Mutagenetix > Incidental Mutation

Incidental Mutation 'R1568:Zfp873'

175430

Institutional Source

Beutler Lab

Gene Symbol

Zfp873

Ensembl Gene

ENSMUSG00000061371

Gene Name

zinc finger protein 873

Synonyms

MMRRC Submission

039607-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.097) question?

Stock #

R1568 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

82048123-82064745 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 82060279 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 318 (H318Q)

Ref Sequence

ENSEMBL: ENSMUSP00000148219 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105313] [ENSMUST00000209622] [ENSMUST00000210325]

AlphaFold

A0A1B0GT64

Predicted Effect

probably damaging
Transcript: ENSMUST00000105313
AA Change: H281Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000100950
Gene: ENSMUSG00000061371
AA Change: H281Q

Domain	Start	End	E-Value	Type
ZnF_C2H2	68	90	1.12e2	SMART
ZnF_C2H2	96	117	4.69e0	SMART
ZnF_C2H2	123	145	2.06e1	SMART
ZnF_C2H2	151	173	5.5e-3	SMART
ZnF_C2H2	179	201	3.69e-4	SMART
ZnF_C2H2	207	229	3.89e-3	SMART
ZnF_C2H2	235	257	9.88e-5	SMART
ZnF_C2H2	263	285	5.59e-4	SMART
ZnF_C2H2	291	313	2.99e-4	SMART
ZnF_C2H2	319	341	1.95e-3	SMART
ZnF_C2H2	347	369	2.75e-3	SMART
ZnF_C2H2	375	397	7.37e-4	SMART
ZnF_C2H2	403	425	2.53e-2	SMART
ZnF_C2H2	431	453	9.08e-4	SMART
ZnF_C2H2	459	481	5.99e-4	SMART
ZnF_C2H2	487	509	1.22e-4	SMART
ZnF_C2H2	515	537	1.82e-3	SMART
ZnF_C2H2	543	565	2.53e-2	SMART
ZnF_C2H2	571	593	9.73e-4	SMART
ZnF_C2H2	599	619	3.13e1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209614

Predicted Effect

probably benign
Transcript: ENSMUST00000209622

Predicted Effect

probably damaging
Transcript: ENSMUST00000210325
AA Change: H318Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211338

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219748

Coding Region Coverage

1x: 99.1%
3x: 98.2%
10x: 95.8%
20x: 90.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610010F05Rik	T	C	11: 23,589,971	K48E	probably damaging	Het
4931408C20Rik	T	C	1: 26,685,869	T77A	probably benign	Het
Adam18	T	G	8: 24,647,783		probably null	Het
Adgb	A	T	10: 10,442,665	Y138*	probably null	Het
Adra1d	T	C	2: 131,546,172	R488G	possibly damaging	Het
Ahnak	G	A	19: 9,002,375	G341E	probably damaging	Het
Ankmy1	T	C	1: 92,881,116	D690G	probably damaging	Het
Arhgef38	C	T	3: 133,132,464	E21K	probably damaging	Het
Atp8b2	T	C	3: 89,949,848	M402V	probably damaging	Het
Atp8b4	G	T	2: 126,325,394	H1062N	probably benign	Het
Bdnf	A	G	2: 109,723,794	H131R	probably damaging	Het
Cblb	C	T	16: 52,135,829	T265M	probably damaging	Het
Cenpe	T	A	3: 135,239,758	M1011K	probably benign	Het
Clca2	A	T	3: 145,075,649	Y711*	probably null	Het
Clca4a	A	G	3: 144,952,929	Y842H	probably benign	Het
Clspn	T	A	4: 126,581,517	M1021K	probably benign	Het
Cpne8	G	T	15: 90,619,642	R107S	probably damaging	Het
D6Ertd527e	C	G	6: 87,111,524	T223S	unknown	Het
Dna2	C	T	10: 62,949,187	R28W	probably benign	Het
Dnah5	T	A	15: 28,409,177	N3580K	probably damaging	Het
Dsp	T	C	13: 38,175,147	I298T	probably damaging	Het
Dync2h1	T	C	9: 7,157,553	K858R	probably null	Het
Fasn	A	T	11: 120,813,249	V1448E	possibly damaging	Het
Ghdc	A	G	11: 100,768,505	I322T	probably benign	Het
Gins2	T	C	8: 120,582,200	D105G	probably damaging	Het
Insr	A	T	8: 3,165,576	D975E	probably benign	Het
Klrc3	T	C	6: 129,639,547	D169G	probably benign	Het
Krt76	T	A	15: 101,885,008	S532C	unknown	Het
Lamp3	A	T	16: 19,673,525	M323K	probably damaging	Het
Lgmn	T	C	12: 102,394,609	I423M	possibly damaging	Het
Lpgat1	A	T	1: 191,776,426	T359S	possibly damaging	Het
Lrguk	T	A	6: 34,086,438	I466N	probably damaging	Het
Magi3	A	C	3: 104,089,527	M234R	probably benign	Het
Myh14	G	A	7: 44,611,698	R1042*	probably null	Het
Nfia	T	G	4: 98,111,224	Y378D	possibly damaging	Het
Npffr1	T	A	10: 61,626,233	S383T	possibly damaging	Het
Olfr1308	C	A	2: 111,960,240	V278F	probably benign	Het
Olfr1410	T	C	1: 92,607,954	L39P	probably damaging	Het
Olfr1466	C	A	19: 13,342,175	P139Q	probably benign	Het
Olfr658	T	A	7: 104,644,770	I199F	probably benign	Het
Osr1	G	A	12: 9,579,798		probably null	Het
Pde4b	A	C	4: 102,597,699	R375S	probably damaging	Het
Pde8a	A	G	7: 81,292,263	E150G	probably damaging	Het
Pkhd1l1	A	T	15: 44,545,501		probably null	Het
Ppp3ca	A	G	3: 136,928,544	T422A	probably benign	Het
Proser1	T	C	3: 53,477,759	V354A	possibly damaging	Het
Rgs20	G	T	1: 5,020,827	R127S	probably benign	Het
Sec22a	T	C	16: 35,347,628	D171G	probably benign	Het
Secisbp2	A	G	13: 51,673,107	E417G	possibly damaging	Het
Serpinb6b	T	C	13: 32,974,912	L32S	probably damaging	Het
Sf3b1	C	G	1: 55,019,395	E12Q	possibly damaging	Het
Slc39a10	A	T	1: 46,826,215	S487T	probably benign	Het
Slc6a1	G	T	6: 114,307,770	G263V	probably damaging	Het
Spag6	A	G	2: 18,733,114	D265G	probably benign	Het
Sybu	G	T	15: 44,718,832	S132*	probably null	Het
Virma	T	C	4: 11,528,776	S1288P	probably damaging	Het
Vmn1r229	T	A	17: 20,814,805	V104D	probably damaging	Het
Vmn1r238	T	C	18: 3,123,358	T19A	probably benign	Het
Vmn2r86	C	T	10: 130,453,141	V164I	probably benign	Het
Wfdc13	G	T	2: 164,686,934	A64S	probably damaging	Het
Zyg11a	A	G	4: 108,183,646		probably null	Het

Other mutations in Zfp873

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02250:Zfp873	APN	10	82058418	start codon destroyed	probably null	0.45
G1Funyon:Zfp873	UTSW	10	82060879	missense	probably damaging	1.00
R0666:Zfp873	UTSW	10	82060761	missense	possibly damaging	0.75
R1739:Zfp873	UTSW	10	82060707	missense	probably damaging	1.00
R1848:Zfp873	UTSW	10	82060572	missense	probably benign	0.33
R1892:Zfp873	UTSW	10	82061246	missense	probably damaging	1.00
R2061:Zfp873	UTSW	10	82060157	missense	probably benign	0.01
R3735:Zfp873	UTSW	10	82061181	missense	probably benign	0.15
R4422:Zfp873	UTSW	10	82060874	missense	probably benign	0.13
R4674:Zfp873	UTSW	10	82059980	missense	possibly damaging	0.53
R4839:Zfp873	UTSW	10	82060519	missense	probably damaging	0.98
R5146:Zfp873	UTSW	10	82060224	missense	probably damaging	1.00
R5154:Zfp873	UTSW	10	82060191	missense	possibly damaging	0.54
R5160:Zfp873	UTSW	10	82061042	missense	possibly damaging	0.54
R5811:Zfp873	UTSW	10	82060733	missense	probably damaging	1.00
R6625:Zfp873	UTSW	10	82060304	missense	probably damaging	1.00
R6667:Zfp873	UTSW	10	82060589	missense	probably benign	0.22
R6742:Zfp873	UTSW	10	82058422	missense	probably damaging	1.00
R6878:Zfp873	UTSW	10	82060695	missense	probably benign	0.33
R7055:Zfp873	UTSW	10	82059998	missense	probably damaging	1.00
R7296:Zfp873	UTSW	10	82061237	missense	probably damaging	1.00
R7381:Zfp873	UTSW	10	82060971	missense	probably damaging	1.00
R7448:Zfp873	UTSW	10	82060627	missense	probably damaging	1.00
R7464:Zfp873	UTSW	10	82060376	missense	possibly damaging	0.51
R7470:Zfp873	UTSW	10	82059939	missense	probably benign	0.19
R7640:Zfp873	UTSW	10	82060275	missense	possibly damaging	0.72
R7862:Zfp873	UTSW	10	82060275	missense	probably benign	0.03
R8017:Zfp873	UTSW	10	82060359	missense	probably benign	0.01
R8301:Zfp873	UTSW	10	82060879	missense	probably damaging	1.00
R8765:Zfp873	UTSW	10	82060238	missense	probably damaging	1.00
R8997:Zfp873	UTSW	10	82061156	missense	probably benign	0.03
R9305:Zfp873	UTSW	10	82060680	missense	probably benign	0.00
R9462:Zfp873	UTSW	10	82061297	missense	probably benign	0.31
Z1177:Zfp873	UTSW	10	82061165	missense	probably damaging	1.00

Predicted Primers

Posted On

2014-04-24