- GAGGATTTAGCCCATGAATCAC -3'
(R):5'- CTTGGGCACAGTAGAGTTGATAC -3'

Posted On

2014-04-24