Incidental Mutation 'R1568:Vmn2r86'
ID 175431
Institutional Source Beutler Lab
Gene Symbol Vmn2r86
Ensembl Gene ENSMUSG00000092162
Gene Name vomeronasal 2, receptor 86
Synonyms EG625109
MMRRC Submission 039607-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R1568 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 130282068-130291763 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 130289010 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 164 (V164I)
Ref Sequence ENSEMBL: ENSMUSP00000126596 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170257]
AlphaFold G5E8Y4
Predicted Effect probably benign
Transcript: ENSMUST00000170257
AA Change: V164I

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000126596
Gene: ENSMUSG00000092162
AA Change: V164I

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 77 425 1.1e-25 PFAM
Pfam:NCD3G 508 562 2.4e-19 PFAM
Pfam:7tm_3 595 829 6.4e-55 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.8%
  • 20x: 90.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam18 T G 8: 25,137,799 (GRCm39) probably null Het
Adgb A T 10: 10,318,409 (GRCm39) Y138* probably null Het
Adra1d T C 2: 131,388,092 (GRCm39) R488G possibly damaging Het
Ahnak G A 19: 8,979,739 (GRCm39) G341E probably damaging Het
Ankmy1 T C 1: 92,808,838 (GRCm39) D690G probably damaging Het
Arhgef38 C T 3: 132,838,225 (GRCm39) E21K probably damaging Het
Atp8b2 T C 3: 89,857,155 (GRCm39) M402V probably damaging Het
Atp8b4 G T 2: 126,167,314 (GRCm39) H1062N probably benign Het
Bdnf A G 2: 109,554,139 (GRCm39) H131R probably damaging Het
Cblb C T 16: 51,956,192 (GRCm39) T265M probably damaging Het
Cenpe T A 3: 134,945,519 (GRCm39) M1011K probably benign Het
Clca3a2 A T 3: 144,781,410 (GRCm39) Y711* probably null Het
Clca4a A G 3: 144,658,690 (GRCm39) Y842H probably benign Het
Clspn T A 4: 126,475,310 (GRCm39) M1021K probably benign Het
Cpne8 G T 15: 90,503,845 (GRCm39) R107S probably damaging Het
D6Ertd527e C G 6: 87,088,506 (GRCm39) T223S unknown Het
Dna2 C T 10: 62,784,966 (GRCm39) R28W probably benign Het
Dnah5 T A 15: 28,409,323 (GRCm39) N3580K probably damaging Het
Dsp T C 13: 38,359,123 (GRCm39) I298T probably damaging Het
Dync2h1 T C 9: 7,157,553 (GRCm39) K858R probably null Het
Fasn A T 11: 120,704,075 (GRCm39) V1448E possibly damaging Het
Ghdc A G 11: 100,659,331 (GRCm39) I322T probably benign Het
Gins2 T C 8: 121,308,939 (GRCm39) D105G probably damaging Het
Insr A T 8: 3,215,576 (GRCm39) D975E probably benign Het
Klrc3 T C 6: 129,616,510 (GRCm39) D169G probably benign Het
Krt76 T A 15: 101,793,443 (GRCm39) S532C unknown Het
Lamp3 A T 16: 19,492,275 (GRCm39) M323K probably damaging Het
Lgmn T C 12: 102,360,868 (GRCm39) I423M possibly damaging Het
Lpgat1 A T 1: 191,508,538 (GRCm39) T359S possibly damaging Het
Lrguk T A 6: 34,063,373 (GRCm39) I466N probably damaging Het
Magi3 A C 3: 103,996,843 (GRCm39) M234R probably benign Het
Myh14 G A 7: 44,261,122 (GRCm39) R1042* probably null Het
Nfia T G 4: 97,999,461 (GRCm39) Y378D possibly damaging Het
Npffr1 T A 10: 61,462,012 (GRCm39) S383T possibly damaging Het
Or4f57 C A 2: 111,790,585 (GRCm39) V278F probably benign Het
Or52n4 T A 7: 104,293,977 (GRCm39) I199F probably benign Het
Or5b112 C A 19: 13,319,539 (GRCm39) P139Q probably benign Het
Or9s14 T C 1: 92,535,676 (GRCm39) L39P probably damaging Het
Osr1 G A 12: 9,629,798 (GRCm39) probably null Het
Pde4b A C 4: 102,454,896 (GRCm39) R375S probably damaging Het
Pde8a A G 7: 80,942,011 (GRCm39) E150G probably damaging Het
Pkhd1l1 A T 15: 44,408,897 (GRCm39) probably null Het
Ppp3ca A G 3: 136,634,305 (GRCm39) T422A probably benign Het
Proser1 T C 3: 53,385,180 (GRCm39) V354A possibly damaging Het
Rgs20 G T 1: 5,091,050 (GRCm39) R127S probably benign Het
Sanbr T C 11: 23,539,971 (GRCm39) K48E probably damaging Het
Sec22a T C 16: 35,167,998 (GRCm39) D171G probably benign Het
Secisbp2 A G 13: 51,827,143 (GRCm39) E417G possibly damaging Het
Serpinb6b T C 13: 33,158,895 (GRCm39) L32S probably damaging Het
Sf3b1 C G 1: 55,058,554 (GRCm39) E12Q possibly damaging Het
Slc39a10 A T 1: 46,865,375 (GRCm39) S487T probably benign Het
Slc6a1 G T 6: 114,284,731 (GRCm39) G263V probably damaging Het
Spag6 A G 2: 18,737,925 (GRCm39) D265G probably benign Het
Spata31e2 T C 1: 26,724,950 (GRCm39) T77A probably benign Het
Sybu G T 15: 44,582,228 (GRCm39) S132* probably null Het
Virma T C 4: 11,528,776 (GRCm39) S1288P probably damaging Het
Vmn1r229 T A 17: 21,035,067 (GRCm39) V104D probably damaging Het
Vmn1r238 T C 18: 3,123,358 (GRCm39) T19A probably benign Het
Wfdc13 G T 2: 164,528,854 (GRCm39) A64S probably damaging Het
Zfp873 C A 10: 81,896,113 (GRCm39) H318Q probably damaging Het
Zyg11a A G 4: 108,040,843 (GRCm39) probably null Het
Other mutations in Vmn2r86
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01295:Vmn2r86 APN 10 130,288,895 (GRCm39) missense probably damaging 0.99
IGL01328:Vmn2r86 APN 10 130,288,365 (GRCm39) missense possibly damaging 0.78
IGL01377:Vmn2r86 APN 10 130,288,855 (GRCm39) missense probably damaging 0.99
IGL01548:Vmn2r86 APN 10 130,282,151 (GRCm39) missense probably benign 0.22
IGL01804:Vmn2r86 APN 10 130,288,858 (GRCm39) missense probably damaging 0.99
IGL01921:Vmn2r86 APN 10 130,291,610 (GRCm39) missense probably benign 0.00
IGL02406:Vmn2r86 APN 10 130,284,508 (GRCm39) missense possibly damaging 0.81
IGL02625:Vmn2r86 APN 10 130,288,781 (GRCm39) missense probably damaging 1.00
IGL02960:Vmn2r86 APN 10 130,289,636 (GRCm39) missense possibly damaging 0.74
IGL03104:Vmn2r86 APN 10 130,282,501 (GRCm39) missense probably damaging 1.00
R0408:Vmn2r86 UTSW 10 130,282,723 (GRCm39) missense probably damaging 1.00
R0437:Vmn2r86 UTSW 10 130,282,412 (GRCm39) missense probably damaging 1.00
R0577:Vmn2r86 UTSW 10 130,288,444 (GRCm39) missense probably benign 0.04
R0726:Vmn2r86 UTSW 10 130,282,265 (GRCm39) missense probably damaging 1.00
R0811:Vmn2r86 UTSW 10 130,289,497 (GRCm39) missense probably benign 0.00
R0812:Vmn2r86 UTSW 10 130,289,497 (GRCm39) missense probably benign 0.00
R1055:Vmn2r86 UTSW 10 130,282,226 (GRCm39) missense probably damaging 1.00
R1066:Vmn2r86 UTSW 10 130,282,145 (GRCm39) missense probably benign 0.01
R1199:Vmn2r86 UTSW 10 130,284,443 (GRCm39) splice site probably benign
R1332:Vmn2r86 UTSW 10 130,282,739 (GRCm39) missense probably damaging 1.00
R1866:Vmn2r86 UTSW 10 130,282,255 (GRCm39) missense probably damaging 1.00
R1897:Vmn2r86 UTSW 10 130,288,314 (GRCm39) missense probably damaging 1.00
R2017:Vmn2r86 UTSW 10 130,282,582 (GRCm39) missense probably benign 0.39
R3162:Vmn2r86 UTSW 10 130,291,673 (GRCm39) missense probably damaging 0.99
R3162:Vmn2r86 UTSW 10 130,291,673 (GRCm39) missense probably damaging 0.99
R3858:Vmn2r86 UTSW 10 130,291,594 (GRCm39) missense probably benign
R4049:Vmn2r86 UTSW 10 130,282,966 (GRCm39) missense probably damaging 0.98
R4378:Vmn2r86 UTSW 10 130,288,469 (GRCm39) missense possibly damaging 0.67
R4411:Vmn2r86 UTSW 10 130,288,469 (GRCm39) missense possibly damaging 0.67
R4413:Vmn2r86 UTSW 10 130,288,469 (GRCm39) missense possibly damaging 0.67
R4422:Vmn2r86 UTSW 10 130,288,845 (GRCm39) missense possibly damaging 0.87
R4738:Vmn2r86 UTSW 10 130,282,939 (GRCm39) missense probably damaging 0.99
R4767:Vmn2r86 UTSW 10 130,291,606 (GRCm39) missense probably benign 0.00
R4872:Vmn2r86 UTSW 10 130,289,460 (GRCm39) missense probably damaging 0.98
R4880:Vmn2r86 UTSW 10 130,289,484 (GRCm39) missense probably benign 0.33
R5092:Vmn2r86 UTSW 10 130,282,456 (GRCm39) missense probably damaging 1.00
R5421:Vmn2r86 UTSW 10 130,282,805 (GRCm39) missense probably benign 0.41
R6007:Vmn2r86 UTSW 10 130,289,535 (GRCm39) missense probably damaging 1.00
R6330:Vmn2r86 UTSW 10 130,282,396 (GRCm39) missense probably benign 0.05
R6355:Vmn2r86 UTSW 10 130,291,763 (GRCm39) start codon destroyed probably damaging 0.98
R6397:Vmn2r86 UTSW 10 130,282,131 (GRCm39) nonsense probably null
R6419:Vmn2r86 UTSW 10 130,282,795 (GRCm39) missense probably damaging 1.00
R6933:Vmn2r86 UTSW 10 130,282,126 (GRCm39) missense probably damaging 1.00
R6937:Vmn2r86 UTSW 10 130,284,523 (GRCm39) missense probably damaging 1.00
R6959:Vmn2r86 UTSW 10 130,282,400 (GRCm39) missense probably damaging 1.00
R7010:Vmn2r86 UTSW 10 130,291,726 (GRCm39) missense probably benign
R7549:Vmn2r86 UTSW 10 130,282,697 (GRCm39) missense probably damaging 1.00
R8179:Vmn2r86 UTSW 10 130,288,953 (GRCm39) missense probably benign 0.00
R8257:Vmn2r86 UTSW 10 130,288,279 (GRCm39) missense possibly damaging 0.87
R8286:Vmn2r86 UTSW 10 130,285,855 (GRCm39) missense probably benign 0.03
R8479:Vmn2r86 UTSW 10 130,282,735 (GRCm39) missense probably damaging 1.00
R8805:Vmn2r86 UTSW 10 130,282,396 (GRCm39) missense probably benign 0.05
R8960:Vmn2r86 UTSW 10 130,289,672 (GRCm39) missense probably benign 0.27
R9021:Vmn2r86 UTSW 10 130,282,934 (GRCm39) missense probably damaging 1.00
R9120:Vmn2r86 UTSW 10 130,289,677 (GRCm39) missense probably benign 0.00
R9137:Vmn2r86 UTSW 10 130,282,409 (GRCm39) missense probably damaging 1.00
R9311:Vmn2r86 UTSW 10 130,288,440 (GRCm39) missense probably damaging 1.00
R9312:Vmn2r86 UTSW 10 130,288,406 (GRCm39) missense probably benign 0.02
R9433:Vmn2r86 UTSW 10 130,282,567 (GRCm39) missense possibly damaging 0.88
R9696:Vmn2r86 UTSW 10 130,285,702 (GRCm39) missense possibly damaging 0.49
Predicted Primers PCR Primer
(F):5'- GAAGCTGAATACCCTGGTCATCATCTG -3'
(R):5'- CTGGCAATTGATTCTTGGACACCAAC -3'

Sequencing Primer
(F):5'- TCATCATCTGAGATGACCAGTC -3'
(R):5'- cacacacacacacacacag -3'
Posted On 2014-04-24