Incidental Mutation 'R1565:Zc3h7b'
ID 175225
Institutional Source Beutler Lab
Gene Symbol Zc3h7b
Ensembl Gene ENSMUSG00000022390
Gene Name zinc finger CCCH type containing 7B
Synonyms Scrg3
MMRRC Submission 039604-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.208) question?
Stock # R1565 (G1)
Quality Score 174
Status Validated
Chromosome 15
Chromosomal Location 81745057-81796260 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 81777088 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 376 (P376L)
Ref Sequence ENSEMBL: ENSMUSP00000105181 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109554] [ENSMUST00000230946]
AlphaFold F8VPP8
Predicted Effect probably benign
Transcript: ENSMUST00000109554
AA Change: P376L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000105181
Gene: ENSMUSG00000022390
AA Change: P376L

DomainStartEndE-ValueType
Pfam:TPR_11 34 113 2.3e-12 PFAM
Pfam:TPR_1 82 115 2.4e-6 PFAM
Pfam:TPR_8 82 115 8.2e-4 PFAM
Pfam:TPR_8 116 143 4.8e-3 PFAM
low complexity region 294 309 N/A INTRINSIC
low complexity region 340 354 N/A INTRINSIC
ZnF_C3H1 482 508 2.15e1 SMART
ZnF_C3H1 612 638 2.03e1 SMART
ZnF_C3H1 757 782 8.31e0 SMART
ZnF_C2H2 843 867 2.86e-1 SMART
ZnF_C3H1 889 914 7.81e-1 SMART
low complexity region 959 981 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229044
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230368
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230590
Predicted Effect probably benign
Transcript: ENSMUST00000230946
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231108
Meta Mutation Damage Score 0.0709 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.5%
  • 20x: 90.0%
Validation Efficiency 96% (82/85)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(9) : Gene trapped(9)

Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810021J22Rik G A 11: 58,880,501 (GRCm38) G270S probably benign Het
Abtb1 T C 6: 88,836,554 (GRCm38) T401A probably benign Het
Adamts14 A T 10: 61,270,897 (GRCm38) M148K probably damaging Het
Adcy5 A G 16: 35,268,957 (GRCm38) E508G probably damaging Het
Ankfy1 T A 11: 72,757,318 (GRCm38) L875H probably damaging Het
Cacng3 A T 7: 122,768,401 (GRCm38) D168V probably damaging Het
Clpb G A 7: 101,785,461 (GRCm38) R488Q probably benign Het
Cpxm2 A T 7: 132,062,145 (GRCm38) Y350N probably damaging Het
D130040H23Rik T A 8: 69,303,160 (GRCm38) *406R probably null Het
Dnah10 T A 5: 124,829,614 (GRCm38) D4236E probably damaging Het
Dpf3 T A 12: 83,370,617 (GRCm38) Y27F probably damaging Het
Esp4 T C 17: 40,602,595 (GRCm38) *118Q probably null Het
Fam222b T C 11: 78,154,662 (GRCm38) S222P possibly damaging Het
Flnc T C 6: 29,455,171 (GRCm38) V1933A probably damaging Het
Gem T C 4: 11,713,709 (GRCm38) F282L possibly damaging Het
Gli2 T C 1: 118,841,930 (GRCm38) T631A possibly damaging Het
Gm13088 G A 4: 143,655,617 (GRCm38) Q170* probably null Het
Gpld1 T A 13: 24,956,068 (GRCm38) V116E probably damaging Het
Gpr176 A G 2: 118,280,214 (GRCm38) M188T probably benign Het
Grk5 T C 19: 61,089,972 (GRCm38) V489A probably damaging Het
H2-Ke6 C T 17: 34,027,495 (GRCm38) V105I possibly damaging Het
Hpdl T C 4: 116,820,883 (GRCm38) N127S probably damaging Het
Id4 G T 13: 48,262,294 (GRCm38) V151L possibly damaging Het
Kcnh8 G T 17: 52,956,881 (GRCm38) G802V probably benign Het
Lamc1 C A 1: 153,242,743 (GRCm38) S894I probably benign Het
Larp1b A G 3: 40,972,384 (GRCm38) N184S probably damaging Het
Lhx1 A T 11: 84,519,821 (GRCm38) S226T probably benign Het
Lmo7 A T 14: 101,887,521 (GRCm38) Q472L probably damaging Het
Mog G C 17: 37,017,582 (GRCm38) N152K possibly damaging Het
Mttp A G 3: 138,116,405 (GRCm38) probably null Het
Mycbp2 A G 14: 103,252,509 (GRCm38) V953A possibly damaging Het
Myo3a A T 2: 22,340,280 (GRCm38) Y509F probably damaging Het
Myo9b A G 8: 71,315,192 (GRCm38) N303S possibly damaging Het
Nek3 T C 8: 22,132,201 (GRCm38) probably null Het
Nlrc4 A T 17: 74,441,931 (GRCm38) D771E probably benign Het
Nup160 A T 2: 90,722,061 (GRCm38) N1127I possibly damaging Het
Oas1h A T 5: 120,862,600 (GRCm38) N91I probably damaging Het
Olfr1225 A T 2: 89,170,627 (GRCm38) V195D probably benign Het
Olfr1226 G T 2: 89,193,883 (GRCm38) S50R probably damaging Het
Olfr1342 T A 4: 118,690,192 (GRCm38) N87Y probably damaging Het
Parp4 T C 14: 56,589,872 (GRCm38) probably benign Het
Pi4ka G A 16: 17,281,900 (GRCm38) C96Y probably null Het
Pira2 A T 7: 3,844,549 (GRCm38) F47Y probably damaging Het
Pkhd1 C A 1: 20,347,457 (GRCm38) G2490V probably damaging Het
Plekhg1 C T 10: 3,940,526 (GRCm38) T394I probably damaging Het
Psmd1 T C 1: 86,091,997 (GRCm38) probably benign Het
Rab3ip A T 10: 116,939,223 (GRCm38) C77S probably benign Het
Reln A T 5: 21,925,213 (GRCm38) M2700K probably benign Het
Rfx1 A G 8: 84,073,946 (GRCm38) T59A probably benign Het
Ric8b G T 10: 84,980,099 (GRCm38) V405L probably benign Het
Rufy3 G T 5: 88,640,632 (GRCm38) A479S probably damaging Het
Sardh A T 2: 27,242,719 (GRCm38) Y166N probably damaging Het
Slamf6 T G 1: 171,934,408 (GRCm38) V132G possibly damaging Het
Slc12a3 T G 8: 94,345,877 (GRCm38) H674Q possibly damaging Het
Sned1 G A 1: 93,281,654 (GRCm38) V830M possibly damaging Het
Srsf9 A G 5: 115,327,370 (GRCm38) N21S possibly damaging Het
Stkld1 A T 2: 26,950,090 (GRCm38) T391S probably benign Het
Sumf2 C A 5: 129,859,914 (GRCm38) N230K probably damaging Het
Tbc1d22a T C 15: 86,235,569 (GRCm38) V22A possibly damaging Het
Thsd7b T A 1: 129,596,041 (GRCm38) S194T possibly damaging Het
Tmem27 A G X: 164,118,234 (GRCm38) D184G possibly damaging Het
Tnn T A 1: 160,097,265 (GRCm38) Y1173F probably damaging Het
Top2a A G 11: 99,001,054 (GRCm38) F1122L probably damaging Het
Trappc9 G A 15: 73,025,967 (GRCm38) R377W probably damaging Het
Trim39 G A 17: 36,268,854 (GRCm38) R70W probably damaging Het
Ttn G A 2: 76,794,261 (GRCm38) T15289I probably damaging Het
Ugt2b38 A T 5: 87,411,914 (GRCm38) V373E probably damaging Het
Usp54 A G 14: 20,607,159 (GRCm38) S24P probably damaging Het
Vmn2r27 C T 6: 124,231,634 (GRCm38) G51S probably benign Het
Xylt2 C T 11: 94,667,594 (GRCm38) A579T probably benign Het
Zbtb21 A G 16: 97,952,427 (GRCm38) S247P probably benign Het
Zfp251 C T 15: 76,853,039 (GRCm38) R613K possibly damaging Het
Zfp251 T A 15: 76,853,038 (GRCm38) R613S probably damaging Het
Zfp91 T C 19: 12,779,075 (GRCm38) D135G probably benign Het
Other mutations in Zc3h7b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01726:Zc3h7b APN 15 81,771,799 (GRCm38) missense possibly damaging 0.95
IGL01955:Zc3h7b APN 15 81,792,004 (GRCm38) missense probably benign 0.10
IGL02526:Zc3h7b APN 15 81,793,137 (GRCm38) missense probably benign 0.10
IGL02582:Zc3h7b APN 15 81,769,140 (GRCm38) missense probably benign 0.05
IGL02736:Zc3h7b APN 15 81,791,974 (GRCm38) missense probably benign 0.02
F6893:Zc3h7b UTSW 15 81,778,671 (GRCm38) missense possibly damaging 0.94
R0212:Zc3h7b UTSW 15 81,776,328 (GRCm38) missense probably benign 0.00
R0242:Zc3h7b UTSW 15 81,768,830 (GRCm38) splice site probably benign
R0471:Zc3h7b UTSW 15 81,781,968 (GRCm38) missense probably damaging 1.00
R0590:Zc3h7b UTSW 15 81,776,998 (GRCm38) missense possibly damaging 0.74
R1530:Zc3h7b UTSW 15 81,777,088 (GRCm38) missense probably benign
R1563:Zc3h7b UTSW 15 81,777,088 (GRCm38) missense probably benign
R1566:Zc3h7b UTSW 15 81,768,834 (GRCm38) missense possibly damaging 0.91
R1670:Zc3h7b UTSW 15 81,777,067 (GRCm38) missense probably benign
R1712:Zc3h7b UTSW 15 81,777,088 (GRCm38) missense probably benign
R1727:Zc3h7b UTSW 15 81,768,029 (GRCm38) missense probably damaging 1.00
R2069:Zc3h7b UTSW 15 81,792,328 (GRCm38) missense probably damaging 0.98
R2375:Zc3h7b UTSW 15 81,792,502 (GRCm38) missense probably benign 0.17
R2656:Zc3h7b UTSW 15 81,780,430 (GRCm38) missense probably damaging 1.00
R4660:Zc3h7b UTSW 15 81,792,250 (GRCm38) missense probably benign 0.07
R4764:Zc3h7b UTSW 15 81,769,183 (GRCm38) critical splice donor site probably null
R4815:Zc3h7b UTSW 15 81,793,663 (GRCm38) missense probably damaging 1.00
R4999:Zc3h7b UTSW 15 81,779,133 (GRCm38) missense probably damaging 1.00
R5086:Zc3h7b UTSW 15 81,793,174 (GRCm38) missense probably damaging 0.96
R5169:Zc3h7b UTSW 15 81,773,314 (GRCm38) missense probably benign 0.01
R5395:Zc3h7b UTSW 15 81,772,501 (GRCm38) missense possibly damaging 0.50
R5407:Zc3h7b UTSW 15 81,785,891 (GRCm38) missense probably damaging 0.99
R5587:Zc3h7b UTSW 15 81,771,858 (GRCm38) missense possibly damaging 0.80
R5721:Zc3h7b UTSW 15 81,773,298 (GRCm38) missense probably benign 0.02
R6001:Zc3h7b UTSW 15 81,792,035 (GRCm38) missense possibly damaging 0.89
R6151:Zc3h7b UTSW 15 81,778,710 (GRCm38) critical splice donor site probably null
R6248:Zc3h7b UTSW 15 81,783,185 (GRCm38) missense probably damaging 1.00
R6397:Zc3h7b UTSW 15 81,792,854 (GRCm38) missense probably benign 0.03
R6502:Zc3h7b UTSW 15 81,769,051 (GRCm38) missense probably benign 0.01
R7248:Zc3h7b UTSW 15 81,771,787 (GRCm38) missense possibly damaging 0.46
R7397:Zc3h7b UTSW 15 81,769,153 (GRCm38) missense possibly damaging 0.50
R7450:Zc3h7b UTSW 15 81,783,080 (GRCm38) missense probably benign
R7471:Zc3h7b UTSW 15 81,780,481 (GRCm38) missense probably damaging 1.00
R7575:Zc3h7b UTSW 15 81,777,885 (GRCm38) nonsense probably null
R7645:Zc3h7b UTSW 15 81,780,602 (GRCm38) missense probably damaging 1.00
R7650:Zc3h7b UTSW 15 81,793,650 (GRCm38) missense possibly damaging 0.81
R7881:Zc3h7b UTSW 15 81,780,478 (GRCm38) missense probably damaging 1.00
R7918:Zc3h7b UTSW 15 81,768,988 (GRCm38) missense probably damaging 0.98
R8001:Zc3h7b UTSW 15 81,779,260 (GRCm38) nonsense probably null
R8504:Zc3h7b UTSW 15 81,780,518 (GRCm38) missense probably damaging 1.00
R8855:Zc3h7b UTSW 15 81,772,480 (GRCm38) missense probably benign 0.01
R8856:Zc3h7b UTSW 15 81,772,480 (GRCm38) missense probably benign 0.01
R8857:Zc3h7b UTSW 15 81,772,480 (GRCm38) missense probably benign 0.01
R8865:Zc3h7b UTSW 15 81,772,480 (GRCm38) missense probably benign 0.01
R8866:Zc3h7b UTSW 15 81,772,480 (GRCm38) missense probably benign 0.01
R8867:Zc3h7b UTSW 15 81,772,480 (GRCm38) missense probably benign 0.01
R8868:Zc3h7b UTSW 15 81,772,480 (GRCm38) missense probably benign 0.01
R9071:Zc3h7b UTSW 15 81,793,763 (GRCm38) makesense probably null
R9136:Zc3h7b UTSW 15 81,769,111 (GRCm38) missense probably damaging 1.00
R9169:Zc3h7b UTSW 15 81,776,983 (GRCm38) missense probably benign 0.19
R9701:Zc3h7b UTSW 15 81,792,304 (GRCm38) missense probably damaging 1.00
R9802:Zc3h7b UTSW 15 81,792,304 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCTGGAATGTCATACCCACACGG -3'
(R):5'- TGATCTAGAGTGAGACATCCAGCCC -3'

Sequencing Primer
(F):5'- GTATGCCTAGTGAGCTGCCTC -3'
(R):5'- CTCAAGCTCAGGAAGTGCTG -3'
Posted On 2014-04-24