Incidental Mutation 'R1565:Nlrc4'
ID |
175235 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Nlrc4
|
Ensembl Gene |
ENSMUSG00000039193 |
Gene Name |
NLR family, CARD domain containing 4 |
Synonyms |
9530011P19Rik, Card12, Ipaf |
MMRRC Submission |
039604-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.166)
|
Stock # |
R1565 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
74733254-74766140 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 74748926 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 771
(D771E)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000059637
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000052124]
|
AlphaFold |
Q3UP24 |
PDB Structure |
Crystal structure of NLRC4 reveals its autoinhibition mechanism [X-RAY DIFFRACTION]
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000052124
AA Change: D771E
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
SMART Domains |
Protein: ENSMUSP00000059637 Gene: ENSMUSG00000039193 AA Change: D771E
Domain | Start | End | E-Value | Type |
Pfam:CARD
|
1 |
87 |
1.4e-20 |
PFAM |
Pfam:NACHT
|
163 |
314 |
1.3e-28 |
PFAM |
SCOP:d1yrga_
|
734 |
1015 |
3e-20 |
SMART |
|
Meta Mutation Damage Score |
0.0718 |
Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.5%
- 20x: 90.0%
|
Validation Efficiency |
96% (82/85) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] PHENOTYPE: Homozygotes for a null allele show lack of caspase-1 activation in macrophages infected with Legionella and Salmonella, and enhanced permissivity to Legionella replication. Homozygotes for another null allele fail to show caspase dependent cell death andIL-1beta secretion upon Salmonella infection. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 74 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2810021J22Rik |
G |
A |
11: 58,771,327 (GRCm39) |
G270S |
probably benign |
Het |
Abtb1 |
T |
C |
6: 88,813,536 (GRCm39) |
T401A |
probably benign |
Het |
Adamts14 |
A |
T |
10: 61,106,676 (GRCm39) |
M148K |
probably damaging |
Het |
Adcy5 |
A |
G |
16: 35,089,327 (GRCm39) |
E508G |
probably damaging |
Het |
Ankfy1 |
T |
A |
11: 72,648,144 (GRCm39) |
L875H |
probably damaging |
Het |
Cacng3 |
A |
T |
7: 122,367,624 (GRCm39) |
D168V |
probably damaging |
Het |
Clpb |
G |
A |
7: 101,434,668 (GRCm39) |
R488Q |
probably benign |
Het |
Cltrn |
A |
G |
X: 162,901,230 (GRCm39) |
D184G |
possibly damaging |
Het |
Cpxm2 |
A |
T |
7: 131,663,874 (GRCm39) |
Y350N |
probably damaging |
Het |
D130040H23Rik |
T |
A |
8: 69,755,812 (GRCm39) |
*406R |
probably null |
Het |
Dnah10 |
T |
A |
5: 124,906,678 (GRCm39) |
D4236E |
probably damaging |
Het |
Dpf3 |
T |
A |
12: 83,417,391 (GRCm39) |
Y27F |
probably damaging |
Het |
Esp4 |
T |
C |
17: 40,913,486 (GRCm39) |
*118Q |
probably null |
Het |
Fam222b |
T |
C |
11: 78,045,488 (GRCm39) |
S222P |
possibly damaging |
Het |
Flnc |
T |
C |
6: 29,455,170 (GRCm39) |
V1933A |
probably damaging |
Het |
Gem |
T |
C |
4: 11,713,709 (GRCm39) |
F282L |
possibly damaging |
Het |
Gli2 |
T |
C |
1: 118,769,660 (GRCm39) |
T631A |
possibly damaging |
Het |
Gpld1 |
T |
A |
13: 25,140,051 (GRCm39) |
V116E |
probably damaging |
Het |
Gpr176 |
A |
G |
2: 118,110,695 (GRCm39) |
M188T |
probably benign |
Het |
Grk5 |
T |
C |
19: 61,078,410 (GRCm39) |
V489A |
probably damaging |
Het |
Hpdl |
T |
C |
4: 116,678,080 (GRCm39) |
N127S |
probably damaging |
Het |
Hsd17b8 |
C |
T |
17: 34,246,469 (GRCm39) |
V105I |
possibly damaging |
Het |
Id4 |
G |
T |
13: 48,415,770 (GRCm39) |
V151L |
possibly damaging |
Het |
Kcnh8 |
G |
T |
17: 53,263,909 (GRCm39) |
G802V |
probably benign |
Het |
Lamc1 |
C |
A |
1: 153,118,489 (GRCm39) |
S894I |
probably benign |
Het |
Larp1b |
A |
G |
3: 40,926,819 (GRCm39) |
N184S |
probably damaging |
Het |
Lhx1 |
A |
T |
11: 84,410,647 (GRCm39) |
S226T |
probably benign |
Het |
Lmo7 |
A |
T |
14: 102,124,957 (GRCm39) |
Q472L |
probably damaging |
Het |
Mog |
G |
C |
17: 37,328,474 (GRCm39) |
N152K |
possibly damaging |
Het |
Mttp |
A |
G |
3: 137,822,166 (GRCm39) |
|
probably null |
Het |
Mycbp2 |
A |
G |
14: 103,489,945 (GRCm39) |
V953A |
possibly damaging |
Het |
Myo3a |
A |
T |
2: 22,345,091 (GRCm39) |
Y509F |
probably damaging |
Het |
Myo9b |
A |
G |
8: 71,767,836 (GRCm39) |
N303S |
possibly damaging |
Het |
Nek3 |
T |
C |
8: 22,622,217 (GRCm39) |
|
probably null |
Het |
Nup160 |
A |
T |
2: 90,552,405 (GRCm39) |
N1127I |
possibly damaging |
Het |
Oas1h |
A |
T |
5: 121,000,663 (GRCm39) |
N91I |
probably damaging |
Het |
Or13p4 |
T |
A |
4: 118,547,389 (GRCm39) |
N87Y |
probably damaging |
Het |
Or4c120 |
A |
T |
2: 89,000,971 (GRCm39) |
V195D |
probably benign |
Het |
Or4c121 |
G |
T |
2: 89,024,227 (GRCm39) |
S50R |
probably damaging |
Het |
Parp4 |
T |
C |
14: 56,827,329 (GRCm39) |
|
probably benign |
Het |
Pi4ka |
G |
A |
16: 17,099,764 (GRCm39) |
C96Y |
probably null |
Het |
Pira2 |
A |
T |
7: 3,847,548 (GRCm39) |
F47Y |
probably damaging |
Het |
Pkhd1 |
C |
A |
1: 20,417,681 (GRCm39) |
G2490V |
probably damaging |
Het |
Plekhg1 |
C |
T |
10: 3,890,526 (GRCm39) |
T394I |
probably damaging |
Het |
Pramel22 |
G |
A |
4: 143,382,187 (GRCm39) |
Q170* |
probably null |
Het |
Psmd1 |
T |
C |
1: 86,019,719 (GRCm39) |
|
probably benign |
Het |
Rab3ip |
A |
T |
10: 116,775,128 (GRCm39) |
C77S |
probably benign |
Het |
Reln |
A |
T |
5: 22,130,211 (GRCm39) |
M2700K |
probably benign |
Het |
Rfx1 |
A |
G |
8: 84,800,575 (GRCm39) |
T59A |
probably benign |
Het |
Ric8b |
G |
T |
10: 84,815,963 (GRCm39) |
V405L |
probably benign |
Het |
Rufy3 |
G |
T |
5: 88,788,491 (GRCm39) |
A479S |
probably damaging |
Het |
Sardh |
A |
T |
2: 27,132,731 (GRCm39) |
Y166N |
probably damaging |
Het |
Slamf6 |
T |
G |
1: 171,761,975 (GRCm39) |
V132G |
possibly damaging |
Het |
Slc12a3 |
T |
G |
8: 95,072,505 (GRCm39) |
H674Q |
possibly damaging |
Het |
Sned1 |
G |
A |
1: 93,209,376 (GRCm39) |
V830M |
possibly damaging |
Het |
Srsf9 |
A |
G |
5: 115,465,429 (GRCm39) |
N21S |
possibly damaging |
Het |
Stkld1 |
A |
T |
2: 26,840,102 (GRCm39) |
T391S |
probably benign |
Het |
Sumf2 |
C |
A |
5: 129,888,755 (GRCm39) |
N230K |
probably damaging |
Het |
Tbc1d22a |
T |
C |
15: 86,119,770 (GRCm39) |
V22A |
possibly damaging |
Het |
Thsd7b |
T |
A |
1: 129,523,778 (GRCm39) |
S194T |
possibly damaging |
Het |
Tnn |
T |
A |
1: 159,924,835 (GRCm39) |
Y1173F |
probably damaging |
Het |
Top2a |
A |
G |
11: 98,891,880 (GRCm39) |
F1122L |
probably damaging |
Het |
Trappc9 |
G |
A |
15: 72,897,816 (GRCm39) |
R377W |
probably damaging |
Het |
Trim39 |
G |
A |
17: 36,579,746 (GRCm39) |
R70W |
probably damaging |
Het |
Ttn |
G |
A |
2: 76,624,605 (GRCm39) |
T15289I |
probably damaging |
Het |
Ugt2b38 |
A |
T |
5: 87,559,773 (GRCm39) |
V373E |
probably damaging |
Het |
Usp54 |
A |
G |
14: 20,657,227 (GRCm39) |
S24P |
probably damaging |
Het |
Vmn2r27 |
C |
T |
6: 124,208,593 (GRCm39) |
G51S |
probably benign |
Het |
Xylt2 |
C |
T |
11: 94,558,420 (GRCm39) |
A579T |
probably benign |
Het |
Zbtb21 |
A |
G |
16: 97,753,627 (GRCm39) |
S247P |
probably benign |
Het |
Zc3h7b |
C |
T |
15: 81,661,289 (GRCm39) |
P376L |
probably benign |
Het |
Zfp251 |
T |
A |
15: 76,737,238 (GRCm39) |
R613S |
probably damaging |
Het |
Zfp251 |
C |
T |
15: 76,737,239 (GRCm39) |
R613K |
possibly damaging |
Het |
Zfp91 |
T |
C |
19: 12,756,439 (GRCm39) |
D135G |
probably benign |
Het |
|
Other mutations in Nlrc4 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00392:Nlrc4
|
APN |
17 |
74,753,529 (GRCm39) |
missense |
probably benign |
0.02 |
IGL00427:Nlrc4
|
APN |
17 |
74,754,087 (GRCm39) |
missense |
probably benign |
|
IGL00823:Nlrc4
|
APN |
17 |
74,754,985 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01404:Nlrc4
|
APN |
17 |
74,752,706 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02178:Nlrc4
|
APN |
17 |
74,753,838 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02266:Nlrc4
|
APN |
17 |
74,753,162 (GRCm39) |
missense |
possibly damaging |
0.72 |
IGL03342:Nlrc4
|
APN |
17 |
74,752,313 (GRCm39) |
missense |
probably damaging |
1.00 |
Inwood
|
UTSW |
17 |
74,752,625 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4305001:Nlrc4
|
UTSW |
17 |
74,753,304 (GRCm39) |
missense |
probably damaging |
0.99 |
PIT4466001:Nlrc4
|
UTSW |
17 |
74,734,114 (GRCm39) |
missense |
probably benign |
0.01 |
R0077:Nlrc4
|
UTSW |
17 |
74,753,826 (GRCm39) |
missense |
probably damaging |
1.00 |
R0398:Nlrc4
|
UTSW |
17 |
74,752,915 (GRCm39) |
missense |
probably damaging |
0.99 |
R0639:Nlrc4
|
UTSW |
17 |
74,733,958 (GRCm39) |
missense |
probably benign |
0.16 |
R1498:Nlrc4
|
UTSW |
17 |
74,753,408 (GRCm39) |
missense |
probably benign |
0.43 |
R1624:Nlrc4
|
UTSW |
17 |
74,752,184 (GRCm39) |
missense |
possibly damaging |
0.55 |
R1666:Nlrc4
|
UTSW |
17 |
74,752,901 (GRCm39) |
missense |
probably damaging |
0.97 |
R1668:Nlrc4
|
UTSW |
17 |
74,752,901 (GRCm39) |
missense |
probably damaging |
0.97 |
R1690:Nlrc4
|
UTSW |
17 |
74,744,518 (GRCm39) |
nonsense |
probably null |
|
R1723:Nlrc4
|
UTSW |
17 |
74,748,903 (GRCm39) |
missense |
probably damaging |
1.00 |
R1988:Nlrc4
|
UTSW |
17 |
74,733,938 (GRCm39) |
missense |
probably benign |
0.09 |
R1992:Nlrc4
|
UTSW |
17 |
74,752,628 (GRCm39) |
missense |
probably benign |
0.04 |
R2141:Nlrc4
|
UTSW |
17 |
74,754,946 (GRCm39) |
splice site |
probably benign |
|
R2256:Nlrc4
|
UTSW |
17 |
74,752,625 (GRCm39) |
missense |
probably damaging |
1.00 |
R2897:Nlrc4
|
UTSW |
17 |
74,755,040 (GRCm39) |
missense |
probably benign |
|
R3117:Nlrc4
|
UTSW |
17 |
74,743,063 (GRCm39) |
missense |
probably benign |
0.00 |
R3861:Nlrc4
|
UTSW |
17 |
74,752,616 (GRCm39) |
missense |
probably benign |
0.00 |
R4093:Nlrc4
|
UTSW |
17 |
74,752,953 (GRCm39) |
missense |
probably benign |
0.20 |
R4212:Nlrc4
|
UTSW |
17 |
74,754,110 (GRCm39) |
missense |
possibly damaging |
0.66 |
R4627:Nlrc4
|
UTSW |
17 |
74,753,623 (GRCm39) |
missense |
probably damaging |
1.00 |
R4859:Nlrc4
|
UTSW |
17 |
74,743,032 (GRCm39) |
missense |
probably damaging |
0.97 |
R4968:Nlrc4
|
UTSW |
17 |
74,753,936 (GRCm39) |
missense |
probably benign |
0.20 |
R5133:Nlrc4
|
UTSW |
17 |
74,753,712 (GRCm39) |
missense |
possibly damaging |
0.91 |
R5379:Nlrc4
|
UTSW |
17 |
74,755,078 (GRCm39) |
nonsense |
probably null |
|
R6045:Nlrc4
|
UTSW |
17 |
74,753,954 (GRCm39) |
missense |
probably damaging |
0.98 |
R6654:Nlrc4
|
UTSW |
17 |
74,752,523 (GRCm39) |
missense |
possibly damaging |
0.55 |
R6712:Nlrc4
|
UTSW |
17 |
74,753,831 (GRCm39) |
missense |
probably damaging |
0.96 |
R6976:Nlrc4
|
UTSW |
17 |
74,752,934 (GRCm39) |
missense |
probably damaging |
1.00 |
R7030:Nlrc4
|
UTSW |
17 |
74,753,001 (GRCm39) |
missense |
probably damaging |
1.00 |
R7153:Nlrc4
|
UTSW |
17 |
74,754,098 (GRCm39) |
missense |
possibly damaging |
0.84 |
R7190:Nlrc4
|
UTSW |
17 |
74,752,198 (GRCm39) |
missense |
probably damaging |
1.00 |
R7398:Nlrc4
|
UTSW |
17 |
74,753,537 (GRCm39) |
missense |
probably damaging |
1.00 |
R7417:Nlrc4
|
UTSW |
17 |
74,753,483 (GRCm39) |
missense |
probably benign |
0.18 |
R7468:Nlrc4
|
UTSW |
17 |
74,752,507 (GRCm39) |
missense |
probably benign |
0.00 |
R7639:Nlrc4
|
UTSW |
17 |
74,754,952 (GRCm39) |
critical splice donor site |
probably null |
|
R7716:Nlrc4
|
UTSW |
17 |
74,753,651 (GRCm39) |
missense |
probably damaging |
1.00 |
R7757:Nlrc4
|
UTSW |
17 |
74,755,191 (GRCm39) |
missense |
probably benign |
0.00 |
R7868:Nlrc4
|
UTSW |
17 |
74,755,047 (GRCm39) |
missense |
possibly damaging |
0.75 |
R7890:Nlrc4
|
UTSW |
17 |
74,744,503 (GRCm39) |
missense |
probably benign |
0.00 |
R7920:Nlrc4
|
UTSW |
17 |
74,734,114 (GRCm39) |
missense |
probably benign |
0.01 |
R7950:Nlrc4
|
UTSW |
17 |
74,752,610 (GRCm39) |
missense |
probably damaging |
1.00 |
R8154:Nlrc4
|
UTSW |
17 |
74,752,904 (GRCm39) |
missense |
probably damaging |
1.00 |
R8168:Nlrc4
|
UTSW |
17 |
74,752,206 (GRCm39) |
missense |
probably benign |
0.01 |
R8311:Nlrc4
|
UTSW |
17 |
74,753,540 (GRCm39) |
missense |
probably damaging |
1.00 |
R8716:Nlrc4
|
UTSW |
17 |
74,752,985 (GRCm39) |
missense |
probably damaging |
1.00 |
R9502:Nlrc4
|
UTSW |
17 |
74,752,580 (GRCm39) |
missense |
probably benign |
0.37 |
R9514:Nlrc4
|
UTSW |
17 |
74,753,736 (GRCm39) |
missense |
probably benign |
0.03 |
X0026:Nlrc4
|
UTSW |
17 |
74,753,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- ACAGCTACCTCGGGCCTCC -3'
(R):5'- GGCTCTCCTGCATGATAACTGAAATCTG -3'
Sequencing Primer
(F):5'- aaaaaagagagagagagagagagag -3'
(R):5'- TCTGATTGGTAATAGGAATGACAGTG -3'
|
Posted On |
2014-04-24 |