Incidental Mutation 'R1568:Zfp873'
ID 175430
Institutional Source Beutler Lab
Gene Symbol Zfp873
Ensembl Gene ENSMUSG00000061371
Gene Name zinc finger protein 873
Synonyms
MMRRC Submission 039607-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R1568 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 81883957-81900579 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 81896113 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 318 (H318Q)
Ref Sequence ENSEMBL: ENSMUSP00000148219 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105313] [ENSMUST00000209622] [ENSMUST00000210325]
AlphaFold A0A1B0GT64
Predicted Effect probably damaging
Transcript: ENSMUST00000105313
AA Change: H281Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000100950
Gene: ENSMUSG00000061371
AA Change: H281Q

DomainStartEndE-ValueType
ZnF_C2H2 68 90 1.12e2 SMART
ZnF_C2H2 96 117 4.69e0 SMART
ZnF_C2H2 123 145 2.06e1 SMART
ZnF_C2H2 151 173 5.5e-3 SMART
ZnF_C2H2 179 201 3.69e-4 SMART
ZnF_C2H2 207 229 3.89e-3 SMART
ZnF_C2H2 235 257 9.88e-5 SMART
ZnF_C2H2 263 285 5.59e-4 SMART
ZnF_C2H2 291 313 2.99e-4 SMART
ZnF_C2H2 319 341 1.95e-3 SMART
ZnF_C2H2 347 369 2.75e-3 SMART
ZnF_C2H2 375 397 7.37e-4 SMART
ZnF_C2H2 403 425 2.53e-2 SMART
ZnF_C2H2 431 453 9.08e-4 SMART
ZnF_C2H2 459 481 5.99e-4 SMART
ZnF_C2H2 487 509 1.22e-4 SMART
ZnF_C2H2 515 537 1.82e-3 SMART
ZnF_C2H2 543 565 2.53e-2 SMART
ZnF_C2H2 571 593 9.73e-4 SMART
ZnF_C2H2 599 619 3.13e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209614
Predicted Effect probably benign
Transcript: ENSMUST00000209622
Predicted Effect probably damaging
Transcript: ENSMUST00000210325
AA Change: H318Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211338
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219748
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.8%
  • 20x: 90.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam18 T G 8: 25,137,799 (GRCm39) probably null Het
Adgb A T 10: 10,318,409 (GRCm39) Y138* probably null Het
Adra1d T C 2: 131,388,092 (GRCm39) R488G possibly damaging Het
Ahnak G A 19: 8,979,739 (GRCm39) G341E probably damaging Het
Ankmy1 T C 1: 92,808,838 (GRCm39) D690G probably damaging Het
Arhgef38 C T 3: 132,838,225 (GRCm39) E21K probably damaging Het
Atp8b2 T C 3: 89,857,155 (GRCm39) M402V probably damaging Het
Atp8b4 G T 2: 126,167,314 (GRCm39) H1062N probably benign Het
Bdnf A G 2: 109,554,139 (GRCm39) H131R probably damaging Het
Cblb C T 16: 51,956,192 (GRCm39) T265M probably damaging Het
Cenpe T A 3: 134,945,519 (GRCm39) M1011K probably benign Het
Clca3a2 A T 3: 144,781,410 (GRCm39) Y711* probably null Het
Clca4a A G 3: 144,658,690 (GRCm39) Y842H probably benign Het
Clspn T A 4: 126,475,310 (GRCm39) M1021K probably benign Het
Cpne8 G T 15: 90,503,845 (GRCm39) R107S probably damaging Het
D6Ertd527e C G 6: 87,088,506 (GRCm39) T223S unknown Het
Dna2 C T 10: 62,784,966 (GRCm39) R28W probably benign Het
Dnah5 T A 15: 28,409,323 (GRCm39) N3580K probably damaging Het
Dsp T C 13: 38,359,123 (GRCm39) I298T probably damaging Het
Dync2h1 T C 9: 7,157,553 (GRCm39) K858R probably null Het
Fasn A T 11: 120,704,075 (GRCm39) V1448E possibly damaging Het
Ghdc A G 11: 100,659,331 (GRCm39) I322T probably benign Het
Gins2 T C 8: 121,308,939 (GRCm39) D105G probably damaging Het
Insr A T 8: 3,215,576 (GRCm39) D975E probably benign Het
Klrc3 T C 6: 129,616,510 (GRCm39) D169G probably benign Het
Krt76 T A 15: 101,793,443 (GRCm39) S532C unknown Het
Lamp3 A T 16: 19,492,275 (GRCm39) M323K probably damaging Het
Lgmn T C 12: 102,360,868 (GRCm39) I423M possibly damaging Het
Lpgat1 A T 1: 191,508,538 (GRCm39) T359S possibly damaging Het
Lrguk T A 6: 34,063,373 (GRCm39) I466N probably damaging Het
Magi3 A C 3: 103,996,843 (GRCm39) M234R probably benign Het
Myh14 G A 7: 44,261,122 (GRCm39) R1042* probably null Het
Nfia T G 4: 97,999,461 (GRCm39) Y378D possibly damaging Het
Npffr1 T A 10: 61,462,012 (GRCm39) S383T possibly damaging Het
Or4f57 C A 2: 111,790,585 (GRCm39) V278F probably benign Het
Or52n4 T A 7: 104,293,977 (GRCm39) I199F probably benign Het
Or5b112 C A 19: 13,319,539 (GRCm39) P139Q probably benign Het
Or9s14 T C 1: 92,535,676 (GRCm39) L39P probably damaging Het
Osr1 G A 12: 9,629,798 (GRCm39) probably null Het
Pde4b A C 4: 102,454,896 (GRCm39) R375S probably damaging Het
Pde8a A G 7: 80,942,011 (GRCm39) E150G probably damaging Het
Pkhd1l1 A T 15: 44,408,897 (GRCm39) probably null Het
Ppp3ca A G 3: 136,634,305 (GRCm39) T422A probably benign Het
Proser1 T C 3: 53,385,180 (GRCm39) V354A possibly damaging Het
Rgs20 G T 1: 5,091,050 (GRCm39) R127S probably benign Het
Sanbr T C 11: 23,539,971 (GRCm39) K48E probably damaging Het
Sec22a T C 16: 35,167,998 (GRCm39) D171G probably benign Het
Secisbp2 A G 13: 51,827,143 (GRCm39) E417G possibly damaging Het
Serpinb6b T C 13: 33,158,895 (GRCm39) L32S probably damaging Het
Sf3b1 C G 1: 55,058,554 (GRCm39) E12Q possibly damaging Het
Slc39a10 A T 1: 46,865,375 (GRCm39) S487T probably benign Het
Slc6a1 G T 6: 114,284,731 (GRCm39) G263V probably damaging Het
Spag6 A G 2: 18,737,925 (GRCm39) D265G probably benign Het
Spata31e2 T C 1: 26,724,950 (GRCm39) T77A probably benign Het
Sybu G T 15: 44,582,228 (GRCm39) S132* probably null Het
Virma T C 4: 11,528,776 (GRCm39) S1288P probably damaging Het
Vmn1r229 T A 17: 21,035,067 (GRCm39) V104D probably damaging Het
Vmn1r238 T C 18: 3,123,358 (GRCm39) T19A probably benign Het
Vmn2r86 C T 10: 130,289,010 (GRCm39) V164I probably benign Het
Wfdc13 G T 2: 164,528,854 (GRCm39) A64S probably damaging Het
Zyg11a A G 4: 108,040,843 (GRCm39) probably null Het
Other mutations in Zfp873
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02250:Zfp873 APN 10 81,894,252 (GRCm39) start codon destroyed probably null 0.45
G1Funyon:Zfp873 UTSW 10 81,896,713 (GRCm39) missense probably damaging 1.00
R0666:Zfp873 UTSW 10 81,896,595 (GRCm39) missense possibly damaging 0.75
R1739:Zfp873 UTSW 10 81,896,541 (GRCm39) missense probably damaging 1.00
R1848:Zfp873 UTSW 10 81,896,406 (GRCm39) missense probably benign 0.33
R1892:Zfp873 UTSW 10 81,897,080 (GRCm39) missense probably damaging 1.00
R2061:Zfp873 UTSW 10 81,895,991 (GRCm39) missense probably benign 0.01
R3735:Zfp873 UTSW 10 81,897,015 (GRCm39) missense probably benign 0.15
R4422:Zfp873 UTSW 10 81,896,708 (GRCm39) missense probably benign 0.13
R4674:Zfp873 UTSW 10 81,895,814 (GRCm39) missense possibly damaging 0.53
R4839:Zfp873 UTSW 10 81,896,353 (GRCm39) missense probably damaging 0.98
R5146:Zfp873 UTSW 10 81,896,058 (GRCm39) missense probably damaging 1.00
R5154:Zfp873 UTSW 10 81,896,025 (GRCm39) missense possibly damaging 0.54
R5160:Zfp873 UTSW 10 81,896,876 (GRCm39) missense possibly damaging 0.54
R5811:Zfp873 UTSW 10 81,896,567 (GRCm39) missense probably damaging 1.00
R6625:Zfp873 UTSW 10 81,896,138 (GRCm39) missense probably damaging 1.00
R6667:Zfp873 UTSW 10 81,896,423 (GRCm39) missense probably benign 0.22
R6742:Zfp873 UTSW 10 81,894,256 (GRCm39) missense probably damaging 1.00
R6878:Zfp873 UTSW 10 81,896,529 (GRCm39) missense probably benign 0.33
R7055:Zfp873 UTSW 10 81,895,832 (GRCm39) missense probably damaging 1.00
R7296:Zfp873 UTSW 10 81,897,071 (GRCm39) missense probably damaging 1.00
R7381:Zfp873 UTSW 10 81,896,805 (GRCm39) missense probably damaging 1.00
R7448:Zfp873 UTSW 10 81,896,461 (GRCm39) missense probably damaging 1.00
R7464:Zfp873 UTSW 10 81,896,210 (GRCm39) missense possibly damaging 0.51
R7470:Zfp873 UTSW 10 81,895,773 (GRCm39) missense probably benign 0.19
R7640:Zfp873 UTSW 10 81,896,109 (GRCm39) missense possibly damaging 0.72
R7862:Zfp873 UTSW 10 81,896,109 (GRCm39) missense probably benign 0.03
R8017:Zfp873 UTSW 10 81,896,193 (GRCm39) missense probably benign 0.01
R8301:Zfp873 UTSW 10 81,896,713 (GRCm39) missense probably damaging 1.00
R8765:Zfp873 UTSW 10 81,896,072 (GRCm39) missense probably damaging 1.00
R8997:Zfp873 UTSW 10 81,896,990 (GRCm39) missense probably benign 0.03
R9305:Zfp873 UTSW 10 81,896,514 (GRCm39) missense probably benign 0.00
R9462:Zfp873 UTSW 10 81,897,131 (GRCm39) missense probably benign 0.31
Z1177:Zfp873 UTSW 10 81,896,999 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2014-04-24