Incidental Mutation 'R1568:Zyg11a'
ID 175411
Institutional Source Beutler Lab
Gene Symbol Zyg11a
Ensembl Gene ENSMUSG00000034645
Gene Name zyg-11 family member A, cell cycle regulator
Synonyms
MMRRC Submission 039607-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.129) question?
Stock # R1568 (G1)
Quality Score 216
Status Not validated
Chromosome 4
Chromosomal Location 108038935-108075245 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 108040843 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000152477 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043793] [ENSMUST00000043793] [ENSMUST00000052999] [ENSMUST00000106690] [ENSMUST00000106690] [ENSMUST00000116307] [ENSMUST00000116309] [ENSMUST00000125647] [ENSMUST00000126900] [ENSMUST00000223127] [ENSMUST00000130942]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000043793
SMART Domains Protein: ENSMUSP00000038478
Gene: ENSMUSG00000034645

DomainStartEndE-ValueType
SCOP:d1jdha_ 218 700 2e-11 SMART
Blast:ARM 497 544 1e-5 BLAST
Blast:ARM 547 587 5e-7 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000043793
SMART Domains Protein: ENSMUSP00000038478
Gene: ENSMUSG00000034645

DomainStartEndE-ValueType
SCOP:d1jdha_ 218 700 2e-11 SMART
Blast:ARM 497 544 1e-5 BLAST
Blast:ARM 547 587 5e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000052999
SMART Domains Protein: ENSMUSP00000051268
Gene: ENSMUSG00000028601

DomainStartEndE-ValueType
Pfam:ECH_1 41 296 1.1e-60 PFAM
Pfam:ECH_2 46 225 5.1e-35 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000106690
SMART Domains Protein: ENSMUSP00000102301
Gene: ENSMUSG00000034645

DomainStartEndE-ValueType
SCOP:d1jdha_ 139 621 1e-11 SMART
Blast:ARM 418 465 1e-5 BLAST
Blast:ARM 468 508 1e-7 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000106690
SMART Domains Protein: ENSMUSP00000102301
Gene: ENSMUSG00000034645

DomainStartEndE-ValueType
SCOP:d1jdha_ 139 621 1e-11 SMART
Blast:ARM 418 465 1e-5 BLAST
Blast:ARM 468 508 1e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000106691
SMART Domains Protein: ENSMUSP00000102302
Gene: ENSMUSG00000028601

DomainStartEndE-ValueType
Pfam:ECH_1 1 119 1.6e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000116307
SMART Domains Protein: ENSMUSP00000112009
Gene: ENSMUSG00000028601

DomainStartEndE-ValueType
Pfam:ECH 39 131 6.7e-17 PFAM
Pfam:ECH 124 257 5.3e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000116309
SMART Domains Protein: ENSMUSP00000112011
Gene: ENSMUSG00000028601

DomainStartEndE-ValueType
Pfam:ECH 39 288 3.2e-61 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125647
SMART Domains Protein: ENSMUSP00000123913
Gene: ENSMUSG00000028601

DomainStartEndE-ValueType
low complexity region 45 62 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000126900
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127392
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133049
Predicted Effect probably null
Transcript: ENSMUST00000223127
Predicted Effect probably benign
Transcript: ENSMUST00000135718
SMART Domains Protein: ENSMUSP00000114371
Gene: ENSMUSG00000028601

DomainStartEndE-ValueType
Pfam:ECH_1 1 74 9.6e-16 PFAM
Pfam:ECH_2 2 74 1.1e-11 PFAM
Pfam:ECH_1 69 184 2.8e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000130942
SMART Domains Protein: ENSMUSP00000124746
Gene: ENSMUSG00000028601

DomainStartEndE-ValueType
Pfam:ECH 39 103 8.6e-13 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.8%
  • 20x: 90.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam18 T G 8: 25,137,799 (GRCm39) probably null Het
Adgb A T 10: 10,318,409 (GRCm39) Y138* probably null Het
Adra1d T C 2: 131,388,092 (GRCm39) R488G possibly damaging Het
Ahnak G A 19: 8,979,739 (GRCm39) G341E probably damaging Het
Ankmy1 T C 1: 92,808,838 (GRCm39) D690G probably damaging Het
Arhgef38 C T 3: 132,838,225 (GRCm39) E21K probably damaging Het
Atp8b2 T C 3: 89,857,155 (GRCm39) M402V probably damaging Het
Atp8b4 G T 2: 126,167,314 (GRCm39) H1062N probably benign Het
Bdnf A G 2: 109,554,139 (GRCm39) H131R probably damaging Het
Cblb C T 16: 51,956,192 (GRCm39) T265M probably damaging Het
Cenpe T A 3: 134,945,519 (GRCm39) M1011K probably benign Het
Clca3a2 A T 3: 144,781,410 (GRCm39) Y711* probably null Het
Clca4a A G 3: 144,658,690 (GRCm39) Y842H probably benign Het
Clspn T A 4: 126,475,310 (GRCm39) M1021K probably benign Het
Cpne8 G T 15: 90,503,845 (GRCm39) R107S probably damaging Het
D6Ertd527e C G 6: 87,088,506 (GRCm39) T223S unknown Het
Dna2 C T 10: 62,784,966 (GRCm39) R28W probably benign Het
Dnah5 T A 15: 28,409,323 (GRCm39) N3580K probably damaging Het
Dsp T C 13: 38,359,123 (GRCm39) I298T probably damaging Het
Dync2h1 T C 9: 7,157,553 (GRCm39) K858R probably null Het
Fasn A T 11: 120,704,075 (GRCm39) V1448E possibly damaging Het
Ghdc A G 11: 100,659,331 (GRCm39) I322T probably benign Het
Gins2 T C 8: 121,308,939 (GRCm39) D105G probably damaging Het
Insr A T 8: 3,215,576 (GRCm39) D975E probably benign Het
Klrc3 T C 6: 129,616,510 (GRCm39) D169G probably benign Het
Krt76 T A 15: 101,793,443 (GRCm39) S532C unknown Het
Lamp3 A T 16: 19,492,275 (GRCm39) M323K probably damaging Het
Lgmn T C 12: 102,360,868 (GRCm39) I423M possibly damaging Het
Lpgat1 A T 1: 191,508,538 (GRCm39) T359S possibly damaging Het
Lrguk T A 6: 34,063,373 (GRCm39) I466N probably damaging Het
Magi3 A C 3: 103,996,843 (GRCm39) M234R probably benign Het
Myh14 G A 7: 44,261,122 (GRCm39) R1042* probably null Het
Nfia T G 4: 97,999,461 (GRCm39) Y378D possibly damaging Het
Npffr1 T A 10: 61,462,012 (GRCm39) S383T possibly damaging Het
Or4f57 C A 2: 111,790,585 (GRCm39) V278F probably benign Het
Or52n4 T A 7: 104,293,977 (GRCm39) I199F probably benign Het
Or5b112 C A 19: 13,319,539 (GRCm39) P139Q probably benign Het
Or9s14 T C 1: 92,535,676 (GRCm39) L39P probably damaging Het
Osr1 G A 12: 9,629,798 (GRCm39) probably null Het
Pde4b A C 4: 102,454,896 (GRCm39) R375S probably damaging Het
Pde8a A G 7: 80,942,011 (GRCm39) E150G probably damaging Het
Pkhd1l1 A T 15: 44,408,897 (GRCm39) probably null Het
Ppp3ca A G 3: 136,634,305 (GRCm39) T422A probably benign Het
Proser1 T C 3: 53,385,180 (GRCm39) V354A possibly damaging Het
Rgs20 G T 1: 5,091,050 (GRCm39) R127S probably benign Het
Sanbr T C 11: 23,539,971 (GRCm39) K48E probably damaging Het
Sec22a T C 16: 35,167,998 (GRCm39) D171G probably benign Het
Secisbp2 A G 13: 51,827,143 (GRCm39) E417G possibly damaging Het
Serpinb6b T C 13: 33,158,895 (GRCm39) L32S probably damaging Het
Sf3b1 C G 1: 55,058,554 (GRCm39) E12Q possibly damaging Het
Slc39a10 A T 1: 46,865,375 (GRCm39) S487T probably benign Het
Slc6a1 G T 6: 114,284,731 (GRCm39) G263V probably damaging Het
Spag6 A G 2: 18,737,925 (GRCm39) D265G probably benign Het
Spata31e2 T C 1: 26,724,950 (GRCm39) T77A probably benign Het
Sybu G T 15: 44,582,228 (GRCm39) S132* probably null Het
Virma T C 4: 11,528,776 (GRCm39) S1288P probably damaging Het
Vmn1r229 T A 17: 21,035,067 (GRCm39) V104D probably damaging Het
Vmn1r238 T C 18: 3,123,358 (GRCm39) T19A probably benign Het
Vmn2r86 C T 10: 130,289,010 (GRCm39) V164I probably benign Het
Wfdc13 G T 2: 164,528,854 (GRCm39) A64S probably damaging Het
Zfp873 C A 10: 81,896,113 (GRCm39) H318Q probably damaging Het
Other mutations in Zyg11a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01458:Zyg11a APN 4 108,062,099 (GRCm39) missense probably damaging 0.99
IGL01517:Zyg11a APN 4 108,058,391 (GRCm39) missense probably null 1.00
IGL01619:Zyg11a APN 4 108,062,414 (GRCm39) missense probably damaging 1.00
IGL02253:Zyg11a APN 4 108,040,892 (GRCm39) missense probably null 0.99
R0090:Zyg11a UTSW 4 108,058,544 (GRCm39) splice site probably benign
R0225:Zyg11a UTSW 4 108,061,838 (GRCm39) missense probably damaging 1.00
R0610:Zyg11a UTSW 4 108,062,054 (GRCm39) missense probably damaging 1.00
R0827:Zyg11a UTSW 4 108,067,239 (GRCm39) splice site probably benign
R1752:Zyg11a UTSW 4 108,062,479 (GRCm39) missense possibly damaging 0.81
R2051:Zyg11a UTSW 4 108,049,244 (GRCm39) splice site probably benign
R2358:Zyg11a UTSW 4 108,053,343 (GRCm39) missense possibly damaging 0.94
R3898:Zyg11a UTSW 4 108,067,391 (GRCm39) missense probably damaging 0.99
R4288:Zyg11a UTSW 4 108,041,666 (GRCm39) missense probably damaging 1.00
R4381:Zyg11a UTSW 4 108,058,517 (GRCm39) missense possibly damaging 0.58
R4709:Zyg11a UTSW 4 108,062,268 (GRCm39) missense probably benign 0.00
R4859:Zyg11a UTSW 4 108,067,387 (GRCm39) missense probably damaging 0.98
R5303:Zyg11a UTSW 4 108,041,629 (GRCm39) critical splice donor site probably null
R5349:Zyg11a UTSW 4 108,040,929 (GRCm39) missense probably damaging 1.00
R5363:Zyg11a UTSW 4 108,046,819 (GRCm39) missense probably damaging 1.00
R5517:Zyg11a UTSW 4 108,061,943 (GRCm39) missense possibly damaging 0.94
R6175:Zyg11a UTSW 4 108,046,878 (GRCm39) missense probably benign 0.01
R6254:Zyg11a UTSW 4 108,038,991 (GRCm39) missense probably damaging 1.00
R6678:Zyg11a UTSW 4 108,046,878 (GRCm39) missense probably benign 0.01
R7524:Zyg11a UTSW 4 108,049,271 (GRCm39) missense probably damaging 1.00
R7789:Zyg11a UTSW 4 108,040,845 (GRCm39) missense probably damaging 1.00
R8022:Zyg11a UTSW 4 108,046,765 (GRCm39) critical splice donor site probably null
R8437:Zyg11a UTSW 4 108,075,103 (GRCm39) missense probably damaging 1.00
R8986:Zyg11a UTSW 4 108,041,628 (GRCm39) critical splice donor site probably null
R9129:Zyg11a UTSW 4 108,039,009 (GRCm39) missense probably benign 0.00
R9383:Zyg11a UTSW 4 108,046,926 (GRCm39) missense probably damaging 1.00
R9457:Zyg11a UTSW 4 108,075,102 (GRCm39) missense probably damaging 1.00
R9489:Zyg11a UTSW 4 108,062,376 (GRCm39) missense probably damaging 0.96
R9511:Zyg11a UTSW 4 108,062,420 (GRCm39) missense probably damaging 1.00
X0061:Zyg11a UTSW 4 108,051,190 (GRCm39) missense probably damaging 1.00
Z1176:Zyg11a UTSW 4 108,058,479 (GRCm39) missense probably damaging 1.00
Z1177:Zyg11a UTSW 4 108,061,997 (GRCm39) missense possibly damaging 0.90
Predicted Primers
Posted On 2014-04-24