Incidental Mutation 'R1624:Brwd1'
| ID |
174928 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Brwd1
|
| Ensembl Gene |
ENSMUSG00000022914 |
| Gene Name |
bromodomain and WD repeat domain containing 1 |
| Synonyms |
5330419I02Rik, Wdr9, G1-403-16, D530019K20Rik, repro5 |
| MMRRC Submission |
039661-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1624 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
95793292-95883726 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 95809344 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 1895
(N1895K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000117066
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023631]
[ENSMUST00000099502]
[ENSMUST00000153398]
|
| AlphaFold |
Q921C3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023631
|
| SMART Domains |
Protein: ENSMUSP00000023631
Gene: ENSMUSG00000022914
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099502
|
| SMART Domains |
Protein: ENSMUSP00000097101
Gene: ENSMUSG00000022914
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127777
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000153398
AA Change: N1895K
PolyPhen 2
Score 0.670 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000117066
Gene: ENSMUSG00000022914
AA Change: N1895K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
internal_repeat_1
|
1491 |
1957 |
1.45e-251 |
PROSPERO |
|
internal_repeat_1
|
1956 |
2422 |
1.45e-251 |
PROSPERO |
|
low complexity region
|
2630 |
2639 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156622
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000157037
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 95.9%
- 20x: 91.4%
|
| Validation Efficiency |
99% (90/91) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
PHENOTYPE: Homozygous males and females are infertile. Spermiogenesis is impaired; males have low epididymal sperm concentration with low motility and abnormal sperm head morphology. Female oocytes commonly contain vacuoles and have low developmental competence to 2-cell and blastocyst stages. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2510009E07Rik |
T |
C |
16: 21,472,496 (GRCm39) |
Y68C |
probably damaging |
Het |
| 6820408C15Rik |
A |
T |
2: 152,276,031 (GRCm39) |
H81L |
probably damaging |
Het |
| Acbd4 |
A |
G |
11: 102,994,785 (GRCm39) |
T48A |
probably damaging |
Het |
| Acp3 |
T |
A |
9: 104,197,200 (GRCm39) |
E146D |
probably benign |
Het |
| Acsm1 |
T |
A |
7: 119,251,796 (GRCm39) |
I307N |
probably damaging |
Het |
| Adcy4 |
T |
C |
14: 56,019,384 (GRCm39) |
T89A |
possibly damaging |
Het |
| Agl |
T |
C |
3: 116,580,895 (GRCm39) |
T356A |
probably benign |
Het |
| Ago1 |
A |
G |
4: 126,357,534 (GRCm39) |
I47T |
probably damaging |
Het |
| Akr1c6 |
T |
A |
13: 4,496,363 (GRCm39) |
Y75N |
probably benign |
Het |
| Anxa2 |
T |
A |
9: 69,386,990 (GRCm39) |
S92T |
probably benign |
Het |
| Arid4b |
T |
C |
13: 14,358,979 (GRCm39) |
S585P |
probably damaging |
Het |
| Arl4d |
T |
C |
11: 101,557,842 (GRCm39) |
S123P |
possibly damaging |
Het |
| Atad2 |
A |
T |
15: 57,963,415 (GRCm39) |
D1067E |
probably damaging |
Het |
| Brap |
C |
A |
5: 121,820,922 (GRCm39) |
T403K |
possibly damaging |
Het |
| Ccdc187 |
T |
C |
2: 26,171,087 (GRCm39) |
T464A |
probably benign |
Het |
| Ccn6 |
G |
A |
10: 39,029,239 (GRCm39) |
R230W |
probably damaging |
Het |
| Cdh11 |
T |
C |
8: 103,391,233 (GRCm39) |
|
probably benign |
Het |
| Chd9 |
A |
T |
8: 91,725,163 (GRCm39) |
Y691F |
probably benign |
Het |
| Clhc1 |
A |
T |
11: 29,519,287 (GRCm39) |
I365F |
possibly damaging |
Het |
| Col11a1 |
A |
G |
3: 113,951,804 (GRCm39) |
Q1078R |
probably damaging |
Het |
| Creb3 |
G |
A |
4: 43,566,375 (GRCm39) |
V294I |
possibly damaging |
Het |
| Cspg4 |
T |
C |
9: 56,795,754 (GRCm39) |
I1163T |
probably damaging |
Het |
| Cyp3a57 |
A |
C |
5: 145,327,225 (GRCm39) |
|
probably null |
Het |
| Dnah3 |
A |
T |
7: 119,618,918 (GRCm39) |
I1661N |
probably damaging |
Het |
| Dpysl4 |
A |
C |
7: 138,669,469 (GRCm39) |
D49A |
probably damaging |
Het |
| Efhb |
T |
A |
17: 53,733,306 (GRCm39) |
I522F |
probably damaging |
Het |
| Epha4 |
T |
C |
1: 77,376,329 (GRCm39) |
T517A |
probably damaging |
Het |
| Fasn |
A |
G |
11: 120,703,937 (GRCm39) |
S1466P |
probably damaging |
Het |
| Fgd6 |
A |
T |
10: 93,973,298 (GRCm39) |
D1253V |
probably benign |
Het |
| Fjx1 |
G |
A |
2: 102,281,509 (GRCm39) |
A142V |
probably benign |
Het |
| Foxb1 |
T |
C |
9: 69,666,598 (GRCm39) |
T311A |
probably benign |
Het |
| Fpgs |
A |
G |
2: 32,581,200 (GRCm39) |
|
probably null |
Het |
| Gm10024 |
A |
G |
10: 77,547,606 (GRCm39) |
|
probably null |
Het |
| Gnat3 |
A |
T |
5: 18,208,841 (GRCm39) |
T182S |
possibly damaging |
Het |
| Igsf3 |
T |
A |
3: 101,362,543 (GRCm39) |
F875I |
probably benign |
Het |
| Kif13b |
A |
G |
14: 64,976,068 (GRCm39) |
E461G |
probably damaging |
Het |
| Kif23 |
A |
T |
9: 61,832,982 (GRCm39) |
|
probably null |
Het |
| Kntc1 |
G |
A |
5: 123,896,540 (GRCm39) |
R134Q |
possibly damaging |
Het |
| Krt33a |
A |
T |
11: 99,905,072 (GRCm39) |
Y145N |
probably damaging |
Het |
| Lama5 |
A |
G |
2: 179,848,551 (GRCm39) |
V313A |
probably benign |
Het |
| Lamb1 |
T |
C |
12: 31,328,651 (GRCm39) |
|
probably null |
Het |
| Megf6 |
G |
T |
4: 154,261,578 (GRCm39) |
V68L |
probably benign |
Het |
| Mtor |
C |
T |
4: 148,632,133 (GRCm39) |
L2336F |
probably damaging |
Het |
| Naglu |
T |
C |
11: 100,967,351 (GRCm39) |
S434P |
probably damaging |
Het |
| Ncoa7 |
T |
A |
10: 30,580,655 (GRCm39) |
H101L |
possibly damaging |
Het |
| Nlrc4 |
G |
A |
17: 74,752,184 (GRCm39) |
T733I |
possibly damaging |
Het |
| Nr3c2 |
A |
G |
8: 77,636,573 (GRCm39) |
E558G |
probably damaging |
Het |
| Nsun4 |
A |
T |
4: 115,891,397 (GRCm39) |
N327K |
probably benign |
Het |
| Or11g27 |
A |
G |
14: 50,771,100 (GRCm39) |
Y77C |
probably damaging |
Het |
| Or1x2 |
T |
C |
11: 50,917,952 (GRCm39) |
V41A |
probably damaging |
Het |
| Or2m13 |
T |
A |
16: 19,226,454 (GRCm39) |
Y104F |
probably benign |
Het |
| Or4f6 |
T |
A |
2: 111,838,877 (GRCm39) |
Y218F |
probably damaging |
Het |
| Or6b13 |
T |
C |
7: 139,781,864 (GRCm39) |
N273S |
probably damaging |
Het |
| Pdia2 |
T |
A |
17: 26,415,495 (GRCm39) |
I441F |
probably damaging |
Het |
| Phyh |
T |
C |
2: 4,930,494 (GRCm39) |
S74P |
probably benign |
Het |
| Pigo |
A |
G |
4: 43,024,661 (GRCm39) |
L146P |
probably damaging |
Het |
| Plce1 |
A |
G |
19: 38,713,219 (GRCm39) |
D1191G |
probably damaging |
Het |
| Plrg1 |
T |
C |
3: 82,975,301 (GRCm39) |
|
probably benign |
Het |
| Plrg1 |
G |
A |
3: 82,977,051 (GRCm39) |
R364Q |
probably damaging |
Het |
| Polr3b |
T |
C |
10: 84,515,669 (GRCm39) |
L614S |
probably damaging |
Het |
| Pramel16 |
A |
T |
4: 143,676,400 (GRCm39) |
C235S |
possibly damaging |
Het |
| Prrg4 |
A |
G |
2: 104,663,027 (GRCm39) |
V193A |
probably damaging |
Het |
| Prss16 |
T |
A |
13: 22,187,483 (GRCm39) |
E47V |
probably benign |
Het |
| Ptpru |
G |
A |
4: 131,499,861 (GRCm39) |
T1261I |
probably damaging |
Het |
| Pycard |
A |
G |
7: 127,591,970 (GRCm39) |
S124P |
possibly damaging |
Het |
| Riok1 |
C |
A |
13: 38,221,487 (GRCm39) |
D17E |
probably damaging |
Het |
| Scin |
T |
A |
12: 40,177,929 (GRCm39) |
Y102F |
probably benign |
Het |
| Scmh1 |
A |
G |
4: 120,386,425 (GRCm39) |
H655R |
probably damaging |
Het |
| Scyl2 |
A |
T |
10: 89,476,598 (GRCm39) |
N842K |
probably benign |
Het |
| Sec23b |
T |
A |
2: 144,409,049 (GRCm39) |
M211K |
probably benign |
Het |
| Serpina3i |
A |
C |
12: 104,234,897 (GRCm39) |
*409C |
probably null |
Het |
| Sgk2 |
G |
A |
2: 162,839,779 (GRCm39) |
R129H |
probably benign |
Het |
| Slc39a13 |
A |
G |
2: 90,898,871 (GRCm39) |
I80T |
probably damaging |
Het |
| Smarcad1 |
A |
G |
6: 65,029,631 (GRCm39) |
D73G |
probably benign |
Het |
| Spata18 |
A |
C |
5: 73,826,888 (GRCm39) |
T276P |
probably damaging |
Het |
| Srgap1 |
T |
G |
10: 121,691,278 (GRCm39) |
M319L |
probably benign |
Het |
| Stx7 |
T |
A |
10: 24,060,903 (GRCm39) |
V210E |
probably damaging |
Het |
| Tjp2 |
T |
A |
19: 24,108,776 (GRCm39) |
H112L |
probably benign |
Het |
| Tuba8 |
A |
T |
6: 121,197,385 (GRCm39) |
I16F |
probably damaging |
Het |
| Ube3c |
G |
A |
5: 29,851,617 (GRCm39) |
A815T |
probably benign |
Het |
| Vmn2r5 |
A |
T |
3: 64,417,116 (GRCm39) |
V14E |
probably benign |
Het |
| Vmn2r79 |
A |
T |
7: 86,653,247 (GRCm39) |
|
probably null |
Het |
| Zdbf2 |
A |
G |
1: 63,343,018 (GRCm39) |
T466A |
possibly damaging |
Het |
|
| Other mutations in Brwd1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00690:Brwd1
|
APN |
16 |
95,818,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00974:Brwd1
|
APN |
16 |
95,844,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Brwd1
|
APN |
16 |
95,817,373 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01447:Brwd1
|
APN |
16 |
95,848,579 (GRCm39) |
nonsense |
probably null |
|
|
IGL01459:Brwd1
|
APN |
16 |
95,848,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01631:Brwd1
|
APN |
16 |
95,847,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02184:Brwd1
|
APN |
16 |
95,815,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02264:Brwd1
|
APN |
16 |
95,820,656 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02679:Brwd1
|
APN |
16 |
95,804,023 (GRCm39) |
missense |
probably benign |
|
|
IGL02833:Brwd1
|
APN |
16 |
95,853,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02960:Brwd1
|
APN |
16 |
95,858,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03053:Brwd1
|
APN |
16 |
95,818,877 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03074:Brwd1
|
APN |
16 |
95,813,050 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03135:Brwd1
|
APN |
16 |
95,822,458 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03168:Brwd1
|
APN |
16 |
95,818,877 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03214:Brwd1
|
APN |
16 |
95,839,100 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL03328:Brwd1
|
APN |
16 |
95,803,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
bromide
|
UTSW |
16 |
95,866,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Embers
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Glowing
|
UTSW |
16 |
95,837,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Soporific
|
UTSW |
16 |
95,835,043 (GRCm39) |
nonsense |
probably null |
|
|
G1citation:Brwd1
|
UTSW |
16 |
95,842,474 (GRCm39) |
missense |
probably benign |
0.42 |
|
PIT4243001:Brwd1
|
UTSW |
16 |
95,803,871 (GRCm39) |
nonsense |
probably null |
|
|
R0012:Brwd1
|
UTSW |
16 |
95,860,852 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0012:Brwd1
|
UTSW |
16 |
95,860,852 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0030:Brwd1
|
UTSW |
16 |
95,822,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0135:Brwd1
|
UTSW |
16 |
95,848,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0366:Brwd1
|
UTSW |
16 |
95,839,164 (GRCm39) |
nonsense |
probably null |
|
|
R0551:Brwd1
|
UTSW |
16 |
95,837,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0586:Brwd1
|
UTSW |
16 |
95,844,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0865:Brwd1
|
UTSW |
16 |
95,869,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1226:Brwd1
|
UTSW |
16 |
95,832,748 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1329:Brwd1
|
UTSW |
16 |
95,804,434 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1378:Brwd1
|
UTSW |
16 |
95,842,570 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1420:Brwd1
|
UTSW |
16 |
95,837,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1441:Brwd1
|
UTSW |
16 |
95,867,351 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1484:Brwd1
|
UTSW |
16 |
95,829,491 (GRCm39) |
splice site |
probably null |
|
|
R1636:Brwd1
|
UTSW |
16 |
95,860,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1988:Brwd1
|
UTSW |
16 |
95,822,437 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1998:Brwd1
|
UTSW |
16 |
95,822,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2066:Brwd1
|
UTSW |
16 |
95,847,665 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2898:Brwd1
|
UTSW |
16 |
95,867,300 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2983:Brwd1
|
UTSW |
16 |
95,867,774 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3966:Brwd1
|
UTSW |
16 |
95,845,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4086:Brwd1
|
UTSW |
16 |
95,847,572 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4257:Brwd1
|
UTSW |
16 |
95,824,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4290:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4292:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4293:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4614:Brwd1
|
UTSW |
16 |
95,848,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Brwd1
|
UTSW |
16 |
95,804,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5025:Brwd1
|
UTSW |
16 |
95,855,172 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5155:Brwd1
|
UTSW |
16 |
95,803,993 (GRCm39) |
nonsense |
probably null |
|
|
R5229:Brwd1
|
UTSW |
16 |
95,803,409 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5246:Brwd1
|
UTSW |
16 |
95,803,757 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5668:Brwd1
|
UTSW |
16 |
95,817,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5763:Brwd1
|
UTSW |
16 |
95,835,043 (GRCm39) |
nonsense |
probably null |
|
|
R5782:Brwd1
|
UTSW |
16 |
95,844,243 (GRCm39) |
nonsense |
probably null |
|
|
R5831:Brwd1
|
UTSW |
16 |
95,820,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5836:Brwd1
|
UTSW |
16 |
95,865,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5906:Brwd1
|
UTSW |
16 |
95,859,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5995:Brwd1
|
UTSW |
16 |
95,865,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6143:Brwd1
|
UTSW |
16 |
95,804,156 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6241:Brwd1
|
UTSW |
16 |
95,815,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6313:Brwd1
|
UTSW |
16 |
95,809,141 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6362:Brwd1
|
UTSW |
16 |
95,803,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6551:Brwd1
|
UTSW |
16 |
95,795,162 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6736:Brwd1
|
UTSW |
16 |
95,869,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6822:Brwd1
|
UTSW |
16 |
95,842,474 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7080:Brwd1
|
UTSW |
16 |
95,810,730 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7131:Brwd1
|
UTSW |
16 |
95,867,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7208:Brwd1
|
UTSW |
16 |
95,837,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7322:Brwd1
|
UTSW |
16 |
95,867,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7483:Brwd1
|
UTSW |
16 |
95,857,373 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7615:Brwd1
|
UTSW |
16 |
95,835,039 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7621:Brwd1
|
UTSW |
16 |
95,866,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7665:Brwd1
|
UTSW |
16 |
95,842,543 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7697:Brwd1
|
UTSW |
16 |
95,847,601 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7740:Brwd1
|
UTSW |
16 |
95,828,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8120:Brwd1
|
UTSW |
16 |
95,820,649 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8187:Brwd1
|
UTSW |
16 |
95,803,934 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8359:Brwd1
|
UTSW |
16 |
95,817,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8480:Brwd1
|
UTSW |
16 |
95,848,630 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8511:Brwd1
|
UTSW |
16 |
95,859,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9046:Brwd1
|
UTSW |
16 |
95,829,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9074:Brwd1
|
UTSW |
16 |
95,824,610 (GRCm39) |
missense |
|
|
|
R9102:Brwd1
|
UTSW |
16 |
95,869,725 (GRCm39) |
missense |
probably benign |
0.43 |
|
R9115:Brwd1
|
UTSW |
16 |
95,848,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9130:Brwd1
|
UTSW |
16 |
95,866,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9200:Brwd1
|
UTSW |
16 |
95,839,154 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9246:Brwd1
|
UTSW |
16 |
95,804,016 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9407:Brwd1
|
UTSW |
16 |
95,803,693 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9444:Brwd1
|
UTSW |
16 |
95,855,180 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9451:Brwd1
|
UTSW |
16 |
95,845,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9673:Brwd1
|
UTSW |
16 |
95,813,096 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Brwd1
|
UTSW |
16 |
95,795,015 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9753:Brwd1
|
UTSW |
16 |
95,825,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0017:Brwd1
|
UTSW |
16 |
95,845,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0028:Brwd1
|
UTSW |
16 |
95,813,123 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCCTGAAGAGACACCAGCACTTG -3'
(R):5'- AAGGACCAGCTTATTTCCTGCCG -3'
Sequencing Primer
(F):5'- GAGACACCAGCACTTGTCTTG -3'
(R):5'- GCCTCACTATGTTGGTAAGAAGTC -3'
|
| Posted On |
2014-04-24 |
Incidental Mutation