Incidental Mutation 'R1624:Olfr1310'
ID174854
Institutional Source Beutler Lab
Gene Symbol Olfr1310
Ensembl Gene ENSMUSG00000108827
Gene Nameolfactory receptor 1310
SynonymsGA_x6K02T2Q125-73056609-73055671, MOR245-3
MMRRC Submission 039661-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.326) question?
Stock #R1624 (G1)
Quality Score225
Status Validated
Chromosome2
Chromosomal Location112004574-112012708 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 112008532 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 218 (Y218F)
Ref Sequence ENSEMBL: ENSMUSP00000149701 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000207169] [ENSMUST00000213559]
Predicted Effect probably damaging
Transcript: ENSMUST00000099602
AA Change: Y218F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097197
Gene: ENSMUSG00000074949
AA Change: Y218F

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 7.7e-41 PFAM
Pfam:7TM_GPCR_Srsx 35 301 3.3e-8 PFAM
Pfam:7tm_1 41 287 5.9e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207169
AA Change: Y218F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000213559
AA Change: Y218F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.5885 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 95.9%
  • 20x: 91.4%
Validation Efficiency 99% (90/91)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2510009E07Rik T C 16: 21,653,746 Y68C probably damaging Het
6820408C15Rik A T 2: 152,434,111 H81L probably damaging Het
Acbd4 A G 11: 103,103,959 T48A probably damaging Het
Acpp T A 9: 104,320,001 E146D probably benign Het
Acsm1 T A 7: 119,652,573 I307N probably damaging Het
Adcy4 T C 14: 55,781,927 T89A possibly damaging Het
Agl T C 3: 116,787,246 T356A probably benign Het
Ago1 A G 4: 126,463,741 I47T probably damaging Het
Akr1c6 T A 13: 4,446,364 Y75N probably benign Het
Anxa2 T A 9: 69,479,708 S92T probably benign Het
Arid4b T C 13: 14,184,394 S585P probably damaging Het
Arl4d T C 11: 101,667,016 S123P possibly damaging Het
Atad2 A T 15: 58,100,019 D1067E probably damaging Het
Brap C A 5: 121,682,859 T403K possibly damaging Het
Brwd1 A T 16: 96,008,144 N1895K possibly damaging Het
Ccdc187 T C 2: 26,281,075 T464A probably benign Het
Cdh11 T C 8: 102,664,601 probably benign Het
Chd9 A T 8: 90,998,535 Y691F probably benign Het
Clhc1 A T 11: 29,569,287 I365F possibly damaging Het
Col11a1 A G 3: 114,158,155 Q1078R probably damaging Het
Creb3 G A 4: 43,566,375 V294I possibly damaging Het
Cspg4 T C 9: 56,888,470 I1163T probably damaging Het
Cyp3a57 A C 5: 145,390,415 probably null Het
Dnah3 A T 7: 120,019,695 I1661N probably damaging Het
Dpysl4 A C 7: 139,089,553 D49A probably damaging Het
Efhb T A 17: 53,426,278 I522F probably damaging Het
Epha4 T C 1: 77,399,692 T517A probably damaging Het
Fasn A G 11: 120,813,111 S1466P probably damaging Het
Fgd6 A T 10: 94,137,436 D1253V probably benign Het
Fjx1 G A 2: 102,451,164 A142V probably benign Het
Foxb1 T C 9: 69,759,316 T311A probably benign Het
Fpgs A G 2: 32,691,188 probably null Het
Gm10024 A G 10: 77,711,772 probably null Het
Gnat3 A T 5: 18,003,843 T182S possibly damaging Het
Igsf3 T A 3: 101,455,227 F875I probably benign Het
Kif13b A G 14: 64,738,619 E461G probably damaging Het
Kif23 A T 9: 61,925,700 probably null Het
Kntc1 G A 5: 123,758,477 R134Q possibly damaging Het
Krt33a A T 11: 100,014,246 Y145N probably damaging Het
Lama5 A G 2: 180,206,758 V313A probably benign Het
Lamb1 T C 12: 31,278,652 probably null Het
Megf6 G T 4: 154,177,121 V68L probably benign Het
Mtor C T 4: 148,547,676 L2336F probably damaging Het
Naglu T C 11: 101,076,525 S434P probably damaging Het
Ncoa7 T A 10: 30,704,659 H101L possibly damaging Het
Nlrc4 G A 17: 74,445,189 T733I possibly damaging Het
Nr3c2 A G 8: 76,909,944 E558G probably damaging Het
Nsun4 A T 4: 116,034,200 N327K probably benign Het
Olfr165 T A 16: 19,407,704 Y104F probably benign Het
Olfr524 T C 7: 140,201,951 N273S probably damaging Het
Olfr54 T C 11: 51,027,125 V41A probably damaging Het
Olfr743 A G 14: 50,533,643 Y77C probably damaging Het
Pdia2 T A 17: 26,196,521 I441F probably damaging Het
Phyh T C 2: 4,925,683 S74P probably benign Het
Pigo A G 4: 43,024,661 L146P probably damaging Het
Plce1 A G 19: 38,724,775 D1191G probably damaging Het
Plrg1 T C 3: 83,067,994 probably benign Het
Plrg1 G A 3: 83,069,744 R364Q probably damaging Het
Polr3b T C 10: 84,679,805 L614S probably damaging Het
Pramef25 A T 4: 143,949,830 C235S possibly damaging Het
Prrg4 A G 2: 104,832,682 V193A probably damaging Het
Prss16 T A 13: 22,003,313 E47V probably benign Het
Ptpru G A 4: 131,772,550 T1261I probably damaging Het
Pycard A G 7: 127,992,798 S124P possibly damaging Het
Riok1 C A 13: 38,037,511 D17E probably damaging Het
Scin T A 12: 40,127,930 Y102F probably benign Het
Scmh1 A G 4: 120,529,228 H655R probably damaging Het
Scyl2 A T 10: 89,640,736 N842K probably benign Het
Sec23b T A 2: 144,567,129 M211K probably benign Het
Serpina3i A C 12: 104,268,638 *409C probably null Het
Sgk2 G A 2: 162,997,859 R129H probably benign Het
Slc39a13 A G 2: 91,068,526 I80T probably damaging Het
Smarcad1 A G 6: 65,052,647 D73G probably benign Het
Spata18 A C 5: 73,669,545 T276P probably damaging Het
Srgap1 T G 10: 121,855,373 M319L probably benign Het
Stx7 T A 10: 24,185,005 V210E probably damaging Het
Tjp2 T A 19: 24,131,412 H112L probably benign Het
Tuba8 A T 6: 121,220,426 I16F probably damaging Het
Ube3c G A 5: 29,646,619 A815T probably benign Het
Vmn2r5 A T 3: 64,509,695 V14E probably benign Het
Vmn2r79 A T 7: 87,004,039 probably null Het
Wisp3 G A 10: 39,153,243 R230W probably damaging Het
Zdbf2 A G 1: 63,303,859 T466A possibly damaging Het
Other mutations in Olfr1310
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01947:Olfr1310 APN 2 112009016 missense possibly damaging 0.86
IGL02700:Olfr1310 APN 2 112008691 missense probably benign 0.04
IGL03008:Olfr1310 APN 2 112008523 missense possibly damaging 0.95
IGL03121:Olfr1310 APN 2 112008608 missense probably benign 0.02
R0025:Olfr1310 UTSW 2 112009020 missense probably damaging 0.98
R1851:Olfr1310 UTSW 2 112008691 missense probably benign 0.04
R3872:Olfr1310 UTSW 2 112008323 missense possibly damaging 0.95
R3873:Olfr1310 UTSW 2 112008323 missense possibly damaging 0.95
R3874:Olfr1310 UTSW 2 112008323 missense possibly damaging 0.95
R4651:Olfr1310 UTSW 2 112008250 missense probably damaging 1.00
R4652:Olfr1310 UTSW 2 112008250 missense probably damaging 1.00
R4834:Olfr1310 UTSW 2 112008931 missense probably damaging 1.00
R5076:Olfr1310 UTSW 2 112008592 missense probably damaging 0.99
R7262:Olfr1310 UTSW 2 112008557 missense probably damaging 1.00
R7339:Olfr1310 UTSW 2 112008475 missense probably damaging 1.00
R7657:Olfr1310 UTSW 2 112008748 missense probably benign 0.02
R7798:Olfr1310 UTSW 2 112008272 missense probably benign
R7875:Olfr1310 UTSW 2 112008847 missense probably benign 0.32
X0027:Olfr1310 UTSW 2 112008824 missense probably damaging 1.00
Z1176:Olfr1310 UTSW 2 112008457 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGACTGCATAGTCTTCTCATTGCTACC -3'
(R):5'- CTGTGGCCCTAATGAACTAGACAGCTT -3'

Sequencing Primer
(F):5'- AGTAATAACTGCATCAAAGATGGC -3'
(R):5'- GAACTAGACAGCTTTTTCTGTGACC -3'
Posted On2014-04-24