Incidental Mutation 'R1565:Mog'
ID 175232
Institutional Source Beutler Lab
Gene Symbol Mog
Ensembl Gene ENSMUSG00000076439
Gene Name myelin oligodendrocyte glycoprotein
Synonyms B230317G11Rik
MMRRC Submission 039604-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R1565 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 37010743-37023398 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to C at 37017582 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 152 (N152K)
Ref Sequence ENSEMBL: ENSMUSP00000129489 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102665] [ENSMUST00000167275]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000102665
AA Change: N152K

PolyPhen 2 Score 0.591 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000099726
Gene: ENSMUSG00000076439
AA Change: N152K

low complexity region 4 27 N/A INTRINSIC
IGv 48 129 2.28e-16 SMART
transmembrane domain 156 178 N/A INTRINSIC
transmembrane domain 209 231 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158194
Predicted Effect possibly damaging
Transcript: ENSMUST00000167275
AA Change: N152K

PolyPhen 2 Score 0.728 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000129489
Gene: ENSMUSG00000076439
AA Change: N152K

low complexity region 4 27 N/A INTRINSIC
IGv 48 129 2.28e-16 SMART
transmembrane domain 156 178 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.5%
  • 20x: 90.0%
Validation Efficiency 96% (82/85)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: While one line of homozygous mutant mice showed resistance to experimental autoimmune encephalomyelitis (EAE), another showed increased susceptibility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810021J22Rik G A 11: 58,880,501 (GRCm38) G270S probably benign Het
Abtb1 T C 6: 88,836,554 (GRCm38) T401A probably benign Het
Adamts14 A T 10: 61,270,897 (GRCm38) M148K probably damaging Het
Adcy5 A G 16: 35,268,957 (GRCm38) E508G probably damaging Het
Ankfy1 T A 11: 72,757,318 (GRCm38) L875H probably damaging Het
Cacng3 A T 7: 122,768,401 (GRCm38) D168V probably damaging Het
Clpb G A 7: 101,785,461 (GRCm38) R488Q probably benign Het
Cpxm2 A T 7: 132,062,145 (GRCm38) Y350N probably damaging Het
D130040H23Rik T A 8: 69,303,160 (GRCm38) *406R probably null Het
Dnah10 T A 5: 124,829,614 (GRCm38) D4236E probably damaging Het
Dpf3 T A 12: 83,370,617 (GRCm38) Y27F probably damaging Het
Esp4 T C 17: 40,602,595 (GRCm38) *118Q probably null Het
Fam222b T C 11: 78,154,662 (GRCm38) S222P possibly damaging Het
Flnc T C 6: 29,455,171 (GRCm38) V1933A probably damaging Het
Gem T C 4: 11,713,709 (GRCm38) F282L possibly damaging Het
Gli2 T C 1: 118,841,930 (GRCm38) T631A possibly damaging Het
Gm13088 G A 4: 143,655,617 (GRCm38) Q170* probably null Het
Gpld1 T A 13: 24,956,068 (GRCm38) V116E probably damaging Het
Gpr176 A G 2: 118,280,214 (GRCm38) M188T probably benign Het
Grk5 T C 19: 61,089,972 (GRCm38) V489A probably damaging Het
H2-Ke6 C T 17: 34,027,495 (GRCm38) V105I possibly damaging Het
Hpdl T C 4: 116,820,883 (GRCm38) N127S probably damaging Het
Id4 G T 13: 48,262,294 (GRCm38) V151L possibly damaging Het
Kcnh8 G T 17: 52,956,881 (GRCm38) G802V probably benign Het
Lamc1 C A 1: 153,242,743 (GRCm38) S894I probably benign Het
Larp1b A G 3: 40,972,384 (GRCm38) N184S probably damaging Het
Lhx1 A T 11: 84,519,821 (GRCm38) S226T probably benign Het
Lmo7 A T 14: 101,887,521 (GRCm38) Q472L probably damaging Het
Mttp A G 3: 138,116,405 (GRCm38) probably null Het
Mycbp2 A G 14: 103,252,509 (GRCm38) V953A possibly damaging Het
Myo3a A T 2: 22,340,280 (GRCm38) Y509F probably damaging Het
Myo9b A G 8: 71,315,192 (GRCm38) N303S possibly damaging Het
Nek3 T C 8: 22,132,201 (GRCm38) probably null Het
Nlrc4 A T 17: 74,441,931 (GRCm38) D771E probably benign Het
Nup160 A T 2: 90,722,061 (GRCm38) N1127I possibly damaging Het
Oas1h A T 5: 120,862,600 (GRCm38) N91I probably damaging Het
Olfr1225 A T 2: 89,170,627 (GRCm38) V195D probably benign Het
Olfr1226 G T 2: 89,193,883 (GRCm38) S50R probably damaging Het
Olfr1342 T A 4: 118,690,192 (GRCm38) N87Y probably damaging Het
Parp4 T C 14: 56,589,872 (GRCm38) probably benign Het
Pi4ka G A 16: 17,281,900 (GRCm38) C96Y probably null Het
Pira2 A T 7: 3,844,549 (GRCm38) F47Y probably damaging Het
Pkhd1 C A 1: 20,347,457 (GRCm38) G2490V probably damaging Het
Plekhg1 C T 10: 3,940,526 (GRCm38) T394I probably damaging Het
Psmd1 T C 1: 86,091,997 (GRCm38) probably benign Het
Rab3ip A T 10: 116,939,223 (GRCm38) C77S probably benign Het
Reln A T 5: 21,925,213 (GRCm38) M2700K probably benign Het
Rfx1 A G 8: 84,073,946 (GRCm38) T59A probably benign Het
Ric8b G T 10: 84,980,099 (GRCm38) V405L probably benign Het
Rufy3 G T 5: 88,640,632 (GRCm38) A479S probably damaging Het
Sardh A T 2: 27,242,719 (GRCm38) Y166N probably damaging Het
Slamf6 T G 1: 171,934,408 (GRCm38) V132G possibly damaging Het
Slc12a3 T G 8: 94,345,877 (GRCm38) H674Q possibly damaging Het
Sned1 G A 1: 93,281,654 (GRCm38) V830M possibly damaging Het
Srsf9 A G 5: 115,327,370 (GRCm38) N21S possibly damaging Het
Stkld1 A T 2: 26,950,090 (GRCm38) T391S probably benign Het
Sumf2 C A 5: 129,859,914 (GRCm38) N230K probably damaging Het
Tbc1d22a T C 15: 86,235,569 (GRCm38) V22A possibly damaging Het
Thsd7b T A 1: 129,596,041 (GRCm38) S194T possibly damaging Het
Tmem27 A G X: 164,118,234 (GRCm38) D184G possibly damaging Het
Tnn T A 1: 160,097,265 (GRCm38) Y1173F probably damaging Het
Top2a A G 11: 99,001,054 (GRCm38) F1122L probably damaging Het
Trappc9 G A 15: 73,025,967 (GRCm38) R377W probably damaging Het
Trim39 G A 17: 36,268,854 (GRCm38) R70W probably damaging Het
Ttn G A 2: 76,794,261 (GRCm38) T15289I probably damaging Het
Ugt2b38 A T 5: 87,411,914 (GRCm38) V373E probably damaging Het
Usp54 A G 14: 20,607,159 (GRCm38) S24P probably damaging Het
Vmn2r27 C T 6: 124,231,634 (GRCm38) G51S probably benign Het
Xylt2 C T 11: 94,667,594 (GRCm38) A579T probably benign Het
Zbtb21 A G 16: 97,952,427 (GRCm38) S247P probably benign Het
Zc3h7b C T 15: 81,777,088 (GRCm38) P376L probably benign Het
Zfp251 T A 15: 76,853,038 (GRCm38) R613S probably damaging Het
Zfp251 C T 15: 76,853,039 (GRCm38) R613K possibly damaging Het
Zfp91 T C 19: 12,779,075 (GRCm38) D135G probably benign Het
Other mutations in Mog
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Mog APN 17 37,017,485 (GRCm38) splice site probably null
IGL02991:Mog UTSW 17 37,023,199 (GRCm38) start codon destroyed probably null
R0200:Mog UTSW 17 37,012,419 (GRCm38) missense probably damaging 0.97
R0972:Mog UTSW 17 37,017,532 (GRCm38) missense probably benign 0.14
R3623:Mog UTSW 17 37,012,446 (GRCm38) missense possibly damaging 0.66
R3624:Mog UTSW 17 37,012,446 (GRCm38) missense possibly damaging 0.66
R4079:Mog UTSW 17 37,012,410 (GRCm38) missense probably damaging 1.00
R4772:Mog UTSW 17 37,023,157 (GRCm38) missense unknown
R4944:Mog UTSW 17 37,020,541 (GRCm38) missense probably damaging 0.99
R4991:Mog UTSW 17 37,017,489 (GRCm38) splice site probably null
R5254:Mog UTSW 17 37,012,372 (GRCm38) missense probably benign 0.18
R5963:Mog UTSW 17 37,012,348 (GRCm38) nonsense probably null
R7257:Mog UTSW 17 37,023,127 (GRCm38) missense unknown
R7498:Mog UTSW 17 37,012,092 (GRCm38) splice site probably null
R9262:Mog UTSW 17 37,014,756 (GRCm38) missense possibly damaging 0.86
Predicted Primers PCR Primer

Sequencing Primer
(F):5'- ggctggcactattactccac -3'
(R):5'- agcaatcctcctgctttagac -3'
Posted On 2014-04-24